Harvard Catalyst Profiles

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Nikolaos Daskalakis, Ph.D., M.D.

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Biography
education and training
University of Athens, Athens, GreeceMD12/2006Medicine
Leiden University, Leiden, The NetherlandsPhD12/2011Neuropsychopharmacology
Leiden University Medical Center, Leiden, The Netherlands12/2011Neuroendocrinology
Icahn School of Medicine, New York, New York01/2014Systems biology

Overview
overview
Nikolaos P. Daskalakis, MD, PhD, is the director of the Neurogenomics and Translational Bioinformatics Laboratory at McLean Hospital and an assistant professor of psychiatry at Harvard Medical School. He is also an affiliate member of the Broad Institute, MIT Computer Science and Artificial Intelligence Laboratory, and the National Center for PTSD. Dr. Daskalakis received his MD from the University of Athens, his PhD in neuropsychopharmacology from Leiden University, and completed post-doctoral research fellowships in clinical neuroendocrinology at Leiden University and in systems biology at the Icahn School of Medicine.

Dr. Daskalakis focuses on the interaction between stress and the brain, conducting translational studies and following an integrative systems biology approach. His lab uses transcriptomic and epigenomic profiling of brain and blood samples to identify gene networks associated with vulnerability and resilience to PTSD. Dr. Daskalakis leads the Systems Biology working group of the Psychiatric Genomics Consortium for PTSD. He is an editor for Brain Sciences, Frontiers (in Behavioral Neuroscience, Endocrinology, Neuroscience, and Psychiatry) and Neurobiology of Stress.
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Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21MH121909-01A1 (DASKALAKIS, NIKOLAOS) Sep 1, 2020 - Aug 31, 2022
    NIH/NIMH
    INTEGRATING NEUROIMAGING AND BRAIN GENE EXPRESSION FOR FUNCTIONAL CHARACTERIZATION OF PSYCHIATRIC GWAS
    Role: Principal Investigator
  2. R01MH119227-01A1 (KAUFMAN, MILISSA L) Apr 1, 2020 - Jan 31, 2025
    NIH/NIMH
    MULTIMODAL APPROACHES TO NEUROBIOLOGY OF TRAUMATIC DISSOCIATION
    Role: Co-Investigator
  3. P50MH115874 (CARLEZON, WILLIAM A.) Apr 1, 2019 - Feb 28, 2024
    NIH
    Silvio O. Conte Center for Stress Peptide Advanced Research, Education, & Dissemination (SPARED) at McLean Hospital
    Role: Co-Investigator
  4. R01MH117292 (RESSLER, KERRY J.) Jul 25, 2018 - Apr 30, 2023
    NIH
    Site 3/3, Understanding PTSD through Postmortem Targeted Brain Multiomics
    Role: Co-Investigator
  5. R01MH106595 (NIEVERGELT, CAROLINE M) Aug 19, 2016 - Jun 30, 2024
    NIH
    Psychiatric Genomics Consortium for PTSD
    Role: Co-Investigator

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Bibliographic
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bassil K, Krontira AC, Leroy T, Escoto AIH, Snijders C, Pernia CD, Pasterkamp RJ, de Nijs L, van den Hove D, Kenis G, Boks MP, Vadodaria K, Daskalakis NP, Binder EB, Rutten BPF. In vitro modeling of the neurobiological effects of glucocorticoids: A review. Neurobiol Stress. 2023 Mar; 23:100530. PMID: 36891528; PMCID: PMC9986648.
    Citations:    
  2. Soliva-Estruch M, Tamashiro KL, Daskalakis NP. Genetics and epigenetics of stress: New avenues for an old concept. Neurobiol Stress. 2023 Mar; 23:100525. PMID: 36873728; PMCID: PMC9975307.
    Citations:    
  3. Bountress KE, Bustamante D, Subbie-Saenz de Viteri S, Chatzinakos C, Sheerin C, Daskalakis NP, Edenberg HJ, Peterson RE, Webb BT, Meyers J, Amstadter A. Differences in genetic correlations between posttraumatic stress disorder and alcohol-related problems phenotypes compared to alcohol consumption-related phenotypes. Psychol Med. 2022 Sep 30; 1-11. PMID: 36177877.
    Citations:    Fields:    
  4. Barzilay R, Visoki E, Schultz LM, Warrier V, Daskalakis NP, Almasy L. Genetic risk, parental history, and suicide attempts in a diverse sample of US adolescents. Front Psychiatry. 2022; 13:941772. PMID: 36186872.
    Citations:    
  5. Daskalakis NP, Meijer OC, de Kloet ER. Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted therapy. Neurobiol Stress. 2022 May; 18:100455. PMID: 35601687; PMCID: PMC9118500.
    Citations: 4     
  6. Marchese S, Cancelmo L, Diab O, Cahn L, Aaronson C, Daskalakis NP, Schaffer J, Horn SR, Johnson JS, Schechter C, Desarnaud F, Bierer LM, Makotkine I, Flory JD, Crane M, Moline JM, Udasin IG, Harrison DJ, Roussos P, Charney DS, Koenen KC, Southwick SM, Yehuda R, Pietrzak RH, Huckins LM, Feder A. Altered gene expression and PTSD symptom dimensions in World Trade Center responders. Mol Psychiatry. 2022 04; 27(4):2225-2246. PMID: 35177824.
    Citations:    Fields:    Translation:Humans
  7. Vermetten E, Snijders C, Daskalakis NP, Rutten BPF. Revisiting the Need for a PTSD Brain Bank; Commentary on Friedman. Psychiatry. 2022; 85(2):203-211. PMID: 35588487.
    Citations:    Fields:    Translation:Humans
  8. Daskalakis NP, Schultz LM, Visoki E, Moore TM, Argabright ST, Harnett NG, DiDomenico GE, Warrier V, Almasy L, Barzilay R. Contributions of PTSD polygenic risk and environmental stress to suicidality in preadolescents. Neurobiol Stress. 2021 Nov; 15:100411. PMID: 34765698; PMCID: PMC8569631.
    Citations: 7     
  9. Maihofer AX, Choi KW, Coleman JRI, Daskalakis NP, Denckla CA, Ketema E, Morey RA, Polimanti R, Ratanatharathorn A, Torres K, Wingo AP, Zai CC, Aiello AE, Almli LM, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegovic E, Borglum AD, Babic D, Bækvad-Hansen M, Baker DG, Beckham JC, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Bradley B, Brashear M, Breen G, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Calabrese JR, Caldas-de-Almeida JM, Chen CY, Dale AM, Dalvie S, Deckert J, Delahanty DL, Dennis MF, Disner SG, Domschke K, Duncan LE, Džubur Kulenovic A, Erbes CR, Evans A, Farrer LA, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gautam A, Gelaye B, Gelernter J, Geuze E, Gillespie CF, Goçi A, Gordon SD, Guffanti G, Hammamieh R, Hauser MA, Heath AC, Hemmings SMJ, Hougaard DM, Jakovljevic M, Jett M, Johnson EO, Jones I, Jovanovic T, Qin XJ, Karstoft KI, Kaufman ML, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kranzler HR, Kremen WS, Lawford BR, Lebois LAM, Lewis C, Liberzon I, Linnstaedt SD, Logue MW, Lori A, Lugonja B, Luykx JJ, Lyons MJ, Maples-Keller JL, Marmar C, Martin NG, Maurer D, Mavissakalian MR, McFarlane A, McGlinchey RE, McLaughlin KA, McLean SA, Mehta D, Mellor R, Michopoulos V, Milberg W, Miller MW, Morris CP, Mors O, Mortensen PB, Nelson EC, Nordentoft M, Norman SB, O'Donnell M, Orcutt HK, Panizzon MS, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Rice JP, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero KJ, Rung A, Rutten BPF, Saccone NL, Sanchez SE, Schijven D, Seedat S, Seligowski AV, Seng JS, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stevens JS, Teicher MH, Thompson WK, Trapido E, Uddin M, Ursano RJ, van den Heuvel LL, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Werge T, Williams MA, Williamson DE, Winternitz S, Wolf C, Wolf EJ, Yehuda R, Young KA, Young RM, Zhao H, Zoellner LA, Haas M, Lasseter H, Provost AC, Salem RM, Sebat J, Shaffer RA, Wu T, Ripke S, Daly MJ, Ressler KJ, Koenen KC, Stein MB, Nievergelt CM. Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. Biol Psychiatry. 2022 04 01; 91(7):626-636. PMID: 34865855; PMCID: PMC8917986.
    Citations:    Fields:    Translation:Humans
  10. Logue MW, Zhou Z, Morrison FG, Wolf EJ, Daskalakis NP, Chatzinakos C, Georgiadis F, Labadorf AT, Girgenti MJ, Young KA, Williamson DE, Zhao X, Grenier JG, Huber BR, Miller MW. Gene expression in the dorsolateral and ventromedial prefrontal cortices implicates immune-related gene networks in PTSD. Neurobiol Stress. 2021 Nov; 15:100398. PMID: 34646915; PMCID: PMC8498459.
    Citations: 7     
  11. Dalvie S, Chatzinakos C, Al Zoubi O, Georgiadis F, Lancashire L, Daskalakis NP. From genetics to systems biology of stress-related mental disorders. Neurobiol Stress. 2021 Nov; 15:100393. PMID: 34584908; PMCID: PMC8456113.
    Citations: 5     
  12. Lori A, Schultebraucks K, Galatzer-Levy I, Daskalakis NP, Katrinli S, Smith AK, Myers AJ, Richholt R, Huentelman M, Guffanti G, Wuchty S, Gould F, Harvey PD, Nemeroff CB, Jovanovic T, Gerasimov ES, Maples-Keller JL, Stevens JS, Michopoulos V, Rothbaum BO, Wingo AP, Ressler KJ. Transcriptome-wide association study of post-trauma symptom trajectories identified GRIN3B as a potential biomarker for PTSD development. Neuropsychopharmacology. 2021 09; 46(10):1811-1820. PMID: 34188182; PMCID: PMC8357796.
    Citations: 5     Fields:    Translation:HumansCells
  13. Hartmann J, Bajaj T, Klengel C, Chatzinakos C, Ebert T, Dedic N, McCullough KM, Lardenoije R, Joëls M, Meijer OC, McCann KE, Dudek SM, Sarabdjitsingh RA, Daskalakis NP, Klengel T, Gassen NC, Schmidt MV, Ressler KJ. Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5. Cell Rep. 2021 06 01; 35(9):109185. PMID: 34077736; PMCID: PMC8244946.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  14. Karanikas E, Daskalakis NP, Agorastos A. Oxidative Dysregulation in Early Life Stress and Posttraumatic Stress Disorder: A Comprehensive Review. Brain Sci. 2021 May 29; 11(6). PMID: 34072322.
    Citations: 10     
  15. Dalvie S, Daskalakis NP. The Biological Effects of Trauma. Complex Psychiatry. 2021 Aug; 7(1-2):16-18. PMID: 35592091.
    Citations:    
  16. Ferland-Beckham C, Chaby LE, Daskalakis NP, Knox D, Liberzon I, Lim MM, McIntyre C, Perrine SA, Risbrough VB, Sabban EL, Jeromin A, Haas M. Systematic Review and Methodological Considerations for the Use of Single Prolonged Stress and Fear Extinction Retention in Rodents. Front Behav Neurosci. 2021; 15:652636. PMID: 34054443.
    Citations: 7     
  17. Chatzinakos C, Lee D, Cai N, Vladimirov VI, Webb BT, Riley BP, Flint J, Kendler KS, Ressler KJ, Daskalakis NP, Bacanu SA. Increasing the resolution and precision of psychiatric genome-wide association studies by re-imputing summary statistics using a large, diverse reference panel. Am J Med Genet B Neuropsychiatr Genet. 2021 01; 186(1):16-27. PMID: 33576176.
    Citations: 2     Fields:    Translation:Humans
  18. Chatzinakos C, Georgiadis F, Daskalakis NP. GWAS meets transcriptomics: from genetic letters to transcriptomic words of neuropsychiatric risk. Neuropsychopharmacology. 2021 01; 46(1):255-256. PMID: 32873903.
    Citations: 5     Fields:    Translation:Cells
  19. Daskalakis NP, Xu C, Bader HN, Chatzinakos C, Weber P, Makotkine I, Lehrner A, Bierer LM, Binder EB, Yehuda R. Intergenerational trauma is associated with expression alterations in glucocorticoid- and immune-related genes. Neuropsychopharmacology. 2021 03; 46(4):763-773. PMID: 33173192; PMCID: PMC8027026.
    Citations: 6     Fields:    Translation:HumansCells
  20. McCullough KM, Chatzinakos C, Hartmann J, Missig G, Neve RL, Fenster RJ, Carlezon WA, Daskalakis NP, Ressler KJ. Author Correction: Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning. Nat Commun. 2020 Oct 27; 11(1):5529. PMID: 33110083.
    Citations:    Fields:    
  21. Wolf EJ, Chen CD, Zhao X, Zhou Z, Morrison FG, Daskalakis NP, Stone A, Schichman S, Grenier JG, Fein-Schaffer D, Huber BR, Abraham CR, Miller MW, Logue MW. Klotho, PTSD, and advanced epigenetic age in cortical tissue. Neuropsychopharmacology. 2021 03; 46(4):721-730. PMID: 33096543; PMCID: PMC8027437.
    Citations: 10     Fields:    Translation:HumansCells
  22. McCullough KM, Chatzinakos C, Hartmann J, Missig G, Neve RL, Fenster RJ, Carlezon WA, Daskalakis NP, Ressler KJ. Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning. Nat Commun. 2020 10 14; 11(1):5180. PMID: 33057013.
    Citations: 9     Fields:    Translation:AnimalsCells
  23. Chatzinakos C, Georgiadis F, Lee D, Cai N, Vladimirov VI, Docherty A, Webb BT, Riley BP, Flint J, Kendler KS, Daskalakis NP, Bacanu SA. TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders. Am J Med Genet B Neuropsychiatr Genet. 2020 12; 183(8):454-463. PMID: 32954640.
    Citations: 7     Fields:    Translation:HumansCells
  24. Huckins LM, Chatzinakos C, Breen MS, Hartmann J, Klengel T, da Silva Almeida AC, Dobbyn A, Girdhar K, Hoffman GE, Klengel C, Logue MW, Lori A, Maihofer AX, Morrison FG, Nguyen HT, Park Y, Ruderfer D, Sloofman LG, van Rooij SJH, Baker DG, Chen CY, Cox N, Duncan LE, Geyer MA, Glatt SJ, Im HK, Risbrough VB, Smoller JW, Stein DJ, Yehuda R, Liberzon I, Koenen KC, Jovanovic T, Kellis M, Miller MW, Bacanu SA, Nievergelt CM, Buxbaum JD, Sklar P, Ressler KJ, Stahl EA, Daskalakis NP. Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Rep. 2020 06 02; 31(9):107716. PMID: 32492425; PMCID: PMC7359754.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  25. Lasseter HC, Provost AC, Chaby LE, Daskalakis NP, Haas M, Jeromin A. Cross-platform comparison of highly sensitive immunoassay technologies for cytokine markers: Platform performance in post-traumatic stress disorder and Parkinson's disease. Cytokine X. 2020 Jun; 2(2):100027. PMID: 33604555.
    Citations: 12     
  26. Bierer LM, Bader HN, Daskalakis NP, Lehrner A, Provençal N, Wiechmann T, Klengel T, Makotkine I, Binder EB, Yehuda R. Intergenerational Effects of Maternal Holocaust Exposure on FKBP5 Methylation. Am J Psychiatry. 2020 08 01; 177(8):744-753. PMID: 32312110.
    Citations: 12     Fields:    Translation:HumansCells
  27. Wolf EJ, Logue MW, Zhao X, Daskalakis NP, Morrison FG, Escarfulleri S, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Chen C, Abraham CR, Miller MW. PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation. Psychoneuroendocrinology. 2020 07; 117:104656. PMID: 32438247; PMCID: PMC7293549.
    Citations: 5     Fields:    Translation:HumansCells
  28. Logue MW, Miller MW, Wolf EJ, Huber BR, Morrison FG, Zhou Z, Zheng Y, Smith AK, Daskalakis NP, Ratanatharathorn A, Uddin M, Nievergelt CM, Ashley-Koch AE, Baker DG, Beckham JC, Garrett ME, Boks MP, Geuze E, Grant GA, Hauser MA, Kessler RC, Kimbrel NA, Maihofer AX, Marx CE, Qin XJ, Risbrough VB, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Ware EB, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Hayes JP, Verfaellie M. An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci. Clin Epigenetics. 2020 03 14; 12(1):46. PMID: 32171335; PMCID: PMC7071645.
    Citations: 24     Fields:    Translation:HumansCells
  29. Breen MS, Bierer LM, Daskalakis NP, Bader HN, Makotkine I, Chattopadhyay M, Xu C, Grice AB, Tocheva AS, Flory JD, Buxbaum JD, Meaney MJ, Brennand K, Yehuda R. Correction: Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development. Transl Psychiatry. 2020 Jan 06; 10(1):1. PMID: 32066695.
    Citations: 2     Fields:    
  30. Jeromin A, Lasseter HC, Provost AC, Daskalakis NP, Etkin A, Gehrman P, Lancashire L, Marx BP, McGlinchey R, Haas M. Driving Progress in Posttraumatic Stress Disorder Biomarkers. Biol Psychiatry. 2020 03 15; 87(6):e13-e14. PMID: 31623824.
    Citations: 2     Fields:    Translation:Humans
  31. Nievergelt CM, Maihofer AX, Klengel T, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Dalvie S, Duncan LE, Gelernter J, Levey DF, Logue MW, Polimanti R, Provost AC, Ratanatharathorn A, Stein MB, Torres K, Aiello AE, Almli LM, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegovic E, Babic D, Bækvad-Hansen M, Baker DG, Beckham JC, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Børglum AD, Bradley B, Brashear M, Breen G, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Calabrese JR, Caldas-de-Almeida JM, Dale AM, Daly MJ, Daskalakis NP, Deckert J, Delahanty DL, Dennis MF, Disner SG, Domschke K, Dzubur-Kulenovic A, Erbes CR, Evans A, Farrer LA, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Geuze E, Gillespie C, Uka AG, Gordon SD, Guffanti G, Hammamieh R, Harnal S, Hauser MA, Heath AC, Hemmings SMJ, Hougaard DM, Jakovljevic M, Jett M, Johnson EO, Jones I, Jovanovic T, Qin XJ, Junglen AG, Karstoft KI, Kaufman ML, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kranzler HR, Kremen WS, Lawford BR, Lebois LAM, Lewis CE, Linnstaedt SD, Lori A, Lugonja B, Luykx JJ, Lyons MJ, Maples-Keller J, Marmar C, Martin AR, Martin NG, Maurer D, Mavissakalian MR, McFarlane A, McGlinchey RE, McLaughlin KA, McLean SA, McLeay S, Mehta D, Milberg WP, Miller MW, Morey RA, Morris CP, Mors O, Mortensen PB, Neale BM, Nelson EC, Nordentoft M, Norman SB, O'Donnell M, Orcutt HK, Panizzon MS, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Rice JP, Ripke S, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero K, Rung A, Rutten BPF, Saccone NL, Sanchez SE, Schijven D, Seedat S, Seligowski AV, Seng JS, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stevens JS, Sumner JA, Teicher MH, Thompson WK, Trapido E, Uddin M, Ursano RJ, van den Heuvel LL, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Werge T, Williams MA, Williamson DE, Winternitz S, Wolf C, Wolf EJ, Wolff JD, Yehuda R, Young RM, Young KA, Zhao H, Zoellner LA, Liberzon I, Ressler KJ, Haas M, Koenen KC. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nat Commun. 2019 10 08; 10(1):4558. PMID: 31594949; PMCID: PMC6783435.
    Citations: 134     Fields:    Translation:Humans
  32. Mavrikaki M, Pantano L, Potter D, Rogers-Grazado MA, Anastasiadou E, Slack FJ, Amr SS, Ressler KJ, Daskalakis NP, Chartoff E. Sex-Dependent Changes in miRNA Expression in the Bed Nucleus of the Stria Terminalis Following Stress. Front Mol Neurosci. 2019; 12:236. PMID: 31636537; PMCID: PMC6788329.
    Citations: 10     
  33. Breen MS, Bierer LM, Daskalakis NP, Bader HN, Makotkine I, Chattopadhyay M, Xu C, Buxbaum Grice A, Tocheva AS, Flory JD, Buxbaum JD, Meaney MJ, Brennand K, Yehuda R. Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development. Transl Psychiatry. 2019 08 21; 9(1):201. PMID: 31434874; PMCID: PMC6704073.
    Citations: 13     Fields:    Translation:HumansCells
  34. Domingo-Fernández D, Provost A, Kodamullil AT, Marín-Llaó J, Lasseter H, Diaz K, Daskalakis NP, Lancashire L, Hofmann-Apitius M, Haas M. PTSD Biomarker Database: deep dive metadatabase for PTSD biomarkers, visualizations and analysis tools. Database (Oxford). 2019 01 01; 2019. PMID: 31260040; PMCID: PMC6601392.
    Citations: 3     Fields:    Translation:Humans
  35. Vaz-Silva J, Gomes P, Jin Q, Zhu M, Zhuravleva V, Quintremil S, Meira T, Silva J, Dioli C, Soares-Cunha C, Daskalakis NP, Sousa N, Sotiropoulos I, Waites CL. Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction. EMBO J. 2018 10 15; 37(20). PMID: 30166454; PMCID: PMC6187216.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  36. McCullough KM, Daskalakis NP, Gafford G, Morrison FG, Ressler KJ. Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction. Transl Psychiatry. 2018 08 22; 8(1):164. PMID: 30135420; PMCID: PMC6105686.
    Citations: 12     Fields:    Translation:AnimalsCells
  37. Daskalakis NP, Rijal CM, King C, Huckins LM, Ressler KJ. Recent Genetics and Epigenetics Approaches to PTSD. Curr Psychiatry Rep. 2018 04 05; 20(5):30. PMID: 29623448; PMCID: PMC6486832.
    Citations: 43     Fields:    Translation:Humans
  38. Daskalakis NP, Provost AC, Hunter RG, Guffanti G. Noncoding RNAs: Stress, Glucocorticoids, and Posttraumatic Stress Disorder. Biol Psychiatry. 2018 05 15; 83(10):849-865. PMID: 29559087.
    Citations: 24     Fields:    Translation:Humans
  39. Schür RR, Boks MP, Rutten BPF, Daskalakis NP, de Nijs L, van Zuiden M, Kavelaars A, Heijnen CJ, Joëls M, Kahn RS, Geuze E, Vermetten E, Vinkers CH. Longitudinal changes in glucocorticoid receptor exon 1F methylation and psychopathology after military deployment. Transl Psychiatry. 2017 07 25; 7(7):e1181. PMID: 28742078.
    Citations: 13     Fields:    Translation:HumansCells
  40. Rutten BPF, Vermetten E, Vinkers CH, Ursini G, Daskalakis NP, Pishva E, de Nijs L, Houtepen LC, Eijssen L, Jaffe AE, Kenis G, Viechtbauer W, van den Hove D, Schraut KG, Lesch KP, Kleinman JE, Hyde TM, Weinberger DR, Schalkwyk L, Lunnon K, Mill J, Cohen H, Yehuda R, Baker DG, Maihofer AX, Nievergelt CM, Geuze E, Boks MPM. Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder. Mol Psychiatry. 2018 05; 23(5):1145-1156. PMID: 28630453.
    Citations: 48     Fields:    Translation:HumansCells
  41. Harony-Nicolas H, Kay M, du Hoffmann J, Klein ME, Bozdagi-Gunal O, Riad M, Daskalakis NP, Sonar S, Castillo PE, Hof PR, Shapiro ML, Baxter MG, Wagner S, Buxbaum JD. Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat. Elife. 2017 01 31; 6. PMID: 28139198.
    Citations: 55     Fields:    Translation:AnimalsCells
  42. Daskalakis NP, Cohen H, Nievergelt CM, Baker DG, Buxbaum JD, Russo SJ, Yehuda R. New translational perspectives for blood-based biomarkers of PTSD: From glucocorticoid to immune mediators of stress susceptibility. Exp Neurol. 2016 Oct; 284(Pt B):133-140. PMID: 27481726; PMCID: PMC5056828.
    Citations: 42     Fields:    Translation:Humans
  43. Daskalakis NP, De Kloet ER, Yehuda R, Malaspina D, Kranz TM. Early Life Stress Effects on Glucocorticoid-BDNF Interplay in the Hippocampus. Front Mol Neurosci. 2015; 8:68. PMID: 26635521; PMCID: PMC4644789.
    Citations: 42     
  44. Hammels C, Pishva E, De Vry J, van den Hove DL, Prickaerts J, van Winkel R, Selten JP, Lesch KP, Daskalakis NP, Steinbusch HW, van Os J, Kenis G, Rutten BP. Defeat stress in rodents: From behavior to molecules. Neurosci Biobehav Rev. 2015 Dec; 59:111-40. PMID: 26475995.
    Citations: 68     Fields:    Translation:HumansAnimals
  45. Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, Binder EB. Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation. Biol Psychiatry. 2016 09 01; 80(5):372-80. PMID: 26410355.
    Citations: 179     Fields:    Translation:HumansCells
  46. Daskalakis NP, Binder EB. Schizophrenia in the spectrum of gene-stress interactions: the FKBP5 example. Schizophr Bull. 2015 Mar; 41(2):323-9. PMID: 25592294.
    Citations: 17     Fields:    Translation:Humans
  47. Daskalakis NP, Yehuda R. Early maternal influences on stress circuitry: implications for resilience and susceptibility to physical and mental disorders. Front Endocrinol (Lausanne). 2014; 5:244. PMID: 25642210.
    Citations: 3     Fields:    
  48. Daskalakis NP, Yehuda R. Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: systematic review of contributing factors. Front Neurosci. 2014; 8:369. PMID: 25484853; PMCID: PMC4240065.
    Citations: 40     
  49. Daskalakis NP, Enthoven L, Schoonheere E, de Kloet ER, Oitzl MS. Immediate Effects of Maternal Deprivation on the (Re)Activity of the HPA-Axis Differ in CD1 and C57Bl/6J Mouse Pups. Front Endocrinol (Lausanne). 2014; 5:190. PMID: 25414695.
    Citations: 7     Fields:    
  50. Yehuda R, Pratchett LC, Elmes MW, Lehrner A, Daskalakis NP, Koch E, Makotkine I, Flory JD, Bierer LM. Glucocorticoid-related predictors and correlates of post-traumatic stress disorder treatment response in combat veterans. Interface Focus. 2014 Oct 06; 4(5):20140048. PMID: 25285201.
    Citations: 27     
  51. Daskalakis NP, Yehuda R. Principles for developing animal models of military PTSD. Eur J Psychotraumatol. 2014; 5. PMID: 25206946.
    Citations: 11     Fields:    
  52. Daskalakis NP, Cohen H, Cai G, Buxbaum JD, Yehuda R. Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13529-34. PMID: 25114262.
    Citations: 51     Fields:    Translation:AnimalsCells
  53. Yehuda R, Daskalakis NP, Lehrner A, Desarnaud F, Bader HN, Makotkine I, Flory JD, Bierer LM, Meaney MJ. Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring. Am J Psychiatry. 2014 Aug; 171(8):872-880. PMID: 24832930; PMCID: PMC4127390.
    Citations: 112     Fields:    Translation:HumansCells
  54. Bader HN, Bierer LM, Lehrner A, Makotkine I, Daskalakis NP, Yehuda R. Maternal Age at Holocaust Exposure and Maternal PTSD Independently Influence Urinary Cortisol Levels in Adult Offspring. Front Endocrinol (Lausanne). 2014; 5:103. PMID: 25071719.
    Citations: 12     Fields:    
  55. Bierer LM, Bader HN, Daskalakis NP, Lehrner AL, Makotkine I, Seckl JR, Yehuda R. Elevation of 11ß-hydroxysteroid dehydrogenase type 2 activity in Holocaust survivor offspring: evidence for an intergenerational effect of maternal trauma exposure. Psychoneuroendocrinology. 2014 Oct; 48:1-10. PMID: 24971590; PMCID: PMC4127389.
    Citations: 20     Fields:    Translation:HumansCellsPHPublic Health
  56. Yehuda R, Flory JD, Bierer LM, Henn-Haase C, Lehrner A, Desarnaud F, Makotkine I, Daskalakis NP, Marmar CR, Meaney MJ. Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with posttraumatic stress disorder. Biol Psychiatry. 2015 Feb 15; 77(4):356-64. PMID: 24661442.
    Citations: 113     Fields:    Translation:HumansCells
  57. Lehrner A, Bierer LM, Passarelli V, Pratchett LC, Flory JD, Bader HN, Harris IR, Bedi A, Daskalakis NP, Makotkine I, Yehuda R. Maternal PTSD associates with greater glucocorticoid sensitivity in offspring of Holocaust survivors. Psychoneuroendocrinology. 2014 Feb; 40:213-20. PMID: 24485493.
    Citations: 39     Fields:    Translation:Humans
  58. Yehuda R, Daskalakis NP, Desarnaud F, Makotkine I, Lehrner AL, Koch E, Flory JD, Buxbaum JD, Meaney MJ, Bierer LM. Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD. Front Psychiatry. 2013; 4:118. PMID: 24098286.
    Citations: 107     
  59. Daskalakis NP, Diamantopoulou A, Claessens SEF, Remmers E, Tjälve M, Oitzl MS, Champagne DL, de Kloet ER. Early experience of a novel-environment in isolation primes a fearful phenotype characterized by persistent amygdala activation. Psychoneuroendocrinology. 2014 Jan; 39:39-57. PMID: 24275003.
    Citations: 17     Fields:    Translation:Animals
  60. Daskalakis NP, Lehrner A, Yehuda R. Endocrine aspects of post-traumatic stress disorder and implications for diagnosis and treatment. Endocrinol Metab Clin North Am. 2013 Sep; 42(3):503-13. PMID: 24011883.
    Citations: 68     Fields:    Translation:Humans
  61. Daskalakis NP, Yehuda R, Diamond DM. Animal models in translational studies of PTSD. Psychoneuroendocrinology. 2013 Sep; 38(9):1895-911. PMID: 23845512.
    Citations: 43     Fields:    Translation:HumansAnimals
  62. Daskalakis NP, Bagot RC, Parker KJ, Vinkers CH, de Kloet ER. The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome. Psychoneuroendocrinology. 2013 Sep; 38(9):1858-73. PMID: 23838101.
    Citations: 163     Fields:    Translation:HumansAnimals
  63. Claessens SE, Daskalakis NP, Oitzl MS, de Kloet ER. Early handling modulates outcome of neonatal dexamethasone exposure. Horm Behav. 2012 Sep; 62(4):433-41. PMID: 22892314.
    Citations: 6     Fields:    Translation:Animals
  64. Tiemensma J, Daskalakis NP, van der Veen EM, Ramondt S, Richardson SK, Broadbent E, Romijn JA, Pereira AM, Biermasz NR, Kaptein AA. Drawings reflect a new dimension of the psychological impact of long-term remission of Cushing's syndrome. J Clin Endocrinol Metab. 2012 Sep; 97(9):3123-31. PMID: 22723334.
    Citations: 10     Fields:    Translation:Humans
  65. Daskalakis NP, Oitzl MS, Schächinger H, Champagne DL, de Kloet ER. Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity. Physiol Behav. 2012 Jul 16; 106(5):707-21. PMID: 22306534.
    Citations: 31     Fields:    Translation:Animals
  66. Daskalakis NP, Claessens SE, Laboyrie JJ, Enthoven L, Oitzl MS, Champagne DL, de Kloet ER. The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion. Horm Behav. 2011 Jul; 60(2):165-76. PMID: 21570400.
    Citations: 21     Fields:    Translation:Animals
  67. Claessens SE, Daskalakis NP, van der Veen R, Oitzl MS, de Kloet ER, Champagne DL. Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences. Psychopharmacology (Berl). 2011 Mar; 214(1):141-54. PMID: 21165737.
    Citations: 44     Fields:    Translation:HumansAnimals
  68. Richter S, Schulz A, Zech CM, Oitzl MS, Daskalakis NP, Blumenthal TD, Schächinger H. Cortisol rapidly disrupts prepulse inhibition in healthy men. Psychoneuroendocrinology. 2011 Jan; 36(1):109-14. PMID: 20685043.
    Citations: 8     Fields:    Translation:Humans
  69. Daskalakis NP, Kaperoni M, Koros C, de Kloet ER, Kitraki E. Environmental and tactile stimulation modulates the neonatal handling effect on adult rat spatial memory. Int J Dev Neurosci. 2009 Dec; 27(8):747-55. PMID: 19720127.
    Citations: 6     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.