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Lauren Elizabeth Surface, Ph.D.

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Mentoring
Available: 12/01/19, Expires: 09/01/21

Osteoporosis and low bone mass (osteopenia) are estimated to affect 55 percent of the American population over the age of 50, with bisphosphonates (BPs) among the most accessible and least expensive treatments. Despite their widespread use, the molecular pathways by which BPs work are poorly understood. Uncovering these pathways will assist clinicians in managing osteoporosis and related diseases. We have recently conducted genome-wide screens to identify molecular targets of these drugs. In this project, the student will investigate a select set of these targets, namely two transcription factors, that have recently been implicated in bone mineral density changes.

The student will be trained in and utilize techniques in molecular and cellular biology, including, but not limited to, culture of bone cells, flow cytometry, histology, and epigenomic and transcriptomic analysis. If desired, the student may also be trained in using rodent models.

This project commitment could range from small summer focused project to a year plus commitment depending on student's interest and scope.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K99AR073903 (SURFACE, LAUREN ELIZABETH) Aug 1, 2019 - Jul 31, 2021
    NIH/NIAMS
    Deciphering mechanisms of nitrogen-containing bisphosphonates
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Surface LE, Burrow DT, Li J, Park J, Kumar S, Lyu C, Song N, Yu Z, Rajagopal A, Bae Y, Lee BH, Mumm S, Gu CC, Baker JC, Mohseni M, Sum M, Huskey M, Duan S, Bijanki VN, Civitelli R, Gardner MJ, McAndrew CM, Ricci WM, Gurnett CA, Diemer K, Wan F, Costantino CL, Shannon KM, Raje N, Dodson TB, Haber DA, Carette JE, Varadarajan M, Brummelkamp TR, Birsoy K, Sabatini DM, Haller G, Peterson TR. ATRAID regulates the action of nitrogen-containing bisphosphonates on bone. Sci Transl Med. 2020 May 20; 12(544). PMID: 32434850.
    Citations:    
  2. Yu Z, Surface LE, Park CY, Horlbeck MA, Wyant GA, Abu-Remaileh M, Peterson TR, Sabatini DM, Weissman JS, O'Shea EK. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates. Elife. 2018 05 10; 7. PMID: 29745899.
    Citations:    Fields:    
  3. Surface LE, Fields PA, Subramanian V, Behmer R, Udeshi N, Peach SE, Carr SA, Jaffe JD, Boyer LA. H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs. Cell Rep. 2016 Feb 09; 14(5):1142-1155. PMID: 26804911.
    Citations: 8     Fields:    Translation:AnimalsCells
  4. Subramanian V, Mazumder A, Surface LE, Butty VL, Fields PA, Alwan A, Torrey L, Thai KK, Levine SS, Bathe M, Boyer LA. H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression programs during ESC differentiation. PLoS Genet. 2013; 9(8):e1003725. PMID: 23990805.
    Citations: 13     Fields:    Translation:AnimalsCells
  5. Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA, Steinhauser ML, Ding H, Butty VL, Torrey L, Haas S, Abo R, Tabebordbar M, Lee RT, Burge CB, Boyer LA. Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. Cell. 2013 Jan 31; 152(3):570-83. PMID: 23352431.
    Citations: 248     Fields:    Translation:HumansAnimalsCells
  6. Surface LE, Thornton SR, Boyer LA. Polycomb group proteins set the stage for early lineage commitment. Cell Stem Cell. 2010 Sep 03; 7(3):288-98. PMID: 20804966.
    Citations: 107     Fields:    Translation:HumansCells
  7. Lockshon D, Surface LE, Kerr EO, Kaeberlein M, Kennedy BK. The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function. Genetics. 2007 Jan; 175(1):77-91. PMID: 17151231.
    Citations: 47     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.