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Chen Chu, Ph.D.

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Chinese Academy of Sciences, ShanghaiPh.D.01/2016Biochemistry and Molecular Biology
Shanghai Jiao Tong University, ShanghaiM.M.03/2010Pharmaceutics
Shanghai Jiao Tong University, ShanghaiB.S.06/2007Pharmacy
Shanghai Jiao Tong University, ShanghaiB.A.06/2007Japanese
Di Ao Scholarship
Pfizer Scholarship
Excellent graduate of Shanghai Jiao Tong University


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Schaefer IM, Hemming ML, Lundberg MZ, Serrata MP, Goldaracena I, Liu N, Yin P, Paulo JA, Gygi SP, George S, Morgan JA, Bertagnolli MM, Sicinska ET, Chu C, Zheng S, Mariño-Enríquez A, Hornick JL, Raut CP, Ou WB, Demetri GD, Saka SK, Fletcher JA. Concurrent inhibition of CDK2 adds to the anti-tumour activity of CDK4/6 inhibition in GIST. Br J Cancer. 2022 11; 127(11):2072-2085. PMID: 36175617; PMCID: PMC9681737.
    Citations:    Fields:    
  2. Zhong L, Yang X, Zhou Y, Xiao J, Li H, Tao J, Xi Q, Chu C, Li C, Yang X, Yang C, Zhang Y, Shuai P, Liu Y, Yu M, Shi Y, Hu J, Zhang W, Gong B, Yang Z. Exploring the R-ISS stage-specific regular networks in the progression of multiple myeloma at single-cell resolution. Sci China Life Sci. 2022 09; 65(9):1811-1823. PMID: 35437648.
    Citations: 1     Fields:    Translation:Humans
  3. Zhu Q, Kirby JA, Chu C, Gou LT. Small Noncoding RNAs in Reproduction and Infertility. Biomedicines. 2021 Dec 12; 9(12). PMID: 34944700.
    Citations: 1     
  4. Dang F, Nie L, Zhou J, Shimizu K, Chu C, Wu Z, Fassl A, Ke S, Wang Y, Zhang J, Zhang T, Tu Z, Inuzuka H, Sicinski P, Bass AJ, Wei W. Inhibition of CK1e potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer. Nat Commun. 2021 09 10; 12(1):5386. PMID: 34508104; PMCID: PMC8433397.
    Citations:    Fields:    Translation:HumansCells
  5. Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H. Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia. J Clin Invest. 2021 08 16; 131(16). PMID: 34255748; PMCID: PMC8363288.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  6. Ahmed S, Tao J, Wang M, Zhai Y, Liu W, Jayachandran M, Chu C, Qu S, Zhang J, Zhang Y, Fei Z. An improved lentiviral system for efficient expression and purification of ß-defensins in mammalian cells. Biotechnol J. 2021 Sep; 16(9):e2100023. PMID: 34053189.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Chu C, Geng Y, Zhou Y, Sicinski P. Cyclin E in normal physiology and disease states. Trends Cell Biol. 2021 09; 31(9):732-746. PMID: 34052101; PMCID: PMC8364501.
    Citations: 11     Fields:    Translation:HumansAnimals
  8. Chu C, Yu L, Henry-Berger J, Ru YF, Kocer A, Champroux A, Li ZT, He M, Xie SS, Ma WB, Ni MJ, Ni ZM, Guo YL, Fei ZL, Gou LT, Liu Q, Sharma S, Zhou Y, Liu MF, Chen CD, Eamens AL, Nixon B, Zhou YC, Drevet JR, Zhang YL. Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice. Asian J Androl. 2020 Nov-Dec; 22(6):590-601. PMID: 32270769.
    Citations: 4     Fields:    Translation:AnimalsCells
  9. Zhou Y, Geng Y, Zhang Y, Zhou Y, Chu C, Sharma S, Fassl A, Butter D, Sicinski P. The requirement for cyclin E in c-Myc overexpressing breast cancers. Cell Cycle. 2020 10; 19(20):2589-2599. PMID: 32975478.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. Gao Y, Nihira NT, Bu X, Chu C, Zhang J, Kolodziejczyk A, Fan Y, Chan NT, Ma L, Liu J, Wang D, Dai X, Liu H, Ono M, Nakanishi A, Inuzuka H, North BJ, Huang YH, Sharma S, Geng Y, Xu W, Liu XS, Li L, Miki Y, Sicinski P, Freeman GJ, Wei W. Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy. Nat Cell Biol. 2020 09; 22(9):1064-1075. PMID: 32839551; PMCID: PMC7484128.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  11. Michowski W, Chick JM, Chu C, Kolodziejczyk A, Wang Y, Suski JM, Abraham B, Anders L, Day D, Dunkl LM, Li Cheong Man M, Zhang T, Laphanuwat P, Bacon NA, Liu L, Fassl A, Sharma S, Otto T, Jecrois E, Han R, Sweeney KE, Marro S, Wernig M, Geng Y, Moses A, Li C, Gygi SP, Young RA, Sicinski P. Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells. Mol Cell. 2020 05 07; 78(3):459-476.e13. PMID: 32240602.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  12. Tang C, Ni M, Xie S, Zhang Y, Zhang C, Ni Z, Chu C, Wu L, Zhou Y, Zhang Y. DICER1 regulates antibacterial function of epididymis by modulating transcription of ß-defensins. J Mol Cell Biol. 2019 05 01; 11(5):408-420. PMID: 30215742.
    Citations:    Fields:    Translation:HumansAnimalsCells
  13. Chu C, Zhang YL, Yu L, Sharma S, Fei ZL, Drevet JR. Epididymal small non-coding RNA studies: progress over the past decade. Andrology. 2019 09; 7(5):681-689. PMID: 31044548.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  14. Lei Chen, Chen Chu, Yu-Hang Zhang, Mingyue Zheng, LiuCun Zhu, XiangYin Kong, Tao Huang. Identification of Drug-Drug Interactions Using Chemical Interactions. Current Bioinformatics. 2017; 12(6):526-534.
  15. Chu C, Yu L, Wu B, Ma L, Gou LT, He M, Guo Y, Li ZT, Gao W, Shi H, Liu MF, Wang H, Chen CD, Drevet JR, Zhou Y, Zhang Y. A sequence of 28S rRNA-derived small RNAs is enriched in mature sperm and various somatic tissues and possibly associates with inflammation. J Mol Cell Biol. 2017 06 01; 9(3):256-259. PMID: 28486659.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  16. Huang G, Chu C, Huang T, Kong X, Zhang Y, Zhang N, Cai YD. Exploring Mouse Protein Function via Multiple Approaches. PLoS One. 2016; 11(11):e0166580. PMID: 27846315.
    Citations: 9     Fields:    Translation:AnimalsCells
  17. Zhang YH, Chu C, Wang S, Chen L, Lu J, Kong X, Huang T, Li H, Cai YD. The Use of Gene Ontology Term and KEGG Pathway Enrichment for Analysis of Drug Half-Life. PLoS One. 2016; 11(10):e0165496. PMID: 27780226.
    Citations: 3     Fields:    Translation:HumansCells
  18. He M, Ding Y, Chu C, Tang J, Xiao Q, Luo ZG. Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury. Proc Natl Acad Sci U S A. 2016 10 04; 113(40):11324-11329. PMID: 27638205; PMCID: PMC5056063.
    Citations: 70     Fields:    Translation:AnimalsCells
  19. Chen L, Chu C, Zhang YH, Zhu C, Kong X, Huang T, Cai YD. Analysis of Gene Expression Profiles in the Human Brain Stem, Cerebellum and Cerebral Cortex. PLoS One. 2016; 11(7):e0159395. PMID: 27434030; PMCID: PMC4951119.
    Citations: 6     Fields:    Translation:HumansCells
  20. Chen L, Zhang YH, Zou Q, Chu C, Ji Z. Analysis of the chemical toxicity effects using the enrichment of Gene Ontology terms and KEGG pathways. Biochim Biophys Acta. 2016 11; 1860(11 Pt B):2619-26. PMID: 27208425.
    Citations: 6     Fields:    
  21. Wan X, Ru Y, Chu C, Ni Z, Zhou Y, Wang S, Zhou Z, Zhang Y. Bisphenol A accelerates capacitation-associated protein tyrosine phosphorylation of rat sperm by activating protein kinase A. Acta Biochim Biophys Sin (Shanghai). 2016 Jun; 48(6):573-80. PMID: 27174873; PMCID: PMC4913528.
    Citations: 4     Fields:    Translation:AnimalsCells
  22. Xing Z, Chu C, Chen L, Kong X. The use of Gene Ontology terms and KEGG pathways for analysis and prediction of oncogenes. Biochim Biophys Acta. 2016 11; 1860(11 Pt B):2725-34. PMID: 26801878.
    Citations: 23     Fields:    Translation:HumansCells
  23. Chen L, Chu C, Feng K. Predicting the types of metabolic pathway of compounds using molecular fragments and sequential minimal optimization. Comb Chem High Throughput Screen. 2016; 19(2):136-43. PMID: 26552441.
    Citations: 17     Fields:    
  24. Cheng S, Zhu C, Chu C, Huang T, Kong X, Zhu LC. Prediction of bioactive compound pathways using chemical interaction and structural information. Comb Chem High Throughput Screen. 2016; 19(2):161-9. PMID: 26552436.
    Citations: 1     Fields:    Translation:Cells
  25. Chen L, Chu C, Lu J, Kong X, Huang T, Cai YD. A computational method for the identification of new candidate carcinogenic and non-carcinogenic chemicals. Mol Biosyst. 2015 Sep; 11(9):2541-50. PMID: 26194467.
    Citations: 6     Fields:    Translation:Humans
  26. Chen L, Chu C, Lu J, Kong X, Huang T, Cai YD. Gene Ontology and KEGG Pathway Enrichment Analysis of a Drug Target-Based Classification System. PLoS One. 2015; 10(5):e0126492. PMID: 25951454; PMCID: PMC4423955.
    Citations: 25     Fields:    
  27. Chu C, Zheng G, Hu S, Zhang J, Xie S, Ma W, Ni M, Tang C, Zhou L, Zhou Y, Liu M, Li Y, Zhang Y. Epididymal Region-Specific miRNA Expression and DNA Methylation and Their Roles in Controlling Gene Expression in Rats. PLoS One. 2015; 10(4):e0124450. PMID: 25901964.
    Citations: 6     Fields:    Translation:AnimalsCells
  28. Chen L, Chu C, Huang T, Kong X, Cai YD. Prediction and analysis of cell-penetrating peptides using pseudo-amino acid composition and random forest models. Amino Acids. 2015 Jul; 47(7):1485-93. PMID: 25894890.
    Citations: 20     Fields:    Translation:Cells
  29. Chen L, Chu C, Kong X, Huang G, Huang T, Cai YD. A hybrid computational method for the discovery of novel reproduction-related genes. PLoS One. 2015; 10(3):e0117090. PMID: 25768094.
    Citations: 9     Fields:    Translation:Humans
  30. Chen L, Chu C, Kong X, Huang T, Cai YD. Discovery of new candidate genes related to brain development using protein interaction information. PLoS One. 2015; 10(1):e0118003. PMID: 25635857.
    Citations: 5     Fields:    Translation:Humans
  31. Wang CM, Hu SG, Ru YF, Yao GX, Ma WB, Gu YH, Chu C, Wang SL, Zhou ZM, Liu Q, Zhou YC, Zhang YL. Different effects of androgen on the expression of Fut1, Fut2, Fut4 and Fut9 in male mouse reproductive tract. Int J Mol Sci. 2013 Nov 21; 14(11):23188-202. PMID: 24284406.
    Citations: 2     Fields:    Translation:AnimalsCells
  32. Chu C, Xin A, Zhou Y, Zhang Y. A simple protocol for producing high-titer lentivirus. Acta Biochim Biophys Sin (Shanghai). 2013 Dec; 45(12):1079-82. PMID: 24113089.
    Citations: 2     Fields:    Translation:HumansCells
  33. Ma L, Yu H, Ni Z, Hu S, Ma W, Chu C, Liu Q, Zhang Y. Spink13, an epididymis-specific gene of the Kazal-type serine protease inhibitor (SPINK) family, is essential for the acrosomal integrity and male fertility. J Biol Chem. 2013 Apr 05; 288(14):10154-10165. PMID: 23430248.
    Citations: 16     Fields:    Translation:AnimalsCells
  34. Chen Y, Chu C, Zhou Y, Ru Y, Chen H, Chen F, He Q, Zhang Y, Zhang L, Shi J. Reversible pore-structure evolution in hollow silica nanocapsules: large pores for siRNA delivery and nanoparticle collecting. Small. 2011 Oct 17; 7(20):2935-44. PMID: 21901827.
    Citations: 8     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.