Harvard Catalyst Profiles

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Randy D. Trumbower, Ph.D.


Duke University, DurhamMS, PT08/1999Physical Therapy
University of Connecticut, StorrsMS, PhD12/2005Engineering
Northwestern University, ChicagoPostdoc10/2009Neurophysiology, Engineering


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 2020A013583 (Randy D Trumbower) Jan 1, 2021 - Dec 30, 2021
    ONWARD Medical Inc.
    The Up-LIFT study of non-Invasive ARC therapy for SCI
    Role Description: The Up-LIFT study is a prospective, single-arm study designed to evaluate the safety and effectiveness of non-invasive electrical spinal cord stimulation (ARC Therapy) administered by the LIFT System to treat upper extremity functional deficits in people with chronic tetraplegia.
    Role: Site Principal Investigator
  2. W81XWH-14-SCIRP-CTA (Randy Trumbower) Nov 1, 2016 - Oct 31, 2022
    Department of Defense
    Daily acute intermittent hypoxia to enhance walking recovery in persons with subacute SCI
    Role Description: This proposal will investigate the efficacy and safety of dAIH to enhance walking recovery in persons with subacute, incomplete SCI. We hypothesize that dAIH alone or with walking practice will improve walking recovery in ambulatory and non-ambulatory persons with subacute SCI without eliciting maladaptive changes. To test this hypothesis, we propose a double-blind, placebo-controlled, block-randomized clinical trial.
    Role: Principal Investigator
  3. WFLUS02614 (Randy D Trumbower) Jan 1, 2015 - Dec 30, 2021
    Wings for Life Foundation
    Repetitive Exposure of intermittent hypoxia to enhance walking recovery in persons with chronic spinal cord injury
    Role Description: The ultimate goal of this research is to assess the potential of repetitive intermittent hypoxia as a therapeutic approach to stimulate recovery of walking function in persons with chronic spinal cord injury.
    Role: Principal Investigator
  4. R01HD081274 (TRUMBOWER, RANDY) Sep 10, 2014 - Feb 28, 2021
    Mechanisms of intermittent hypoxia-induced motor recovery in persons with SCI
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vose AK, Welch JF, Nair J, Dale EA, Fox EJ, Muir GD, Trumbower RD, Mitchell GS. Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease. Exp Neurol. 2022 01; 347:113891. PMID: 34637802.
    Citations:    Fields:    Translation:HumansAnimals
  2. Tan AQ, Sohn WJ, Naidu A, Trumbower RD. Daily acute intermittent hypoxia combined with walking practice enhances walking performance but not intralimb motor coordination in persons with chronic incomplete spinal cord injury. Exp Neurol. 2021 06; 340:113669. PMID: 33647273.
    Citations: 3     Fields:    Translation:Humans
  3. Christiansen L, Chen B, Lei Y, Urbin MA, Richardson MSA, Oudega M, Sandhu M, Rymer WZ, Trumbower RD, Mitchell GS, Perez MA. Acute intermittent hypoxia boosts spinal plasticity in humans with tetraplegia. Exp Neurol. 2021 01; 335:113483. PMID: 32987000.
    Citations: 7     Fields:    Translation:HumansCells
  4. Vivodtzev I, Tan AQ, Hermann M, Jayaraman A, Stahl V, Rymer WZ, Mitchell GS, Hayes HB, Trumbower RD. Mild to Moderate Sleep Apnea Is Linked to Hypoxia-induced Motor Recovery after Spinal Cord Injury. Am J Respir Crit Care Med. 2020 09 15; 202(6):887-890. PMID: 32369393.
    Citations: 8     Fields:    Translation:Humans
  5. Tan AQ, Papadopoulos JM, Corsten AN, Trumbower RD. An automated pressure-swing absorption system to administer low oxygen therapy for persons with spinal cord injury. Exp Neurol. 2020 11; 333:113408. PMID: 32682613.
    Citations: 2     Fields:    Translation:Humans
  6. Naidu A, Peters DM, Tan AQ, Barth S, Crane A, Link A, Balakrishnan S, Hayes HB, Slocum C, Zafonte RD, Trumbower RD. Daily acute intermittent hypoxia to improve walking function in persons with subacute spinal cord injury: a randomized clinical trial study protocol. BMC Neurol. 2020 Jul 08; 20(1):273. PMID: 32641012.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  7. Tan AQ, Barth S, Trumbower RD. Acute intermittent hypoxia as a potential adjuvant to improve walking following spinal cord injury: evidence, challenges, and future directions. Curr Phys Med Rehabil Rep. 2020 Sep; 8(3):188-198. PMID: 33738145.
  8. Thibaudier Y, Tan AQ, Peters DM, Trumbower RD. Differential deficits in spatial and temporal interlimb coordination during walking in persons with incomplete spinal cord injury. Gait Posture. 2020 01; 75:121-128. PMID: 31675554.
    Citations: 3     Fields:    Translation:Humans
  9. Trumbower RD, Wolf SL. A Forward Move: Interfacing Biotechnology and Physical Therapy In and Out of the Classroom. Phys Ther. 2019 05 01; 99(5):519-525. PMID: 30690519.
    Citations: 1     Fields:    Translation:Humans
  10. Trumbower RD. Stimulating the Injured Spinal Cord: Plenty to Grasp. J Neurotrauma. 2018 09 15; 35(18):2143-2144. PMID: 30009669.
    Citations:    Fields:    Translation:Humans
  11. Sohn WJ, Tan AQ, Hayes HB, Pochiraju S, Deffeyes J, Trumbower RD. Variability of Leg Kinematics during Overground Walking in Persons with Chronic Incomplete Spinal Cord Injury. J Neurotrauma. 2018 11 01; 35(21):2519-2529. PMID: 29648987.
    Citations: 5     Fields:    Translation:Humans
  12. Peters DM, Thibaudier Y, Deffeyes JE, Baer GT, Hayes HB, Trumbower RD. Constraints on Stance-Phase Force Production during Overground Walking in Persons with Chronic Incomplete Spinal Cord Injury. J Neurotrauma. 2018 02 01; 35(3):467-477. PMID: 28762876.
    Citations: 2     Fields:    Translation:Humans
  13. Trumbower RD, Hayes HB, Mitchell GS, Wolf SL, Stahl VA. Effects of acute intermittent hypoxia on hand use after spinal cord trauma: A preliminary study. Neurology. 2017 Oct 31; 89(18):1904-1907. PMID: 28972191.
    Citations: 22     Fields:    Translation:Humans
  14. Ross HH, Ambrosio F, Trumbower RD, Reier PJ, Behrman AL, Wolf SL. Neural Stem Cell Therapy and Rehabilitation in the Central Nervous System: Emerging Partnerships. Phys Ther. 2016 May; 96(5):734-42. PMID: 26847015.
    Citations: 12     Fields:    Translation:HumansCells
  15. Ting LH, Chiel HJ, Trumbower RD, Allen JL, McKay JL, Hackney ME, Kesar TM. Neuromechanical principles underlying movement modularity and their implications for rehabilitation. Neuron. 2015 Apr 08; 86(1):38-54. PMID: 25856485.
    Citations: 118     Fields:    Translation:Humans
  16. Stahl VA, Hayes HB, Buetefisch CM, Wolf SL, Trumbower RD. Modulation of hand aperture during reaching in persons with incomplete cervical spinal cord injury. Exp Brain Res. 2015 Mar; 233(3):871-84. PMID: 25511164.
    Citations: 6     Fields:    Translation:Humans
  17. Hayes HB, Chvatal SA, French MA, Ting LH, Trumbower RD. Neuromuscular constraints on muscle coordination during overground walking in persons with chronic incomplete spinal cord injury. Clin Neurophysiol. 2014 Oct; 125(10):2024-35. PMID: 24618214.
    Citations: 41     Fields:    Translation:Humans
  18. Hayes HB, Jayaraman A, Herrmann M, Mitchell GS, Rymer WZ, Trumbower RD. Daily intermittent hypoxia enhances walking after chronic spinal cord injury: a randomized trial. Neurology. 2014 Jan 14; 82(2):104-13. PMID: 24285617.
    Citations: 85     Fields:    Translation:Humans
  19. Trumbower RD, Finley JM, Shemmell JB, Honeycutt CF, Perreault EJ. Bilateral impairments in task-dependent modulation of the long-latency stretch reflex following stroke. Clin Neurophysiol. 2013 Jul; 124(7):1373-80. PMID: 23453250.
    Citations: 14     Fields:    Translation:Humans
  20. Krutky MA, Trumbower RD, Perreault EJ. Influence of environmental stability on the regulation of end-point impedance during the maintenance of arm posture. J Neurophysiol. 2013 Feb; 109(4):1045-54. PMID: 23221409.
    Citations: 7     Fields:    Translation:Humans
  21. Trumbower RD, Jayaraman A, Mitchell GS, Rymer WZ. Exposure to acute intermittent hypoxia augments somatic motor function in humans with incomplete spinal cord injury. Neurorehabil Neural Repair. 2012 Feb; 26(2):163-72. PMID: 21821826.
    Citations: 90     Fields:    Translation:Humans
  22. Trumbower RD, Ravichandran VJ, Krutky MA, Perreault EJ. Contributions of altered stretch reflex coordination to arm impairments following stroke. J Neurophysiol. 2010 Dec; 104(6):3612-24. PMID: 20962072.
    Citations: 34     Fields:    Translation:Humans
  23. Lewis GN, MacKinnon CD, Trumbower R, Perreault EJ. Co-contraction modifies the stretch reflex elicited in muscles shortened by a joint perturbation. Exp Brain Res. 2010 Nov; 207(1-2):39-48. PMID: 20878148.
    Citations: 7     Fields:    Translation:Humans
  24. Krutky MA, Ravichandran VJ, Trumbower RD, Perreault EJ. Interactions between limb and environmental mechanics influence stretch reflex sensitivity in the human arm. J Neurophysiol. 2010 Jan; 103(1):429-40. PMID: 19906880.
    Citations: 45     Fields:    Translation:Humans
  25. Trumbower RD, Krutky MA, Yang BS, Perreault EJ. Use of self-selected postures to regulate multi-joint stiffness during unconstrained tasks. PLoS One. 2009; 4(5):e5411. PMID: 19412540.
    Citations: 22     Fields:    Translation:Humans
  26. Krutky MA, Trumbower RD, Perreault EJ. Effects of environmental instabilities on endpoint stiffness during the maintenance of human arm posture. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:5938-41. PMID: 19965062.
    Citations: 5     Fields:    Translation:Humans
  27. Perreault EJ, Chen K, Trumbower RD, Lewis G. Interactions with compliant loads alter stretch reflex gains but not intermuscular coordination. J Neurophysiol. 2008 May; 99(5):2101-13. PMID: 18287550.
    Citations: 59     Fields:    Translation:Humans
  28. Trumbower RD, Ravichandran VJ, Krutky MA, Perreault EJ. Altered multijoint reflex coordination is indicative of motor impairment level following stroke. Annu Int Conf IEEE Eng Med Biol Soc. 2008; 2008:3558-61. PMID: 19163477.
    Citations: 4     Fields:    Translation:Humans
  29. Krutky MA, Ravichandran VJ, Trumbower RD, Perreault EJ. Reflex modulation is linked to the orientation of arm mechanics relative to the environment. Annu Int Conf IEEE Eng Med Biol Soc. 2008; 2008:5350-3. PMID: 19163926.
    Citations: 2     Fields:    Translation:Humans
  30. Trumbower RD, Rajasekaran S, Faghri PD. Identifying offline muscle strength profiles sufficient for short-duration FES-LCE exercise: a PAC learning model approach. J Clin Monit Comput. 2006 Jun; 20(3):209-20. PMID: 16775658.
    Citations: 1     Fields:    Translation:Humans
  31. Trumbower RD, Faghri PD. Kinematic analyses of semireclined leg cycling in able-bodied and spinal cord injured individuals. Spinal Cord. 2005 Sep; 43(9):543-9. PMID: 15838528.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  32. Trumbower RD, Faghri PD. Improving pedal power during semireclined leg cycling. IEEE Eng Med Biol Mag. 2004 Mar-Apr; 23(2):62-71. PMID: 15264472.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  33. Enderle JD, Liebler CM, Haapala SA, Hart JL, Thonakkaraparayil NT, Romonosky LL, Rodriguez F, Trumbower RD. The University of Connecticut Biomedical Engineering Mentoring Program for high school students. Biomed Sci Instrum. 2004; 40:484-90. PMID: 15134006.
    Citations:    Fields:    Translation:Humans
  34. Trumbower RD, Enderle JD. Virtual instruments in undergraduate biomedical engineering laboratories. IEEE Eng Med Biol Mag. 2003 Jul-Aug; 22(4):101-10. PMID: 14515700.
    Citations: 2     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.