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James Gorman, M.D.,Ph.D.

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Biography
Harvard Medical School, BostonMD06/1997Medicine
Harvard Graduate School of Arts and Sciences, Cambridge, MAPh.D.06/1997Immunology
Yale University, New Haven, CTBS, MS06/1987Biology

Overview
Our current research focuses on neuro-inflammation and the development of drugs targeting microglia and astrocytes in neurodegenerative and psychiatric diseases. We are pursuing validation of novel approaches to transport drugs across the blood brain barrier. In addition, we are advancing the application of these transport approaches and novel blood brain barrier models, synthetic biology, and immune materials to probe fundamental neurobiological and neuro-inflammatory processes, and to translate these approaches into discovery and development of novel CNS-directed therapeutics.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rashidian M, Ingram JR, Dougan M, Dongre A, Whang KA, LeGall C, Cragnolini JJ, Bierie B, Gostissa M, Gorman J, Grotenbreg GM, Bhan A, Weinberg RA, Ploegh HL. Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells. J Exp Med. 2017 Aug 07; 214(8):2243-2255. PMID: 28666979.
    View in: PubMed
  2. Freeman BJ, Ludbrook GL, Hall S, Cousins M, Mitchell B, Jaros M, Wyand M, Wyand M, Gorman JR. In response. Spine (Phila Pa 1976). 2014 Jul 01; 39(15):1263. PMID: 25171071.
    View in: PubMed
  3. Freeman BJ, Ludbrook GL, Hall S, Cousins M, Mitchell B, Jaros M, Wyand M, Gorman JR. Randomized, double-blind, placebo-controlled, trial of transforaminal epidural etanercept for the treatment of symptomatic lumbar disc herniation. Spine (Phila Pa 1976). 2013 Nov 01; 38(23):1986-94. PMID: 24165696.
    View in: PubMed
  4. Gorman James, Chartash Elliot, Compagnone Daniele, Fischkoff Steven, Kamen Robert, Kaymakcalan Zehra, Kupper Hartmut, Moesta Peter, Salfeld Jochen, Spiegler Clive, Teoh Leah, and Turner Brian. Recombinant Antibodies. Bringing the First Phage-Derived Antibody to the Clinic. 2002.
  5. van der Stoep N, Gorman JR, Alt FW. Reevaluation of 3'Ekappa function in stage- and lineage-specific rearrangement and somatic hypermutation. Immunity. 1998 Jun; 8(6):743-50. PMID: 9655488.
    View in: PubMed
  6. Gorman JR, Alt FW. Regulation of immunoglobulin light chain isotype expression. Adv Immunol. 1998; 69:113-81. PMID: 9646844.
    View in: PubMed
  7. Merrell K, Wells S, Henderson A, Gorman J, Alt F, Stall A, Calame K. The absence of the transcription activator TFE3 impairs activation of B cells in vivo. Mol Cell Biol. 1997 Jun; 17(6):3335-44. PMID: 9154832; PMCID: PMC232186.
  8. Gorman JR, van der Stoep N, Monroe R, Cogne M, Davidson L, Alt FW. The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes. Immunity. 1996 Sep; 5(3):241-52. PMID: 8808679.
    View in: PubMed
  9. Lakso M, Pichel JG, Gorman JR, Sauer B, Okamoto Y, Lee E, Alt FW, Westphal H. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):5860-5. PMID: 8650183; PMCID: PMC39152.
  10. Sleckman BP, Gorman JR, Alt FW. Accessibility control of antigen-receptor variable-region gene assembly: role of cis-acting elements. Annu Rev Immunol. 1996; 14:459-81. PMID: 8717521.
    View in: PubMed
  11. Cogné M, Lansford R, Bottaro A, Zhang J, Gorman J, Young F, Cheng HL, Alt FW. A class switch control region at the 3' end of the immunoglobulin heavy chain locus. Cell. 1994 Jun 03; 77(5):737-47. PMID: 8205622.
    View in: PubMed
  12. Chen J, Gorman JR, Stewart V, Williams B, Jacks T, Alt FW. Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells. Curr Biol. 1993 Jul 01; 3(7):405-13. PMID: 15335707.
    View in: PubMed
  13. Alt FW, Oltz EM, Young F, Gorman J, Taccioli G, Chen J. VDJ recombination. Immunol Today. 1992 Aug; 13(8):306-14. PMID: 1510813.
    View in: PubMed
  14. Gorman JR and Locke SE. Comprehensive Textbook of Psychiatry, Kaplan H and Sadock B editors. Neural, endocrine, and immune interactions. 1989.
  15. Locke SE and Gorman JR. Comprehensive Textbook of Psychiatry, Kaplan H and Sadock B editors. Behavior and Immunity. 1989.
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