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Aaron M Hosios, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Son S, Stevens MM, Chao HX, Thoreen C, Hosios AM, Schweitzer LD, Weng Y, Wood K, Sabatini D, Vander Heiden MG, Manalis S. Author Correction: Cooperative nutrient accumulation sustains growth of mammalian cells. Sci Rep. 2020 Jul 21; 10(1):12054. PMID: 32694612.
  2. Luengo A, Abbott KL, Davidson SM, Hosios AM, Faubert B, Chan SH, Freinkman E, Zacharias LG, Mathews TP, Clish CB, DeBerardinis RJ, Lewis CA, Vander Heiden MG. Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer. Nat Commun. 2019 12 06; 10(1):5604. PMID: 31811141.
  3. Liu VM, Howell AJ, Hosios AM, Li Z, Israelsen WJ, Vander Heiden MG. Cancer-associated mutations in human pyruvate kinase M2 impair enzyme activity. FEBS Lett. 2020 Feb; 594(4):646-664. PMID: 31642061.
  4. Dexter JP, Ward PS, Dasgupta T, Hosios AM, Gunawardena J, Vander Heiden MG. Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate. J Biol Chem. 2018 12 28; 293(52):20051-20061. PMID: 30381394.
    Citations:    Fields:    
  5. Cox AG, Tsomides A, Yimlamai D, Hwang KL, Miesfeld J, Galli GG, Fowl BH, Fort M, Ma KY, Sullivan MR, Hosios AM, Snay E, Yuan M, Brown KK, Lien EC, Chhangawala S, Steinhauser ML, Asara JM, Houvras Y, Link B, Vander Heiden MG, Camargo FD, Goessling W. Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. EMBO J. 2018 11 15; 37(22). PMID: 30348863.
    Citations:    Fields:    
  6. Hosios AM, Manning BD. Lysosomal catch-and-release controls mTORC1. Nat Cell Biol. 2018 Sep; 20(9):996-997. PMID: 30154562.
    Citations:    Fields:    
  7. Sullivan LB, Luengo A, Danai LV, Bush LN, Diehl FF, Hosios AM, Lau AN, Elmiligy S, Malstrom S, Lewis CA, Vander Heiden MG. Aspartate is an endogenous metabolic limitation for tumour growth. Nat Cell Biol. 2018 07; 20(7):782-788. PMID: 29941931.
    Citations:    Fields:    
  8. Hosios AM, Vander Heiden MG. The redox requirements of proliferating mammalian cells. J Biol Chem. 2018 05 18; 293(20):7490-7498. PMID: 29339555.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. Hosios AM, Vander Heiden MG. Endothelial Cells Get ß-ox-ed In to Support Lymphangiogenesis. Dev Cell. 2017 01 23; 40(2):118-119. PMID: 28118598.
    Citations: 1     Fields:    Translation:HumansCells
  10. Gui DY, Sullivan LB, Luengo A, Hosios AM, Bush LN, Gitego N, Davidson SM, Freinkman E, Thomas CJ, Vander Heiden MG. Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin. Cell Metab. 2016 11 08; 24(5):716-727. PMID: 27746050.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  11. Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science. 2016 09 09; 353(6304):1161-5. PMID: 27609895.
    Citations: 51     Fields:    Translation:HumansAnimals
  12. Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, Steinhauser ML, Manalis SR, Vander Heiden MG. Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Dev Cell. 2016 Mar 07; 36(5):540-9. PMID: 26954548.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  13. Hecht VC, Sullivan LB, Kimmerling RJ, Kim DH, Hosios AM, Stockslager MA, Stevens MM, Kang JH, Wirtz D, Vander Heiden MG, Manalis SR. Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. J Cell Biol. 2016 Feb 15; 212(4):439-47. PMID: 26880201.
    Citations:    Fields:    Translation:AnimalsCells
  14. Son S, Stevens MM, Chao HX, Thoreen C, Hosios AM, Schweitzer LD, Weng Y, Wood K, Sabatini D, Vander Heiden MG, Manalis S. Cooperative nutrient accumulation sustains growth of mammalian cells. Sci Rep. 2015 Dec 01; 5:17401. PMID: 26620632.
    Citations: 2     Fields:    Translation:HumansCells
  15. Hosios AM, Fiske BP, Gui DY, Vander Heiden MG. Lack of Evidence for PKM2 Protein Kinase Activity. Mol Cell. 2015 Sep 03; 59(5):850-7. PMID: 26300261.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  16. Sullivan LB, Gui DY, Hosios AM, Bush LN, Freinkman E, Vander Heiden MG. Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells. Cell. 2015 Jul 30; 162(3):552-63. PMID: 26232225.
    Citations: 123     Fields:    Translation:HumansCells
  17. Hosios AM, Vander Heiden MG. Acetate metabolism in cancer cells. Cancer Metab. 2014; 2(1):27. PMID: 25505945.
    Citations: 7     
  18. Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt SM, Vander Heiden MG. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Mol Cell. 2015 Jan 08; 57(1):95-107. PMID: 25482511.
    Citations: 52     Fields:    Translation:AnimalsCells
  19. Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, Jacks T, Kibbey RG, Wulf GM, Di Vizio D, Mills GB, Cantley LC, Vander Heiden MG. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 2013 Oct 10; 155(2):397-409. PMID: 24120138.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  20. Reaves ML, Young BD, Hosios AM, Xu YF, Rabinowitz JD. Pyrimidine homeostasis is accomplished by directed overflow metabolism. Nature. 2013 Aug 08; 500(7461):237-41. PMID: 23903661.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.