Harvard Catalyst Profiles

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Leon Leanse, Ph.D.

Title
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Department
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Biography
London school of Hygiene and Tropical Medicine, U.KMSc09/2013Medical Microbiology
Imperial College London, U.KPhD08/2017Molecular Microbiology
2018 - 2019
ASLMS Research Grant
2020 - 2021
ASLMS Research Grant
2021 - 2022
Bullock Postdoctoral Fellowship

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. Bullock fellowship (Leon G Leanse) Feb 15, 2021 - Feb 14, 2022
    MGH
    Reversing antibiotic resistance phenotypes with the ‘flick of a switch’
    Role: Principal investigator
  2. BS.01.20 (Leon G Leanse) Aug 4, 2020 - Aug 3, 2021
    American Society for laser medicine and surgery
    Blue light makes antibiotics great again!
    Role: Principal investigator
  3. BS.01.18 (Leon G Leanse) Jan 7, 2018 - May 31, 2020
    American Society for Laser Medicine and Surgery
    Synergistic action of antimicrobial blue light and quinine for the inactivation of multidrug-resistant bacterial infections
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Leanse LG, Dos Anjos C, Wang Y, Murray CK, Hooper DC, Dai T. Effective Treatment of Cutaneous Mold Infections by Antimicrobial Blue Light That Is Potentiated by Quinine. J Infect Dis. 2021 Sep 17; 224(6):1069-1076. PMID: 33528496.
    Citations:    Fields:    
  2. He S, Leanse LG, Feng Y. Artificial intelligence and machine learning assisted drug delivery for effective treatment of infectious diseases. Adv Drug Deliv Rev. 2021 Aug 28; 178:113922. PMID: 34461198.
    Citations:    Fields:    
  3. Leanse, LG, dos Anjos, C, Besegato, JF, Dai, T, Rastelli, ANS. Laser Phys Lett. Shedding UVC light on Covid-19 to protect dentistry staff and patients. 2021; 18(8). View Publication.
  4. Marasini S, Leanse LG, Dai T. Can microorganisms develop resistance against light based anti-infective agents? Adv Drug Deliv Rev. 2021 08; 175:113822. PMID: 34089778.
    Citations:    Fields:    
  5. Leanse LG, Zeng X, Dai T. Potentiated antimicrobial blue light killing of methicillin resistant Staphylococcus aureus by pyocyanin. J Photochem Photobiol B. 2021 Feb; 215:112109. PMID: 33486397.
    Citations:    Fields:    Translation:AnimalsCells
  6. Gao J, Wang S, Dong X, Leanse LG, Dai T, Wang Z. Co-delivery of resolvin D1 and antibiotics with nanovesicles to lungs resolves inflammation and clears bacteria in mice. Commun Biol. 2020 11 16; 3(1):680. PMID: 33199819.
    Citations: 4     Translation:HumansAnimalsCells
  7. Magana M, Pushpanathan M, Santos AL, Leanse L, Fernandez M, Ioannidis A, Giulianotti MA, Apidianakis Y, Bradfute S, Ferguson AL, Cherkasov A, Seleem MN, Pinilla C, de la Fuente-Nunez C, Lazaridis T, Dai T, Houghten RA, Hancock REW, Tegos GP. The value of antimicrobial peptides in the age of resistance. Lancet Infect Dis. 2020 09; 20(9):e216-e230. PMID: 32653070.
    Citations: 65     Fields:    Translation:Cells
  8. Leanse LG, Goh XS, Cheng JX, Hooper DC, Dai T. Dual-wavelength photo-killing of methicillin-resistant Staphylococcus aureus. JCI Insight. 2020 06 04; 5(11). PMID: 32493838.
    Citations: 2     Fields:    Translation:AnimalsCells
  9. Liu X, Chang Q, Ferrer-Espada R, Leanse LG, Goh XS, Wang X, Gelfand JA, Dai T. Photoinactivation of Moraxella catarrhalis Using 405-nm Blue Light: Implications for the Treatment of Otitis Media. Photochem Photobiol. 2020 05; 96(3):611-617. PMID: 32105346.
    Citations: 1     Fields:    Translation:HumansCells
  10. Leanse LG, Dong PT, Goh XS, Lu M, Cheng JX, Hooper DC, Dai T. Quinine Enhances Photo-Inactivation of Gram-Negative Bacteria. J Infect Dis. 2020 02 03; 221(4):618-626. PMID: 31565732.
    Citations: 5     Fields:    Translation:AnimalsCells
  11. Leanse LG, Goh XS, Dai T. Quinine Improves the Fungicidal Effects of Antimicrobial Blue Light: Implications for the Treatment of Cutaneous Candidiasis. Lasers Surg Med. 2020 07; 52(6):569-575. PMID: 31746024.
    Citations: 1     Fields:    
  12. Dong PT, Mohammad H, Hui J, Leanse LG, Li J, Liang L, Dai T, Seleem MN, Cheng JX. Photolysis of Staphyloxanthin in Methicillin-Resistant Staphylococcus aureus Potentiates Killing by Reactive Oxygen Species. Adv Sci (Weinh). 2019 Jun 05; 6(11):1900030. PMID: 31179216.
    Citations: 7     
  13. Leanse LG, Harrington OD, Fang Y, Ahmed I, Goh XS, Dai T. Evaluating the Potential for Resistance Development to Antimicrobial Blue Light (at 405 nm) in Gram-Negative Bacteria: In vitro and in vivo Studies. Front Microbiol. 2018; 9:2403. PMID: 30459719.
    Citations: 11     
  14. Li Y, Li Y, Fernandez Crespo R, Leanse LG, Langford PR, Bossé JT. Characterization of the Actinobacillus pleuropneumoniae SXT-related integrative and conjugative element ICEApl2 and analysis of the encoded FloR protein: hydrophobic residues in transmembrane domains contribute dynamically to florfenicol and chloramphenicol efflux. J Antimicrob Chemother. 2018 Jan 01; 73(1):57-65. PMID: 29029160.
    Citations: 5     Fields:    Translation:AnimalsCells
  15. Bossé JT, Chaudhuri RR, Li Y, Leanse LG, Fernandez Crespo R, Coupland P, Holden MT, Bazzolli DM, Maskell DJ, Tucker AW, Wren BW, Rycroft AN, Langford PR. Complete Genome Sequence of MIDG2331, a Genetically Tractable Serovar 8 Clinical Isolate of Actinobacillus pleuropneumoniae. Genome Announc. 2016 Jan 28; 4(1). PMID: 26823596.
    Citations: 9     
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.