Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Songjie Cai, Ph.D., M.D.

Profile Picture

Osaka University Graduate School of Medicine, JapanPhD3/2016Transplant and Immunology
Shanghai Jiao Tong University School of Medicine, ChinaMD6/2005Clinical Medicine
Shanghai East Hospital Affiliated to Tongji University, ChinaResident10/2010General Surgery
Osaka University Graduate School of Medicine, JapanAssistant Professor4/2017Transplant and Immunology
Mentee/Mentor Awards of 13th TTS Basic Science Symposium
Mentee/Mentor Awards of 26th International Congress of TTS
Young Innovator Award of AST Cutting Edge of Transplantation 2017
Young Investigator Award for the American Transplant Congress (ATC) 2019

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 16H07467 (Songjie Cai) Oct 3, 2016 - Apr 3, 2017
    Japan Society for the Promotion of science (JSPS)
    Uptake of 5-aminolevulinic acid and excretion of protoporphurin IX in human induced pluripotent stem cells
    Role: PI

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Borges TJ, Murakami N, Lape IT, Gassen RB, Liu K, Cai S, Daccache J, Safa K, Shimizu T, Ohori S, Paterson AM, Cravedi P, Azzi J, Sage PT, Sharpe AH, Li XC, Riella LV. Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via ICOS-dependent mechanisms. JCI Insight. 2021 12 22; 6(24). PMID: 34752418.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Xu S, Liu Y, Hu R, Wang M, Stöhr O, Xiong Y, Chen L, Kang H, Zheng L, Cai S, He L, Wang C, Copps KD, White MF, Miao J. TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states. Elife. 2021 10 08; 10. PMID: 34622775.
    Citations:    Fields:    Translation:AnimalsCells
  3. Eskandari SK, Sulkaj I, Melo MB, Li N, Allos H, Alhaddad JB, Kollar B, Borges TJ, Eskandari AS, Zinter MA, Cai S, Assaker JP, Choi JY, Al Dulaijan BS, Mansouri A, Haik Y, Tannous BA, van Son WJ, Leuvenink HGD, Pomahac B, Riella LV, Tang L, Seelen MAJ, Irvine DJ, Azzi JR. Regulatory T cells engineered with TCR signaling-responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter. Sci Transl Med. 2020 11 11; 12(569). PMID: 33177180.
    Citations: 2     Fields:    Translation:AnimalsCells
  4. Cai S, Choi JY, Borges TJ, Zhang H, Miao J, Ichimura T, Li X, Xu S, Chu P, Eskandari SK, Allos H, Alhaddad JB, Muhsin SA, Yatim K, Riella LV, Sage PT, Chandraker AK, Azzi JR. Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo. Sci Rep. 2020 08 28; 10(1):14249. PMID: 32859934.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Zavidij O, Haradhvala NJ, Mouhieddine TH, Sklavenitis-Pistofidis R, Cai S, Reidy M, Rahmat M, Flaifel A, Ferland B, Su NK, Agius MP, Park J, Manier S, Bustoros M, Huynh D, Capelletti M, Berrios B, Liu CJ, He MX, Braggio E, Fonseca R, Maruvka Y, Guerriero JL, Goldman M, van Allen E, McCarroll SA, Azzi J, Getz G, Ghobrial IM. Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma. Nat Cancer. 2020 05; 1(5):493-506. PMID: 33409501.
    Citations: 45     
  6. Wang S, Cai S, Zhang W, Liu X, Li Y, Zhang C, Zeng Y, Xu M, Rong R, Yang T, Shi B, Chandraker A, Yang C, Zhu T. High-mobility group box 1 protein antagonizes the immunosuppressive capacity and therapeutic effect of mesenchymal stem cells in acute kidney injury. J Transl Med. 2020 04 20; 18(1):175. PMID: 32312307.
    Citations: 3     Fields:    Translation:AnimalsCells
  7. Choi JY, Eskandari SK, Cai S, Sulkaj I, Assaker JP, Allos H, AlHaddad J, Muhsin SA, Alhussain E, Mansouri A, Yeung MY, Seelen MAJ, Kim HJ, Cantor H, Azzi JR. Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts. Proc Natl Acad Sci U S A. 2020 03 17; 117(11):6042-6046. PMID: 32111690.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Magee CN, Murakami N, Borges TJ, Shimizu T, Safa K, Ohori S, Cai S, Uffing A, Azzi J, Elyaman W, Charbonnier LM, Liu K, Toprak D, Visner G, Chatila TA, Siebel CW, Najafian N, Riella LV. Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms. Circulation. 2019 09 09; 140(10):846-863. PMID: 31266349.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  9. Cai S, Zhao J, Ueno T, Chandraker A. Potential Roles of Siglecs in the Regulation of Allo-Immune Reaction. Curr Protein Pept Sci. 2019; 20(8):823-828. PMID: 31060487.
    Citations:    Fields:    Translation:HumansAnimalsCells
  10. Cai S, Chandraker A. Cell Therapy in Solid Organ Transplantation. Curr Gene Ther. 2019; 19(2):71-80. PMID: 31161989.
    Citations: 2     Fields:    Translation:HumansCells
  11. Wang Y, Zenkoh J, Gerelchuluun A, Sun L, Cai S, Li X, Tsuboi K. Administration of Dendritic Cells and Anti-PD-1 Antibody Converts X-ray Irradiated Tumors Into Effective In situ Vaccines. Int J Radiat Oncol Biol Phys. 2019 03 15; 103(4):958-969. PMID: 30458232.
    Citations: 2     Fields:    Translation:AnimalsCells
  12. Cai S, Hou J, Fujino M, Zhang Q, Ichimaru N, Takahara S, Araki R, Lu L, Chen JM, Zhuang J, Zhu P, Li XK. iPSC-Derived Regulatory Dendritic Cells Inhibit Allograft Rejection by Generating Alloantigen-Specific Regulatory T Cells. Stem Cell Reports. 2017 05 09; 8(5):1174-1189. PMID: 28434942.
    Citations: 16     Fields:    Translation:AnimalsCells
  13. Cai S, Ichimaru N, Takahara S. How Do Dendritic Cells Play the Role in Ischemia/Reperfusion Triggered Kidney Allograft Rejection. Curr Gene Ther. 2017; 17(6):400-404. PMID: 29446738.
    Citations:    Fields:    Translation:HumansAnimalsCells
  14. Fujino M, Zhu P, Cai S, Nishio Y, Zhuang J, Li XK. MicroRNAs Involved in Acute Rejection and Tolerance in Murine Cardiac Allografts. Exp Clin Transplant. 2016 Aug; 14(4):424-30. PMID: 27227980.
    Citations: 2     Fields:    Translation:Animals
  15. Cai S, Ichimaru N, Zhao M, Fujino M, Ito H, Ota U, Nakajima M, Tanaka T, Nonomura N, Li XK, Takahara S. Prolonged Mouse Cardiac Graft Cold Storage via Attenuating Ischemia-Reperfusion Injury Using a New Antioxidant-Based Preservation Solution. Transplantation. 2016 05; 100(5):1032-40. PMID: 26845308.
    Citations: 7     Fields:    Translation:AnimalsCells
  16. Nishio Y, Fujino M, Cai S, Kitajima Y, Saito T, Tsumura H, Ito M, Ito Y, Nagahara Y, Li XK. Impaired CD98 signaling protects against graft-versus-host disease by increasing regulatory T cells. Transpl Immunol. 2016 Mar; 35:34-9. PMID: 26836475.
    Citations: 4     Fields:    Translation:AnimalsCells
  17. Hou J, Fujino M, Cai S, Ding Q, Li XK. Noninvasive Monitoring and Evaluation of the Renal Structure and Function in a Mouse Model of Unilateral Ureteral Occlusion Using Microcomputed Tomography. Int Surg. 2015 Jul; 100(7-8):1237-43. PMID: 26595500.
    Citations: 1     Fields:    Translation:Animals
  18. Hou J, Fujino M, Cai S, Ding Q, Li XK. Noninvasive monitoring of mouse renal allograft rejection using micro-CT. Ann Surg Treat Res. 2015 May; 88(5):276-80. PMID: 25960991.
    Citations: 1     
  19. Shigeta T, Sakamoto S, Li XK, Cai S, Liu C, Kurokawa R, Nakazawa A, Kasahara M, Uemoto S. Luminal injection of hydrogen-rich solution attenuates intestinal ischemia-reperfusion injury in rats. Transplantation. 2015 Mar; 99(3):500-7. PMID: 25539463.
    Citations: 20     Fields:    Translation:Animals
  20. Zhang Q, Ichimaru N, Higuchi S, Cai S, Hou J, Fujino M, Nonomura N, Kobayashi M, Ando H, Uno A, Sakurai K, Mochizuki S, Adachi Y, Ohno N, Zou H, Xu J, Li XK, Takahara S. Permanent acceptance of mouse cardiac allografts with CD40 siRNA to induce regulatory myeloid cells by use of a novel polysaccharide siRNA delivery system. Gene Ther. 2015 Mar; 22(3):217-26. PMID: 25567536.
    Citations: 3     Fields:    Translation:AnimalsCells
  21. Hou J, Zhang Q, Fujino M, Cai S, Ito H, Takahashi K, Abe F, Nakajima M, Tanaka T, Xu J, Zou H, Ding Q, Li XK. 5-Aminolevulinic acid with ferrous iron induces permanent cardiac allograft acceptance in mice via induction of regulatory cells. J Heart Lung Transplant. 2015 Feb; 34(2):254-63. PMID: 25455753.
    Citations: 8     Fields:    Translation:AnimalsCells
  22. Zhang Q, Fujino M, Iwasaki S, Hirano H, Cai S, Kitajima Y, Xu J, Li XK. Generation and characterization of regulatory dendritic cells derived from murine induced pluripotent stem cells. Sci Rep. 2014 Feb 05; 4:3979. PMID: 24496181.
    Citations: 11     Fields:    Translation:AnimalsCells
  23. Hou J, Cai S, Kitajima Y, Fujino M, Ito H, Takahashi K, Abe F, Tanaka T, Ding Q, Li XK. 5-Aminolevulinic acid combined with ferrous iron induces carbon monoxide generation in mouse kidneys and protects from renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2013 Oct 15; 305(8):F1149-57. PMID: 23904222.
    Citations: 14     Fields:    Translation:Animals
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Cai's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (138)
Co-Authors (33)
Similar People (60)
Same Department 
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.