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Guoping Li, Ph.D.

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Biography
Tongji University, Shanghai, ChinaPhD06/2017Pluripotent Stem Cells and Embryonic Development
2019 - 2020
AHA postdoc fellowship
2021
The Young Investigator Award - First Place

Overview
I am interested in 1. the regulation and roles of cellular and extracellular tRNA-derived small RNAs (tDRs) in a variety of human diseases, including cardiovascular diseases and neurodegenerative diseases; 2. engineering extracellular vesicles (EVs) as drug delivery vehicles or therapeutics.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35HL150807 (DAS, SAUMYA) Jun 1, 2020 - May 31, 2027
    NIH
    Functional role and therapeutic targeting of exosomes and extracellular RNA biomarkers in heart failure
    Role: Co-Investigator
  2. 19POST34381027 (Guoping Li) Jan 1, 2019 - Dec 31, 2020
    AHA
    The role and regulation of tRNA-derived fragments in myocardial ischemia/reperfusion injury
    Role Description: The goal of this grant is to create a comprehensive expression profile of tRNA-derived fragments in primary cardiomyocytes and fibroblasts under three crucial ischemia/reperfusion-related perturbations, including nutrient deprivation, hypoxia, and oxidative stress.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li G, Das S. Making a sPLAsh: The expanding repertoire of EV signaling. Cell Metab. 2022 04 05; 34(4):508-510. PMID: 35385702.
    Citations:    Fields:    Translation:HumansCells
  2. Li G, Manning AC, Bagi A, Yang X, Gokulnath P, Spanos M, Howard J, Chan PP, Sweeney T, Kitchen R, Li H, Laurent BD, Aranki SF, Kontaridis MI, Laurent LC, Van Keuren-Jensen K, Muehlschlegel J, Lowe TM, Das S. Distinct Stress-Dependent Signatures of Cellular and Extracellular tRNA-Derived Small RNAs. Adv Sci (Weinh). 2022 06; 9(17):e2200829. PMID: 35373532; PMCID: PMC9189662.
    Citations: 1     Fields:    Translation:HumansCells
  3. Li H, Trager LE, Liu X, Hastings MH, Xiao C, Guerra J, To S, Li G, Yeri A, Rodosthenous R, Silverman MG, Das S, Ambardekar AV, Bristow MR, González-Rosa JM, Rosenzweig A. lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth. Circulation. 2022 04 19; 145(16):1218-1233. PMID: 35114812; PMCID: PMC9056949.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  4. Cherbonneau F, Li G, Gokulnath P, Sahu P, Prunevieille A, Kitchen R, Benichou G, Larghero J, Domian I, Das S. TRACE-seq: A transgenic system for unbiased and non-invasive transcriptome profiling of living cells. iScience. 2022 Feb 18; 25(2):103806. PMID: 35198871; PMCID: PMC8844816.
    Citations:    
  5. Valkov N, Das A, Tucker NR, Li G, Salvador AM, Chaffin MD, Pereira De Oliveira Junior G, Kur I, Gokulnath P, Ziegler O, Yeri A, Lu S, Khamesra A, Xiao C, Rodosthenous R, Srinivasan S, Toxavidis V, Tigges J, Laurent LC, Momma S, Kitchen R, Ellinor P, Ghiran I, Das S. SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart. Life Sci Alliance. 2021 12; 4(12). PMID: 34663679; PMCID: PMC8548207.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Yang X, Li G, Guan M, Bapat A, Dai Q, Zhong C, Yang T, Luo C, An N, Liu W, Yang F, Pan H, Wang P, Gao Y, Gong Y, Das S, Shang H, Xing Y. Potential Gene Association Studies of Chemotherapy-Induced Cardiotoxicity: A Systematic Review and Meta-Analysis. Front Cardiovasc Med. 2021; 8:651269. PMID: 34150864.
    Citations: 3     
  7. Li M, Li G, Kiyokawa J, Tirmizi Z, Richardson LG, Ning J, Das S, Martuza RL, Stemmer-Rachamimov A, Rabkin SD, Wakimoto H. Characterization and oncolytic virus targeting of FAP-expressing tumor-associated pericytes in glioblastoma. Acta Neuropathol Commun. 2020 12 11; 8(1):221. PMID: 33308315.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  8. Li J, Salvador AM, Li G, Valkov N, Ziegler O, Yeri A, Yang Xiao C, Meechoovet B, Alsop E, Rodosthenous RS, Kundu P, Huan T, Levy D, Tigges J, Pico AR, Ghiran I, Silverman MG, Meng X, Kitchen R, Xu J, Van Keuren-Jensen K, Shah R, Xiao J, Das S. Mir-30d Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling. Circ Res. 2021 01 08; 128(1):e1-e23. PMID: 33092465; PMCID: PMC7790887.
    Citations: 24     Fields:    Translation:AnimalsCells
  9. Yang X, Li G, Yang T, Guan M, An N, Yang F, Dai Q, Zhong C, Luo C, Gao Y, Das S, Xing Y, Shang H. Possible Susceptibility Genes for Intervention against Chemotherapy-Induced Cardiotoxicity. Oxid Med Cell Longev. 2020; 2020:4894625. PMID: 33110473.
    Citations: 5     Fields:    Translation:Humans
  10. Bai M, Ye D, Guo X, Xi J, Liu N, Wu Y, Jia W, Wang G, Chen W, Li G, Jiapaer Z, Kang J. Critical regulation of a NDIME/MEF2C axis in embryonic stem cell neural differentiation and autism. EMBO Rep. 2020 11 05; 21(11):e50283. PMID: 33016573.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Wang H, Xie Y, Salvador AM, Zhang Z, Chen K, Li G, Xiao J. Exosomes: Multifaceted Messengers in Atherosclerosis. Curr Atheroscler Rep. 2020 08 09; 22(10):57. PMID: 32772195.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  12. Zhao C, Li G, Li J. Non-coding RNAs and Cardiac Aging. Adv Exp Med Biol. 2020; 1229:247-258. PMID: 32285416.
    Citations: 3     Fields:    Translation:Humans
  13. Jiapaer Z, Li G, Ye D, Bai M, Li J, Guo X, Du Y, Su D, Jia W, Chen W, Wang G, Yu Y, Zhu F, Wan X, Kang J. LincU Preserves Naïve Pluripotency by Restricting ERK Activity in Embryonic Stem Cells. Stem Cell Reports. 2018 08 14; 11(2):395-409. PMID: 30017820.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  14. Yang D, Qiao J, Wang G, Lan Y, Li G, Guo X, Xi J, Ye D, Zhu S, Chen W, Jia W, Leng Y, Wan X, Kang J. N6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential. Nucleic Acids Res. 2018 05 04; 46(8):3906-3920. PMID: 29529255.
    Citations: 105     Fields:    Translation:AnimalsCells
  15. Weng R, Lu C, Liu X, Li G, Lan Y, Qiao J, Bai M, Wang Z, Guo X, Ye D, Jiapaer Z, Yang Y, Xia C, Wang G, Kang J. Long Noncoding RNA-1604 Orchestrates Neural Differentiation through the miR-200c/ZEB Axis. Stem Cells. 2018 03; 36(3):325-336. PMID: 29205638.
    Citations: 18     Fields:    Translation:AnimalsCells
  16. Xi J, Wu Y, Li G, Ma L, Feng K, Guo X, Jia W, Wang G, Yang G, Li P, Kang J. Mir-29b Mediates the Neural Tube versus Neural Crest Fate Decision during Embryonic Stem Cell Neural Differentiation. Stem Cell Reports. 2017 08 08; 9(2):571-586. PMID: 28757169; PMCID: PMC5550033.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  17. Li G, Jiapaer Z, Weng R, Hui Y, Jia W, Xi J, Wang G, Zhu S, Zhang X, Feng D, Liu L, Zhang X, Kang J. Dysregulation of the SIRT1/OCT6 Axis Contributes to Environmental Stress-Induced Neural Induction Defects. Stem Cell Reports. 2017 05 09; 8(5):1270-1286. PMID: 28434941.
    Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  18. Wang C, Li G, Wu Y, Xi J, Kang J. LincRNA1230 inhibits the differentiation of mouse ES cells towards neural progenitors. Sci China Life Sci. 2016 May; 59(5):443-54. PMID: 26920680.
    Citations: 7     Fields:    Translation:AnimalsCells
  19. Liu Q, Wang G, Chen Y, Li G, Yang D, Kang J. A miR-590/Acvr2a/Rad51b axis regulates DNA damage repair during mESC proliferation. Stem Cell Reports. 2014 Dec 09; 3(6):1103-17. PMID: 25458897; PMCID: PMC4264031.
    Citations: 17     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.