Harvard Catalyst Profiles

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Florian Kahles, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L, Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M, Swirski FK. Sleep modulates haematopoiesis and protects against atherosclerosis. Nature. 2019 02; 566(7744):383-387. PMID: 30760925.
    Citations:    
  2. He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK. Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease. Nature. 2019 02; 566(7742):115-119. PMID: 30700910.
    Citations:    Fields:    
  3. Schnack L, Sohrabi Y, Lagache SMM, Kahles F, Bruemmer D, Waltenberger J, Findeisen HM. Mechanisms of Trained Innate Immunity in oxLDL Primed Human Coronary Smooth Muscle Cells. Front Immunol. 2019; 10:13. PMID: 30728822.
    Citations:    
  4. Anzai A, Mindur JE, Halle L, Sano S, Choi JL, He S, McAlpine CS, Chan CT, Kahles F, Valet C, Fenn AM, Nairz M, Rattik S, Iwamoto Y, Fairweather D, Walsh K, Libby P, Nahrendorf M, Swirski FK. Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis. J Exp Med. 2019 Feb 04; 216(2):369-383. PMID: 30670465.
    Citations:    Fields:    
  5. Sohrabi Y, Lagache SMM, Schnack L, Godfrey R, Kahles F, Bruemmer D, Waltenberger J, Findeisen HM. mTOR-Dependent Oxidative Stress Regulates oxLDL-Induced Trained Innate Immunity in Human Monocytes. Front Immunol. 2018; 9:3155. PMID: 30723479.
    Citations:    
  6. Diebold S, Moellmann J, Kahles F, Haj-Yehia E, Liehn EA, Nickel A, Lebherz C, Maack C, Marx N, Lehrke M. Myocardial infarction is sufficient to increase GLP-1 secretion, leading to improved left ventricular contractility and mitochondrial respiratory capacity. Diabetes Obes Metab. 2018 12; 20(12):2911-2918. PMID: 30033664.
    Citations:    Fields:    
  7. Kahles F, Liberman A, Halim C, Rau M, Möllmann J, Mertens RW, Rückbeil M, Diepolder I, Walla B, Diebold S, Burgmaier M, Lebherz C, Marx N, Lehrke M. The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE-/- mice by blocking monocyte/macrophage activation. Mol Metab. 2018 08; 14:150-157. PMID: 29884547.
    Citations:    Fields:    
  8. Kollikowski AM, Kahles F, Kintsler S, Hamada S, Reith S, Knüchel R, Röcken C, Mottaghy FM, Marx N, Burgmaier M. In vivo quantification of amyloid burden in TTR-related cardiac amyloidosis. Intractable Rare Dis Res. 2017 Nov; 6(4):291-294. PMID: 29259858.
    Citations:    
  9. Kahles F, Schuh A, Lehrke M, Burgmaier M, Marx N, Reith S. [Non-ST-Segment Elevation Myocardial Infarction Caused by Spontaneous Coronary Thrombosis by Intimal Rupture]. Dtsch Med Wochenschr. 2017 Nov; 142(22):1686-1689. PMID: 29078214.
    Citations:    Fields:    Translation:Humans
  10. Burgmaier M, Reith S, Schurgers L, Kahles F, Marx N, Reutelingsperger C. Circulating annexin A5 levels are associated with carotid intima-media thickness but not coronary plaque composition. Diab Vasc Dis Res. 2017 09; 14(5):415-422. PMID: 28592134.
    Citations:    Fields:    Translation:HumansCells
  11. Lebherz C, Schlieper G, Möllmann J, Kahles F, Schwarz M, Brünsing J, Dimkovic N, Koch A, Trautwein C, Flöge J, Marx N, Tacke F, Lehrke M. GLP-1 Levels Predict Mortality in Patients with Critical Illness as Well as End-Stage Renal Disease. Am J Med. 2017 07; 130(7):833-841.e3. PMID: 28366423.
    Citations: 2     Fields:    Translation:Humans
  12. Möllmann J, Kahles F, Lebherz C, Kappel B, Baeck C, Tacke F, Werner C, Federici M, Marx N, Lehrke M. The PDE4 inhibitor roflumilast reduces weight gain by increasing energy expenditure and leads to improved glucose metabolism. Diabetes Obes Metab. 2017 04; 19(4):496-508. PMID: 27917591.
    Citations:    Fields:    Translation:AnimalsCells
  13. Kahles F, Findeisen HM. Does osteopontin induce adipose tissue inflammation by local macrophage proliferation? Mol Metab. 2016 12; 5(12):1147-1148. PMID: 27900257.
    Citations:    Fields:    Translation:HumansAnimalsCells
  14. Kahles F, Meyer C, Diebold S, Foldenauer AC, Stöhr R, Möllmann J, Lebherz C, Findeisen HM, Marx N, Lehrke M. Glucose-dependent insulinotropic peptide secretion is induced by inflammatory stimuli in an interleukin-1-dependent manner in mice. Diabetes Obes Metab. 2016 11; 18(11):1147-1151. PMID: 27350651.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Lebherz C, Kahles F, Piotrowski K, Vogeser M, Foldenauer AC, Nassau K, Kilger E, Marx N, Parhofer KG, Lehrke M. Interleukin-6 predicts inflammation-induced increase of Glucagon-like peptide-1 in humans in response to cardiac surgery with association to parameters of glucose metabolism. Cardiovasc Diabetol. 2016 Feb 03; 15:21. PMID: 26842302.
    Citations: 5     Fields:    Translation:HumansCells
  16. Kahles F, Meyer C, Möllmann J, Diebold S, Findeisen HM, Lebherz C, Trautwein C, Koch A, Tacke F, Marx N, Lehrke M. [IL-6 dependent GLP-1 secretion during acute inflammation]. Med Klin Intensivmed Notfmed. 2015 Sep; 110(6):462-4. PMID: 26250691.
    Citations:    Fields:    Translation:HumansAnimalsCells
  17. Lehrke M, Kahles F, Makowska A, Tilstam PV, Diebold S, Marx J, Stöhr R, Hess K, Endorf EB, Bruemmer D, Marx N, Findeisen HM. PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner. J Mol Cell Cardiol. 2015 Apr; 81:23-33. PMID: 25640159.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  18. Kahles F, Meyer C, Möllmann J, Diebold S, Findeisen HM, Lebherz C, Trautwein C, Koch A, Tacke F, Marx N, Lehrke M. GLP-1 secretion is increased by inflammatory stimuli in an IL-6-dependent manner, leading to hyperinsulinemia and blood glucose lowering. Diabetes. 2014 Oct; 63(10):3221-9. PMID: 24947356.
    Citations: 25     Fields:    Translation:HumansAnimals
  19. Kahles F, Findeisen HM, Bruemmer D. Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes. Mol Metab. 2014 Jul; 3(4):384-93. PMID: 24944898.
    Citations: 52     Fields:    
  20. Burgmaier M, Liberman A, Möllmann J, Kahles F, Reith S, Lebherz C, Marx N, Lehrke M. Glucagon-like peptide-1 (GLP-1) and its split products GLP-1(9-37) and GLP-1(28-37) stabilize atherosclerotic lesions in apoe?/? mice. Atherosclerosis. 2013 Dec; 231(2):427-35. PMID: 24267262.
    Citations: 10     Fields:    Translation:AnimalsCells
  21. Findeisen HM, Kahles FK, Bruemmer D. Epigenetic regulation of vascular smooth muscle cell function in atherosclerosis. Curr Atheroscler Rep. 2013 May; 15(5):319. PMID: 23630979.
    Citations:    Fields:    Translation:HumansCells
  22. Findeisen HM, Kahles FK, Bruemmer D. Epigenetic regulation of vascular smooth muscle cell function in atherosclerosis. Curr Atheroscler Rep. 2013 Apr; 15(4):319. PMID: 23423526.
    Citations: 13     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.