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Christopher Tam Nguyen, Ph.D.


Available: 10/19/20, Expires: 10/19/21

Welcome to the future! We have developed a set of accelerated cardiac MRI sequences for fast robust imaging of the heart. When combined, we have the potential to decrease clinical cardiac MRI exams by 4x from 1 hour to 15 min reducing cost and increasing throughput.

Welcome to the future! We have developed a set of accelerated cardiac MRI sequences for fast robust imaging of the heart. When combined, we have the potential to decrease clinical cardiac MRI exams by 4x from 1 hour to 15 min reducing cost and increasing throughput.

This exciting abbreviated scan needs clinical validation and we are looking for HMS students who can help with the analysis. Anatomy and physiology of the heart are required. Students will work with the PI, postdocs, and other radiology/cardiology faculty at MGH

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL151704 (NGUYEN, CHRISTOPHER T) Jul 15, 2020 - May 31, 2025
    Serial evaluation of cardioprotective effects of exercise training in heart failure using cardiac diffusion tensor MRI
    Role: Principal Investigator
  2. R21EB024701 (NGUYEN, CHRISTOPHER T) Jul 15, 2017 - Apr 30, 2020
    Longitudinal evaluation of cardiosphere-derived cell regenerative treatment onmyocardial fiber architecture using diffusion tensor cardiac magnetic resonance for dilatedcardiomyopathy
    Role: Principal Investigator
  3. R01HL135242 (NGUYEN, CHRISTOPHER T) Jan 15, 2017 - Dec 31, 2021
    Stress-rest calf muscle perfusion: a functional diagnostic test for peripheral arterial disease (PAD)
    Role: Principal Investigator
  4. F31EB018152 (NGUYEN, CHRISTOPHER T) Sep 8, 2014 - Jun 15, 2015
    Clinically Translatable Cardiac Diffusion MR for Non-Contrast Characterization of
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nguyen CT, Christodoulou AG, Coll-Font J, Ma S, Xie Y, Reese TG, Mekkaoui C, Lewis GD, Bi X, Sosnovik DE, Li D. Free-breathing diffusion tensor MRI of the whole left ventricle using second-order motion compensation and multitasking respiratory motion correction. Magn Reson Med. 2021 05; 85(5):2634-2648. PMID: 33252140.
    Citations:    Fields:    
  2. Islam MR, Luo R, Valaris S, Haley EB, Takase H, Chen YI, Dickerson BC, Schon K, Arai K, Nguyen CT, Wrann CD. Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice. Brain Plast. 2020 Oct 01; 5(2):147-159. PMID: 33282678.
  3. Park C, Fan Y, Hager G, Yuk H, Singh M, Rojas A, Hameed A, Saeed M, Vasilyev NV, Steele TWJ, Zhao X, Nguyen CT, Roche ET. An organosynthetic dynamic heart model with enhanced biomimicry guided by cardiac diffusion tensor imaging. Sci Robot. 2020 01 29; 5(38). PMID: 33022595.
    Citations: 1     Translation:HumansAnimals
  4. van den Boomen M, Manhard MK, Snel GJH, Han S, Emblem KE, Slart RHJA, Sosnovik DE, Catana C, Rosen BR, Prakken NHJ, Nguyen CT, Borra RJH, Setsompop K. Blood Oxygen Level-Dependent MRI of the Myocardium with Multiecho Gradient-Echo Spin-Echo Imaging. Radiology. 2020 03; 294(3):538-545. PMID: 31961241.
    Citations: 2     Fields:    Translation:Humans
  5. Kim D, Wisnowski JL, Nguyen CT, Haldar JP. Multidimensional correlation spectroscopic imaging of exponential decays: From theoretical principles to in vivo human applications. NMR Biomed. 2020 12; 33(12):e4244. PMID: 31909534.
    Citations: 3     Fields:    
  6. Ma S, Nguyen CT, Han F, Wang N, Deng Z, Binesh N, Moser FG, Christodoulou AG, Li D. Three-dimensional simultaneous brain T1 , T2 , and ADC mapping with MR Multitasking. Magn Reson Med. 2020 07; 84(1):72-88. PMID: 31765496.
    Citations: 2     Fields:    
  7. Akerberg AA, Burns CE, Burns CG, Nguyen C. Deep learning enables automated volumetric assessments of cardiac function in zebrafish. Dis Model Mech. 2019 10 25; 12(10). PMID: 31548281.
    Citations: 3     Fields:    Translation:Animals
  8. Lee SE, Nguyen C, Xie Y, Deng Z, Zhou Z, Li D, Chang HJ. Recent Advances in Cardiac Magnetic Resonance Imaging. Korean Circ J. 2019 Feb; 49(2):146-159. PMID: 30468040.
    Citations: 1     
  9. Shaw JL, Yang Q, Zhou Z, Deng Z, Nguyen C, Li D, Christodoulou AG. Free-breathing, non-ECG, continuous myocardial T1 mapping with cardiovascular magnetic resonance multitasking. Magn Reson Med. 2019 04; 81(4):2450-2463. PMID: 30450749.
    Citations: 9     Fields:    Translation:Humans
  10. Buckberg GD, Nanda NC, Nguyen C, Kocica MJ. What Is the Heart? Anatomy, Function, Pathophysiology, and Misconceptions. J Cardiovasc Dev Dis. 2018 Jun 04; 5(2). PMID: 29867011.
    Citations: 8     
  11. Kim D, Wisnowski JL, Nguyen CT, Haldar JP. PROBING IN VIVO MICROSTRUCTURE WITH T1-T2 RELAXATION CORRELATION SPECTROSCOPIC IMAGING. Proc IEEE Int Symp Biomed Imaging. 2018 Apr; 2018:675-678. PMID: 30854157.
    Citations: 2     
  12. Lee SE, Nguyen C, Yoon J, Chang HJ, Kim S, Kim CH, Li D. Three-dimensional Cardiomyocytes Structure Revealed By Diffusion Tensor Imaging and Its Validation Using a Tissue-Clearing Technique. Sci Rep. 2018 04 27; 8(1):6640. PMID: 29703900.
    Citations: 4     Fields:    Translation:AnimalsCells
  13. Christodoulou AG, Shaw JL, Nguyen C, Yang Q, Xie Y, Wang N, Li D. Magnetic resonance multitasking for motion-resolved quantitative cardiovascular imaging. Nat Biomed Eng. 2018 Apr; 2(4):215-226. PMID: 30237910.
    Citations: 35     Fields:    
  14. Li P, You S, Nguyen C, Wang Y, Kim J, Sirohi D, Ziembiec A, Luthringer D, Lin SC, Daskivich T, Wu J, Freeman MR, Saouaf R, Li D, Kim HL. Genes involved in prostate cancer progression determine MRI visibility. Theranostics. 2018; 8(7):1752-1765. PMID: 29556354.
    Citations: 15     Fields:    Translation:HumansAnimals
  15. Nguyen CT, Dawkins J, Bi X, Marbán E, Li D. Diffusion Tensor Cardiac Magnetic Resonance Reveals Exosomes From Cardiosphere-Derived Cells Preserve Myocardial Fiber Architecture After Myocardial Infarction. JACC Basic Transl Sci. 2018 Feb; 3(1):97-109. PMID: 29600288.
    Citations: 8     
  16. Ma S, Nguyen CT, Christodoulou AG, Luthringer D, Kobashigawa J, Lee SE, Chang HJ, Li D. Accelerated Cardiac Diffusion Tensor Imaging Using Joint Low-Rank and Sparsity Constraints. IEEE Trans Biomed Eng. 2018 10; 65(10):2219-2230. PMID: 29989936.
    Citations: 2     Fields:    Translation:Humans
  17. Zhou Z, Nguyen C, Chen Y, Shaw JL, Deng Z, Xie Y, Dawkins J, Marbán E, Li D. Optimized CEST cardiovascular magnetic resonance for assessment of metabolic activity in the heart. J Cardiovasc Magn Reson. 2017 Nov 30; 19(1):95. PMID: 29191206.
    Citations: 4     Fields:    Translation:HumansAnimals
  18. Patel DN, Nguyen C, Sirohi D, Falahatian V, Saouaf R, Luthringer D, Li D, Kim HL. Use of cylindrical coordinates to localize prostate cancers on MRI and prostatectomy pathology. Urol Oncol. 2017 12; 35(12):673.e15-673.e20. PMID: 28916150.
    Citations:    Fields:    Translation:Humans
  19. Deng Z, Fan Z, Lee SE, Nguyen C, Xie Y, Pang J, Bi X, Yang Q, Choi BW, Kim JS, Berman D, Chang HJ, Li D. Noninvasive measurement of pressure gradient across a coronary stenosis using phase contrast (PC)-MRI: A feasibility study. Magn Reson Med. 2017 02; 77(2):529-537. PMID: 28019028.
    Citations: 3     Fields:    Translation:Humans
  20. Xie Y, Kim YJ, Pang J, Kim JS, Yang Q, Wei J, Nguyen CT, Deng Z, Choi BW, Fan Z, Bairey Merz CN, Shah PK, Berman DS, Chang HJ, Li D. Coronary Atherosclerosis T1-Weighed Characterization With Integrated Anatomical Reference: Comparison With High-Risk Plaque Features Detected by Invasive Coronary Imaging. JACC Cardiovasc Imaging. 2017 06; 10(6):637-648. PMID: 27743950.
    Citations: 12     Fields:    Translation:Humans
  21. Nguyen CT, Buckberg G, Li D. Magnetic Resonance Diffusion Tensor Imaging Provides New Insights Into the Microstructural Alterations in Dilated Cardiomyopathy. Circ Cardiovasc Imaging. 2016 10; 9(10). PMID: 27729369.
    Citations:    Fields:    Translation:Humans
  22. Nguyen C, Fan Z, Xie Y, Pang J, Speier P, Bi X, Kobashigawa J, Li D. In vivo diffusion-tensor MRI of the human heart on a 3 tesla clinical scanner: An optimized second order (M2) motion compensated diffusion-preparation approach. Magn Reson Med. 2016 11; 76(5):1354-1363. PMID: 27550078.
    Citations: 16     Fields:    Translation:Humans
  23. Sharif-Afshar AR, Nguyen C, Feng TS, Payor L, Fan Z, Saouaf R, Li D, Kim HL. Prospective Pilot Trial to Evaluate a High Resolution Diffusion-Weighted MRI in Prostate Cancer Patients. EBioMedicine. 2016 May; 7:80-4. PMID: 27322461.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  24. Nguyen C, Lu M, Fan Z, Bi X, Kellman P, Zhao S, Li D. Contrast-free detection of myocardial fibrosis in hypertrophic cardiomyopathy patients with diffusion-weighted cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2015 Dec 02; 17:107. PMID: 26631061.
    Citations: 17     Fields:    Translation:Humans
  25. Xie G, Zhang N, Xie Y, Nguyen C, Deng Z, Bi X, Fan Z, Liu X, Li D, Fan Z. DANTE-prepared three-dimensional FLASH: A fast isotropic-resolution MR approach to morphological evaluation of the peripheral arterial wall at 3 Tesla. J Magn Reson Imaging. 2016 Feb; 43(2):343-51. PMID: 26139414.
    Citations: 6     Fields:    Translation:Humans
  26. Sharif-Afshar AR, Feng T, Koopman S, Nguyen C, Li Q, Shkolyar E, Saouaf R, Kim HL. Impact of post prostate biopsy hemorrhage on multiparametric magnetic resonance imaging. Can J Urol. 2015 Apr; 22(2):7698-702. PMID: 25891332.
    Citations: 2     Fields:    Translation:Humans
  27. Nguyen C, Sharif-Afshar AR, Fan Z, Xie Y, Wilson S, Bi X, Payor L, Saouaf R, Kim H, Li D. 3D high-resolution diffusion-weighted MRI at 3T: Preliminary application in prostate cancer patients undergoing active surveillance protocol for low-risk prostate cancer. Magn Reson Med. 2016 Feb; 75(2):616-26. PMID: 25761871.
    Citations: 7     Fields:    Translation:Humans
  28. Feng TS, Sharif-Afshar AR, Smith SC, Miller J, Nguyen C, Li Q, Luthringer D, Li D, Saouaf R, Kim HL. Multiparametric magnetic resonance imaging localizes established extracapsular extension of prostate cancer. Urol Oncol. 2015 Mar; 33(3):109.e15-22. PMID: 25512160.
    Citations: 14     Fields:    Translation:Humans
  29. Xie Y, Yu W, Fan Z, Nguyen C, Bi X, An J, Zhang T, Zhang Z, Li D. High resolution 3D diffusion cardiovascular magnetic resonance of carotid vessel wall to detect lipid core without contrast media. J Cardiovasc Magn Reson. 2014 Sep 17; 16:67. PMID: 25238168.
    Citations: 11     Fields:    Translation:Humans
  30. Nguyen C, Fan Z, Xie Y, Dawkins J, Tseliou E, Bi X, Sharif B, Dharmakumar R, Marbán E, Li D. In vivo contrast free chronic myocardial infarction characterization using diffusion-weighted cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2014 Sep 17; 16:68. PMID: 25230598.
    Citations: 21     Fields:    Translation:Animals
  31. Nguyen C, Fan Z, Sharif B, He Y, Dharmakumar R, Berman DS, Li D. In vivo three-dimensional high resolution cardiac diffusion-weighted MRI: a motion compensated diffusion-prepared balanced steady-state free precession approach. Magn Reson Med. 2014 Nov; 72(5):1257-67. PMID: 24259113.
    Citations: 34     Fields:    Translation:Humans
  32. Bucci M, Mandelli ML, Berman JI, Amirbekian B, Nguyen C, Berger MS, Henry RG. Quantifying diffusion MRI tractography of the corticospinal tract in brain tumors with deterministic and probabilistic methods. Neuroimage Clin. 2013; 3:361-8. PMID: 24273719.
    Citations: 35     Fields:    
  33. Li YO, Yang FG, Nguyen CT, Cooper SR, LaHue SC, Venugopal S, Mukherjee P. Independent component analysis of DTI reveals multivariate microstructural correlations of white matter in the human brain. Hum Brain Mapp. 2012 Jun; 33(6):1431-51. PMID: 21567660.
    Citations: 17     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.