Harvard Catalyst Profiles

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Tatum Mortimer, Ph.D.

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  1. F32AI145157 (MORTIMER, TATUM DANIELLE) Sep 1, 2019 - Aug 31, 2022
    NIH
    Acquisition, maintenance, and transmission of antibiotic resistance in Neisseria gonorrhoeae
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rubin DH, Mortimer TD, Grad YH. Neisseria gonorrhoeae diagnostic escape from a gyrA-based test for ciprofloxacin susceptibility and the effect on zoliflodacin resistance: a bacterial genetics and experimental evolution study. Lancet Microbe. 2023 Feb 28. PMID: 36868257.
    Citations:    
  2. Bristow CC, Mortimer TD, Morris S, Grad Y, Soge OO, Wakatake E, Pascual R, Murphy SM, Fryling KE, Adamson PC, Dillon JA, Palmer NR, Le HHL, Van Le H, Ovalles Ureña RM, Mitchev N, Mlisana K, Wi T, Dickson SP, Klausner JD. Whole Genome Sequencing to Predict Antimicrobial Susceptibility Profiles in Neisseria gonorrhoeae. J Infect Dis. 2023 Feb 03. PMID: 36735316.
    Citations:    Fields:    
  3. Martin SL, Mortimer TD, Grad YH. Machine learning models for Neisseria gonorrhoeae antimicrobial susceptibility tests. Ann N Y Acad Sci. 2023 02; 1520(1):74-88. PMID: 36573759; PMCID: PMC9974846.
    Citations:    Fields:    Translation:HumansCells
  4. Smith TM, Youngblom MA, Kernien JF, Mohamed MA, Fry SS, Bohr LL, Mortimer TD, O'Neill MB, Pepperell CS. Rapid adaptation of a complex trait during experimental evolution of Mycobacterium tuberculosis. Elife. 2022 06 21; 11. PMID: 35726854; PMCID: PMC9213004.
    Citations:    Fields:    Translation:HumansCells
  5. Hadjineophytou C, Anonsen JH, Svingerud T, Mortimer TD, Grad YH, Scott NE, Koomey M. Sculpting the Bacterial O-Glycoproteome: Functional Analyses of Orthologous Oligosaccharyltransferases with Diverse Targeting Specificities. mBio. 2022 06 28; 13(3):e0379721. PMID: 35471082; PMCID: PMC9239064.
    Citations:    Fields:    Translation:Cells
  6. Mortimer TD. Interactions between Loci Contributing to Antimicrobial Resistance and Virulence in Neisseria gonorrhoeae. mBio. 2022 06 28; 13(3):e0041222. PMID: 35420483; PMCID: PMC9239038.
    Citations:    Fields:    Translation:Cells
  7. Mortimer TD, Zhang JJ, Ma KC, Grad YH. Loci for prediction of penicillin and tetracycline susceptibility in Neisseria gonorrhoeae: a genome-wide association study. Lancet Microbe. 2022 05; 3(5):e376-e381. PMID: 35544098; PMCID: PMC9095990.
    Citations: 3     Translation:HumansCells
  8. Mortimer TD, Pathela P, Crawley A, Rakeman JL, Lin Y, Harris SR, Blank S, Schillinger JA, Grad YH. The Distribution and Spread of Susceptible and Resistant Neisseria gonorrhoeae Across Demographic Groups in a Major Metropolitan Center. Clin Infect Dis. 2021 11 02; 73(9):e3146-e3155. PMID: 32829411.
    Citations: 10     Fields:    Translation:HumansCells
  9. Sánchez-Busó L, Yeats CA, Taylor B, Goater RJ, Underwood A, Abudahab K, Argimón S, Ma KC, Mortimer TD, Golparian D, Cole MJ, Grad YH, Martin I, Raphael BH, Shafer WM, Town K, Wi T, Harris SR, Unemo M, Aanensen DM. A community-driven resource for genomic epidemiology and antimicrobial resistance prediction of Neisseria gonorrhoeae at Pathogenwatch. Genome Med. 2021 04 19; 13(1):61. PMID: 33875000; PMCID: PMC8054416.
    Citations: 28     Fields:    Translation:Cells
  10. Yahara K, Ma KC, Mortimer TD, Shimuta K, Nakayama SI, Hirabayashi A, Suzuki M, Jinnai M, Ohya H, Kuroki T, Watanabe Y, Yasuda M, Deguchi T, Eldholm V, Harrison OB, Maiden MCJ, Grad YH, Ohnishi M. Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae. Genome Med. 2021 03 30; 13(1):51. PMID: 33785063; PMCID: PMC8008663.
    Citations: 10     Fields:    Translation:Cells
  11. Murphy TC, Mortimer TD, Nicholas RA, Wadsworth CB. Draft Genome Sequences of Three Penicillin-Resistant Neisseria gonorrhoeae Strains Isolated in Cincinnati, Ohio, in 1994. Microbiol Resour Announc. 2021 Mar 18; 10(11). PMID: 33737358.
    Citations: 1     
  12. Ogbebor O, Mortimer TD, Fryling K, Zhang JJ, Bhanot N, Grad YH. Disseminated Gonococcal Infection Complicated by Prosthetic Joint Infection: Case Report and Genomic and Phylogenetic Analysis. Open Forum Infect Dis. 2021 Feb; 8(2):ofaa632. PMID: 33553473.
    Citations: 2     
  13. Ma KC, Mortimer TD, Duckett MA, Hicks AL, Wheeler NE, Sánchez-Busó L, Grad YH. Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae. Nat Commun. 2020 10 23; 11(1):5374. PMID: 33097713.
    Citations: 22     Fields:    Translation:HumansCells
  14. Vegvari C, Grad YH, White PJ, Didelot X, Whittles LK, Scangarella-Oman NE, Mitrani-Gold FS, Dumont E, Perry CR, Gilchrist K, Hossain M, Mortimer TD, Anderson RM, Gardiner D. Using rapid point-of-care tests to inform antibiotic choice to mitigate drug resistance in gonorrhoea. Euro Surveill. 2020 10; 25(43). PMID: 33124551; PMCID: PMC7596916.
    Citations: 5     Fields:    Translation:HumansCells
  15. Ma KC, Mortimer TD, Grad YH. Efflux Pump Antibiotic Binding Site Mutations Are Associated with Azithromycin Nonsusceptibility in Clinical Neisseria gonorrhoeae Isolates. mBio. 2020 08 25; 11(4). PMID: 32843551.
    Citations: 8     Fields:    Translation:HumansCells
  16. Ma KC, Mortimer TD, Hicks AL, Wheeler NE, Sánchez-Busó L, Golparian D, Taiaroa G, Rubin DHF, Wang Y, Williamson DA, Unemo M, Harris SR, Grad YH. Adaptation to the cervical environment is associated with increased antibiotic susceptibility in Neisseria gonorrhoeae. Nat Commun. 2020 08 17; 11(1):4126. PMID: 32807804.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  17. Hicks AL, Kissler SM, Mortimer TD, Ma KC, Taiaroa G, Ashcroft M, Williamson DA, Lipsitch M, Grad YH. Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants. Elife. 2020 06 30; 9. PMID: 32602459.
    Citations: 2     Fields:    Translation:Cells
  18. Bohr LL, Mortimer TD, Pepperell CS. Lateral Gene Transfer Shapes Diversity of Gardnerella spp. Front Cell Infect Microbiol. 2020; 10:293. PMID: 32656099; PMCID: PMC7324480.
    Citations: 9     Fields:    Translation:HumansCells
  19. Palace SG, Wang Y, Rubin DH, Welsh MA, Mortimer TD, Cole K, Eyre DW, Walker S, Grad YH. RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates. Elife. 2020 02 03; 9. PMID: 32011233.
    Citations: 15     Fields:    Translation:Cells
  20. Doroshenko A, Pepperell CS, Heffernan C, Egedahl ML, Mortimer TD, Smith TM, Bussan HE, Tyrrell GJ, Long R. Epidemiological and genomic determinants of tuberculosis outbreaks in First Nations communities in Canada. BMC Med. 2018 08 08; 16(1):128. PMID: 30086755.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  21. Mortimer TD, Grad YH. Applications of genomics to slow the spread of multidrug-resistant Neisseria gonorrhoeae. Ann N Y Acad Sci. 2019 01; 1435(1):93-109. PMID: 29876934; PMCID: PMC6281808.
    Citations: 15     Fields:    Translation:HumansCells
  22. Mortimer TD, Weber AM, Pepperell CS. Signatures of Selection at Drug Resistance Loci in Mycobacterium tuberculosis. mSystems. 2018 Jan-Feb; 3(1). PMID: 29404424.
    Citations: 21     
  23. Mortimer TD, Annis DS, O'Neill MB, Bohr LL, Smith TM, Poinar HN, Mosher DF, Pepperell CS. Adaptation in a Fibronectin Binding Autolysin of Staphylococcus saprophyticus. mSphere. 2017 Nov-Dec; 2(6). PMID: 29202045; PMCID: PMC5705806.
    Citations: 5     Fields:    
  24. Mortimer TD, Weber AM, Pepperell CS. Evolutionary Thrift: Mycobacteria Repurpose Plasmid Diversity during Adaptation of Type VII Secretion Systems. Genome Biol Evol. 2017 03 01; 9(3):398-413. PMID: 28391322.
    Citations: 9     Fields:    Translation:HumansCells
  25. Devault AM, Mortimer TD, Kitchen A, Kiesewetter H, Enk JM, Golding GB, Southon J, Kuch M, Duggan AT, Aylward W, Gardner SN, Allen JE, King AM, Wright G, Kuroda M, Kato K, Briggs DE, Fornaciari G, Holmes EC, Poinar HN, Pepperell CS. A molecular portrait of maternal sepsis from Byzantine Troy. Elife. 2017 01 10; 6. PMID: 28072390; PMCID: PMC5224923.
    Citations: 15     Fields:    Translation:HumansCells
  26. Dang UJ, Devault AM, Mortimer TD, Pepperell CS, Poinar HN, Golding GB. Estimation of Gene Insertion/Deletion Rates with Missing Data. Genetics. 2016 Oct; 204(2):513-529. PMID: 27565162; PMCID: PMC5068843.
    Citations: 1     Fields:    Translation:Cells
  27. O'Neill MB, Mortimer TD, Pepperell CS. Diversity of Mycobacterium tuberculosis across Evolutionary Scales. PLoS Pathog. 2015; 11(11):e1005257. PMID: 26562841; PMCID: PMC4642946.
    Citations: 30     Fields:    Translation:HumansCells
  28. Mortimer TD, Pepperell CS. Genomic signatures of distributive conjugal transfer among mycobacteria. Genome Biol Evol. 2014 Aug 30; 6(9):2489-500. PMID: 25173757.
    Citations: 22     Fields:    Translation:HumansCells
  29. Moncla LH, Ross TM, Dinis JM, Weinfurter JT, Mortimer TD, Schultz-Darken N, Brunner K, Capuano SV, Boettcher C, Post J, Johnson M, Bloom CE, Weiler AM, Friedrich TC. A novel nonhuman primate model for influenza transmission. PLoS One. 2013; 8(11):e78750. PMID: 24244352.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.