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Robert Leon Summers, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Relitti N, Federico S, Pozzetti L, Butini S, Lamponi S, Taramelli D, D'Alessandro S, Martin RE, Shafik SH, Summers RL, Babij SK, Habluetzel A, Tapanelli S, Caldelari R, Gemma S, Campiani G. Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity. Eur J Med Chem. 2021 Apr 05; 215:113227. PMID: 33601312.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Sailer ZR, Shafik SH, Summers RL, Joule A, Patterson-Robert A, Martin RE, Harms MJ. Inferring a complete genotype-phenotype map from a small number of measured phenotypes. PLoS Comput Biol. 2020 09; 16(9):e1008243. PMID: 32991585.
    Citations:    Fields:    Translation:Animals
  3. Shafik SH, Cobbold SA, Barkat K, Richards SN, Lancaster NS, Llinás M, Hogg SJ, Summers RL, McConville MJ, Martin RE. The natural function of the malaria parasite's chloroquine resistance transporter. Nat Commun. 2020 08 06; 11(1):3922. PMID: 32764664.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Rosling JEO, Ridgway MC, Summers RL, Kirk K, Lehane AM. Biochemical characterization and chemical inhibition of PfATP4-associated Na+-ATPase activity in Plasmodium falciparum membranes. J Biol Chem. 2018 08 24; 293(34):13327-13337. PMID: 29986883.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  5. van Schalkwyk DA, Nash MN, Shafik SH, Summers RL, Lehane AM, Smith PJ, Martin RE. Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs. J Infect Dis. 2016 Mar 01; 213(5):800-10. PMID: 26503982.
    Citations: 12     Fields:    Translation:AnimalsCells
  6. Teng R, Lehane AM, Winterberg M, Shafik SH, Summers RL, Martin RE, van Schalkwyk DA, Junankar PR, Kirk K. 1H-NMR metabolite profiles of different strains of Plasmodium falciparum. Biosci Rep. 2014 Nov 21; 34(6):e00150. PMID: 25405893.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  7. Bellanca S, Summers RL, Meyrath M, Dave A, Nash MN, Dittmer M, Sanchez CP, Stein WD, Martin RE, Lanzer M. Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites. J Biol Chem. 2014 Dec 26; 289(52):36336-51. PMID: 25378409.
    Citations: 18     Fields:    Translation:AnimalsCells
  8. Summers RL, Dave A, Dolstra TJ, Bellanca S, Marchetti RV, Nash MN, Richards SN, Goh V, Schenk RL, Stein WD, Kirk K, Sanchez CP, Lanzer M, Martin RE. Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):E1759-67. PMID: 24728833.
    Citations: 33     Fields:    Translation:AnimalsCells
  9. Deane KJ, Summers RL, Lehane AM, Martin RE, Barrow RA. Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT. ACS Med Chem Lett. 2014 May 08; 5(5):576-81. PMID: 24900883.
    Citations: 4     
  10. Hrycyna CA, Summers RL, Lehane AM, Pires MM, Namanja H, Bohn K, Kuriakose J, Ferdig M, Henrich PP, Fidock DA, Kirk K, Chmielewski J, Martin RE. Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum. ACS Chem Biol. 2014 Mar 21; 9(3):722-30. PMID: 24369685.
    Citations: 11     Fields:    Translation:AnimalsCells
  11. Gemma S, Camodeca C, Brindisi M, Brogi S, Kukreja G, Kunjir S, Gabellieri E, Lucantoni L, Habluetzel A, Taramelli D, Basilico N, Gualdani R, Tadini-Buoninsegni F, Bartolommei G, Moncelli MR, Martin RE, Summers RL, Lamponi S, Savini L, Fiorini I, Valoti M, Novellino E, Campiani G, Butini S. Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents. J Med Chem. 2012 Dec 13; 55(23):10387-404. PMID: 23145816.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  12. Gemma S, Camodeca C, Sanna Coccone S, Joshi BP, Bernetti M, Moretti V, Brogi S, Bonache de Marcos MC, Savini L, Taramelli D, Basilico N, Parapini S, Rottmann M, Brun R, Lamponi S, Caccia S, Guiso G, Summers RL, Martin RE, Saponara S, Gorelli B, Novellino E, Campiani G, Butini S. Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. J Med Chem. 2012 Aug 09; 55(15):6948-67. PMID: 22783984.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Summers RL, Nash MN, Martin RE. Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics. Cell Mol Life Sci. 2012 Jun; 69(12):1967-95. PMID: 22286067.
    Citations: 36     Fields:    Translation:HumansAnimals
  14. Zishiri VK, Joshi MC, Hunter R, Chibale K, Smith PJ, Summers RL, Martin RE, Egan TJ. Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT). J Med Chem. 2011 Oct 13; 54(19):6956-68. PMID: 21875063.
    Citations: 14     Fields:    Translation:AnimalsCells
  15. Summers RL, Martin RE. Functional characteristics of the malaria parasite's "chloroquine resistance transporter": implications for chemotherapy. Virulence. 2010 Jul-Aug; 1(4):304-8. PMID: 21178460.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.