Harvard Catalyst Profiles

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Daniel Robert Dempsey, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K99GM130961 (DEMPSEY, DANIEL R.) Sep 17, 2019 - Aug 31, 2021
    Molecular Mechanisms of PTEN and USP7 Regulation
    Role: Principal Investigator
  2. F32GM120855 (DEMPSEY, DANIEL R.) Aug 16, 2016 - Aug 15, 2018
    Structural and Functional Analysis of the Post-translational Modifications of PTEN and MKP-1
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jiang H, D'Agostino GD, Cole PA, Dempsey DR. Selective protein N-terminal labeling with N-hydroxysuccinimide esters. Methods Enzymol. 2020; 639:333-353. PMID: 32475408.
    Citations:    Fields:    
  2. Henager SH, Henriquez S, Dempsey DR, Cole PA. Analysis of Site-Specific Phosphorylation of PTEN by Using Enzyme-Catalyzed Expressed Protein Ligation. Chembiochem. 2020 01 15; 21(1-2):64-68. PMID: 31206229.
    Citations: 2     Fields:    
  3. Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell. 2018 08 09; 174(4):897-907.e14. PMID: 30078705.
    Citations: 13     Fields:    Translation:HumansCells
  4. Dempsey DR, Jiang H, Kalin JH, Chen Z, Cole PA. Site-Specific Protein Labeling with N-Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms. J Am Chem Soc. 2018 08 01; 140(30):9374-9378. PMID: 30016585.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  5. Dempsey DR, Cole PA. Protein Chemical Approaches to Understanding PTEN Lipid Phosphatase Regulation. Methods Enzymol. 2018; 607:405-422. PMID: 30149868.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Handa S, Dempsey DR, Ramamoorthy D, Cook N, Guida WC, Spradling TJ, White JK, Woodcock HL, Merkler DJ. Mechanistic Studies of 1-Deoxy-D-Xylulose-5-Phosphate Synthase from Deinococcus radiodurans. Biochem Mol Biol J. 2018; 4(1). PMID: 29552677.
    Citations: 2     
  7. Dempsey DR, Nichols DA, Battistini MR, Pemberton O, Ospina SR, Zhang X, Carpenter AM, O'Flynn BG, Leahy JW, Kanwar A, Lewandowski EM, Chen Y, Merkler DJ. Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine. Sci Rep. 2017 10 18; 7(1):13432. PMID: 29044148.
    Citations: 3     Fields:    Translation:AnimalsCells
  8. Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA. A Tunable Brake for HECT Ubiquitin Ligases. Mol Cell. 2017 May 04; 66(3):345-357.e6. PMID: 28475870.
    Citations: 21     Fields:    Translation:HumansCells
  9. Henager SH, Chu N, Chen Z, Bolduc D, Dempsey DR, Hwang Y, Wells J, Cole PA. Enzyme-catalyzed expressed protein ligation. Nat Methods. 2016 Nov; 13(11):925-927. PMID: 27669326.
    Citations: 11     Fields:    Translation:AnimalsCells
  10. Chen Z, Dempsey DR, Thomas SN, Hayward D, Bolduc DM, Cole PA. Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation. J Biol Chem. 2016 Jul 01; 291(27):14160-9. PMID: 27226612.
    Citations: 12     Fields:    Translation:HumansCells
  11. Jeffries KA, Dempsey DR, Farrell EK, Anderson RL, Garbade GJ, Gurina TS, Gruhonjic I, Gunderson CA, Merkler DJ. Glycine N-acyltransferase-like 3 is responsible for long-chain N-acylglycine formation in N18TG2 cells. J Lipid Res. 2016 05; 57(5):781-90. PMID: 27016726.
    Citations: 6     Fields:    Translation:AnimalsCells
  12. Dempsey DR, Carpenter AM, Ospina SR, Merkler DJ. Probing the chemical mechanism and critical regulatory amino acid residues of Drosophila melanogaster arylalkylamine N-acyltransferase like 2. Insect Biochem Mol Biol. 2015 Nov; 66:1-12. PMID: 26476413.
    Citations: 6     Fields:    Translation:AnimalsCells
  13. Taylor MS, Dempsey DR, Hwang Y, Chen Z, Chu N, Boeke JD, Cole PA. Mechanistic analysis of ghrelin-O-acyltransferase using substrate analogs. Bioorg Chem. 2015 Oct; 62:64-73. PMID: 26246082.
    Citations: 4     Fields:    Translation:AnimalsCells
  14. Dempsey DR, Jeffries KA, Handa S, Carpenter AM, Rodriguez-Ospina S, Breydo L, Merkler DJ. Mechanistic and Structural Analysis of a Drosophila melanogaster Enzyme, Arylalkylamine N-Acetyltransferase Like 7, an Enzyme That Catalyzes the Formation of N-Acetylarylalkylamides and N-Acetylhistamine. Biochemistry. 2015 Apr 28; 54(16):2644-58. PMID: 25850002.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  15. Dempsey DR, Jeffries KA, Bond JD, Carpenter AM, Rodriguez-Ospina S, Breydo L, Caswell KK, Merkler DJ. Mechanistic and structural analysis of Drosophila melanogaster arylalkylamine N-acetyltransferases. Biochemistry. 2014 Dec 16; 53(49):7777-93. PMID: 25406072.
    Citations: 14     Fields:    Translation:AnimalsCells
  16. Jeffries KA, Dempsey DR, Behari AL, Anderson RL, Merkler DJ. Drosophila melanogaster as a model system to study long-chain fatty acid amide metabolism. FEBS Lett. 2014 May 02; 588(9):1596-602. PMID: 24650760.
    Citations: 14     Fields:    Translation:Animals
  17. Dempsey DR, Bond JD, Carpenter AM, Rodriguez Ospina S, Merkler DJ. Expression, purification, and characterization of mouse glycine N-acyltransferase in Escherichia coli. Protein Expr Purif. 2014 May; 97:23-8. PMID: 24576660.
    Citations: 6     Fields:    Translation:AnimalsCells
  18. Dempsey DR, Jeffries KA, Anderson RL, Carpenter AM, Rodriquez Opsina S, Merkler DJ. Identification of an arylalkylamine N-acyltransferase from Drosophila melanogaster that catalyzes the formation of long-chain N-acylserotonins. FEBS Lett. 2014 Feb 14; 588(4):594-9. PMID: 24444601.
    Citations: 15     Fields:    Translation:AnimalsCells
  19. Handa S, Spradling TJ, Dempsey DR, Merkler DJ. Production of the catalytic core of human peptidylglycine a-hydroxylating monooxygenase (hPHMcc) in Escherichia coli. Protein Expr Purif. 2012 Jul; 84(1):9-13. PMID: 22554821.
    Citations: 2     Fields:    Translation:HumansCells
  20. Ivkovic M, Dempsey DR, Handa S, Hilton JH, Lowe EW, Merkler DJ. N-acylethanolamines as novel alcohol dehydrogenase 3 substrates. Arch Biochem Biophys. 2011 Feb 15; 506(2):157-64. PMID: 21144815.
    Citations: 3     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.