Harvard Catalyst Profiles

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Tuo Shao, Ph.D.


University of LouisvillePhD08/2017Pharmacology

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Chen Z, Chen J, Chen L, Yoo CH, Rong J, Fu H, Shao T, Coffman K, Steyn SJ, Davenport AT, Daunais JB, Haider A, Collier L, Josephson L, Wey HY, Zhang L, Liang SH. Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand. J Med Chem. 2022 Oct 18. PMID: 36256881.
    Citations:    Fields:    
  2. Haider A, Zhao C, Wang L, Xiao Z, Rong J, Xia X, Chen Z, Pfister SK, Mast N, Yutuc E, Chen J, Li Y, Shao T, Warnock GI, Dawoud A, Connors TR, Oakley DH, Wei H, Wang J, Zheng Z, Xu H, Davenport AT, Daunais JB, Van RS, Shao Y, Wang Y, Zhang MR, Gebhard C, Pikuleva I, Levey AI, Griffiths WJ, Liang SH. Assessment of cholesterol homeostasis in the living human brain. Sci Transl Med. 2022 10 05; 14(665):eadc9967. PMID: 36197966; PMCID: PMC9581941.
    Citations: 1     Fields:    Translation:HumansAnimals
  3. Yu Q, Kumata K, Rong J, Chen Z, Yamasaki T, Chen J, Xiao Z, Ishii H, Hiraishi A, Shao T, Zhang Y, Hu K, Xie L, Fujinaga M, Zhao C, Mori W, Collier T, Haider A, Tomita S, Zhang MR, Liang S. Imaging of Transmembrane AMPA Receptor Regulatory Proteins by Positron Emission Tomography. J Med Chem. 2022 07 14; 65(13):9144-9158. PMID: 35762919.
    Citations:    Fields:    Translation:Animals
  4. Cheng R, Fujinaga M, Yang J, Rong J, Haider A, Ogasawara D, Van RS, Shao T, Chen Z, Zhang X, Calderon Leon ER, Zhang Y, Mori W, Kumata K, Yamasaki T, Xie L, Sun S, Wang L, Ran C, Shao Y, Cravatt B, Josephson L, Zhang MR, Liang SH. A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network. Acta Pharmacol Sin. 2022 Nov; 43(11):3002-3010. PMID: 35513432; PMCID: PMC9622914.
    Citations:    Fields:    
  5. Shao T, Chen Z, Cheng R, Collier L, Josephson L, Chung RT, Liang SH. Preliminary evaluation of [11C]MAGL-0519 as a promising PET ligand for the diagnosis of Hepatocellular carcinoma. Bioorg Chem. 2022 03; 120:105620. PMID: 35051705.
    Citations:    Fields:    Translation:Humans
  6. Li W, Duan X, Zhu C, Liu X, Jeyarajan AJ, Xu M, Tu Z, Sheng Q, Chen D, Zhu C, Shao T, Cheng Z, Salloum S, Schaefer EA, Kruger AJ, Holmes JA, Chung RT, Lin W. Hepatitis B and Hepatitis C Virus Infection Promote Liver Fibrogenesis through a TGF-ß1-Induced OCT4/Nanog Pathway. J Immunol. 2022 02 01; 208(3):672-684. PMID: 35022275; PMCID: PMC8770612.
    Citations:    Fields:    Translation:HumansCells
  7. Li S, Huang P, Jeyarajan AJ, Ma C, Zhu K, Zhu C, Jiang N, Li M, Shao T, Han M, Tan L, Lin W. Assessment of Non-invasive Markers for the Prediction of Esophageal Variceal Hemorrhage. Front Med (Lausanne). 2021; 8:770836. PMID: 34926512.
  8. Deng X, Salgado-Polo F, Shao T, Xiao Z, Van R, Chen J, Rong J, Haider A, Shao Y, Josephson L, Perrakis A, Liang SH. Imaging Autotaxin In Vivo with 18F-Labeled Positron Emission Tomography Ligands. J Med Chem. 2021 10 28; 64(20):15053-15068. PMID: 34662125.
    Citations:    Fields:    Translation:AnimalsCells
  9. Rong J, Mori W, Xia X, Schafroth MA, Zhao C, Van RS, Yamasaki T, Chen J, Xiao Z, Haider A, Ogasawara D, Hiraishi A, Shao T, Zhang Y, Chen Z, Pang F, Hu K, Xie L, Fujinaga M, Kumata K, Gou Y, Fang Y, Gu S, Wei H, Bao L, Xu H, Collier TL, Shao Y, Carson RE, Cravatt BF, Wang L, Zhang MR, Liang SH. Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold. J Med Chem. 2021 10 14; 64(19):14283-14298. PMID: 34569803; PMCID: PMC9090218.
    Citations: 1     Fields:    Translation:AnimalsCells
  10. Haider A, Xiao Z, Xia X, Chen J, Van RS, Kuang S, Zhao C, Rong J, Shao T, Ramesh P, Aravind A, Shao Y, Ran C, Young LJ, Liang SH. Development of a triazolobenzodiazepine-based PET probe for subtype-selective vasopressin 1A receptor imaging. Pharmacol Res. 2021 11; 173:105886. PMID: 34536549; PMCID: PMC8581590.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Shao T, Chen Z, Rong J, Belov V, Chen J, Jeyarajan A, Deng X, Fu H, Yu Q, Rwema SH, Lin W, Papisov M, Josephson L, Chung RT, Liang SH. [18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models. Acta Pharm Sin B. 2022 Jan; 12(1):308-315. PMID: 35127387; PMCID: PMC8799882.
  12. Salloum S, Jeyarajan AJ, Kruger AJ, Holmes JA, Shao T, Sojoodi M, Kim MH, Zhuo Z, Shroff SG, Kassa A, Corey KE, Khan SK, Lin W, Alatrakchi N, Schaefer EAK, Chung RT. Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase. Cell Mol Gastroenterol Hepatol. 2021; 12(4):1297-1310. PMID: 34118488; PMCID: PMC8463869.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Chen Z, Mori W, Rong J, Schafroth MA, Shao T, Van RS, Ogasawara D, Yamasaki T, Hiraishi A, Hatori A, Chen J, Zhang Y, Hu K, Fujinaga M, Sun J, Yu Q, Collier TL, Shao Y, Cravatt BF, Josephson L, Zhang MR, Liang SH. Development of a highly-specific 18F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping. Acta Pharm Sin B. 2021 Jun; 11(6):1686-1695. PMID: 34221877; PMCID: PMC8245801.
    Citations: 1     
  14. Li S, Duan X, Li Y, Li M, Gao Y, Li T, Li S, Tan L, Shao T, Jeyarajan AJ, Chen L, Han M, Lin W, Li X. Differentially expressed immune response genes in COVID-19 patients based on disease severity. Aging (Albany NY). 2021 03 29; 13(7):9265-9276. PMID: 33780352.
    Citations: 7     Fields:    Translation:HumansCells
  15. Zhang X, Zhang Y, Chen Z, Shao T, Van R, Kumata K, Deng X, Fu H, Yamasaki T, Rong J, Hu K, Hatori A, Xie L, Yu Q, Ye W, Xu H, Sheffler DJ, Cosford NDP, Shao Y, Tang P, Wang L, Zhang MR, Liang SH. Synthesis and preliminary studies of 11C-labeled tetrahydro-1,7-naphthyridine-2-carboxamides for PET imaging of metabotropic glutamate receptor 2. Theranostics. 2020; 10(24):11178-11196. PMID: 33042277; PMCID: PMC7532674.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Shao T, Tong Y, Lu S, Jeyarajan AJ, Su F, Dai J, Shi J, Huang J, Hu C, Wu L, Dai X, Cheng Z, Yan J, Huang P, Tian Y, Li S, Chung RT, Chen D. Gamma-Glutamyltransferase Elevation Is Frequent in Patients With COVID-19: A Clinical Epidemiologic Study. Hepatol Commun. 2020 Dec; 4(12):1744-1750. PMID: 32838106; PMCID: PMC7404935.
    Citations: 8     Fields:    
  17. Zhang L, Hu K, Shao T, Hou L, Zhang S, Ye W, Josephson L, Meyer JH, Zhang MR, Vasdev N, Wang J, Xu H, Wang L, Liang SH. Recent developments on PET radiotracers for TSPO and their applications in neuroimaging. Acta Pharm Sin B. 2021 Feb; 11(2):373-393. PMID: 33643818.
    Citations: 18     
  18. Yu Y, Jiang L, Wang H, Shen Z, Cheng Q, Zhang P, Wang J, Wu Q, Fang X, Duan L, Wang S, Wang K, An P, Shao T, Chung RT, Zheng S, Min J, Wang F. Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis. Blood. 2020 08 06; 136(6):726-739. PMID: 32374849; PMCID: PMC7414596.
    Citations: 57     Fields:    Translation:AnimalsCells
  19. Li S, Li J, Zhang Z, Tan L, Shao T, Li M, Li X, Holmes JA, Lin W, Han M. COVID-19 induced liver function abnormality associates with age. Aging (Albany NY). 2020 07 28; 12(14):13895-13904. PMID: 32721928.
    Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
  20. Sun JY, Kumata K, Chen Z, Zhang YD, Chen JH, Hatori A, Fu HL, Rong J, Deng XY, Yamasaki T, Xie L, Hu K, Fujinaga M, Yu QZ, Shao T, Collier TL, Josephson L, Shao YH, Du YF, Wang L, Xu H, Zhang MR, Liang SH. Synthesis and preliminary evaluation of novel 11C-labeled GluN2B-selective NMDA receptor negative allosteric modulators. Acta Pharmacol Sin. 2021 Mar; 42(3):491-498. PMID: 32661351; PMCID: PMC8027431.
    Citations: 4     Fields:    Translation:AnimalsCells
  21. Deng X, Zhang Y, Chen Z, Kumata K, Van R, Rong J, Shao T, Hatori A, Mori W, Yu Q, Hu K, Fujinaga M, Wey HY, Shao Y, Josephson L, Murtas G, Pollegioni L, Zhang MR, Liang S. Synthesis and preliminary evaluation of 4-hydroxy-6-(3-[11C]methoxyphenethyl)pyridazin-3(2H)-one, a 11C-labeled d-amino acid oxidase (DAAO) inhibitor for PET imaging. Bioorg Med Chem Lett. 2020 08 15; 30(16):127326. PMID: 32631531.
    Citations:    Fields:    Translation:HumansAnimalsCells
  22. Pang F, Li Y, Zhang W, Xia C, He Q, Li Z, Xiao L, Song S, Dong P, Zhou H, Shao T, Cai H, Li L. Biodegradable 131 Iodine-Labeled Microspheres: Potential Transarterial Radioembolization Biomaterial for Primary Hepatocellular Carcinoma Treatment. Adv Healthc Mater. 2020 07; 9(13):e2000028. PMID: 32431090.
    Citations: 2     Fields:    Translation:Animals
  23. Chen Z, Chen J, Mast N, Rong J, Deng X, Shao T, Fu H, Yu Q, Sun J, Shao Y, Josephson L, Collier TL, Pikuleva I, Liang SH. Synthesis and pharmacokinetic study of a 11C-labeled cholesterol 24-hydroxylase inhibitor using 'in-loop' [11C]CO2 fixation method. Bioorg Med Chem Lett. 2020 05 01; 30(9):127068. PMID: 32178974.
    Citations: 1     Fields:    Translation:AnimalsCells
  24. Shao T, Chen Z, Belov V, Wang X, Rwema SH, Kumar V, Fu H, Deng X, Rong J, Yu Q, Lang L, Lin W, Josephson L, Samir AE, Chen X, Chung RT, Liang SH. [18F]-Alfatide PET imaging of integrin avß3 for the non-invasive quantification of liver fibrosis. J Hepatol. 2020 07; 73(1):161-169. PMID: 32145257.
    Citations: 3     Fields:    Translation:AnimalsCells
  25. Chen J, Gan J, Sun J, Chen Z, Fu H, Rong J, Deng X, Shang J, Gong J, Shao T, Collier L, Wang L, Xu H, Liang SH. Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors. Tetrahedron Lett. 2020 Mar 19; 61(12). PMID: 32153306.
    Citations: 3     Fields:    
  26. Yu Q, Kumata K, Li H, Zhang Y, Chen Z, Zhang X, Shao T, Hatori A, Yamasaki T, Xie L, Hu K, Wang G, Josephson L, Sun S, Zhang MR, Liang SH. Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging ?-8 dependent transmembrane AMPA receptor regulatory protein by PET. Bioorg Med Chem Lett. 2020 02 15; 30(4):126879. PMID: 31879207.
    Citations:    Fields:    Translation:Animals
  27. Chen Z, Mori W, Fu H, Schafroth MA, Hatori A, Shao T, Zhang G, Van RS, Zhang Y, Hu K, Fujinaga M, Wang L, Belov V, Ogasawara D, Giffenig P, Deng X, Rong J, Yu Q, Zhang X, Papisov MI, Shao Y, Collier TL, Ma JA, Cravatt BF, Josephson L, Zhang MR, Liang SH. Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes. J Med Chem. 2019 10 10; 62(19):8866-8872. PMID: 31518130.
    Citations: 6     Fields:    Translation:AnimalsCells
  28. Zhao C, Liu L, Liu Q, Li F, Zhang L, Zhu F, Shao T, Barve S, Chen Y, Li X, McClain CJ, Feng W. Fibroblast growth factor 21 is required for the therapeutic effects of Lactobacillus rhamnosus GG against fructose-induced fatty liver in mice. Mol Metab. 2019 11; 29:145-157. PMID: 31668386; PMCID: PMC6812038.
    Citations: 8     Fields:    Translation:AnimalsCells
  29. Chen Z, Shao T, Gao W, Fu H, Collier TL, Rong J, Deng X, Yu Q, Zhang X, Davenport AT, Daunais JB, Wey HY, Shao Y, Josephson L, Qiu WW, Liang S. Synthesis and Preliminary Evaluation of [11 C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2) in Parkinson's Disease. ChemMedChem. 2019 09 04; 14(17):1580-1585. PMID: 31365783.
    Citations: 4     Fields:    Translation:HumansAnimals
  30. Duan X, Liu X, Li W, Holmes JA, Kruger AJ, Yang C, Li Y, Xu M, Ye H, Li S, Liao X, Sheng Q, Chen D, Shao T, Cheng Z, Kaj B, Schaefer EA, Li S, Chen L, Lin W, Chung RT. Microrna-130a Downregulates HCV Replication through an atg5-Dependent Autophagy Pathway. Cells. 2019 04 10; 8(4). PMID: 30974864.
    Citations: 8     Fields:    Translation:HumansCells
  31. Chen Z, Mori W, Deng X, Cheng R, Ogasawara D, Zhang G, Schafroth MA, Dahl K, Fu H, Hatori A, Shao T, Zhang Y, Yamasaki T, Zhang X, Rong J, Yu Q, Hu K, Fujinaga M, Xie L, Kumata K, Gou Y, Chen J, Gu S, Bao L, Wang L, Collier TL, Vasdev N, Shao Y, Ma JA, Cravatt BF, Fowler C, Josephson L, Zhang MR, Liang SH. Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton. J Med Chem. 2019 04 11; 62(7):3336-3353. PMID: 30829483; PMCID: PMC6581563.
    Citations: 9     Fields:    Translation:Animals
  32. Fu H, Tang W, Chen Z, Belov VV, Zhang G, Shao T, Zhang X, Yu Q, Rong J, Deng X, Han W, Myers SJ, Giffenig P, Wang L, Josephson L, Shao Y, Davenport AT, Daunais JB, Papisov M, Yuan H, Li Z, Traynelis SF, Liang SH. Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain. ACS Chem Neurosci. 2019 05 15; 10(5):2263-2275. PMID: 30698943; PMCID: PMC6727982.
    Citations: 2     Fields:    Translation:Animals
  33. Shao T, Josephson L, Liang SH. PET/SPECT Molecular Probes for the Diagnosis and Staging of Nonalcoholic Fatty Liver Disease. Mol Imaging. 2019 Jan-Dec; 18:1536012119871455. PMID: 31478458; PMCID: PMC6724487.
    Citations: 1     Fields:    Translation:Humans
  34. Deng X, Hatori A, Chen Z, Kumata K, Shao T, Zhang X, Yamasaki T, Hu K, Yu Q, Ma L, Wang G, Wang L, Shao Y, Josephson L, Sun S, Zhang MR, Liang S. Synthesis and Preliminary Evaluation of 11 C-Labeled VU0467485/AZ13713945 and Its Analogues for Imaging Muscarinic Acetylcholine Receptor Subtype 4. ChemMedChem. 2019 02 05; 14(3):303-309. PMID: 30589226.
    Citations: 1     Fields:    Translation:AnimalsCells
  35. Chen Z, Mori W, Zhang X, Yamasaki T, Dunn PJ, Zhang G, Fu H, Shao T, Zhang Y, Hatori A, Ma L, Fujinaga M, Xie L, Deng X, Li H, Yu Q, Rong J, Josephson L, Ma JA, Shao Y, Tomita S, Zhang MR, Liang SH. Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging ?8-dependent transmembrane AMPA receptor regulatory protein. Eur J Med Chem. 2018 Sep 05; 157:898-908. PMID: 30145376.
    Citations: 6     Fields:    Translation:HumansCells
  36. Shao T, Zhao C, Li F, Gu Z, Liu L, Zhang L, Wang Y, He L, Liu Y, Liu Q, Chen Y, Donde H, Wang R, Jala VR, Barve S, Chen SY, Zhang X, Chen Y, McClain CJ, Feng W. Intestinal HIF-1a deletion exacerbates alcoholic liver disease by inducing intestinal dysbiosis and barrier dysfunction. J Hepatol. 2018 Oct; 69(4):886-895. PMID: 29803899; PMCID: PMC6615474.
    Citations: 60     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.