Harvard Catalyst Profiles

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Kristina Simonyan, Dr.Med., Ph.D., M.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P50DC019900 (SIMONYAN, KRISTINA) Sep 15, 2021 - Aug 31, 2026
    Next-generation clinical phenotyping and pathophysiology of laryngeal dystonia and voice tremor
    Role: Principal Investigator
  2. R01DC019353 (SIMONYAN, KRISTINA) Sep 1, 2021 - Aug 31, 2026
    Adaptive closed-loop brain-computer interface therapeutic intervention in laryngeal dystonia
    Role: Principal Investigator
  3. R01NS088160 (SIMONYAN, KRISTINA) Aug 1, 2015 - May 31, 2021
    Brain Networks in Dystonia
    Role: Principal Investigator
  4. R01DC012545 (SIMONYAN, KRISTINA) Jul 17, 2012 - Aug 31, 2022
    Central mechanisms and treatment response of sodium oxybate in spasmodic dysphonia and voice tremor
    Role: Principal Investigator
  5. R01DC011805 (SIMONYAN, KRISTINA) Mar 19, 2012 - Feb 28, 2022
    Imaging genetics of spasmodic dysphonia
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Valeriani D, Simonyan K. The dynamic connectome of speech control. Philos Trans R Soc Lond B Biol Sci. 2021 10 25; 376(1836):20200256. PMID: 34482717.
    Citations: 1     Fields:    
  2. Jafari A, de Lima Xavier L, Bernstein JD, Simonyan K, Bleier BS. Association of Sinonasal Inflammation With Functional Brain Connectivity. JAMA Otolaryngol Head Neck Surg. 2021 06 01; 147(6):534-543. PMID: 33830194.
    Citations: 1     Fields:    Translation:Humans
  3. Simonyan K, Barkmeier-Kraemer J, Blitzer A, Hallett M, Houde JF, Jacobson Kimberley T, Ozelius LJ, Pitman MJ, Richardson RM, Sharma N, Tanner K. Laryngeal Dystonia: Multidisciplinary Update on Terminology, Pathophysiology, and Research Priorities. Neurology. 2021 05 25; 96(21):989-1001. PMID: 33858994.
    Citations:    Fields:    Translation:Humans
  4. Worthley A, Simonyan K. Suicidal Ideations and Attempts in Patients With Isolated Dystonia. Neurology. 2021 03 16; 96(11):e1551-e1560. PMID: 33504639.
    Citations:    Fields:    Translation:Humans
  5. Khosravani S, Chen G, Ozelius LJ, Simonyan K. Neural endophenotypes and predictors of laryngeal dystonia penetrance and manifestation. Neurobiol Dis. 2021 01; 148:105223. PMID: 33316367.
    Citations:    Fields:    
  6. Valeriani D, Simonyan K. A microstructural neural network biomarker for dystonia diagnosis identified by a DystoniaNet deep learning platform. Proc Natl Acad Sci U S A. 2020 10 20; 117(42):26398-26405. PMID: 33004625.
    Citations: 4     Fields:    Translation:Humans
  7. de Lima Xavier L, Simonyan K. Neural Representations of the Voice Tremor Spectrum. Mov Disord. 2020 12; 35(12):2290-2300. PMID: 32976662.
    Citations: 1     Fields:    Translation:Humans
  8. Hanekamp S, Simonyan K. The large-scale structural connectome of task-specific focal dystonia. Hum Brain Mapp. 2020 08 15; 41(12):3253-3265. PMID: 32311207.
    Citations: 6     Fields:    
  9. Lungu C, Ozelius L, Standaert D, Hallett M, Sieber BA, Swanson-Fisher C, Berman BD, Calakos N, Moore JC, Perlmutter JS, Pirio Richardson SE, Saunders-Pullman R, Scheinfeldt L, Sharma N, Sillitoe R, Simonyan K, Starr PA, Taylor A, Vitek J. Defining research priorities in dystonia. Neurology. 2020 03 24; 94(12):526-537. PMID: 32098856.
    Citations: 4     Fields:    Translation:HumansAnimals
  10. Maguire F, Reilly RB, Simonyan K. Normal Temporal Discrimination in Musician's Dystonia Is Linked to Aberrant Sensorimotor Processing. Mov Disord. 2020 05; 35(5):800-807. PMID: 31930574.
    Citations: 3     Fields:    Translation:Humans
  11. de Lima Xavier L, Hanekamp S, Simonyan K. Sexual Dimorphism Within Brain Regions Controlling Speech Production. Front Neurosci. 2019; 13:795. PMID: 31417351.
    Citations: 3     
  12. de Lima Xavier L, Simonyan K. The extrinsic risk and its association with neural alterations in spasmodic dysphonia. Parkinsonism Relat Disord. 2019 08; 65:117-123. PMID: 31153765.
    Citations: 5     Fields:    Translation:Humans
  13. Battistella G, Simonyan K. Top-down alteration of functional connectivity within the sensorimotor network in focal dystonia. Neurology. 2019 04 16; 92(16):e1843-e1851. PMID: 30918091.
    Citations: 13     Fields:    Translation:Humans
  14. Bianchi S, Fuertinger S, Huddleston H, Frucht SJ, Simonyan K. Functional and structural neural bases of task specificity in isolated focal dystonia. Mov Disord. 2019 04; 34(4):555-563. PMID: 30840778.
    Citations: 12     Fields:    Translation:Humans
  15. Vancea R, Simonyan K, Petracca M, Brys M, Di Rocco A, Ghilardi MF, Inglese M. Cognitive performance in mid-stage Parkinson's disease: functional connectivity under chronic antiparkinson treatment. Brain Imaging Behav. 2019 Feb; 13(1):200-209. PMID: 28942477.
    Citations: 2     Fields:    Translation:Humans
  16. Simonyan K. Recent advances in understanding the role of the basal ganglia. F1000Res. 2019; 8. PMID: 30755797.
    Citations: 9     Fields:    Translation:Humans
  17. Guiry S, Worthley A, Simonyan K. A separation of innate and learned vocal behaviors defines the symptomatology of spasmodic dysphonia. Laryngoscope. 2019 07; 129(7):1627-1633. PMID: 30582159.
    Citations: 3     Fields:    Translation:Humans
  18. Simonyan K, Frucht SJ, Blitzer A, Sichani AH, Rumbach AF. A novel therapeutic agent, sodium oxybate, improves dystonic symptoms via reduced network-wide activity. Sci Rep. 2018 10 31; 8(1):16111. PMID: 30382161.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  19. Simonyan K. Neuroimaging Applications in Dystonia. Int Rev Neurobiol. 2018; 143:1-30. PMID: 30473192.
    Citations: 10     Fields:    Translation:Humans
  20. Fuertinger S, Simonyan K. Task-specificity in focal dystonia is shaped by aberrant diversity of a functional network kernel. Mov Disord. 2018 12; 33(12):1918-1927. PMID: 30264427.
    Citations: 8     Fields:    Translation:Humans
  21. Masuho I, Chavali S, Muntean BS, Skamangas NK, Simonyan K, Patil DN, Kramer GM, Ozelius L, Babu MM, Martemyanov KA. Molecular Deconvolution Platform to Establish Disease Mechanisms by Surveying GPCR Signaling. Cell Rep. 2018 07 17; 24(3):557-568.e5. PMID: 30021154.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  22. Battistella G, Kumar V, Simonyan K. Connectivity profiles of the insular network for speech control in healthy individuals and patients with spasmodic dysphonia. Brain Struct Funct. 2018 Jun; 223(5):2489-2498. PMID: 29520481.
    Citations: 3     Fields:    Translation:Humans
  23. Putzel GG, Battistella G, Rumbach AF, Ozelius LJ, Sabuncu MR, Simonyan K. Polygenic Risk of Spasmodic Dysphonia is Associated With Vulnerable Sensorimotor Connectivity. Cereb Cortex. 2018 01 01; 28(1):158-166. PMID: 29117296.
    Citations: 10     Fields:    Translation:Humans
  24. Fuertinger S, Zinn JC, Sharan AD, Hamzei-Sichani F, Simonyan K. Dopamine drives left-hemispheric lateralization of neural networks during human speech. J Comp Neurol. 2018 04 01; 526(5):920-931. PMID: 29230808.
    Citations: 2     Fields:    Translation:Humans
  25. Blitzer A, Brin MF, Simonyan K, Ozelius LJ, Frucht SJ. Phenomenology, genetics, and CNS network abnormalities in laryngeal dystonia: A 30-year experience. Laryngoscope. 2018 01; 128 Suppl 1:S1-S9. PMID: 29219190.
    Citations: 7     Fields:    Translation:Humans
  26. Simonyan K, Cho H, Hamzehei Sichani A, Rubien-Thomas E, Hallett M. The direct basal ganglia pathway is hyperfunctional in focal dystonia. Brain. 2017 12 01; 140(12):3179-3190. PMID: 29087445.
    Citations: 16     Fields:    Translation:Humans
  27. Killian O, McGovern EM, Beck R, Beiser I, Narasimham S, Quinlivan B, O'Riordan S, Simonyan K, Hutchinson M, Reilly RB. Practice does not make perfect: Temporal discrimination in musicians with and without dystonia. Mov Disord. 2017 12; 32(12):1791-1792. PMID: 29076564.
    Citations: 2     Fields:    Translation:Humans
  28. Fuertinger S, Simonyan K. Connectome-Wide Phenotypical and Genotypical Associations in Focal Dystonia. J Neurosci. 2017 08 02; 37(31):7438-7449. PMID: 28674168.
    Citations: 10     Fields:    Translation:Humans
  29. Vulinovic F, Schaake S, Domingo A, Kumar KR, Defazio G, Mir P, Simonyan K, Ozelius LJ, Brüggemann N, Chung SJ, Rakovic A, Lohmann K, Klein C. Screening study of TUBB4A in isolated dystonia. Parkinsonism Relat Disord. 2017 Aug; 41:118-120. PMID: 28655586.
    Citations: 2     Fields:    Translation:Humans
  30. Mor N, Simonyan K, Blitzer A. Central voice production and pathophysiology of spasmodic dysphonia. Laryngoscope. 2018 01; 128(1):177-183. PMID: 28543038.
    Citations: 5     Fields:    Translation:Humans
  31. Bianchi S, Battistella G, Huddleston H, Scharf R, Fleysher L, Rumbach AF, Frucht SJ, Blitzer A, Ozelius LJ, Simonyan K. Phenotype- and genotype-specific structural alterations in spasmodic dysphonia. Mov Disord. 2017 04; 32(4):560-568. PMID: 28186656.
    Citations: 13     Fields:    Translation:Humans
  32. Kirke DN, Battistella G, Kumar V, Rubien-Thomas E, Choy M, Rumbach A, Simonyan K. Neural correlates of dystonic tremor: a multimodal study of voice tremor in spasmodic dysphonia. Brain Imaging Behav. 2017 02; 11(1):166-175. PMID: 26843004.
    Citations: 20     Fields:    Translation:Humans
  33. Battistella G, Termsarasab P, Ramdhani RA, Fuertinger S, Simonyan K. Isolated Focal Dystonia as a Disorder of Large-Scale Functional Networks. Cereb Cortex. 2017 02 01; 27(2):1203-1215. PMID: 26679193.
    Citations: 33     Fields:    Translation:Humans
  34. Rittiner JE, Caffall ZF, Hernández-Martinez R, Sanderson SM, Pearson JL, Tsukayama KK, Liu AY, Xiao C, Tracy S, Shipman MK, Hickey P, Johnson J, Scott B, Stacy M, Saunders-Pullman R, Bressman S, Simonyan K, Sharma N, Ozelius LJ, Cirulli ET, Calakos N. Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2a Signaling as a Generalizable Mechanism for Dystonia. Neuron. 2016 Dec 21; 92(6):1238-1251. PMID: 27939583.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  35. Simonyan K, Ackermann H, Chang EF, Greenlee JD. New Developments in Understanding the Complexity of Human Speech Production. J Neurosci. 2016 11 09; 36(45):11440-11448. PMID: 27911747.
    Citations: 7     Fields:    Translation:HumansAnimals
  36. Rumbach AF, Blitzer A, Frucht SJ, Simonyan K. An open-label study of sodium oxybate in Spasmodic dysphonia. Laryngoscope. 2017 06; 127(6):1402-1407. PMID: 27808415.
    Citations: 16     Fields:    Translation:Humans
  37. Fuertinger S, Simonyan K. Stability of Network Communities as a Function of Task Complexity. J Cogn Neurosci. 2016 Dec; 28(12):2030-2043. PMID: 27575646.
    Citations: 3     Fields:    Translation:Humans
  38. Fuertinger S, Simonyan K, Sperling MR, Sharan AD, Hamzei-Sichani F. High-frequency brain networks undergo modular breakdown during epileptic seizures. Epilepsia. 2016 07; 57(7):1097-108. PMID: 27221325.
    Citations: 7     Fields:    Translation:Humans
  39. Kumar V, Croxson PL, Simonyan K. Structural Organization of the Laryngeal Motor Cortical Network and Its Implication for Evolution of Speech Production. J Neurosci. 2016 Apr 13; 36(15):4170-81. PMID: 27076417.
    Citations: 24     Fields:    Translation:HumansAnimals
  40. Putzel GG, Fuchs T, Battistella G, Rubien-Thomas E, Frucht SJ, Blitzer A, Ozelius LJ, Simonyan K. GNAL mutation in isolated laryngeal dystonia. Mov Disord. 2016 05; 31(5):750-5. PMID: 27093447.
    Citations: 8     Fields:    Translation:Humans
  41. Termsarasab P, Ramdhani RA, Battistella G, Rubien-Thomas E, Choy M, Farwell IM, Velickovic M, Blitzer A, Frucht SJ, Reilly RB, Hutchinson M, Ozelius LJ, Simonyan K. Neural correlates of abnormal sensory discrimination in laryngeal dystonia. Neuroimage Clin. 2016; 10:18-26. PMID: 26693398.
    Citations: 17     Fields:    Translation:Humans
  42. Fuertinger S, Horwitz B, Simonyan K. The Functional Connectome of Speech Control. PLoS Biol. 2015 Jul; 13(7):e1002209. PMID: 26204475.
    Citations: 33     Fields:    Translation:Humans
  43. Kirke DN, Frucht SJ, Simonyan K. Alcohol responsiveness in laryngeal dystonia: a survey study. J Neurol. 2015 Jun; 262(6):1548-56. PMID: 25929664.
    Citations: 22     Fields:    Translation:Humans
  44. Simonyan K, Fuertinger S. Speech networks at rest and in action: interactions between functional brain networks controlling speech production. J Neurophysiol. 2015 Apr 01; 113(7):2967-78. PMID: 25673742.
    Citations: 30     Fields:    Translation:Humans
  45. Sinclair CF, Simonyan K, Brin MF, Blitzer A. Negative dystonia of the palate: a novel entity and diagnostic consideration in hypernasal speech. Laryngoscope. 2015 Jun; 125(6):1426-32. PMID: 25646795.
    Citations:    Fields:    Translation:Humans
  46. Fürtinger S, Zinn JC, Simonyan K. A neural population model incorporating dopaminergic neurotransmission during complex voluntary behaviors. PLoS Comput Biol. 2014 Nov; 10(11):e1003924. PMID: 25393005.
    Citations: 7     Fields:    Translation:HumansCells
  47. Simonyan K. The laryngeal motor cortex: its organization and connectivity. Curr Opin Neurobiol. 2014 Oct; 28:15-21. PMID: 24929930.
    Citations: 42     Fields:    Translation:HumansCells
  48. Ramdhani RA, Kumar V, Velickovic M, Frucht SJ, Tagliati M, Simonyan K. What's special about task in dystonia? A voxel-based morphometry and diffusion weighted imaging study. Mov Disord. 2014 Aug; 29(9):1141-50. PMID: 24925463.
    Citations: 24     Fields:    Translation:Humans
  49. Simonyan K, Frucht SJ. Long-term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor. Tremor Other Hyperkinet Mov (N Y). 2013; 3. PMID: 24386608.
    Citations: 7     Fields:    
  50. Berman BD, Hallett M, Herscovitch P, Simonyan K. Striatal dopaminergic dysfunction at rest and during task performance in writer's cramp. Brain. 2013 Dec; 136(Pt 12):3645-58. PMID: 24148273.
    Citations: 26     Fields:    Translation:Humans
  51. Simonyan K, Berman BD, Herscovitch P, Hallett M. Abnormal striatal dopaminergic neurotransmission during rest and task production in spasmodic dysphonia. J Neurosci. 2013 Sep 11; 33(37):14705-14. PMID: 24027271.
    Citations: 36     Fields:    Translation:Humans
  52. Horwitz B, Simonyan K. PET neuroimaging: plenty of studies still need to be performed: comment on Cumming: "PET neuroimaging: the white elephant packs his trunk?". Neuroimage. 2014 Jan 01; 84:1101-3. PMID: 23954490.
    Citations: 3     Fields:    Translation:Humans
  53. Ramdhani RA, Simonyan K. Primary dystonia: conceptualizing the disorder through a structural brain imaging lens. Tremor Other Hyperkinet Mov (N Y). 2013; 3. PMID: 23610744.
    Citations: 21     Fields:    
  54. Lohmann K, Wilcox RA, Winkler S, Ramirez A, Rakovic A, Park JS, Arns B, Lohnau T, Groen J, Kasten M, Brüggemann N, Hagenah J, Schmidt A, Kaiser FJ, Kumar KR, Zschiedrich K, Alvarez-Fischer D, Altenmüller E, Ferbert A, Lang AE, Münchau A, Kostic V, Simonyan K, Agzarian M, Ozelius LJ, Langeveld AP, Sue CM, Tijssen MA, Klein C. Whispering dysphonia (DYT4 dystonia) is caused by a mutation in the TUBB4 gene. Ann Neurol. 2013 Apr; 73(4):537-45. PMID: 23595291.
    Citations: 37     Fields:    Translation:HumansCells
  55. Simonyan K, Herscovitch P, Horwitz B. Speech-induced striatal dopamine release is left lateralized and coupled to functional striatal circuits in healthy humans: a combined PET, fMRI and DTI study. Neuroimage. 2013 Apr 15; 70:21-32. PMID: 23277111.
    Citations: 26     Fields:    Translation:Humans
  56. Simonyan K, Feng X, Henriquez VM, Ludlow CL. Combined laryngeal inflammation and trauma mediate long-lasting immunoreactivity response in the brainstem sensory nuclei in the rat. Front Integr Neurosci. 2012; 6:97. PMID: 23162441.
    Citations: 2     
  57. Simonyan K, Blitzer A. Commentary on "Bilateral cerebellar stroke presenting with acute dysphonia and late palatal tremor". Mov Disord. 2012 Mar; 27(3):348. PMID: 22411847.
    Citations:    Fields:    Translation:Humans
  58. Simonyan K, Horwitz B, Jarvis ED. Dopamine regulation of human speech and bird song: a critical review. Brain Lang. 2012 Sep; 122(3):142-50. PMID: 22284300.
    Citations: 29     Fields:    Translation:HumansAnimals
  59. Simonyan K, Ludlow CL. Abnormal structure-function relationship in spasmodic dysphonia. Cereb Cortex. 2012 Feb; 22(2):417-25. PMID: 21666131.
    Citations: 35     Fields:    Translation:Humans
  60. Simonyan K, Horwitz B. Laryngeal motor cortex and control of speech in humans. Neuroscientist. 2011 Apr; 17(2):197-208. PMID: 21362688.
    Citations: 65     Fields:    Translation:HumansCells
  61. Simonyan K, Ludlow CL. Abnormal activation of the primary somatosensory cortex in spasmodic dysphonia: an fMRI study. Cereb Cortex. 2010 Nov; 20(11):2749-59. PMID: 20194686.
    Citations: 52     Fields:    Translation:Humans
  62. Simonyan K, Ludlow CL, Vortmeyer AO. Brainstem pathology in spasmodic dysphonia. Laryngoscope. 2010 Jan; 120(1):121-4. PMID: 19795469.
    Citations: 15     Fields:    Translation:Humans
  63. Simonyan K, Ostuni J, Ludlow CL, Horwitz B. Functional but not structural networks of the human laryngeal motor cortex show left hemispheric lateralization during syllable but not breathing production. J Neurosci. 2009 Nov 25; 29(47):14912-23. PMID: 19940187.
    Citations: 47     Fields:    Translation:Humans
  64. Lowell SY, Poletto CJ, Knorr-Chung BR, Reynolds RC, Simonyan K, Ludlow CL. Sensory stimulation activates both motor and sensory components of the swallowing system. Neuroimage. 2008 Aug 01; 42(1):285-95. PMID: 18515150.
    Citations: 41     Fields:    Translation:Humans
  65. Simonyan K, Tovar-Moll F, Ostuni J, Hallett M, Kalasinsky VF, Lewin-Smith MR, Rushing EJ, Vortmeyer AO, Ludlow CL. Focal white matter changes in spasmodic dysphonia: a combined diffusion tensor imaging and neuropathological study. Brain. 2008 Feb; 131(Pt 2):447-59. PMID: 18083751.
    Citations: 48     Fields:    Translation:Humans
  66. Simonyan K, Saad ZS, Loucks TM, Poletto CJ, Ludlow CL. Functional neuroanatomy of human voluntary cough and sniff production. Neuroimage. 2007 Aug 15; 37(2):401-9. PMID: 17574873.
    Citations: 32     Fields:    Translation:Humans
  67. Loucks TM, Poletto CJ, Simonyan K, Reynolds CL, Ludlow CL. Human brain activation during phonation and exhalation: common volitional control for two upper airway functions. Neuroimage. 2007 May 15; 36(1):131-43. PMID: 17428683.
    Citations: 43     Fields:    Translation:Humans
  68. Rödel RM, Olthoff A, Tergau F, Simonyan K, Kraemer D, Markus H, Kruse E. Human cortical motor representation of the larynx as assessed by transcranial magnetic stimulation (TMS). Laryngoscope. 2004 May; 114(5):918-22. PMID: 15126757.
    Citations: 22     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.