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John Collinge, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Koriath C, Lashley T, Taylor W, Druyeh R, Dimitriadis A, Denning N, Williams J, Warren JD, Fox NC, Schott JM, Rowe JB, Collinge J, Rohrer JD, Mead S. ApoE4 lowers age at onset in patients with frontotemporal dementia and tauopathy independent of amyloid-ß copathology. Alzheimers Dement (Amst). 2019 Dec; 11:277-280. PMID: 30949567.
    Citations:    
  2. Rudge P, Jaunmuktane Z, Hyare H, Ellis M, Koltzenburg M, Collinge J, Brandner S, Mead S. Early neurophysiological biomarkers and spinal cord pathology in inherited prion disease. Brain. 2019 Mar 01; 142(3):760-770. PMID: 30698738.
    Citations:    Fields:    
  3. Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujic-Comic H, Frosch MP, Thonberg H, Maier W, Roschupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, Brown K, Martiniuk F, Medway C, Mash DC, Nöthen MM, Masliah E, Hooper NM, McCormick WC, Daniele A, McCurry SM, Bayer A, McDavid AN, Gallacher J, McKee AC, van den Bussche H, Mesulam M, Brayne C, Miller BL, Riedel-Heller S, Miller CA, Miller JW, Al-Chalabi A, Morris JC, Shaw CE, Myers AJ, Wiltfang J, O'Bryant S, Olichney JM, Alvarez V, Parisi JE, Singleton AB, Paulson HL, Collinge J, Perry WR, Mead S, Peskind E, Cribbs DH, Rossor M, Pierce A, Ryan NS, Poon WW, Nacmias B, Potter H, Sorbi S, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing. Nat Genet. 2019 03; 51(3):414-430. PMID: 30820047.
    Citations:    
  4. Terry C, Harniman RL, Sells J, Wenborn A, Joiner S, Saibil HR, Miles MJ, Collinge J, Wadsworth JDF. Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro. Sci Rep. 2019 Jan 23; 9(1):376. PMID: 30675000.
    Citations:    Fields:    
  5. Mengel D, Hong W, Corbett GT, Liu W, DeSousa A, Solforosi L, Fang C, Frosch MP, Collinge J, Harris DA, Walsh DM. PrP-grafted antibodies bind certain amyloid ß-protein aggregates, but do not prevent toxicity. Brain Res. 2019 May 01; 1710:125-135. PMID: 30593771.
    Citations:    Fields:    
  6. Purro SA, Farrow MA, Linehan J, Nazari T, Thomas DX, Chen Z, Mengel D, Saito T, Saido T, Rudge P, Brandner S, Walsh DM, Collinge J. Transmission of amyloid-ß protein pathology from cadaveric pituitary growth hormone. Nature. 2018 12; 564(7736):415-419. PMID: 30546139.
    Citations:    Fields:    
  7. Clayton EL, Milioto C, Muralidharan B, Norona FE, Edgar JR, Soriano A, Jafar-Nejad P, Rigo F, Collinge J, Isaacs AM. Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown. Brain. 2018 12 01; 141(12):3428-3442. PMID: 30496365.
    Citations:    Fields:    
  8. Ford L, Rudge P, Robinson K, Collinge J, Gorham M, Mead S. The most problematic symptoms of prion disease - an analysis of carer experiences. Int Psychogeriatr. 2018 Oct 24; 1-10. PMID: 30353798.
    Citations:    Fields:    
  9. Mok TH, Koriath C, Jaunmuktane Z, Campbell T, Joiner S, Wadsworth JDF, Hosszu LLP, Brandner S, Parvez A, Truelsen TC, Lund EL, Saha R, Collinge J, Mead S. Evaluating the causality of novel sequence variants in the prion protein gene by example. Neurobiol Aging. 2018 11; 71:265.e1-265.e7. PMID: 29861043.
    Citations:    Fields:    
  10. Purro SA, Mead S, Khalili-Shirazi A, Nicoll AJ, Collinge J. Reply to: Intrinsic Toxicity of Antibodies to the Globular Domain of the Prion Protein. Biol Psychiatry. 2018 10 01; 84(7):e53-e54. PMID: 29752071.
    Citations:    Fields:    
  11. Thompson AGB, Luk C, Heslegrave AJ, Zetterberg H, Mead SH, Collinge J, Jackson GS. Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression. J Neurol Neurosurg Psychiatry. 2018 Sep; 89(9):955-961. PMID: 29487167.
    Citations: 1     Fields:    
  12. Caine D, Nihat A, Crabb P, Rudge P, Cipolotti L, Collinge J, Mead S. The language disorder of prion disease is characteristic of a dynamic aphasia and is rarely an isolated clinical feature. PLoS One. 2018; 13(1):e0190818. PMID: 29304167.
    Citations:    Fields:    Translation:Humans
  13. Joiner S, Asante EA, Linehan JM, Brock L, Brandner S, Bellworthy SJ, Simmons MM, Hope J, Collinge J, Wadsworth JDF. Experimental sheep BSE prions generate the vCJD phenotype when serially passaged in transgenic mice expressing human prion protein. J Neurol Sci. 2018 03 15; 386:4-11. PMID: 29406965.
    Citations:    Fields:    
  14. Purro SA, Nicoll AJ, Collinge J. Prion Protein as a Toxic Acceptor of Amyloid-ß Oligomers. Biol Psychiatry. 2018 02 15; 83(4):358-368. PMID: 29331212.
    Citations: 3     Fields:    
  15. Rudge P, Hyare H, Green A, Collinge J, Mead S. Imaging and CSF analyses effectively distinguish CJD from its mimics. J Neurol Neurosurg Psychiatry. 2018 May; 89(5):461-466. PMID: 29142140.
    Citations: 1     Fields:    
  16. Sarell CJ, Quarterman E, Yip DC, Terry C, Nicoll AJ, Wadsworth JDF, Farrow MA, Walsh DM, Collinge J. Soluble Aß aggregates can inhibit prion propagation. Open Biol. 2017 11; 7(11). PMID: 29142106.
    Citations: 1     Fields:    Translation:AnimalsCells
  17. Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Longstreth WT, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sager MA, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Garzia F, Golamaully F, Septier G, Engelborghs S, Vandenberghe R, De Deyn PP, Fernadez CM, Benito YA, Thonberg H, Forsell C, Lilius L, Kinhult-Stählbom A, Kilander L, Brundin R, Concari L, Helisalmi S, Koivisto AM, Haapasalo A, Dermecourt V, Fievet N, Hanon O, Dufouil C, Brice A, Ritchie K, Dubois B, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017 09; 49(9):1373-1384. PMID: 28714976.
    Citations: 38     Fields:    Translation:HumansCells
  18. Kenny J, Woollacott I, Koriath C, Hosszu L, Adamson G, Rudge P, Rossor MN, Collinge J, Rohrer JD, Mead S. A novel prion protein variant in a patient with semantic dementia. J Neurol Neurosurg Psychiatry. 2017 10; 88(10):890-892. PMID: 28572272.
    Citations:    Fields:    
  19. Zhang D, Qi Y, Klyubin I, Ondrejcak T, Sarell CJ, Cuello AC, Collinge J, Rowan MJ. Targeting glutamatergic and cellular prion protein mechanisms of amyloid ß-mediated persistent synaptic plasticity disruption: Longitudinal studies. Neuropharmacology. 2017 Jul 15; 121:231-246. PMID: 28390893.
    Citations:    Fields:    Translation:HumansAnimalsCells
  20. Clayton EL, Mancuso R, Nielsen TT, Mizielinska S, Holmes H, Powell N, Norona F, Larsen JO, Milioto C, Wilson KM, Lythgoe MF, Ourselin S, Nielsen JE, Johannsen P, Holm I, Collinge J, Oliver PL, Gomez-Nicola D, Isaacs AM. Early microgliosis precedes neuronal loss and behavioural impairment in mice with a frontotemporal dementia-causing CHMP2B mutation. Hum Mol Genet. 2017 03 01; 26(5):873-887. PMID: 28093491.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  21. Mok T, Jaunmuktane Z, Joiner S, Campbell T, Morgan C, Wakerley B, Golestani F, Rudge P, Mead S, Jäger HR, Wadsworth JD, Brandner S, Collinge J. Variant Creutzfeldt-Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129. N Engl J Med. 2017 01 19; 376(3):292-294. PMID: 28099827.
    Citations: 8     Fields:    Translation:Humans
  22. Qiang W, Yau WM, Lu JX, Collinge J, Tycko R. Structural variation in amyloid-ß fibrils from Alzheimer's disease clinical subtypes. Nature. 2017 01 12; 541(7636):217-221. PMID: 28052060.
    Citations: 42     Fields:    Translation:Humans
  23. Wadsworth JDF, Adamson G, Joiner S, Brock L, Powell C, Linehan JM, Beck JA, Brandner S, Mead S, Collinge J. Methods for Molecular Diagnosis of Human Prion Disease. Methods Mol Biol. 2017; 1658:311-346. PMID: 28861799.
    Citations:    Fields:    Translation:HumansCells
  24. Luk C, Jones S, Thomas C, Fox NC, Mok TH, Mead S, Collinge J, Jackson GS. Diagnosing Sporadic Creutzfeldt-Jakob Disease by the Detection of Abnormal Prion Protein in Patient Urine. JAMA Neurol. 2016 Dec 01; 73(12):1454-1460. PMID: 27699415.
    Citations: 3     Fields:    Translation:Humans
  25. Collinge J. Mammalian prions and their wider relevance in neurodegenerative diseases. Nature. 2016 11 10; 539(7628):217-226. PMID: 27830781.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  26. De Vita E, Ridgway GR, White MJ, Porter MC, Caine D, Rudge P, Collinge J, Yousry TA, Jager HR, Mead S, Thornton JS, Hyare H. Neuroanatomical correlates of prion disease progression - a 3T longitudinal voxel-based morphometry study. Neuroimage Clin. 2017; 13:89-96. PMID: 27942451.
    Citations: 1     Fields:    Translation:Humans
  27. Collinge J, Jaunmuktane Z, Mead S, Rudge P, Brandner S. Collinge et al. reply. Nature. 2016 09 15; 537(7620):E7-9. PMID: 27629648.
    Citations:    Fields:    
  28. Collinge J, Jaunmuktane Z, Mead S, Rudge P, Brandner S. Collinge et al. reply. Nature. 2016 07 14; 535(7611):E2-3. PMID: 27411638.
    Citations:    Fields:    Translation:HumansPHPublic Health
  29. Franko E, Wehner T, Joly O, Lowe J, Porter MC, Kenny J, Thompson A, Rudge P, Collinge J, Mead S. Quantitative EEG parameters correlate with the progression of human prion diseases. J Neurol Neurosurg Psychiatry. 2016 Oct; 87(10):1061-7. PMID: 27413165.
    Citations: 1     Fields:    Translation:Humans
  30. Terry C, Wenborn A, Gros N, Sells J, Joiner S, Hosszu LL, Tattum MH, Panico S, Clare DK, Collinge J, Saibil HR, Wadsworth JD. Ex vivo mammalian prions are formed of paired double helical prion protein fibrils. Open Biol. 2016 05; 6(5). PMID: 27249641.
    Citations: 9     Fields:    Translation:AnimalsCells
  31. Properzi F, Badhan A, Klier S, Schmidt C, Klöhn PC, Wadsworth JD, Clarke AR, Jackson GS, Collinge J. Physical, chemical and kinetic factors affecting prion infectivity. Prion. 2016 05 03; 10(3):251-61. PMID: 27282252.
    Citations:    Fields:    Translation:AnimalsCells
  32. Balendra R, Uphill J, Collinson C, Druyeh R, Adamson G, Hummerich H, Zerr I, Gambetti P, Collinge J, Mead S. Variants of PLCXD3 are not associated with variant or sporadic Creutzfeldt-Jakob disease in a large international study. BMC Med Genet. 2016 Apr 07; 17:28. PMID: 27055460.
    Citations:    Fields:    Translation:Humans
  33. Mead S, Burnell M, Lowe J, Thompson A, Lukic A, Porter MC, Carswell C, Kaski D, Kenny J, Mok TH, Bjurstrom N, Franko E, Gorham M, Druyeh R, Wadsworth JD, Jaunmuktane Z, Brandner S, Hyare H, Rudge P, Walker AS, Collinge J. Clinical Trial Simulations Based on Genetic Stratification and the Natural History of a Functional Outcome Measure in Creutzfeldt-Jakob Disease. JAMA Neurol. 2016 Apr; 73(4):447-55. PMID: 26902324.
    Citations: 4     Fields:    Translation:Humans
  34. Schott JM, Crutch SJ, Carrasquillo MM, Uphill J, Shakespeare TJ, Ryan NS, Yong KX, Lehmann M, Ertekin-Taner N, Graff-Radford NR, Boeve BF, Murray ME, Khan QU, Petersen RC, Dickson DW, Knopman DS, Rabinovici GD, Miller BL, González AS, Gil-Néciga E, Snowden JS, Harris J, Pickering-Brown SM, Louwersheimer E, van der Flier WM, Scheltens P, Pijnenburg YA, Galasko D, Sarazin M, Dubois B, Magnin E, Galimberti D, Scarpini E, Cappa SF, Hodges JR, Halliday GM, Bartley L, Carrillo MC, Bras JT, Hardy J, Rossor MN, Collinge J, Fox NC, Mead S. Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease. Alzheimers Dement. 2016 08; 12(8):862-71. PMID: 26993346.
    Citations: 10     Fields:    Translation:Humans
  35. Eisenmenger L, Porter MC, Carswell CJ, Thompson A, Mead S, Rudge P, Collinge J, Brandner S, Jäger HR, Hyare H. Evolution of Diffusion-Weighted Magnetic Resonance Imaging Signal Abnormality in Sporadic Creutzfeldt-Jakob Disease, With Histopathological Correlation. JAMA Neurol. 2016 Jan; 73(1):76-84. PMID: 26569479.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  36. McKinnon C, Goold R, Andre R, Devoy A, Ortega Z, Moonga J, Linehan JM, Brandner S, Lucas JJ, Collinge J, Tabrizi SJ. Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin-proteasome system. Acta Neuropathol. 2016 Mar; 131(3):411-25. PMID: 26646779.
    Citations: 11     Fields:    Translation:Animals
  37. Sawyer EB, Edgeworth JA, Thomas C, Collinge J, Jackson GS. Preclinical detection of infectivity and disease-specific PrP in blood throughout the incubation period of prion disease. Sci Rep. 2015 Dec 03; 5:17742. PMID: 26631638.
    Citations: 5     Fields:    Translation:Animals
  38. Schmidt C, Fizet J, Properzi F, Batchelor M, Sandberg MK, Edgeworth JA, Afran L, Ho S, Badhan A, Klier S, Linehan JM, Brandner S, Hosszu LL, Tattum MH, Jat P, Clarke AR, Klöhn PC, Wadsworth JD, Jackson GS, Collinge J. A systematic investigation of production of synthetic prions from recombinant prion protein. Open Biol. 2015 Dec; 5(12):150165. PMID: 26631378.
    Citations: 7     Fields:    Translation:Animals
  39. Jaunmuktane Z, Mead S, Ellis M, Wadsworth JD, Nicoll AJ, Kenny J, Launchbury F, Linehan J, Richard-Loendt A, Walker AS, Rudge P, Collinge J, Brandner S. Erratum: Evidence for human transmission of amyloid-ß pathology and cerebral amyloid angiopathy. Nature. 2015 Oct 22; 526(7574):595. PMID: 26375001.
    Citations: 3     Fields:    
  40. Jaunmuktane Z, Mead S, Ellis M, Wadsworth JD, Nicoll AJ, Kenny J, Launchbury F, Linehan J, Richard-Loendt A, Walker AS, Rudge P, Collinge J, Brandner S. Evidence for human transmission of amyloid-ß pathology and cerebral amyloid angiopathy. Nature. 2015 Sep 10; 525(7568):247-50. PMID: 26354483.
    Citations: 68     Fields:    Translation:HumansPHPublic Health
  41. Clayton EL, Mizielinska S, Edgar JR, Nielsen TT, Marshall S, Norona FE, Robbins M, Damirji H, Holm IE, Johannsen P, Nielsen JE, Asante EA, Collinge J, Isaacs AM. Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology. Acta Neuropathol. 2015 Oct; 130(4):511-23. PMID: 26358247.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  42. Rudge P, Jaunmuktane Z, Adlard P, Bjurstrom N, Caine D, Lowe J, Norsworthy P, Hummerich H, Druyeh R, Wadsworth JD, Brandner S, Hyare H, Mead S, Collinge J. Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years. Brain. 2015 Nov; 138(Pt 11):3386-99. PMID: 26268531.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  43. Hudson G, Uphill J, Hummerich H, Blevins J, Gambetti P, Zerr I, Collinge J, Mead S, Chinnery PF. Inherited mtDNA variations are not strong risk factors in human prion disease. Neurobiol Aging. 2015 Oct; 36(10):2908.e1-3. PMID: 26239179.
    Citations:    Fields:    Translation:Humans
  44. Asante EA, Grimshaw A, Smidak M, Jakubcova T, Tomlinson A, Jeelani A, Hamdan S, Powell C, Joiner S, Linehan JM, Brandner S, Wadsworth JD, Collinge J. Transmission Properties of Human PrP 102L Prions Challenge the Relevance of Mouse Models of GSS. PLoS Pathog. 2015 Jul; 11(7):e1004953. PMID: 26135918.
    Citations: 9     Fields:    Translation:HumansAnimals
  45. Asante EA, Smidak M, Grimshaw A, Houghton R, Tomlinson A, Jeelani A, Jakubcova T, Hamdan S, Richard-Londt A, Linehan JM, Brandner S, Alpers M, Whitfield J, Mead S, Wadsworth JD, Collinge J. A naturally occurring variant of the human prion protein completely prevents prion disease. Nature. 2015 Jun 25; 522(7557):478-81. PMID: 26061765.
    Citations: 30     Fields:    Translation:HumansAnimals
  46. Risse E, Nicoll AJ, Taylor WA, Wright D, Badoni M, Yang X, Farrow MA, Collinge J. Identification of a Compound That Disrupts Binding of Amyloid-ß to the Prion Protein Using a Novel Fluorescence-based Assay. J Biol Chem. 2015 Jul 03; 290(27):17020-8. PMID: 25995455.
    Citations: 10     Fields:    Translation:HumansCells
  47. Wenborn A, Terry C, Gros N, Joiner S, D'Castro L, Panico S, Sells J, Cronier S, Linehan JM, Brandner S, Saibil HR, Collinge J, Wadsworth JD. A novel and rapid method for obtaining high titre intact prion strains from mammalian brain. Sci Rep. 2015 May 07; 5:10062. PMID: 25950908.
    Citations: 9     Fields:    Translation:HumansAnimals
  48. Mirabile I, Jat PS, Brandner S, Collinge J. Identification of clinical target areas in the brainstem of prion-infected mice. Neuropathol Appl Neurobiol. 2015 Aug; 41(5):613-30. PMID: 25311251.
    Citations: 3     Fields:    Translation:Animals
  49. Caine D, Tinelli RJ, Hyare H, De Vita E, Lowe J, Lukic A, Thompson A, Porter MC, Cipolotti L, Rudge P, Collinge J, Mead S. The cognitive profile of prion disease: a prospective clinical and imaging study. Ann Clin Transl Neurol. 2015 May; 2(5):548-58. PMID: 26000326.
    Citations: 6     
  50. Hyare H, So PW, Brandner S, Collinge J, Parkes HG. MRI detection of prion protein plaques in variant Creutzfeldt-Jakob disease. Neurology. 2015 Apr 07; 84(14):1498-9. PMID: 25846996.
    Citations:    Fields:    Translation:Humans
  51. Lukic A, Uphill J, Brown CA, Beck J, Poulter M, Campbell T, Adamson G, Hummerich H, Whitfield J, Ponto C, Zerr I, Lloyd SE, Collinge J, Mead S. Rare structural genetic variation in human prion diseases. Neurobiol Aging. 2015 May; 36(5):2004.e1-8. PMID: 25726360.
    Citations: 3     Fields:    Translation:HumansCells
  52. Minikel EV, Zerr I, Collins SJ, Ponto C, Boyd A, Klug G, Karch A, Kenny J, Collinge J, Takada LT, Forner S, Fong JC, Mead S, Geschwind MD. Ascertainment bias causes false signal of anticipation in genetic prion disease. Am J Hum Genet. 2014 Oct 02; 95(4):371-82. PMID: 25279981.
    Citations: 2     Fields:    Translation:Humans
  53. Rossi M, Mead S, Collinge J, Rudge P, Vincent A. Neuronal antibodies in patients with suspected or confirmed sporadic Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry. 2015 Jun; 86(6):692-4. PMID: 25246643.
    Citations: 9     Fields:    Translation:HumansCells
  54. Slattery CF, Beck JA, Harper L, Adamson G, Abdi Z, Uphill J, Campbell T, Druyeh R, Mahoney CJ, Rohrer JD, Kenny J, Lowe J, Leung KK, Barnes J, Clegg SL, Blair M, Nicholas JM, Guerreiro RJ, Rowe JB, Ponto C, Zerr I, Kretzschmar H, Gambetti P, Crutch SJ, Warren JD, Rossor MN, Fox NC, Collinge J, Schott JM, Mead S. R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia. Alzheimers Dement. 2014 Nov; 10(6):602-608.e4. PMID: 25160042.
    Citations: 15     Fields:    Translation:Humans
  55. Jackson GS, Burk-Rafel J, Mead S, Collinge J. Blood test for variant Creutzfeldt-Jakob disease--reply. JAMA Neurol. 2014 Aug; 71(8):1054-5. PMID: 25111211.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  56. Trevitt CR, Hosszu LL, Batchelor M, Panico S, Terry C, Nicoll AJ, Risse E, Taylor WA, Sandberg MK, Al-Doujaily H, Linehan JM, Saibil HR, Scott DJ, Collinge J, Waltho JP, Clarke AR. N-terminal domain of prion protein directs its oligomeric association. J Biol Chem. 2014 Sep 12; 289(37):25497-508. PMID: 25074940.
    Citations: 4     Fields:    Translation:HumansCells
  57. Sandberg MK, Al-Doujaily H, Sharps B, De Oliveira MW, Schmidt C, Richard-Londt A, Lyall S, Linehan JM, Brandner S, Wadsworth JD, Clarke AR, Collinge J. Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked. Nat Commun. 2014 Jul 09; 5:4347. PMID: 25005024.
    Citations: 27     Fields:    Translation:HumansAnimals
  58. Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JB, Dobson-Stone C, Brooks WS, Schofield PR, Halliday GM, Hodges JR, Piguet O, Bartley L, Thompson E, Haan E, Hernández I, Ruiz A, Boada M, Borroni B, Padovani A, Cruchaga C, Cairns NJ, Benussi L, Binetti G, Ghidoni R, Forloni G, Galimberti D, Fenoglio C, Serpente M, Scarpini E, Clarimón J, Lleó A, Blesa R, Waldö ML, Nilsson K, Nilsson C, Mackenzie IR, Hsiung GY, Mann DM, Grafman J, Morris CM, Attems J, Griffiths TD, McKeith IG, Thomas AJ, Pietrini P, Huey ED, Wassermann EM, Baborie A, Jaros E, Tierney MC, Pastor P, Razquin C, Ortega-Cubero S, Alonso E, Perneczky R, Diehl-Schmid J, Alexopoulos P, Kurz A, Rainero I, Rubino E, Pinessi L, Rogaeva E, St George-Hyslop P, Rossi G, Tagliavini F, Giaccone G, Rowe JB, Schlachetzki JC, Uphill J, Collinge J, Mead S, Danek A, Van Deerlin VM, Grossman M, Trojanowski JQ, van der Zee J, Deschamps W, Van Langenhove T, Cruts M, Van Broeckhoven C, Cappa SF, Le Ber I, Hannequin D, Golfier V, Vercelletto M, Brice A, Nacmias B, Sorbi S, Bagnoli S, Piaceri I, Nielsen JE, Hjermind LE, Riemenschneider M, Mayhaus M, Ibach B, Gasparoni G, Pichler S, Gu W, Rossor MN, Fox NC, Warren JD, Spillantini MG, Morris HR, Rizzu P, Heutink P, Snowden JS, Rollinson S, Richardson A, Gerhard A, Bruni AC, Maletta R, Frangipane F, Cupidi C, Bernardi L, Anfossi M, Gallo M, Conidi ME, Smirne N, Rademakers R, Baker M, Dickson DW, Graff-Radford NR, Petersen RC, Knopman D, Josephs KA, Boeve BF, Parisi JE, Seeley WW, Miller BL, Karydas AM, Rosen H, van Swieten JC, Dopper EG, Seelaar H, Pijnenburg YA, Scheltens P, Logroscino G, Capozzo R, Novelli V, Puca AA, Franceschi M, Postiglione A, Milan G, Sorrentino P, Kristiansen M, Chiang HH, Graff C, Pasquier F, Rollin A, Deramecourt V, Lebert F, Kapogiannis D, Ferrucci L, Pickering-Brown S, Singleton AB, Hardy J, Momeni P. Frontotemporal dementia and its subtypes: a genome-wide association study. Lancet Neurol. 2014 Jul; 13(7):686-99. PMID: 24943344.
    Citations: 46     Fields:    Translation:Humans
  59. Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, Jun G, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Denning N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Schmidt H, Kunkle B, Dunstan ML, Vronskaya M, Johnson AD, Ruiz A, Bihoreau MT, Reitz C, Pasquier F, Hollingworth P, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Hernández I, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, George-Hyslop PS, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Garcia FS, Fox NC, Hardy J, Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Scarpini E, Bonuccelli U, Mancuso M, Siciliano G, Moebus S, Mecocci P, Zompo MD, Maier W, Hampel H, Pilotto A, Frank-García A, Panza F, Solfrizzi V, Caffarra P, Nacmias B, Perry W, Mayhaus M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER, Schmidt R, Rujescu D, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Haines JL, Lathrop M, Pericak-Vance MA, Launer LJ, Van Broeckhoven C, Farrer LA, van Duijn CM, Ramirez A, Seshadri S, Schellenberg GD, Amouyel P, Williams J. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. PLoS One. 2014; 9(6):e94661. PMID: 24922517.
    Citations: 25     Fields:    Translation:Humans
  60. Marbiah MM, Harvey A, West BT, Louzolo A, Banerjee P, Alden J, Grigoriadis A, Hummerich H, Kan HM, Cai Y, Bloom GS, Jat P, Collinge J, Klöhn PC. Identification of a gene regulatory network associated with prion replication. EMBO J. 2014 Jul 17; 33(14):1527-47. PMID: 24843046.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  61. Brown CA, Schmidt C, Poulter M, Hummerich H, Klöhn PC, Jat P, Mead S, Collinge J, Lloyd SE. In vitro screen of prion disease susceptibility genes using the scrapie cell assay. Hum Mol Genet. 2014 Oct 01; 23(19):5102-8. PMID: 24833721.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  62. Klyubin I, Nicoll AJ, Khalili-Shirazi A, Farmer M, Canning S, Mably A, Linehan J, Brown A, Wakeling M, Brandner S, Walsh DM, Rowan MJ, Collinge J. Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aß synaptotoxicity. J Neurosci. 2014 Apr 30; 34(18):6140-5. PMID: 24790184.
    Citations: 15     Fields:    Translation:HumansAnimals
  63. Owen J, Beck J, Campbell T, Adamson G, Gorham M, Thompson A, Smithson S, Rosser E, Rudge P, Collinge J, Mead S. Predictive testing for inherited prion disease: report of 22 years experience. Eur J Hum Genet. 2014 Dec; 22(12):1351-6. PMID: 24713662.
    Citations: 1     Fields:    Translation:Humans
  64. Jackson GS, Burk-Rafel J, Edgeworth JA, Sicilia A, Abdilahi S, Korteweg J, Mackey J, Thomas C, Wang G, Schott JM, Mummery C, Chinnery PF, Mead S, Collinge J. Population screening for variant Creutzfeldt-Jakob disease using a novel blood test: diagnostic accuracy and feasibility study. JAMA Neurol. 2014 Apr; 71(4):421-8. PMID: 24590363.
    Citations: 7     Fields:    Translation:HumansAnimalsPHPublic Health
  65. Grizenkova J, Akhtar S, Brandner S, Collinge J, Lloyd SE. Microglial Cx3cr1 knockout reduces prion disease incubation time in mice. BMC Neurosci. 2014 Mar 21; 15:44. PMID: 24655482.
    Citations: 9     Fields:    Translation:AnimalsCells
  66. Hu NW, Nicoll AJ, Zhang D, Mably AJ, O'Malley T, Purro SA, Terry C, Collinge J, Walsh DM, Rowan MJ. mGlu5 receptors and cellular prion protein mediate amyloid-ß-facilitated synaptic long-term depression in vivo. Nat Commun. 2014 Mar 04; 5:3374. PMID: 24594908.
    Citations: 39     Fields:    Translation:Animals
  67. Mead S, Wadsworth JD, Porter MC, Linehan JM, Pietkiewicz W, Jackson GS, Brandner S, Collinge J. Variant Creutzfeldt-Jakob disease with extremely low lymphoreticular deposition of prion protein. JAMA Neurol. 2014 Mar; 71(3):340-3. PMID: 24445428.
    Citations: 5     Fields:    Translation:Humans
  68. Thompson A, MacKay A, Rudge P, Lukic A, Porter MC, Lowe J, Collinge J, Mead S. Behavioral and psychiatric symptoms in prion disease. Am J Psychiatry. 2014 Mar; 171(3):265-74. PMID: 24585329.
    Citations: 6     Fields:    Translation:Humans
  69. Jackson GS, Burk-Rafel J, Edgeworth JA, Sicilia A, Abdilahi S, Korteweg J, Mackey J, Thomas C, Wang G, Mead S, Collinge J. A highly specific blood test for vCJD. Blood. 2014 Jan 16; 123(3):452-3. PMID: 24434999.
    Citations: 7     Fields:    Translation:Humans
  70. Angus-Leppan H, Rudge P, Mead S, Collinge J, Vincent A. Creutzfeld-Jakob disease--reply. JAMA Neurol. 2013 Dec; 70(12):1589. PMID: 24322520.
    Citations:    Fields:    Translation:Humans
  71. Mead S, Gandhi S, Beck J, Caine D, Gallujipali D, Carswell C, Hyare H, Joiner S, Ayling H, Lashley T, Linehan JM, Al-Doujaily H, Sharps B, Revesz T, Sandberg MK, Reilly MM, Koltzenburg M, Forbes A, Rudge P, Brandner S, Warren JD, Wadsworth JDF, Wood NW, Holton JL, Collinge J. A novel prion disease associated with diarrhea and autonomic neuropathy. N Engl J Med. 2013 Nov 14; 369(20):1904-14. PMID: 24224623.
    Citations: 25     Fields:    Translation:HumansAnimals
  72. Wadsworth JD, Joiner S, Linehan JM, Balkema-Buschmann A, Spiropoulos J, Simmons MM, Griffiths PC, Groschup MH, Hope J, Brandner S, Asante EA, Collinge J. Atypical scrapie prions from sheep and lack of disease in transgenic mice overexpressing human prion protein. Emerg Infect Dis. 2013 Nov; 19(11):1731-9. PMID: 24188521.
    Citations: 4     Fields:    Translation:HumansAnimals
  73. Asante EA, Linehan JM, Smidak M, Tomlinson A, Grimshaw A, Jeelani A, Jakubcova T, Hamdan S, Powell C, Brandner S, Wadsworth JD, Collinge J. Inherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein. PLoS Pathog. 2013; 9(9):e1003643. PMID: 24086135.
    Citations: 15     Fields:    Translation:HumansAnimals
  74. Beck J, Pittman A, Adamson G, Campbell T, Kenny J, Houlden H, Rohrer JD, de Silva R, Shoai M, Uphill J, Poulter M, Hardy J, Mummery CJ, Warren JD, Schott JM, Fox NC, Rossor MN, Collinge J, Mead S. Validation of next-generation sequencing technologies in genetic diagnosis of dementia. Neurobiol Aging. 2014 Jan; 35(1):261-5. PMID: 23998997.
    Citations: 17     Fields:    Translation:HumansCells
  75. Klöhn PC, Castro-Seoane R, Collinge J. Exosome release from infected dendritic cells: a clue for a fast spread of prions in the periphery? J Infect. 2013 Nov; 67(5):359-68. PMID: 23911964.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  76. Fratta P, Poulter M, Lashley T, Rohrer JD, Polke JM, Beck J, Ryan N, Hensman D, Mizielinska S, Waite AJ, Lai MC, Gendron TF, Petrucelli L, Fisher EM, Revesz T, Warren JD, Collinge J, Isaacs AM, Mead S. Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia. Acta Neuropathol. 2013 Sep; 126(3):401-9. PMID: 23818065.
    Citations: 39     Fields:    Translation:HumansCells
  77. Angus-Leppan H, Rudge P, Mead S, Collinge J, Vincent A. Autoantibodies in sporadic Creutzfeldt-Jakob disease. JAMA Neurol. 2013 Jul; 70(7):919-22. PMID: 23699783.
    Citations: 14     Fields:    Translation:Humans
  78. Goold R, McKinnon C, Rabbanian S, Collinge J, Schiavo G, Tabrizi SJ. Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane. J Cell Sci. 2013 Aug 15; 126(Pt 16):3552-62. PMID: 23813960.
    Citations: 20     Fields:    Translation:AnimalsCells
  79. Reiniger L, Mirabile I, Lukic A, Wadsworth JD, Linehan JM, Groves M, Lowe J, Druyeh R, Rudge P, Collinge J, Mead S, Brandner S. Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases. Acta Neuropathol Commun. 2013 May 09; 1:8. PMID: 24252267.
    Citations: 3     Fields:    Translation:Humans
  80. Thompson AG, Lowe J, Fox Z, Lukic A, Porter MC, Ford L, Gorham M, Gopalakrishnan GS, Rudge P, Walker AS, Collinge J, Mead S. The Medical Research Council prion disease rating scale: a new outcome measure for prion disease therapeutic trials developed and validated using systematic observational studies. Brain. 2013 Apr; 136(Pt 4):1116-27. PMID: 23550114.
    Citations: 14     Fields:    Translation:Humans
  81. Lloyd SE, Mead S, Collinge J. Genetics of prion diseases. Curr Opin Genet Dev. 2013 Jun; 23(3):345-51. PMID: 23518043.
    Citations: 14     Fields:    Translation:HumansAnimals
  82. Beck J, Poulter M, Hensman D, Rohrer JD, Mahoney CJ, Adamson G, Campbell T, Uphill J, Borg A, Fratta P, Orrell RW, Malaspina A, Rowe J, Brown J, Hodges J, Sidle K, Polke JM, Houlden H, Schott JM, Fox NC, Rossor MN, Tabrizi SJ, Isaacs AM, Hardy J, Warren JD, Collinge J, Mead S. Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population. Am J Hum Genet. 2013 Mar 07; 92(3):345-53. PMID: 23434116.
    Citations: 74     Fields:    Translation:HumansCells
  83. Akhtar S, Grizenkova J, Wenborn A, Hummerich H, Fernandez de Marco M, Brandner S, Collinge J, Lloyd SE. Sod1 deficiency reduces incubation time in mouse models of prion disease. PLoS One. 2013; 8(1):e54454. PMID: 23349894.
    Citations: 11     Fields:    Translation:HumansAnimals
  84. Nicoll AJ, Panico S, Freir DB, Wright D, Terry C, Risse E, Herron CE, O'Malley T, Wadsworth JD, Farrow MA, Walsh DM, Saibil HR, Collinge J. Amyloid-ß nanotubes are associated with prion protein-dependent synaptotoxicity. Nat Commun. 2013; 4:2416. PMID: 24022506.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  85. Carswell C, Thompson A, Lukic A, Stevens J, Rudge P, Mead S, Collinge J, Hyare H. MRI findings are often missed in the diagnosis of Creutzfeldt-Jakob disease. BMC Neurol. 2012 Dec 05; 12:153. PMID: 23216655.
    Citations: 7     Fields:    Translation:Humans
  86. Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J. TREM2 variants in Alzheimer's disease. N Engl J Med. 2013 Jan 10; 368(2):117-27. PMID: 23150934.
    Citations: 544     Fields:    Translation:HumansAnimals
  87. Carswell C, Rañopa M, Pal S, Macfarlane R, Siddique D, Thomas D, Webb T, Wroe S, Walker S, Darbyshire J, Collinge J, Mead S, Rudge P. Video Rating in Neurodegenerative Disease Clinical Trials: The Experience of PRION-1. Dement Geriatr Cogn Dis Extra. 2012 Jan; 2(1):286-97. PMID: 22962552.
    Citations:    
  88. Grizenkova J, Akhtar S, Hummerich H, Tomlinson A, Asante EA, Wenborn A, Fizet J, Poulter M, Wiseman FK, Fisher EM, Tybulewicz VL, Brandner S, Collinge J, Lloyd SE. Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13722-7. PMID: 22869728.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  89. Ghazi-Noori S, Froud KE, Mizielinska S, Powell C, Smidak M, Fernandez de Marco M, O'Malley C, Farmer M, Parkinson N, Fisher EM, Asante EA, Brandner S, Collinge J, Isaacs AM. Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice. Brain. 2012 Mar; 135(Pt 3):819-32. PMID: 22366797.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  90. Mahoney CJ, Beck J, Rohrer JD, Lashley T, Mok K, Shakespeare T, Yeatman T, Warrington EK, Schott JM, Fox NC, Rossor MN, Hardy J, Collinge J, Revesz T, Mead S, Warren JD. Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features. Brain. 2012 Mar; 135(Pt 3):736-50. PMID: 22366791.
    Citations: 108     Fields:    Translation:HumansCells
  91. Castro-Seoane R, Hummerich H, Sweeting T, Tattum MH, Linehan JM, Fernandez de Marco M, Brandner S, Collinge J, Klöhn PC. Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection. PLoS Pathog. 2012 Feb; 8(2):e1002538. PMID: 22359509.
    Citations: 19     Fields:    Translation:AnimalsCells
  92. Collinge J. Cell biology. The risk of prion zoonoses. Science. 2012 Jan 27; 335(6067):411-3. PMID: 22282797.
    Citations: 7     Fields:    Translation:HumansAnimals
  93. Klöhn PC, Farmer M, Linehan JM, O'Malley C, Fernandez de Marco M, Taylor W, Farrow M, Khalili-Shirazi A, Brandner S, Collinge J. PrP antibodies do not trigger mouse hippocampal neuron apoptosis. Science. 2012 Jan 06; 335(6064):52. PMID: 22223800.
    Citations: 19     Fields:    Translation:AnimalsCells
  94. Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Johnston JA, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Kölsch H, Heun R, Schürmann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Davies G, Harris SE, Starr JM, Deary IJ, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Jones L, Holmans PA, O'Donovan MC, Owen MJ, Williams J. The role of variation at AßPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. J Alzheimers Dis. 2012; 28(2):377-87. PMID: 22027014.
    Citations: 19     Fields:    Translation:Humans
  95. Mead S, Uphill J, Beck J, Poulter M, Campbell T, Lowe J, Adamson G, Hummerich H, Klopp N, Rückert IM, Wichmann HE, Azazi D, Plagnol V, Pako WH, Whitfield J, Alpers MP, Whittaker J, Balding DJ, Zerr I, Kretzschmar H, Collinge J. Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. Hum Mol Genet. 2012 Apr 15; 21(8):1897-906. PMID: 22210626.
    Citations: 19     Fields:    Translation:Humans
  96. Akhtar S, Wenborn A, Brandner S, Collinge J, Lloyd SE. Sex effects in mouse prion disease incubation time. PLoS One. 2011; 6(12):e28741. PMID: 22174884.
    Citations: 4     Fields:    Translation:Animals
  97. Beck J, Collinge J, Mead S. Prion protein gene M232R variation is probably an uncommon polymorphism rather than a pathogenic mutation. Brain. 2012 Feb; 135(Pt 2):e209; author reply e210. PMID: 22108575.
    Citations: 4     Fields:    Translation:Humans
  98. Sims R, Dwyer S, Harold D, Gerrish A, Hollingworth P, Chapman J, Jones N, Abraham R, Ivanov D, Pahwa JS, Moskvina V, Dowzell K, Thomas C, Stretton A, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuiness B, Todd S, Johnston JA, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Livingston G, Bass NJ, Gurling H, McQuillin A, Jones L, Holmans PA, O'Donovan M, Owen MJ, Williams J. No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2011 Dec; 156B(7):764-71. PMID: 21812096.
    Citations: 7     Fields:    Translation:HumansCells
  99. Deriziotis P, André R, Smith DM, Goold R, Kinghorn KJ, Kristiansen M, Nathan JA, Rosenzweig R, Krutauz D, Glickman MH, Collinge J, Goldberg AL, Tabrizi SJ. Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry. EMBO J. 2011 Jul 08; 30(15):3065-77. PMID: 21743439.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  100. Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J. Interaction between prion protein and toxic amyloid ß assemblies can be therapeutically targeted at multiple sites. Nat Commun. 2011 Jun 07; 2:336. PMID: 21654636.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  101. Kaski DN, Pennington C, Beck J, Poulter M, Uphill J, Bishop MT, Linehan JM, O'Malley C, Wadsworth JD, Joiner S, Knight RS, Ironside JW, Brandner S, Collinge J, Mead S. Inherited prion disease with 4-octapeptide repeat insertion: disease requires the interaction of multiple genetic risk factors. Brain. 2011 Jun; 134(Pt 6):1829-38. PMID: 21616973.
    Citations: 6     Fields:    Translation:Humans
  102. Hyare H, Ramlackhansingh A, Gelosa G, Edison P, Rudge P, Brandner S, Brooks DJ, Collinge J, Mead S. 11C-PiB PET does not detect PrP-amyloid in prion disease patients including variant Creutzfeldt-Jakob disease. J Neurol Neurosurg Psychiatry. 2012 Mar; 83(3):340-1. PMID: 21478204.
    Citations: 3     Fields:    Translation:Humans
  103. Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Beaumont H, Warden D, Wilcock G, Love S, Kehoe PG, Hooper NM, Vardy ER, Hardy J, Mead S, Fox NC, Rossor M, Collinge J, Maier W, Jessen F, Rüther E, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Gallacher J, Hüll M, Rujescu D, Giegling I, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC, van Duijn CM, Breteler MM, Ikram MA, DeStefano AL, Fitzpatrick AL, Lopez O, Launer LJ, Seshadri S, Berr C, Campion D, Epelbaum J, Dartigues JF, Tzourio C, Alpérovitch A, Lathrop M, Feulner TM, Friedrich P, Riehle C, Krawczak M, Schreiber S, Mayhaus M, Nicolhaus S, Wagenpfeil S, Steinberg S, Stefansson H, Stefansson K, Snaedal J, Björnsson S, Jonsson PV, Chouraki V, Genier-Boley B, Hiltunen M, Soininen H, Combarros O, Zelenika D, Delepine M, Bullido MJ, Pasquier F, Mateo I, Frank-Garcia A, Porcellini E, Hanon O, Coto E, Alvarez V, Bosco P, Siciliano G, Mancuso M, Panza F, Solfrizzi V, Nacmias B, Sorbi S, Bossù P, Piccardi P, Arosio B, Annoni G, Seripa D, Pilotto A, Scarpini E, Galimberti D, Brice A, Hannequin D, Licastro F, Jones L, Holmans PA, Jonsson T, Riemenschneider M, Morgan K, Younkin SG, Owen MJ, O'Donovan M, Amouyel P, Williams J. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet. 2011 May; 43(5):429-35. PMID: 21460840.
    Citations: 584     Fields:    Translation:Humans
  104. Rohrer JD, Warren JD, Reiman D, Uphill J, Beck J, Collinge J, Rossor MN, Isaacs AM, Mead S. A novel exon 2 I27V VCP variant is associated with dissimilar clinical syndromes. J Neurol. 2011 Aug; 258(8):1494-6. PMID: 21387114.
    Citations: 14     Fields:    Translation:Humans
  105. Sandberg MK, Al-Doujaily H, Sharps B, Clarke AR, Collinge J. Prion propagation and toxicity in vivo occur in two distinct mechanistic phases. Nature. 2011 Feb 24; 470(7335):540-2. PMID: 21350487.
    Citations: 108     Fields:    Translation:AnimalsCells
  106. Edgeworth JA, Farmer M, Sicilia A, Tavares P, Beck J, Campbell T, Lowe J, Mead S, Rudge P, Collinge J, Jackson GS. Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay. Lancet. 2011 Feb 05; 377(9764):487-93. PMID: 21295339.
    Citations: 47     Fields:    Translation:HumansCells
  107. Lukic A, Mead S, Rudge P, Collinge J. Comment on validation of diagnostic criteria for variant Creutzfeldt-Jakob disease. Ann Neurol. 2011 Jan; 69(1):212; author reply 212-3. PMID: 21280094.
    Citations: 1     Fields:    Translation:Humans
  108. Lloyd S, Mead S, Collinge J. Genetics of prion disease. Top Curr Chem. 2011; 305:1-22. PMID: 21528440.
    Citations: 27     Fields:    Translation:HumansAnimals
  109. McNaughton D, Knight W, Guerreiro R, Ryan N, Lowe J, Poulter M, Nicholl DJ, Hardy J, Revesz T, Lowe J, Rossor M, Collinge J, Mead S. Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series. Neurobiol Aging. 2012 Feb; 33(2):426.e13-21. PMID: 21193246.
    Citations: 28     Fields:    Translation:Humans
  110. D'Castro L, Wenborn A, Gros N, Joiner S, Cronier S, Collinge J, Wadsworth JD. Isolation of proteinase K-sensitive prions using pronase E and phosphotungstic acid. PLoS One. 2010 Dec 20; 5(12):e15679. PMID: 21187933.
    Citations: 20     Fields:    Translation:HumansAnimals
  111. Wadsworth JD, Dalmau-Mena I, Joiner S, Linehan JM, O'Malley C, Powell C, Brandner S, Asante EA, Ironside JW, Hilton DA, Collinge J. Effect of fixation on brain and lymphoreticular vCJD prions and bioassay of key positive specimens from a retrospective vCJD prevalence study. J Pathol. 2011 Mar; 223(4):511-8. PMID: 21294124.
    Citations: 8     Fields:    Translation:HumansAnimals
  112. Grizenkova J, Akhtar S, Collinge J, Lloyd SE. The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse. PLoS One. 2010 Dec 06; 5(12):e15019. PMID: 21151910.
    Citations: 7     Fields:    Translation:Animals
  113. Tattum MH, Jones S, Pal S, Khalili-Shirazi A, Collinge J, Jackson GS. A highly sensitive immunoassay for the detection of prion-infected material in whole human blood without the use of proteinase K. Transfusion. 2010 Dec; 50(12):2619-27. PMID: 20561299.
    Citations: 8     Fields:    Translation:HumansAnimalsPHPublic Health
  114. Edgeworth JA, Sicilia A, Linehan J, Brandner S, Jackson GS, Collinge J. A standardized comparison of commercially available prion decontamination reagents using the Standard Steel-Binding Assay. J Gen Virol. 2011 Mar; 92(Pt 3):718-26. PMID: 21084494.
    Citations: 6     Fields:    Translation:HumansAnimalsPHPublic Health
  115. Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Peters O, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Rüther E, Carrasquillo MM, Pankratz VS, Younkin SG, Hardy J, O'Donovan MC, Owen MJ, Williams J. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One. 2010 Nov 15; 5(11):e13950. PMID: 21085570.
    Citations: 108     Fields:    Translation:Humans
  116. O'Nuallain B, Freir DB, Nicoll AJ, Risse E, Ferguson N, Herron CE, Collinge J, Walsh DM. Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils. J Neurosci. 2010 Oct 27; 30(43):14411-9. PMID: 20980598.
    Citations: 78     Fields:    Translation:AnimalsCells
  117. Siddique D, Hyare H, Wroe S, Webb T, Macfarlane R, Rudge P, Collinge J, Powell C, Brandner S, So PW, Walker S, Mead S, Yousry T, Thornton JS. Magnetization transfer ratio may be a surrogate of spongiform change in human prion diseases. Brain. 2010 Oct; 133(10):3058-68. PMID: 20881162.
    Citations: 4     Fields:    Translation:HumansCells
  118. Nicoll AJ, Trevitt CR, Tattum MH, Risse E, Quarterman E, Ibarra AA, Wright C, Jackson GS, Sessions RB, Farrow M, Waltho JP, Clarke AR, Collinge J. Pharmacological chaperone for the structured domain of human prion protein. Proc Natl Acad Sci U S A. 2010 Oct 12; 107(41):17610-5. PMID: 20876144.
    Citations: 18     Fields:    Translation:HumansCells
  119. Hosszu LL, Tattum MH, Jones S, Trevitt CR, Wells MA, Waltho JP, Collinge J, Jackson GS, Clarke AR. The H187R mutation of the human prion protein induces conversion of recombinant prion protein to the PrP(Sc)-like form. Biochemistry. 2010 Oct 12; 49(40):8729-38. PMID: 20718410.
    Citations: 10     Fields:    Translation:HumansCells
  120. Wadsworth JD, Collinge J. Molecular pathology of human prion disease. Acta Neuropathol. 2011 Jan; 121(1):69-77. PMID: 20694796.
    Citations: 25     Fields:    Translation:HumansAnimals
  121. Lukic A, Beck J, Joiner S, Fearnley J, Sturman S, Brandner S, Wadsworth JD, Collinge J, Mead S. Heterozygosity at polymorphic codon 219 in variant creutzfeldt-jakob disease. Arch Neurol. 2010 Aug; 67(8):1021-3. PMID: 20697057.
    Citations: 11     Fields:    Translation:Humans
  122. Edgeworth JA, Gros N, Alden J, Joiner S, Wadsworth JD, Linehan J, Brandner S, Jackson GS, Weissmann C, Collinge J. Spontaneous generation of mammalian prions. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14402-6. PMID: 20660771.
    Citations: 19     Fields:    Translation:Animals
  123. Sandberg MK, Al-Doujaily H, Sigurdson CJ, Glatzel M, O'Malley C, Powell C, Asante EA, Linehan JM, Brandner S, Wadsworth JD, Collinge J. Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein. J Gen Virol. 2010 Oct; 91(Pt 10):2651-7. PMID: 20610667.
    Citations: 26     Fields:    Translation:HumansAnimals
  124. Beck JA, Poulter M, Campbell TA, Adamson G, Uphill JB, Guerreiro R, Jackson GS, Stevens JC, Manji H, Collinge J, Mead S. PRNP allelic series from 19 years of prion protein gene sequencing at the MRC Prion Unit. Hum Mutat. 2010 Jul; 31(7):E1551-63. PMID: 20583301.
    Citations: 19     Fields:    Translation:Humans
  125. Collinge J. Medicine. Prion strain mutation and selection. Science. 2010 May 28; 328(5982):1111-2. PMID: 20508117.
    Citations: 28     Fields:    Translation:AnimalsCells
  126. Urwin H, Josephs KA, Rohrer JD, Mackenzie IR, Neumann M, Authier A, Seelaar H, Van Swieten JC, Brown JM, Johannsen P, Nielsen JE, Holm IE, Dickson DW, Rademakers R, Graff-Radford NR, Parisi JE, Petersen RC, Hatanpaa KJ, White CL, Weiner MF, Geser F, Van Deerlin VM, Trojanowski JQ, Miller BL, Seeley WW, van der Zee J, Kumar-Singh S, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bigio EH, Deng HX, Halliday GM, Kril JJ, Munoz DG, Mann DM, Pickering-Brown SM, Doodeman V, Adamson G, Ghazi-Noori S, Fisher EM, Holton JL, Revesz T, Rossor MN, Collinge J, Mead S, Isaacs AM. FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration. Acta Neuropathol. 2010 Jul; 120(1):33-41. PMID: 20490813.
    Citations: 82     Fields:    Translation:Humans
  127. Reiniger L, Lukic A, Linehan J, Rudge P, Collinge J, Mead S, Brandner S. Tau, prions and Aß: the triad of neurodegeneration. Acta Neuropathol. 2011 Jan; 121(1):5-20. PMID: 20473510.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  128. Chia R, Tattum MH, Jones S, Collinge J, Fisher EM, Jackson GS. Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis. PLoS One. 2010 May 13; 5(5):e10627. PMID: 20498711.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  129. Urwin H, Authier A, Nielsen JE, Metcalf D, Powell C, Froud K, Malcolm DS, Holm I, Johannsen P, Brown J, Fisher EM, van der Zee J, Bruyland M, Van Broeckhoven C, Collinge J, Brandner S, Futter C, Isaacs AM. Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations. Hum Mol Genet. 2010 Jun 01; 19(11):2228-38. PMID: 20223751.
    Citations: 51     Fields:    Translation:HumansCells
  130. Guerreiro RJ, Beck J, Gibbs JR, Santana I, Rossor MN, Schott JM, Nalls MA, Ribeiro H, Santiago B, Fox NC, Oliveira C, Collinge J, Mead S, Singleton A, Hardy J. Genetic variability in CLU and its association with Alzheimer's disease. PLoS One. 2010 Mar 03; 5(3):e9510. PMID: 20209083.
    Citations: 23     Fields:    Translation:Humans
  131. Tattum MH, Jones S, Pal S, Collinge J, Jackson GS. Discrimination between prion-infected and normal blood samples by protein misfolding cyclic amplification. Transfusion. 2010 May; 50(5):996-1002. PMID: 20180925.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  132. Kaski D, Mead S, Hyare H, Cooper S, Jampana R, Overell J, Knight R, Collinge J, Rudge P. Variant CJD in an individual heterozygous for PRNP codon 129. Lancet. 2009 Dec 19; 374(9707):2128. PMID: 20109837.
    Citations: 16     Fields:    Translation:Humans
  133. Mead S, Whitfield J, Poulter M, Shah P, Uphill J, Campbell T, Al-Dujaily H, Hummerich H, Beck J, Mein CA, Verzilli C, Whittaker J, Alpers MP, Collinge J. A novel protective prion protein variant that colocalizes with kuru exposure. N Engl J Med. 2009 Nov 19; 361(21):2056-65. PMID: 19923577.
    Citations: 35     Fields:    Translation:HumansPHPublic Health
  134. Lloyd SE, Maytham EG, Grizenkova J, Hummerich H, Collinge J. A Copine family member, Cpne8, is a candidate quantitative trait gene for prion disease incubation time in mouse. Neurogenetics. 2010 May; 11(2):185-91. PMID: 19795140.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  135. Lloyd SE, Rossor M, Fox N, Mead S, Collinge J. HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q. BMC Med Genet. 2009 Sep 15; 10:90. PMID: 19754925.
    Citations: 5     Fields:    Translation:HumansCells
  136. Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet. 2009 Oct; 41(10):1088-93. PMID: 19734902.
    Citations: 866     Fields:    Translation:HumansCells
  137. Lloyd SE, Grizenkova J, Pota H, Collinge J. Shadoo (Sprn) and prion disease incubation time in mice. Mamm Genome. 2009 Jun; 20(6):367-74. PMID: 19513788.
    Citations: 4     Fields:    Translation:Animals
  138. Rollinson S, Rohrer JD, van der Zee J, Sleegers K, Mead S, Engelborghs S, Collinge J, De Deyn PP, Mann DM, Van Broeckhoven C, Pickering-Brown SM. No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration. Neurobiol Aging. 2011 Apr; 32(4):754-5. PMID: 19446372.
    Citations: 22     Fields:    Translation:Humans
  139. Hosszu LL, Trevitt CR, Jones S, Batchelor M, Scott DJ, Jackson GS, Collinge J, Waltho JP, Clarke AR. Conformational properties of beta-PrP. J Biol Chem. 2009 Aug 14; 284(33):21981-90. PMID: 19369250.
    Citations: 10     Fields:    Translation:HumansCells
  140. Hart T, Hosszu LL, Trevitt CR, Jackson GS, Waltho JP, Collinge J, Clarke AR. Folding kinetics of the human prion protein probed by temperature jump. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5651-6. PMID: 19321423.
    Citations: 20     Fields:    Translation:HumansCells
  141. Collinge J, Gorham M, Hudson F, Kennedy A, Keogh G, Pal S, Rossor M, Rudge P, Siddique D, Spyer M, Thomas D, Walker S, Webb T, Wroe S, Darbyshire J. Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial. Lancet Neurol. 2009 Apr; 8(4):334-44. PMID: 19278902.
    Citations: 59     Fields:    Translation:HumansCTClinical Trials
  142. Asante EA, Gowland I, Grimshaw A, Linehan JM, Smidak M, Houghton R, Osiguwa O, Tomlinson A, Joiner S, Brandner S, Wadsworth JD, Collinge J. Absence of spontaneous disease and comparative prion susceptibility of transgenic mice expressing mutant human prion proteins. J Gen Virol. 2009 Mar; 90(Pt 3):546-58. PMID: 19218199.
    Citations: 27     Fields:    Translation:HumansAnimals
  143. Lloyd SE, Maytham EG, Pota H, Grizenkova J, Molou E, Uphill J, Hummerich H, Whitfield J, Alpers MP, Mead S, Collinge J. HECTD2 is associated with susceptibility to mouse and human prion disease. PLoS Genet. 2009 Feb; 5(2):e1000383. PMID: 19214206.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  144. Rollinson S, Rizzu P, Sikkink S, Baker M, Halliwell N, Snowden J, Traynor BJ, Ruano D, Cairns N, Rohrer JD, Mead S, Collinge J, Rossor M, Akay E, Guerreiro R, Rademakers R, Morrison KE, Pastor P, Alonso E, Martinez-Lage P, Graff-Radford N, Neary D, Heutink P, Mann DM, Van Swieten J, Pickering-Brown SM. Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration. Neurobiol Aging. 2009 Apr; 30(4):656-65. PMID: 19217189.
    Citations: 17     Fields:    Translation:HumansCells
  145. Urwin H, Ghazi-Noori S, Collinge J, Isaacs A. The role of CHMP2B in frontotemporal dementia. Biochem Soc Trans. 2009 Feb; 37(Pt 1):208-12. PMID: 19143633.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  146. Nicoll AJ, Collinge J. Preventing prion pathogenicity by targeting the cellular prion protein. Infect Disord Drug Targets. 2009 Feb; 9(1):48-57. PMID: 19200015.
    Citations: 13     Fields:    Translation:HumansAnimals
  147. Mead S, Poulter M, Uphill J, Beck J, Whitfield J, Webb TE, Campbell T, Adamson G, Deriziotis P, Tabrizi SJ, Hummerich H, Verzilli C, Alpers MP, Whittaker JC, Collinge J. Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study. Lancet Neurol. 2009 Jan; 8(1):57-66. PMID: 19081515.
    Citations: 44     Fields:    Translation:HumansCellsPHPublic Health
  148. Mead S, Poulter M, Beck J, Uphill J, Jones C, Ang CE, Mein CA, Collinge J. Successful amplification of degraded DNA for use with high-throughput SNP genotyping platforms. Hum Mutat. 2008 Dec; 29(12):1452-8. PMID: 18551557.
    Citations: 8     Fields:    Translation:Humans
  149. Cronier S, Gros N, Tattum MH, Jackson GS, Clarke AR, Collinge J, Wadsworth JD. Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin. Biochem J. 2008 Dec 01; 416(2):297-305. PMID: 18684106.
    Citations: 75     Fields:    Translation:HumansAnimals
  150. Brandner S, Whitfield J, Boone K, Puwa A, O'Malley C, Linehan JM, Joiner S, Scaravilli F, Calder I, P Alpers M, Wadsworth JD, Collinge J. Central and peripheral pathology of kuru: pathological analysis of a recent case and comparison with other forms of human prion disease. Philos Trans R Soc Lond B Biol Sci. 2008 Nov 27; 363(1510):3755-63. PMID: 18849292.
    Citations: 15     Fields:    Translation:Humans
  151. Collinge J, Alpers MP. Reminiscences and reflections on kuru, personal and scientific. Philos Trans R Soc Lond B Biol Sci. 2008 Nov 27; 363(1510):3613. PMID: 18849244.
    Citations:    Fields:    Translation:Humans
  152. Collinge J. Review. Lessons of kuru research: background to recent studies with some personal reflections. Philos Trans R Soc Lond B Biol Sci. 2008 Nov 27; 363(1510):3689-96. PMID: 18849283.
    Citations: 5     Fields:    Translation:Humans
  153. Wadsworth JD, Joiner S, Linehan JM, Asante EA, Brandner S, Collinge J. Review. The origin of the prion agent of kuru: molecular and biological strain typing. Philos Trans R Soc Lond B Biol Sci. 2008 Nov 27; 363(1510):3747-53. PMID: 18849291.
    Citations: 12     Fields:    Translation:Animals
  154. Mead S, Whitfield J, Poulter M, Shah P, Uphill J, Beck J, Campbell T, Al-Dujaily H, Hummerich H, Alpers MP, Collinge J. Genetic susceptibility, evolution and the kuru epidemic. Philos Trans R Soc Lond B Biol Sci. 2008 Nov 27; 363(1510):3741-6. PMID: 18849290.
    Citations: 10     Fields:    Translation:Humans
  155. Collinge J, Whitfield J, McKintosh E, Frosh A, Mead S, Hill AF, Brandner S, Thomas D, Alpers MP. A clinical study of kuru patients with long incubation periods at the end of the epidemic in Papua New Guinea. Philos Trans R Soc Lond B Biol Sci. 2008 Nov 27; 363(1510):3725-39. PMID: 18849289.
    Citations: 22     Fields:    Translation:HumansPHPublic Health
  156. Whitfield JT, Pako WH, Collinge J, Alpers MP. Mortuary rites of the South Fore and kuru. Philos Trans R Soc Lond B Biol Sci. 2008 Nov 27; 363(1510):3721-4. PMID: 18849288.
    Citations: 7     Fields:    Translation:Humans
  157. Collinge J, Alpers MP. Introduction. Philos Trans R Soc Lond B Biol Sci. 2008 Nov 27; 363(1510):3607-12. PMID: 18672464.
    Citations: 1     Fields:    Translation:Humans
  158. Webb TE, Pal S, Siddique D, Heaney DC, Linehan JM, Wadsworth JD, Joiner S, Beck J, Wroe SJ, Stevenson V, Brandner S, Mead S, Collinge J. First report of Creutzfeldt-Jakob disease occurring in 2 siblings unexplained by PRNP mutation. J Neuropathol Exp Neurol. 2008 Sep; 67(9):838-41. PMID: 18716560.
    Citations: 6     Fields:    Translation:Humans
  159. O'Shea M, Maytham EG, Linehan JM, Brandner S, Collinge J, Lloyd SE. Investigation of mcp1 as a quantitative trait gene for prion disease incubation time in mouse. Genetics. 2008 Sep; 180(1):559-66. PMID: 18716327.
    Citations: 12     Fields:    Translation:Animals
  160. Rohrer JD, Warren JD, Barnes J, Mead S, Beck J, Pepple T, Boyes R, Omar R, Collinge