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Anna Santoro, Ph.D.

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Biography
education and training
University of Naples Federico II, Naples, ItalyPharm.D.07/2010Pharmacology
University of Naples Federico II, Naples, ItalyPhD05/2014Pharmacology
Yale University, New Haven, CTPostdoctoral associate05/2017Neuroendocrinology and metabolism
Beth Israel Deaconess Medical Center, Harvard University, Boston (MA)Research Fellow02/2020Endocrinology and metabolism
Beth Israel Deaconess Medical Center, Harvard University, Boston (MA)Instructor in MedicinepresentEndocrinology and Metabolism
Neuroendocrine Interactions in Rheumatology and inflammatory Diseases (NEIRID) laboratory, Santiago de Compostela, SpainVisiting Scientist08/2014Rheumatology and inflammatory Diseases
awards and honors
- 2011
Award for the best thesis in Pharmacology in memory of Prof. Paola Persico
- 2018
Travel Award
2019 - 2021
T32 fellowship

Overview

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Patel R, Santoro A, Hofer P, Tan D, Oberer M, Nelson AT, Konduri S, Siegel D, Zechner R, Saghatelian A, Kahn BB. ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. Nature. 2022 06; 606(7916):968-975. PMID: 35676490; PMCID: PMC9242854.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  2. Santoro A, McGraw TE, Kahn BB. Insulin action in adipocytes, adipose remodeling, and systemic effects. Cell Metab. 2021 04 06; 33(4):748-757. PMID: 33826917; PMCID: PMC8078167.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  3. Zhou P, Santoro A, Peroni OD, Nelson AT, Saghatelian A, Siegel D, Kahn BB. PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms. J Clin Invest. 2019 10 01; 129(10):4138-4150. PMID: 31449056; PMCID: PMC6763232.
    Citations: 27     Fields:    Translation:AnimalsCells
  4. Syed I, Lee J, Peroni OD, Yore MM, Moraes-Vieira PM, Santoro A, Wellenstein K, Smith U, McGraw TE, Saghatelian A, Kahn BB. Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects. Cell Metab. 2018 10 02; 28(4):543-546. PMID: 30244974; PMCID: PMC6542592.
    Citations: 13     Fields:    Translation:Animals
  5. Di Guida F, Pirozzi C, Magliocca S, Santoro A, Lama A, Russo R, Nieddu M, Burrai L, Boatto G, Mollica MP, Sodano F, Lazzarato L, Chegaev K, Meli R, Raso GM, Rimoli MG. Galactosylated Pro-Drug of Ursodeoxycholic Acid: Design, Synthesis, Characterization, and Pharmacological Effects in a Rat Model of Estrogen-Induced Cholestasis. Mol Pharm. 2018 01 02; 15(1):21-30. PMID: 29140706.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  6. Toda C, Santoro A, Kim JD, Diano S. POMC Neurons: From Birth to Death. Annu Rev Physiol. 2017 02 10; 79:209-236. PMID: 28192062; PMCID: PMC5669621.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  7. Santoro A, Campolo M, Liu C, Sesaki H, Meli R, Liu ZW, Kim JD, Diano S. DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell Metab. 2017 03 07; 25(3):647-660. PMID: 28190775; PMCID: PMC5366041.
    Citations: 38     Fields:    Translation:AnimalsCells
  8. Lama A, Santoro A, Corrado B, Pirozzi C, Paciello O, Pagano TB, Russo S, Calignano A, Mattace Raso G, Meli R. Extracorporeal shock waves alone or combined with raloxifene promote bone formation and suppress resorption in ovariectomized rats. PLoS One. 2017; 12(2):e0171276. PMID: 28158228.
    Citations: 7     Fields:    Translation:AnimalsCells
  9. Simeoli R, Mattace Raso G, Pirozzi C, Lama A, Santoro A, Russo R, Montero-Melendez T, Berni Canani R, Calignano A, Perretti M, Meli R. An orally administered butyrate-releasing derivative reduces neutrophil recruitment and inflammation in dextran sulphate sodium-induced murine colitis. Br J Pharmacol. 2017 06; 174(11):1484-1496. PMID: 27684049.
    Citations: 32     Fields:    Translation:AnimalsCells
  10. Santoro A, Mattace Raso G, Taliani S, Da Pozzo E, Simorini F, Costa B, Martini C, Laneri S, Sacchi A, Cosimelli B, Calignano A, Da Settimo F, Meli R. TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis. Eur J Pharm Sci. 2016 Jun 10; 88:124-31. PMID: 27094781.
    Citations: 16     Fields:    Translation:AnimalsCells
  11. Santoro A, Conde J, Scotece M, Abella V, Lois A, Lopez V, Pino J, Gomez R, Gomez-Reino JJ, Gualillo O. SERPINE2 Inhibits IL-1a-Induced MMP-13 Expression in Human Chondrocytes: Involvement of ERK/NF-?B/AP-1 Pathways. PLoS One. 2015; 10(8):e0135979. PMID: 26305372; PMCID: PMC4549255.
    Citations: 22     Fields:    Translation:HumansCells
  12. Santoro A, Ferrante MC, Di Guida F, Pirozzi C, Lama A, Simeoli R, Clausi MT, Monnolo A, Mollica MP, Mattace Raso G, Meli R. Polychlorinated Biphenyls (PCB 101, 153, and 180) Impair Murine Macrophage Responsiveness to Lipopolysaccharide: Involvement of NF-?B Pathway. Toxicol Sci. 2015 Sep; 147(1):255-69. PMID: 26141388; PMCID: PMC7107302.
    Citations: 8     Fields:    Translation:AnimalsCells
  13. Santoro A, Mattace Raso G, Meli R. Drug targeting of leptin resistance. Life Sci. 2015 Nov 01; 140:64-74. PMID: 26071010.
    Citations: 18     Fields:    Translation:HumansCells
  14. Santoro A, Conde J, Scotece M, Abella V, López V, Pino J, Gómez R, Gómez-Reino JJ, Gualillo O. Choosing the right chondrocyte cell line: Focus on nitric oxide. J Orthop Res. 2015 Dec; 33(12):1784-8. PMID: 26016689.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  15. Mattace Raso G, Pirozzi C, d'Emmanuele di Villa Bianca R, Simeoli R, Santoro A, Lama A, Di Guida F, Russo R, De Caro C, Sorrentino R, Calignano A, Meli R. Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin system. PLoS One. 2015; 10(5):e0123602. PMID: 25951330; PMCID: PMC4423982.
    Citations: 4     Fields:    Translation:Animals
  16. Simeoli R, Mattace Raso G, Lama A, Pirozzi C, Santoro A, Di Guida F, Sanges M, Aksoy E, Calignano A, D'Arienzo A, Meli R. Preventive and therapeutic effects of Lactobacillus paracasei B21060-based synbiotic treatment on gut inflammation and barrier integrity in colitic mice. J Nutr. 2015 Jun; 145(6):1202-10. PMID: 25926411.
    Citations: 16     Fields:    Translation:AnimalsCells
  17. Abella V, Santoro A, Scotece M, Conde J, López-López V, Lazzaro V, Gómez-Reino JJ, Meli R, Gualillo O. Non-dioxin-like polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) induce chondrocyte cell death through multiple pathways. Toxicol Lett. 2015 Apr 02; 234(1):13-9. PMID: 25659934.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  18. Ferrante MC, Amero P, Santoro A, Monnolo A, Simeoli R, Di Guida F, Mattace Raso G, Meli R. Polychlorinated biphenyls (PCB 101, PCB 153 and PCB 180) alter leptin signaling and lipid metabolism in differentiated 3T3-L1 adipocytes. Toxicol Appl Pharmacol. 2014 Sep 15; 279(3):401-408. PMID: 24978599.
    Citations: 17     Fields:    Translation:AnimalsCells
  19. Luongo E, Russo R, Avagliano C, Santoro A, Melisi D, Orefice NS, Raso GM, Meli R, Magliocca S, Nieddu M, Santiago GM, Boatto G, Calignano A, Rimoli MG. Galactosyl prodrug of palmitoylethanolamide: synthesis, stability, cell permeation and cytoprotective activity. Eur J Pharm Sci. 2014 Oct 01; 62:33-9. PMID: 24854456.
    Citations: 3     Fields:    Translation:HumansCells
  20. Ferrante MC, Clausi MT, Naccari C, Fusco G, Mattace Raso G, Santoro A, Meli R. Does the clam Ensis siliqua provide useful information about contamination by polychlorinated biphenyls and organochlorine pesticides beyond that of mussel Mytilus galloprovincialis? Bull Environ Contam Toxicol. 2014 Jun; 92(6):636-41. PMID: 24667855.
    Citations: 1     Fields:    Translation:AnimalsPHPublic Health
  21. Mattace Raso G, Santoro A, Russo R, Simeoli R, Paciello O, Di Carlo C, Diano S, Calignano A, Meli R. Palmitoylethanolamide prevents metabolic alterations and restores leptin sensitivity in ovariectomized rats. Endocrinology. 2014 Apr; 155(4):1291-301. PMID: 24428531; PMCID: PMC5393333.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  22. Raso GM, Simeoli R, Iacono A, Santoro A, Amero P, Paciello O, Russo R, D'Agostino G, Di Costanzo M, Canani RB, Calignano A, Meli R. Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet. J Nutr Biochem. 2014 Jan; 25(1):81-90. PMID: 24314869.
    Citations: 28     Fields:    Translation:AnimalsCells
  23. Mattace Raso G, Simeoli R, Russo R, Santoro A, Pirozzi C, d'Emmanuele di Villa Bianca R, Mitidieri E, Paciello O, Pagano TB, Orefice NS, Meli R, Calignano A. N-Palmitoylethanolamide protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress. Pharmacol Res. 2013 Oct; 76:67-76. PMID: 23917217.
    Citations: 15     Fields:    Translation:Animals
  24. Mattace Raso G, Simeoli R, Russo R, Iacono A, Santoro A, Paciello O, Ferrante MC, Canani RB, Calignano A, Meli R. Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet. PLoS One. 2013; 8(7):e68626. PMID: 23861927.
    Citations: 60     Fields:    Translation:AnimalsCells
  25. Raso GM, Esposito E, Vitiello S, Iacono A, Santoro A, D'Agostino G, Sasso O, Russo R, Piazza PV, Calignano A, Meli R. Palmitoylethanolamide stimulation induces allopregnanolone synthesis in C6 Cells and primary astrocytes: involvement of peroxisome-proliferator activated receptor-a. J Neuroendocrinol. 2011 Jul; 23(7):591-600. PMID: 21554431.
    Citations: 24     Fields:    Translation:AnimalsCells
  26. Ferrante MC, Mattace Raso G, Esposito E, Bianco G, Iacono A, Clausi MT, Amero P, Santoro A, Simeoli R, Autore G, Meli R. Effects of non-dioxin-like polychlorinated biphenyl congeners (PCB 101, PCB 153 and PCB 180) alone or mixed on J774A.1 macrophage cell line: modification of apoptotic pathway. Toxicol Lett. 2011 Apr 10; 202(1):61-8. PMID: 21291966.
    Citations: 14     Fields:    Translation:AnimalsCells
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