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Christopher Bahl, Ph.D.

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University of Maine, Orono, MEBS2005Molecular and Cellular Biology, Biochemistry
University of Maine, Orono, MEMS2006Biochemistry
Geisel School of Medicine at Dartmouth, Hanover, NHPhD2012Biochemistry
University of Washington, Seattle, WASenior Fellow2017Protein Design


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI156570 (BAHL, CHRISTOPHER DAVID) Dec 10, 2020 - Nov 30, 2022
    Computational de novo design of a disulfide-rich miniprotein synthetic library and its application to engineer binders to neutralizing epitopes on Clostridium difficile toxins TcdA and TcdB
    Role: Principal Investigator
  2. R21EB028342 (BAHL, CHRISTOPHER DAVID) May 7, 2020 - Jan 31, 2023
    De novo design of generalizable allosteric modulators and peptide ligands for G protein coupled receptors
    Role: Principal Investigator

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Garrido JL, Medina MA, Bravo F, McGee S, Fuentes-Villalobos F, Calvo M, Pinos Y, Bowman JW, Bahl CD, Barria MI, Brachman RA, Alvarez RA. IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes. Cell Rep. 2022 05 31; 39(9):110904. PMID: 35617962; PMCID: PMC9108089.
    Citations: 1     Fields:    Translation:HumansCells
  2. Uzunçayir S, Vera-Rodriguez A, Regenthal P, Åbacka H, Emanuelsson C, Bahl CD, Lindkvist-Petersson K. Analyses of the complex formation of staphylococcal enterotoxin A and the human gp130 cytokine receptor. FEBS Lett. 2022 04; 596(7):910-923. PMID: 35060124.
    Citations:    Fields:    Translation:HumansAnimals
  3. Koehler Leman J, Lyskov S, Lewis SM, Adolf-Bryfogle J, Alford RF, Barlow K, Ben-Aharon Z, Farrell D, Fell J, Hansen WA, Harmalkar A, Jeliazkov J, Kuenze G, Krys JD, Ljubetic A, Loshbaugh AL, Maguire J, Moretti R, Mulligan VK, Nance ML, Nguyen PT, Ó Conchúir S, Roy Burman SS, Samanta R, Smith ST, Teets F, Tiemann JKS, Watkins A, Woods H, Yachnin BJ, Bahl CD, Bailey-Kellogg C, Baker D, Das R, DiMaio F, Khare SD, Kortemme T, Labonte JW, Lindorff-Larsen K, Meiler J, Schief W, Schueler-Furman O, Siegel JB, Stein A, Yarov-Yarovoy V, Kuhlman B, Leaver-Fay A, Gront D, Gray JJ, Bonneau R. Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks. Nat Commun. 2021 11 29; 12(1):6947. PMID: 34845212; PMCID: PMC8630030.
    Citations: 2     Fields:    Translation:HumansCells
  4. Renella R, Gagne K, Beauchamp E, Fogel J, Perlov A, Sola M, Schlaeger T, Hofmann I, Shimamura A, Ebert BL, Schmitz-Abe K, Markianos K, Murphy K, Sun L, Rockowitz S, Sliz P, Campagna DR, Springer TA, Bahl C, Agarwal S, Fleming MD, Williams DA. Congenital X-linked neutropenia with myelodysplasia and somatic tetraploidy due to a germline mutation in SEPT6. Am J Hematol. 2022 01 01; 97(1):18-29. PMID: 34677878; PMCID: PMC8671325.
    Citations:    Fields:    Translation:HumansCells
  5. Kennedy AL, Myers KC, Bowman J, Gibson CJ, Camarda ND, Furutani E, Muscato GM, Klein RH, Ballotti K, Liu S, Harris CE, Galvin A, Malsch M, Dale D, Gansner JM, Nakano TA, Bertuch A, Vlachos A, Lipton JM, Castillo P, Connelly J, Churpek J, Edwards JR, Hijiya N, Ho RH, Hofmann I, Huang JN, Keel S, Lamble A, Lau BW, Norkin M, Stieglitz E, Stock W, Walkovich K, Boettcher S, Brendel C, Fleming MD, Davies SM, Weller EA, Bahl C, Carter SL, Shimamura A, Lindsley RC. Distinct genetic pathways define pre-malignant versus compensatory clonal hematopoiesis in Shwachman-Diamond syndrome. Nat Commun. 2021 02 26; 12(1):1334. PMID: 33637765.
    Citations: 23     Fields:    Translation:HumansCells
  6. Taher NM, Hvorecny KL, Burke CM, Gilman MSA, Heussler GE, Adolf-Bryfogle J, Bahl CD, O'Toole GA, Madden DR. Biochemical and structural characterization of two cif-like epoxide hydrolases from Burkholderia cenocepacia. Curr Res Struct Biol. 2021; 3:72-84. PMID: 34235487.
  7. Meinen BA, Bahl CD. Breakthroughs in computational design methods open up new frontiers for de novo protein engineering. Protein Eng Des Sel. 2021 02 15; 34. PMID: 33884420.
    Citations: 2     Fields:    
  8. Adolf-Bryfogle J, Teets FD, Bahl CD. Toward complete rational control over protein structure and function through computational design. Curr Opin Struct Biol. 2021 02; 66:170-177. PMID: 33276237; PMCID: PMC7965241.
    Citations: 2     Fields:    Translation:Cells
  9. Gao M, Mackley IGP, Mesbahi-Vasey S, Bamonte HA, Struyvenberg SA, Landolt L, Pederson NJ, Williams LI, Bahl CD, Brooks L, Amacher JF. Structural characterization and computational analysis of PDZ domains in Monosiga brevicollis. Protein Sci. 2020 11; 29(11):2226-2244. PMID: 32914530.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Ford AS, Weitzner BD, Bahl CD. Integration of the Rosetta suite with the python software stack via reproducible packaging and core programming interfaces for distributed simulation. Protein Sci. 2020 01; 29(1):43-51. PMID: 31495995.
    Citations: 6     Fields:    
  11. Buchko GW, Pulavarti SVSRK, Ovchinnikov V, Shaw EA, Rettie SA, Myler PJ, Karplus M, Szyperski T, Baker D, Bahl CD. Cytosolic expression, solution structures, and molecular dynamics simulation of genetically encodable disulfide-rich de novo designed peptides. Protein Sci. 2018 09; 27(9):1611-1623. PMID: 30152054; PMCID: PMC6194292.
    Citations: 5     Fields:    Translation:Cells
  12. Lau YK, Baytshtok V, Howard TA, Fiala BM, Johnson JM, Carter LP, Baker D, Lima CD, Bahl CD. Discovery and engineering of enhanced SUMO protease enzymes. J Biol Chem. 2018 08 24; 293(34):13224-13233. PMID: 29976752.
    Citations: 8     Fields:    Translation:AnimalsCells
  13. Correnti CE, Gewe MM, Mehlin C, Bandaranayake AD, Johnsen WA, Rupert PB, Brusniak MY, Clarke M, Burke SE, De Van Der Schueren W, Pilat K, Turnbaugh SM, May D, Watson A, Chan MK, Bahl CD, Olson JM, Strong RK. Screening, large-scale production and structure-based classification of cystine-dense peptides. Nat Struct Mol Biol. 2018 03; 25(3):270-278. PMID: 29483648; PMCID: PMC5840021.
    Citations: 16     Fields:    Translation:HumansCells
  14. Hvorecny KL, Dolben E, Moreau-Marquis S, Hampton TH, Shabaneh TB, Flitter BA, Bahl CD, Bomberger JM, Levy BD, Stanton BA, Hogan DA, Madden DR. An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung. Am J Physiol Lung Cell Mol Physiol. 2018 01 01; 314(1):L150-L156. PMID: 28982736.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  15. Chevalier A, Silva DA, Rocklin GJ, Hicks DR, Vergara R, Murapa P, Bernard SM, Zhang L, Lam KH, Yao G, Bahl CD, Miyashita SI, Goreshnik I, Fuller JT, Koday MT, Jenkins CM, Colvin T, Carter L, Bohn A, Bryan CM, Fernández-Velasco DA, Stewart L, Dong M, Huang X, Jin R, Wilson IA, Fuller DH, Baker D. Massively parallel de novo protein design for targeted therapeutics. Nature. 2017 10 05; 550(7674):74-79. PMID: 28953867.
    Citations: 122     Fields:    Translation:HumansCells
  16. Hvorecny KL, Bahl CD, Kitamura S, Lee KSS, Hammock BD, Morisseau C, Madden DR. Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase. Structure. 2017 05 02; 25(5):697-707.e4. PMID: 28392259; PMCID: PMC5524515.
    Citations: 6     Fields:    Translation:Cells
  17. Bahl CD, St Laurent JD, Karthikeyan RS, Priya JL, Prajna L, Zegans ME, Madden DR. The cif Virulence Factor Gene Is Present in Isolates From Patients With Pseudomonas aeruginosa Keratitis. Cornea. 2017 Mar; 36(3):358-362. PMID: 28079684.
    Citations: 1     Fields:    Translation:HumansCells
  18. Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls JK, Levy BD, Madden DR, Bomberger JM. Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):136-141. PMID: 27980032; PMCID: PMC5224368.
    Citations: 34     Fields:    Translation:HumansCells
  19. Bhardwaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SV, Kaas Q, Eletsky A, Huang PS, Johnsen WA, Greisen PJ, Rocklin GJ, Song Y, Linsky TW, Watkins A, Rettie SA, Xu X, Carter LP, Bonneau R, Olson JM, Coutsias E, Correnti CE, Szyperski T, Craik DJ, Baker D. Accurate de novo design of hyperstable constrained peptides. Nature. 2016 Oct 20; 538(7625):329-335. PMID: 27626386; PMCID: PMC5161715.
    Citations: 106     Fields:    Translation:Cells
  20. Rödström KEJ, Regenthal P, Bahl C, Ford A, Baker D, Lindkvist-Petersson K. Two common structural motifs for TCR recognition by staphylococcal enterotoxins. Sci Rep. 2016 05 16; 6:25796. PMID: 27180909.
    Citations: 5     Fields:    Translation:Cells
  21. Bahl CD, Hvorecny KL, Morisseau C, Gerber SA, Madden DR. Visualizing the Mechanism of Epoxide Hydrolysis by the Bacterial Virulence Enzyme Cif. Biochemistry. 2016 Feb 09; 55(5):788-97. PMID: 26752215.
    Citations: 6     Fields:    Translation:Cells
  22. Bahl CD, Hvorecny KL, Bomberger JM, Stanton BA, Hammock BD, Morisseau C, Madden DR. Inhibiting an Epoxide Hydrolase Virulence Factor from Pseudomonas aeruginosa Protects CFTR. Angew Chem Int Ed Engl. 2015 Aug 17; 54(34):9881-5. PMID: 26136396; PMCID: PMC4556431.
    Citations: 10     Fields:    Translation:Cells
  23. Bahl CD, Hvorecny KL, Bridges AA, Ballok AE, Bomberger JM, Cady KC, O'Toole GA, Madden DR. Signature motifs identify an Acinetobacter Cif virulence factor with epoxide hydrolase activity. J Biol Chem. 2014 Mar 14; 289(11):7460-9. PMID: 24474692.
    Citations: 12     Fields:    Translation:Cells
  24. Amacher JF, Cushing PR, Bahl CD, Beck T, Madden DR. Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop. J Biol Chem. 2013 Feb 15; 288(7):5114-26. PMID: 23243314.
    Citations: 16     Fields:    Translation:HumansCells
  25. Ballok AE, Bahl CD, Dolben EL, Lindsay AK, St Laurent JD, Hogan DA, Madden DR, O'Toole GA. Epoxide-mediated CifR repression of cif gene expression utilizes two binding sites in Pseudomonas aeruginosa. J Bacteriol. 2012 Oct; 194(19):5315-24. PMID: 22843844.
    Citations: 13     Fields:    Translation:HumansCells
  26. Bahl CD, Madden DR. Pseudomonas aeruginosa Cif defines a distinct class of a/ß epoxide hydrolases utilizing a His/Tyr ring-opening pair. Protein Pept Lett. 2012 Feb; 19(2):186-93. PMID: 21933119.
    Citations: 13     Fields:    Translation:Cells
  27. Bahl CD, Morisseau C, Bomberger JM, Stanton BA, Hammock BD, O'Toole GA, Madden DR. Crystal structure of the cystic fibrosis transmembrane conductance regulator inhibitory factor Cif reveals novel active-site features of an epoxide hydrolase virulence factor. J Bacteriol. 2010 Apr; 192(7):1785-95. PMID: 20118260.
    Citations: 26     Fields:    Translation:Cells
  28. Bahl CD, MacEachran DP, O'Toole GA, Madden DR. Purification, crystallization and preliminary X-ray diffraction analysis of Cif, a virulence factor secreted by Pseudomonas aeruginosa. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jan 01; 66(Pt 1):26-8. PMID: 20057063.
    Citations: 12     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.