Harvard Catalyst Profiles

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Fadi Salah Issa, M.B.,B.S.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. McCallion O, Bilici M, Hester J, Issa F. Regulatory T-cell therapy approaches. Clin Exp Immunol. 2023 Mar 16; 211(2):96-107. PMID: 35960852; PMCID: PMC10019137.
    Citations: 1     Fields:    
  2. Issa F, Cross AR. IL-21 producing Alloreactive T Cells Expand in Parallel to Donor-specific Antibodies. Transplantation. 2023 Feb 23. PMID: 36814091.
    Citations:    Fields:    
  3. Shin H, Hertelendy AJ, Hart A, Tin D, Issa F, Hata R, Ciottone GR. Terrorism-Related Attacks in East Asia from 1970 through 2020. Prehosp Disaster Med. 2023 Apr; 38(2):232-236. PMID: 36710412; PMCID: PMC10027485.
    Citations:    Fields:    
  4. Cross AR, de Andrea CE, Villalba-Esparza M, Landecho MF, Cerundolo L, Weeratunga P, Etherington RE, Denney L, Ogg G, Ho LP, Roberts IS, Hester J, Klenerman P, Melero I, Sansom SN, Issa F. Spatial transcriptomic characterization of COVID-19 pneumonitis identifies immune circuits related to tissue injury. JCI Insight. 2023 Jan 24; 8(2). PMID: 36472908; PMCID: PMC9977306.
    Citations: 1     Fields:    Translation:HumansCells
  5. Hennessy C, Deptula M, Hester J, Issa F. Barriers to Treg therapy in Europe: From production to regulation. Front Med (Lausanne). 2023; 10:1090721. PMID: 36744143; PMCID: PMC9892909.
  6. Tin D, Davis T, Hata R, Court M, Issa F, Hart A, Voskanyan A, Ciottone G. Threat awareness training for non-governmental organizations deploying humanitarian aid workers into conflict environments. Am J Emerg Med. 2023 Jan 13. PMID: 36670019.
    Citations:    Fields:    
  7. O'Neil A, Brook M, Abdul-Wahab S, Hester J, Lombardi G, Issa F. A GMP Protocol for the Manufacture of Tregs for Clinical Application. Methods Mol Biol. 2023; 2559:205-227. PMID: 36180635.
    Citations: 1     Fields:    Translation:Cells
  8. Ohana Sarna Cahan L, Tin D, Markovic V, Ciottone RG, Issa F, Kane AED, Hart A, Weiner DL, Ciottone GR. Pediatric Casualties in Terrorist Attacks: A Semi-Quantitative Analysis of Global Events. Prehosp Disaster Med. 2022 Dec 12; 1-6. PMID: 36503695.
    Citations:    Fields:    
  9. Raffee L, Almasarweh SA, Mazahreh TS, Alawneh K, Alabdallah NB, Al Hamoud MA, Aburayya HA, Ayoub FS, Issa F, Ciottone G. Predicting mortality and morbidity in emergency general surgery patients in a Jordanian Tertiary Medical Center: a retrospective validation study of the Emergency Surgery Score (ESS). BMJ Open. 2022 11 18; 12(11):e061781. PMID: 36400729; PMCID: PMC9677020.
    Citations:    Fields:    Translation:Humans
  10. Adnan MSB, Hart A, Hertelendy AJ, Tin D, Abelanes SM, Issa F, Ciottone GR. Malaysian Disaster Medicine Research: A Bibliographic Study of Publication Trends. Prehosp Disaster Med. 2022 Dec; 37(6):836-842. PMID: 36373499.
    Citations:    Fields:    Translation:HumansCells
  11. Woodward CA, Hertelendy AJ, Hart A, Voskanyan A, Harutyunyan H, Virabyan A, Mukhaelyan A, Mahon SE, Issa FS, Adnan MS, Stepanyan T, Ciottone GR. Emergency Medical Services Preparedness in Dual Disasters: War in the Era of COVID-19 in Armenia. Prehosp Disaster Med. 2022 Dec; 37(6):749-754. PMID: 36328971.
    Citations:    Fields:    
  12. Mistry R, Issa F. No statistically significant difference in long term scarring outcomes of pediatric burns patients treated surgically vs. those treated conservatively. Front Surg. 2022; 9:727983. PMID: 36157426; PMCID: PMC9500338.
  13. Melero I, Villalba-Esparza M, Recalde-Zamacona B, Jiménez-Sánchez D, Teijeira Á, Argueta A, García-Tobar L, Álvarez-Gigli L, Sainz C, Garcia-Ros D, Toledo E, Abengozar-Muela M, Fernández-Alonso M, Rodríguez-Mateos M, Reina G, Carmona-Torre F, Quiroga JA, Del Pozo JL, Cross A, López-Janeiro Á, Hardisson D, Echeveste JI, Lozano MD, Ho LP, Klenerman P, Issa F, Landecho MF, de Andrea CE. Neutrophil Extracellular Traps, Local IL-8 Expression, and Cytotoxic T-Lymphocyte Response in the Lungs of Patients With Fatal COVID-19. Chest. 2022 11; 162(5):1006-1016. PMID: 35714708; PMCID: PMC9197577.
    Citations: 1     Fields:    Translation:HumansCells
  14. Mistry R, Veres M, Issa F. A Systematic Review Comparing Animal and Human Scarring Models. Front Surg. 2022; 9:711094. PMID: 35529910; PMCID: PMC9073696.
  15. Issa F, Gu J, Lu L. Editorial: Regulatory T Cells. Front Cell Dev Biol. 2022; 10:898132. PMID: 35531095; PMCID: PMC9068933.
  16. Tin D, Issa F, Ciottone GR. Attacks on Educational Institutions. Prehosp Disaster Med. 2022 Jun; 37(3):333-337. PMID: 35388785.
    Citations:    Fields:    Translation:Humans
  17. Shankar S, Beckett J, Tipton T, Ogbe A, Kasanyinga M, Dold C, Lumley S, Dengu F, Rompianesi G, Elgilani F, Longet S, Deeks A, Payne RP, Duncan CJA, Richter A, de Silva TI, Turtle L, Bull K, Barnardo M, Friend PJ, Dunachie SJ, Hester J, Issa F, Barnes E, Carroll MW, Klenerman P. SARS-CoV-2-Specific T Cell Responses Are Not Associated with Protection against Reinfection in Hemodialysis Patients. J Am Soc Nephrol. 2022 05; 33(5):883-887. PMID: 35361708; PMCID: PMC9063898.
    Citations: 1     Fields:    Translation:HumansCells
  18. Alnoaimi MM, Hart A, Issa F, Hertelendy A, Voskanyan A, Ciottone G. Variance Analysis of Expatriate Pre-Hospital Provider Training in Bahrain. Open Access Emerg Med. 2022; 14:99-107. PMID: 35280843; PMCID: PMC8906849.
  19. Bottomley MJ, Brook MO, Shankar S, Hester J, Issa F. Towards regulatory cellular therapies in solid organ transplantation. Trends Immunol. 2022 01; 43(1):8-21. PMID: 34844848.
    Citations:    Fields:    Translation:Humans
  20. Hart A, Toma M, Issa F, Neault N. Developing Cultural Awareness Curricular Competencies for Humanitarian Non-Governmental Organization Staff. Prehosp Disaster Med. 2021 Dec; 36(6):669-675. PMID: 34593079.
    Citations:    Fields:    Translation:Humans
  21. Harutyunyan H, Mukhaelyan A, Hertelendy AJ, Voskanyan A, Benham T, Issa F, Hart A, Ciottone GR. The Psychosocial Impact of Compounding Humanitarian Crises Caused by War and COVID-19 Informing Future Disaster Response. Prehosp Disaster Med. 2021 Oct; 36(5):501-502. PMID: 34353399; PMCID: PMC8367870.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  22. Almalki Y, Hart A, Issa F, Hertelendy AJ, Mahon S, Voskanyan A, Ciottone GR. The Holy Month of Ramadan: Mass-Gathering Event Implications for Hospital Surge Capacity Planning in Saudi Arabia. Prehosp Disaster Med. 2021 Aug; 36(4):393-398. PMID: 34187603.
    Citations:    Fields:    Translation:Humans
  23. Stark HL, Wang HC, Kuburic J, Alzhrani A, Hester J, Issa F. Immune Monitoring for Advanced Cell Therapy Trials in Transplantation: Which Assays and When? Front Immunol. 2021; 12:664244. PMID: 33841448; PMCID: PMC8027493.
    Citations: 4     Fields:    Translation:HumansAnimals
  24. Adigbli G, Hua P, Uchiyama M, Roberts I, Hester J, Watt SM, Issa F. Development of LT-HSC-Reconstituted Non-Irradiated NBSGW Mice for the Study of Human Hematopoiesis In Vivo. Front Immunol. 2021; 12:642198. PMID: 33868276; PMCID: PMC8044770.
    Citations: 3     Fields:    Translation:HumansAnimals
  25. Hennessy C, Lewik G, Cross A, Hester J, Issa F. Recent advances in our understanding of the allograft response. Fac Rev. 2021; 10:21. PMID: 33718938; PMCID: PMC7946390.
    Citations: 3     
  26. Sion M, Issa F. Research Highlights. Transplantation. 2020 Dec; 104(12):2457-2458. PMID: 33214492.
    Citations:    Fields:    
  27. Rodrigues J, Chan JK, Issa F. Surgery during the COVID-19 pandemic. Lancet. 2020 11 07; 396(10261):e75. PMID: 33160575; PMCID: PMC7831666.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  28. Kraus A, Awoniyi O, AlMalki Y, Bardeesi ASA, Edwards B, AlHajjaj F, Alossaimi B, Benham T, Bortolin M, Cattamanchi S, Court M, Groves J, Hernandez A, Issa F, Macgregor-Skinner G, Manners P, Molloy M, Romney D, Voskanyan A, Weiner D, Yogman M, Hart A, Ciottone G. Practical Solutions for Healthcare Worker Protection During the COVID-19 Pandemic Response in the Ambulatory, Emergency, and Inpatient Settings. J Occup Environ Med. 2020 Nov; 62(11):e616-e624. PMID: 32826554.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  29. Adigbli G, Ménoret S, Cross AR, Hester J, Issa F, Anegon I. Humanization of Immunodeficient Animals for the Modeling of Transplantation, Graft Versus Host Disease, and Regenerative Medicine. Transplantation. 2020 11; 104(11):2290-2306. PMID: 32068660.
    Citations: 11     Fields:    Translation:HumansAnimals
  30. Benham TL, Hart A, Bortolin M, Court M, Groves J, Kraus A, Newbury B, Voskanyan A, Yogman M, AlHajjaj F, AlMalki Y, Alossaimi B, Awoniyi O, Bardeesi AS, Cattamanchi S, Edwards B, Hernandez A, Issa F, Manners P, Molloy M, Romney D, Weiner D, Ciottone GR. Preparing for the Second Surge: Preventing Posttraumatic Stress Disorder and Building Resilience for Health Care Workers in the Face of COVID-19. Disaster Med Public Health Prep. 2022 04; 16(2):714-717. PMID: 33046178; PMCID: PMC7684017.
    Citations: 8     Fields:    Translation:HumansCells
  31. Beckett J, Hester J, Issa F, Shankar S. Regulatory B cells in transplantation: roadmaps to clinic. Transpl Int. 2020 11; 33(11):1353-1368. PMID: 32725703.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  32. Kawai K, Uchiyama M, Hester J, Issa F. IL-33 drives the production of mouse regulatory T cells with enhanced in vivo suppressive activity in skin transplantation. Am J Transplant. 2021 03; 21(3):978-992. PMID: 33314772; PMCID: PMC7613121.
    Citations: 8     Fields:    Translation:AnimalsCells
  33. Alzhrani A, Bottomley M, Wood K, Hester J, Issa F. Identification, selection, and expansion of non-gene modified alloantigen-reactive Tregs for clinical therapeutic use. Cell Immunol. 2020 11; 357:104214. PMID: 32977154; PMCID: PMC8482792.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  34. Court M, Edwards B, Issa F, Voskanyan A, Ciottone G. Counter-Terrorism Medicine: Creating a Medical Initiative Mandated by Escalating Asymmetric Attacks. Prehosp Disaster Med. 2020 Dec; 35(6):595-598. PMID: 32792026.
    Citations: 4     Fields:    Translation:Humans
  35. Issa F, Strober S, Leventhal JR, Kawai T, Kaufman DB, Levitsky J, Sykes M, Mas V, Wood KJ, Bridges N, Welniak LA, Chandran S, Madsen JC, Nickerson P, Demetris AJ, Lakkis FG, Thomson AW. The Fourth International Workshop on Clinical Transplant Tolerance. Am J Transplant. 2021 01; 21(1):21-31. PMID: 32529725.
    Citations: 9     Fields:    Translation:Humans
  36. Arroyo Hornero R, Georgiadis C, Hua P, Trzupek D, He LZ, Qasim W, Todd JA, Ferreira RC, Wood KJ, Issa F, Hester J. CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells. Commun Biol. 2020 07 14; 3(1):375. PMID: 32665635; PMCID: PMC7360768.
    Citations: 13     Translation:HumansAnimalsCells
  37. Hashimoto H, McCallion O, Kempkes RWM, Hester J, Issa F. Distinct metabolic pathways mediate regulatory T cell differentiation and function. Immunol Lett. 2020 07; 223:53-61. PMID: 32360534.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  38. Chong AS, Rothstein DM, Issa F, Kotsch K, Leuvenink H, Tullius SG. ITS finally here! The first International Transplant Science meeting jointly organized by AST, ESOT, and TTS. Transplantation. 2019 Oct; 103(10):1975-1976. PMID: 31517787.
  39. Hart A, Toma M, Issa F, Ciottone GR. Absence of Cultural Awareness Training in International Non-Governmental Organizations. Prehosp Disaster Med. 2019 Oct; 34(5):486-488. PMID: 31522696.
    Citations:    Fields:    Translation:Humans
  40. Wright S, Issa F. Hypoimmunogenic Genetically Modified Induced Pluripotent Stem Cells for Tissue Regeneration. Transplantation. 2019 09; 103(9):1744-1745. PMID: 30985582.
    Citations:    Fields:    Translation:Cells
  41. Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, Kranc K, Kudo H, Lawson H, McAuliffe J, Milward K, Scudamore CL, Soilleux E, Issa F, Ratcliffe PJ, Pugh CW. Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. J Clin Invest. 2019 06 04; 129(9):3640-3656. PMID: 31162141; PMCID: PMC6715380.
    Citations: 14     Fields:    Translation:AnimalsCells
  42. Issa F. Proteomics Identifies New Therapeutic Targets of Early-stage Hepatocellular Carcinoma. Transplantation. 2019 May; 103(5):855-856. PMID: 31033851.
  43. Issa F, Milward K, Goto R, Betts G, Wood KJ, Hester J. Transiently Activated Human Regulatory T Cells Upregulate BCL-XL Expression and Acquire a Functional Advantage in vivo. Front Immunol. 2019; 10:889. PMID: 31068951.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  44. Tullar C, Issa F. Research Highlights. Transplantation. 2019 Apr; 103(4):651-652. PMID: 30907852.
  45. McCallion O, Hester J, Issa F. Deciphering the Contribution of ?d T Cells to Outcomes in Transplantation. Transplantation. 2018 12; 102(12):1983-1993. PMID: 29994977.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  46. Adigbli G, Issa F. Preserving Treg Function: Beyond mTOR Inhibitors. Transplantation. 2018 02; 102(2):179-182. PMID: 29319616.
    Citations: 1     Fields:    Translation:Cells
  47. Issa F. Mesenchymal Stromal Cell Therapy: After the Gold Rush. Transplantation. 2018 01; 102(1):7-8. PMID: 28858990.
    Citations:    Fields:    Translation:Cells
  48. Kawai K, Uchiyama M, Hester J, Wood K, Issa F. Regulatory T cells for tolerance. Hum Immunol. 2018 May; 79(5):294-303. PMID: 29288698.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  49. Grey ST, Issa F. The 2017 Transplantation Awards: Recognizing a Landmark Clinical Trial and a Basic Science Discovery With Far-Reaching Implications. Transplantation. 2017 11; 101(11):2655-2656. PMID: 29059128.
    Citations:    Fields:    Translation:HumansAnimals
  50. Issa F. In View: Research Highlights. Transplantation. 2017 11; 101(11):2649-2650. PMID: 29059125.
    Citations:    Fields:    
  51. Zaitsu M, Issa F, Hester J, Vanhove B, Wood KJ. Selective blockade of CD28 on human T cells facilitates regulation of alloimmune responses. JCI Insight. 2017 10 05; 2(19). PMID: 28978798.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  52. Issa F. Research Highlights. Transplantation. 2017 Sep; 101(9):1955-1956. PMID: 28832444.
  53. Issa SF, Field WE, Schwab CV, Issa FS, Nauman EA. Contributing Causes of Injury or Death in Grain Entrapment, Engulfment, and Extrication. J Agromedicine. 2017; 22(2):159-169. PMID: 28129077.
    Citations: 1     Fields:    Translation:HumansAnimals
  54. Grey ST, Issa F, Tullius SG. Awards in Transplantation Science Recognize the Best Articles Published in Transplantation. Transplantation. 2017 01; 101(1):10-12. PMID: 27906822.
    Citations:    Fields:    Translation:Humans
  55. Barnes J, Issa F, Vrakas G, Friend P, Giele H. The abdominal wall transplant as a sentinel skin graft. Curr Opin Organ Transplant. 2016 10; 21(5):536-40. PMID: 27495916.
    Citations: 2     Fields:    Translation:Humans
  56. Edmondson SJ, Issa F. Vascularized Composite Allotransplantation: eResources. Transplantation. 2016 07; 100(7):1392-3. PMID: 27326808.
    Citations:    Fields:    Translation:Humans
  57. Issa F. Vascularized composite allograft-specific characteristics of immune responses. Transpl Int. 2016 Jun; 29(6):672-81. PMID: 26927941.
    Citations: 7     Fields:    Translation:HumansAnimals
  58. Tullius SG, Grey ST, Issa F. Awards in Transplantation Science Recognize the Best Manuscripts Published in Transplantation. Transplantation. 2016 Feb; 100(2):249-50. PMID: 26813405.
    Citations:    Fields:    Translation:HumansAnimals
  59. Wood KJ, Issa F, Hester J. Understanding Stem Cell Immunogenicity in Therapeutic Applications. Trends Immunol. 2016 Jan; 37(1):5-16. PMID: 26687737.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  60. Mastoridis S, Issa F, Wood KJ. Novel biomarkers and functional assays to monitor cell-therapy-induced tolerance in organ transplantation. Curr Opin Organ Transplant. 2015 Feb; 20(1):64-71. PMID: 25563993.
    Citations: 5     Fields:    Translation:HumansAnimals
  61. Issa F, Wood KJ. The potential role for regulatory T-cell therapy in vascularized composite allograft transplantation. Curr Opin Organ Transplant. 2014 Dec; 19(6):558-65. PMID: 25333829.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  62. Goto R, Issa F, Heidt S, Taggart D, Wood KJ. Ischemia-reperfusion injury accelerates human antibody-mediated transplant vasculopathy. Transplantation. 2013 Jul 27; 96(2):139-45. PMID: 23856999.
    Citations: 8     Fields:    Translation:HumansAnimals
  63. Chandrasekharan D, Issa F, Wood KJ. Achieving operational tolerance in transplantation: how can lessons from the clinic inform research directions? Transpl Int. 2013 Jun; 26(6):576-89. PMID: 23517251.
    Citations: 17     Fields:    Translation:Humans
  64. Milward K, Issa F, Hester J, Figueroa-Tentori D, Madrigal A, Wood KJ. Multiple unit pooled umbilical cord blood is a viable source of therapeutic regulatory T cells. Transplantation. 2013 Jan 15; 95(1):85-93. PMID: 23263503; PMCID: PMC4516307.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  65. Issa F, Hester J, Milward K, Wood KJ. Homing of regulatory T cells to human skin is important for the prevention of alloimmune-mediated pathology in an in vivo cellular therapy model. PLoS One. 2012; 7(12):e53331. PMID: 23300911.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  66. Issa F, Robb RJ, Wood KJ. The where and when of T cell regulation in transplantation. Trends Immunol. 2013 Mar; 34(3):107-13. PMID: 23228885.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  67. Issa F, Wood KJ. Translating tolerogenic therapies to the clinic - where do we stand? Front Immunol. 2012; 3:254. PMID: 22934094; PMCID: PMC3422982.
    Citations: 14     Fields:    
  68. Issa F, Chandrasekharan D, Wood KJ. Regulatory T cells as modulators of chronic allograft dysfunction. Curr Opin Immunol. 2011 Oct; 23(5):648-54. PMID: 21752619.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  69. Issa F, Hester J, Goto R, Nadig SN, Goodacre TE, Wood K. Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model. Transplantation. 2010 Dec 27; 90(12):1321-7. PMID: 21048528; PMCID: PMC3672995.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  70. Issa F, Wood KJ. CD4+ regulatory T cells in solid organ transplantation. Curr Opin Organ Transplant. 2010 Dec; 15(6):757-64. PMID: 20881492; PMCID: PMC3198838.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  71. Issa F, Schiopu A, Wood KJ. Role of T cells in graft rejection and transplantation tolerance. Expert Rev Clin Immunol. 2010 Jan; 6(1):155-69. PMID: 20383898.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.