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Nikolaos Daskalakis, Ph.D., M.D.

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Biography
University of Athens, Athens, GreeceMD12/2006Medicine
Leiden University, Leiden, The NetherlandsPhD12/2011Neuropsychopharmacology
Leiden University Medical Center, Leiden, The Netherlands12/2011Neuroendocrinology
Icahn School of Medicine, New York, New York01/2014Systems biology

Overview
Nikolaos P. Daskalakis, MD, PhD, is the director of the Neurogenomics and Translational Bioinformatics Laboratory at McLean Hospital and an assistant professor of psychiatry at Harvard Medical School. He is also an affiliate member of the Broad Institute, MIT Computer Science and Artificial Intelligence Laboratory, and the National Center for PTSD. Dr. Daskalakis received his MD from the University of Athens, his PhD in neuropsychopharmacology from Leiden University, and completed post-doctoral research fellowships in clinical neuroendocrinology at Leiden University and in systems biology at the Icahn School of Medicine.

Dr. Daskalakis focuses on the interaction between stress and the brain, conducting translational studies and following an integrative systems biology approach. His lab uses transcriptomic and epigenomic profiling of brain and blood samples to identify gene networks associated with vulnerability and resilience to PTSD. Dr. Daskalakis leads the Systems Biology working group of the Psychiatric Genomics Consortium for PTSD. He is an editor for Brain Sciences, Frontiers (in Behavioral Neuroscience, Endocrinology, Neuroscience, and Psychiatry) and Neurobiology of Stress.

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Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Huckins LM, Chatzinakos C, Breen MS, Hartmann J, Klengel T, da Silva Almeida AC, Dobbyn A, Girdhar K, Hoffman GE, Klengel C, Logue MW, Lori A, Maihofer AX, Morrison FG, Nguyen HT, Park Y, Ruderfer D, Sloofman LG, van Rooij SJH, Baker DG, Chen CY, Cox N, Duncan LE, Geyer MA, Glatt SJ, Im HK, Risbrough VB, Smoller JW, Stein DJ, Yehuda R, Liberzon I, Koenen KC, Jovanovic T, Kellis M, Miller MW, Bacanu SA, Nievergelt CM, Buxbaum JD, Sklar P, Ressler KJ, Stahl EA, Daskalakis NP. Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Rep. 2020 Jun 02; 31(9):107716. PMID: 32492425.
    Citations:    
  2. Bierer LM, Bader HN, Daskalakis NP, Lehrner A, Provençal N, Wiechmann T, Klengel T, Makotkine I, Binder EB, Yehuda R. Intergenerational Effects of Maternal Holocaust Exposure on FKBP5 Methylation. Am J Psychiatry. 2020 Apr 21; appiajp201919060618. PMID: 32312110.
    Citations:    
  3. Wolf EJ, Logue MW, Zhao X, Daskalakis NP, Morrison FG, Escarfulleri S, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Chen C, Abraham CR, Miller MW. PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation. Psychoneuroendocrinology. 2020 Jul; 117:104656. PMID: 32438247.
    Citations:    
  4. Logue MW, Miller MW, Wolf EJ, Huber BR, Morrison FG, Zhou Z, Zheng Y, Smith AK, Daskalakis NP, Ratanatharathorn A, Uddin M, Nievergelt CM, Ashley-Koch AE, Baker DG, Beckham JC, Garrett ME, Boks MP, Geuze E, Grant GA, Hauser MA, Kessler RC, Kimbrel NA, Maihofer AX, Marx CE, Qin XJ, Risbrough VB, Rutten BPF, Stein MB, Ursano RJ, Vermetten E, Vinkers CH, Ware EB, Stone A, Schichman SA, McGlinchey RE, Milberg WP, Hayes JP, Verfaellie M. An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci. Clin Epigenetics. 2020 Mar 14; 12(1):46. PMID: 32171335.
    Citations:    
  5. Breen MS, Bierer LM, Daskalakis NP, Bader HN, Makotkine I, Chattopadhyay M, Xu C, Grice AB, Tocheva AS, Flory JD, Buxbaum JD, Meaney MJ, Brennand K, Yehuda R. Correction: Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development. Transl Psychiatry. 2020 Jan 06; 10(1):1. PMID: 32066695.
    Citations:    
  6. Jeromin A, Lasseter HC, Provost AC, Daskalakis NP, Etkin A, Gehrman P, Lancashire L, Marx BP, McGlinchey R, Haas M. Driving Progress in Posttraumatic Stress Disorder Biomarkers. Biol Psychiatry. 2020 Mar 15; 87(6):e13-e14. PMID: 31623824.
    Citations:    
  7. Nievergelt CM, Maihofer AX, Klengel T, Atkinson EG, Chen CY, Choi KW, Coleman JRI, Dalvie S, Duncan LE, Gelernter J, Levey DF, Logue MW, Polimanti R, Provost AC, Ratanatharathorn A, Stein MB, Torres K, Aiello AE, Almli LM, Amstadter AB, Andersen SB, Andreassen OA, Arbisi PA, Ashley-Koch AE, Austin SB, Avdibegovic E, Babic D, Bækvad-Hansen M, Baker DG, Beckham JC, Bierut LJ, Bisson JI, Boks MP, Bolger EA, Børglum AD, Bradley B, Brashear M, Breen G, Bryant RA, Bustamante AC, Bybjerg-Grauholm J, Calabrese JR, Caldas-de-Almeida JM, Dale AM, Daly MJ, Daskalakis NP, Deckert J, Delahanty DL, Dennis MF, Disner SG, Domschke K, Dzubur-Kulenovic A, Erbes CR, Evans A, Farrer LA, Feeny NC, Flory JD, Forbes D, Franz CE, Galea S, Garrett ME, Gelaye B, Geuze E, Gillespie C, Uka AG, Gordon SD, Guffanti G, Hammamieh R, Harnal S, Hauser MA, Heath AC, Hemmings SMJ, Hougaard DM, Jakovljevic M, Jett M, Johnson EO, Jones I, Jovanovic T, Qin XJ, Junglen AG, Karstoft KI, Kaufman ML, Kessler RC, Khan A, Kimbrel NA, King AP, Koen N, Kranzler HR, Kremen WS, Lawford BR, Lebois LAM, Lewis CE, Linnstaedt SD, Lori A, Lugonja B, Luykx JJ, Lyons MJ, Maples-Keller J, Marmar C, Martin AR, Martin NG, Maurer D, Mavissakalian MR, McFarlane A, McGlinchey RE, McLaughlin KA, McLean SA, McLeay S, Mehta D, Milberg WP, Miller MW, Morey RA, Morris CP, Mors O, Mortensen PB, Neale BM, Nelson EC, Nordentoft M, Norman SB, O'Donnell M, Orcutt HK, Panizzon MS, Peters ES, Peterson AL, Peverill M, Pietrzak RH, Polusny MA, Rice JP, Ripke S, Risbrough VB, Roberts AL, Rothbaum AO, Rothbaum BO, Roy-Byrne P, Ruggiero K, Rung A, Rutten BPF, Saccone NL, Sanchez SE, Schijven D, Seedat S, Seligowski AV, Seng JS, Sheerin CM, Silove D, Smith AK, Smoller JW, Sponheim SR, Stein DJ, Stevens JS, Sumner JA, Teicher MH, Thompson WK, Trapido E, Uddin M, Ursano RJ, van den Heuvel LL, Van Hooff M, Vermetten E, Vinkers CH, Voisey J, Wang Y, Wang Z, Werge T, Williams MA, Williamson DE, Winternitz S, Wolf C, Wolf EJ, Wolff JD, Yehuda R, Young RM, Young KA, Zhao H, Zoellner LA, Liberzon I, Ressler KJ, Haas M, Koenen KC. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nat Commun. 2019 10 08; 10(1):4558. PMID: 31594949.
    Citations:    
  8. Mavrikaki M, Pantano L, Potter D, Rogers-Grazado MA, Anastasiadou E, Slack FJ, Amr SS, Ressler KJ, Daskalakis NP, Chartoff E. Sex-Dependent Changes in miRNA Expression in the Bed Nucleus of the Stria Terminalis Following Stress. Front Mol Neurosci. 2019; 12:236. PMID: 31636537.
    Citations:    
  9. Breen MS, Bierer LM, Daskalakis NP, Bader HN, Makotkine I, Chattopadhyay M, Xu C, Buxbaum Grice A, Tocheva AS, Flory JD, Buxbaum JD, Meaney MJ, Brennand K, Yehuda R. Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development. Transl Psychiatry. 2019 08 21; 9(1):201. PMID: 31434874.
    Citations:    
  10. Domingo-Fernández D, Provost A, Kodamullil AT, Marín-Llaó J, Lasseter H, Diaz K, Daskalakis NP, Lancashire L, Hofmann-Apitius M, Haas M. PTSD Biomarker Database: deep dive metadatabase for PTSD biomarkers, visualizations and analysis tools. Database (Oxford). 2019 01 01; 2019. PMID: 31260040.
    Citations:    
  11. Vaz-Silva J, Gomes P, Jin Q, Zhu M, Zhuravleva V, Quintremil S, Meira T, Silva J, Dioli C, Soares-Cunha C, Daskalakis NP, Sousa N, Sotiropoulos I, Waites CL. Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction. EMBO J. 2018 10 15; 37(20). PMID: 30166454.
    Citations:    
  12. McCullough KM, Daskalakis NP, Gafford G, Morrison FG, Ressler KJ. Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction. Transl Psychiatry. 2018 08 22; 8(1):164. PMID: 30135420.
    Citations:    Fields:    
  13. Daskalakis NP, Rijal CM, King C, Huckins LM, Ressler KJ. Recent Genetics and Epigenetics Approaches to PTSD. Curr Psychiatry Rep. 2018 04 05; 20(5):30. PMID: 29623448.
    Citations: 2     Fields:    
  14. Daskalakis NP, Provost AC, Hunter RG, Guffanti G. Noncoding RNAs: Stress, Glucocorticoids, and Posttraumatic Stress Disorder. Biol Psychiatry. 2018 05 15; 83(10):849-865. PMID: 29559087.
    Citations: 3     Fields:    
  15. Schür RR, Boks MP, Rutten BPF, Daskalakis NP, de Nijs L, van Zuiden M, Kavelaars A, Heijnen CJ, Joëls M, Kahn RS, Geuze E, Vermetten E, Vinkers CH. Longitudinal changes in glucocorticoid receptor exon 1F methylation and psychopathology after military deployment. Transl Psychiatry. 2017 07 25; 7(7):e1181. PMID: 28742078.
    Citations: 2     Fields:    Translation:HumansCells
  16. Rutten BPF, Vermetten E, Vinkers CH, Ursini G, Daskalakis NP, Pishva E, de Nijs L, Houtepen LC, Eijssen L, Jaffe AE, Kenis G, Viechtbauer W, van den Hove D, Schraut KG, Lesch KP, Kleinman JE, Hyde TM, Weinberger DR, Schalkwyk L, Lunnon K, Mill J, Cohen H, Yehuda R, Baker DG, Maihofer AX, Nievergelt CM, Geuze E, Boks MPM. Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder. Mol Psychiatry. 2018 05; 23(5):1145-1156. PMID: 28630453.
    Citations:    
  17. Harony-Nicolas H, Kay M, du Hoffmann J, Klein ME, Bozdagi-Gunal O, Riad M, Daskalakis NP, Sonar S, Castillo PE, Hof PR, Shapiro ML, Baxter MG, Wagner S, Buxbaum JD. Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat. Elife. 2017 01 31; 6. PMID: 28139198.
    Citations:    
  18. Daskalakis NP, Cohen H, Nievergelt CM, Baker DG, Buxbaum JD, Russo SJ, Yehuda R. New translational perspectives for blood-based biomarkers of PTSD: From glucocorticoid to immune mediators of stress susceptibility. Exp Neurol. 2016 Oct; 284(Pt B):133-140. PMID: 27481726.
    Citations: 10     Fields:    Translation:Humans
  19. Daskalakis NP, De Kloet ER, Yehuda R, Malaspina D, Kranz TM. Early Life Stress Effects on Glucocorticoid-BDNF Interplay in the Hippocampus. Front Mol Neurosci. 2015; 8:68. PMID: 26635521.
    Citations: 15     
  20. Hammels C, Pishva E, De Vry J, van den Hove DL, Prickaerts J, van Winkel R, Selten JP, Lesch KP, Daskalakis NP, Steinbusch HW, van Os J, Kenis G, Rutten BP. Defeat stress in rodents: From behavior to molecules. Neurosci Biobehav Rev. 2015 Dec; 59:111-40. PMID: 26475995.
    Citations:    
  21. Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, Binder EB. Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation. Biol Psychiatry. 2016 09 01; 80(5):372-80. PMID: 26410355.
    Citations: 54     Fields:    Translation:HumansCells
  22. Daskalakis NP, Yehuda R. Early maternal influences on stress circuitry: implications for resilience and susceptibility to physical and mental disorders. Front Endocrinol (Lausanne). 2014; 5:244. PMID: 25642210.
    Citations:    
  23. Daskalakis NP, Binder EB. Schizophrenia in the spectrum of gene-stress interactions: the FKBP5 example. Schizophr Bull. 2015 Mar; 41(2):323-9. PMID: 25592294.
    Citations:    
  24. Daskalakis NP, Yehuda R. Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: systematic review of contributing factors. Front Neurosci. 2014; 8:369. PMID: 25484853.
    Citations:    
  25. Daskalakis NP, Enthoven L, Schoonheere E, de Kloet ER, Oitzl MS. Immediate Effects of Maternal Deprivation on the (Re)Activity of the HPA-Axis Differ in CD1 and C57Bl/6J Mouse Pups. Front Endocrinol (Lausanne). 2014; 5:190. PMID: 25414695.
    Citations: 3     
  26. Yehuda R, Pratchett LC, Elmes MW, Lehrner A, Daskalakis NP, Koch E, Makotkine I, Flory JD, Bierer LM. Glucocorticoid-related predictors and correlates of post-traumatic stress disorder treatment response in combat veterans. Interface Focus. 2014 Oct 06; 4(5):20140048. PMID: 25285201.
    Citations:    
  27. Daskalakis NP, Yehuda R. Principles for developing animal models of military PTSD. Eur J Psychotraumatol. 2014; 5. PMID: 25206946.
    Citations:    
  28. Daskalakis NP, Cohen H, Cai G, Buxbaum JD, Yehuda R. Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13529-34. PMID: 25114262.
    Citations:    
  29. Yehuda R, Daskalakis NP, Lehrner A, Desarnaud F, Bader HN, Makotkine I, Flory JD, Bierer LM, Meaney MJ. Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring. Am J Psychiatry. 2014 Aug; 171(8):872-880. PMID: 24832930.
    Citations:    
  30. Bader HN, Bierer LM, Lehrner A, Makotkine I, Daskalakis NP, Yehuda R. Maternal Age at Holocaust Exposure and Maternal PTSD Independently Influence Urinary Cortisol Levels in Adult Offspring. Front Endocrinol (Lausanne). 2014; 5:103. PMID: 25071719.
    Citations:    
  31. Bierer LM, Bader HN, Daskalakis NP, Lehrner AL, Makotkine I, Seckl JR, Yehuda R. Elevation of 11ß-hydroxysteroid dehydrogenase type 2 activity in Holocaust survivor offspring: evidence for an intergenerational effect of maternal trauma exposure. Psychoneuroendocrinology. 2014 Oct; 48:1-10. PMID: 24971590.
    Citations:    
  32. Yehuda R, Flory JD, Bierer LM, Henn-Haase C, Lehrner A, Desarnaud F, Makotkine I, Daskalakis NP, Marmar CR, Meaney MJ. Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with posttraumatic stress disorder. Biol Psychiatry. 2015 Feb 15; 77(4):356-64. PMID: 24661442.
    Citations: 56     Fields:    Translation:HumansCells
  33. Lehrner A, Bierer LM, Passarelli V, Pratchett LC, Flory JD, Bader HN, Harris IR, Bedi A, Daskalakis NP, Makotkine I, Yehuda R. Maternal PTSD associates with greater glucocorticoid sensitivity in offspring of Holocaust survivors. Psychoneuroendocrinology. 2014 Feb; 40:213-20. PMID: 24485493.
    Citations:    
  34. Yehuda R, Daskalakis NP, Desarnaud F, Makotkine I, Lehrner AL, Koch E, Flory JD, Buxbaum JD, Meaney MJ, Bierer LM. Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD. Front Psychiatry. 2013; 4:118. PMID: 24098286.
    Citations: 46     
  35. Daskalakis NP, Diamantopoulou A, Claessens SEF, Remmers E, Tjälve M, Oitzl MS, Champagne DL, de Kloet ER. Early experience of a novel-environment in isolation primes a fearful phenotype characterized by persistent amygdala activation. Psychoneuroendocrinology. 2014 Jan; 39:39-57. PMID: 24275003.
    Citations: 10     Fields:    Translation:Animals
  36. Daskalakis NP, Lehrner A, Yehuda R. Endocrine aspects of post-traumatic stress disorder and implications for diagnosis and treatment. Endocrinol Metab Clin North Am. 2013 Sep; 42(3):503-13. PMID: 24011883.
    Citations:    
  37. Daskalakis NP, Yehuda R, Diamond DM. Animal models in translational studies of PTSD. Psychoneuroendocrinology. 2013 Sep; 38(9):1895-911. PMID: 23845512.
    Citations: 24     Fields:    Translation:HumansAnimals
  38. Daskalakis NP, Bagot RC, Parker KJ, Vinkers CH, de Kloet ER. The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome. Psychoneuroendocrinology. 2013 Sep; 38(9):1858-73. PMID: 23838101.
    Citations: 62     Fields:    Translation:HumansAnimals
  39. Claessens SE, Daskalakis NP, Oitzl MS, de Kloet ER. Early handling modulates outcome of neonatal dexamethasone exposure. Horm Behav. 2012 Sep; 62(4):433-41. PMID: 22892314.
    Citations:    
  40. Tiemensma J, Daskalakis NP, van der Veen EM, Ramondt S, Richardson SK, Broadbent E, Romijn JA, Pereira AM, Biermasz NR, Kaptein AA. Drawings reflect a new dimension of the psychological impact of long-term remission of Cushing's syndrome. J Clin Endocrinol Metab. 2012 Sep; 97(9):3123-31. PMID: 22723334.
    Citations:    
  41. Daskalakis NP, Oitzl MS, Schächinger H, Champagne DL, de Kloet ER. Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity. Physiol Behav. 2012 Jul 16; 106(5):707-21. PMID: 22306534.
    Citations:    
  42. Daskalakis NP, Claessens SE, Laboyrie JJ, Enthoven L, Oitzl MS, Champagne DL, de Kloet ER. The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion. Horm Behav. 2011 Jul; 60(2):165-76. PMID: 21570400.
    Citations:    
  43. Claessens SE, Daskalakis NP, van der Veen R, Oitzl MS, de Kloet ER, Champagne DL. Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences. Psychopharmacology (Berl). 2011 Mar; 214(1):141-54. PMID: 21165737.
    Citations:    
  44. Richter S, Schulz A, Zech CM, Oitzl MS, Daskalakis NP, Blumenthal TD, Schächinger H. Cortisol rapidly disrupts prepulse inhibition in healthy men. Psychoneuroendocrinology. 2011 Jan; 36(1):109-14. PMID: 20685043.
    Citations:    
  45. Daskalakis NP, Kaperoni M, Koros C, de Kloet ER, Kitraki E. Environmental and tactile stimulation modulates the neonatal handling effect on adult rat spatial memory. Int J Dev Neurosci. 2009 Dec; 27(8):747-55. PMID: 19720127.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.