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Sarah J Mitchell, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Palliyaguru DL, Minor RK, Mitchell SJ, Palacio HH, Licata JJ, Ward TM, Abulwerdi G, Elliott P, Westphal C, Ellis JL, Sinclair DA, Price NL, Bernier M, de Cabo R. Combining a high dose of metformin with the SIRT1 activator, SRT1720, reduces lifespan in aged mice fed a high-fat diet. J Gerontol A Biol Sci Med Sci. 2020 Jun 18. PMID: 32556267.
  2. Mitchell SJ, Mitchell GJ, Mitchell JR. Modulation of frailty syndrome by diet: A review of evidence from mouse studies. Mech Ageing Dev. 2019 06; 180:82-88. PMID: 30980835.
  3. Trocha K, Kip P, MacArthur MR, Mitchell SJ, Longchamp A, Treviño-Villarreal JH, Tao M, Bredella MA, De Amorim Bernstein K, Mitchell JR, Ozaki CK. Preoperative Protein or Methionine Restriction Preserves Wound Healing and Reduces Hyperglycemia. J Surg Res. 2019 03; 235:216-222. PMID: 30691797.
    Citations:    Fields:    
  4. Kane AE, Sinclair DA, Mitchell JR, Mitchell SJ. Sex differences in the response to dietary restriction in rodents. Curr Opin Physiol. 2018 Dec; 6:28-34. PMID: 31231711.
  5. Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, Frederick DW, Bohr VA, Schmidt MS, Brenner C, Sinclair DA, Sauve AA, Baur JA, de Cabo R. Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. Cell Metab. 2018 03 06; 27(3):667-676.e4. PMID: 29514072.
    Citations: 3     Fields:    
  6. Kane AE, Huizer-Pajkos A, Mach J, Mitchell SJ, de Cabo R, Le Couteur DG, Howlett SE, Hilmer SN. A Comparison of Two Mouse Frailty Assessment Tools. J Gerontol A Biol Sci Med Sci. 2017 Jul 01; 72(7):904-909. PMID: 28549083.
    Citations: 1     Fields:    Translation:HumansAnimals
  7. Kane AE, Hilmer SN, Mach J, Mitchell SJ, de Cabo R, Howlett SE. Animal models of frailty: current applications in clinical research. Clin Interv Aging. 2016; 11:1519-1529. PMID: 27822024.
    Citations: 6     Fields:    Translation:HumansAnimals
  8. Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab. 2016 06 14; 23(6):1093-1112. PMID: 27304509.
    Citations: 36     Fields:    Translation:AnimalsCells
  9. Mohamad M, Mitchell SJ, Wu LE, White MY, Cordwell SJ, Mach J, Solon-Biet SM, Boyer D, Nines D, Das A, Catherine Li SY, Warren A, Hilmer SN, Fraser R, Sinclair DA, Simpson SJ, de Cabo R, Le Couteur DG, Cogger VC. Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell. 2016 08; 15(4):706-15. PMID: 27095270.
    Citations: 4     Fields:    Translation:AnimalsCells
  10. Kane AE, Huizer-Pajkos A, Mach J, McKenzie C, Mitchell SJ, de Cabo R, Jones B, Cogger V, Le Couteur DG, Hilmer SN. N-Acetyl cysteine does not prevent liver toxicity from chronic low-dose plus subacute high-dose paracetamol exposure in young or old mice. Fundam Clin Pharmacol. 2016 Jun; 30(3):263-75. PMID: 26821200.
    Citations:    Fields:    Translation:Animals
  11. Kane AE, Mitchell SJ, Mach J, Huizer-Pajkos A, McKenzie C, Jones B, Cogger V, Le Couteur DG, de Cabo R, Hilmer SN. Acetaminophen hepatotoxicity in mice: Effect of age, frailty and exposure type. Exp Gerontol. 2016 Jan; 73:95-106. PMID: 26615879.
    Citations: 4     Fields:    Translation:AnimalsCells
  12. Mach J, Huizer-Pajkos A, Mitchell SJ, McKenzie C, Phillips L, Kane A, Jones B, de Cabo R, Cogger V, Le Couteur DG, Hilmer SN. The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats. Fundam Clin Pharmacol. 2016 Feb; 30(1):23-34. PMID: 26454000.
  13. Huizer-Pajkos A, Kane AE, Howlett SE, Mach J, Mitchell SJ, de Cabo R, Le Couteur DG, Hilmer SN. Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging. J Gerontol A Biol Sci Med Sci. 2016 May; 71(5):571-7. PMID: 25940962.
    Citations: 7     Fields:    Translation:HumansAnimals
  14. Mach J, Huizer-Pajkos A, Kane A, Jones B, McKenzie C, Mitchell SJ, de Cabo R, Cogger VC, Le Couteur DG, Hilmer SN. The effect of aging on mitochondrial and cytosolic hepatic intrinsic death pathway and apoptosis associated proteins in Fischer 344 rats. Exp Gerontol. 2015 Jul; 67:54-61. PMID: 25910621.
  15. Kane AE, Hilmer SN, Huizer-Pajkos A, Mach J, Nines D, Boyer D, Gavin K, Mitchell SJ, de Cabo R. Factors that Impact on Interrater Reliability of the Mouse Clinical Frailty Index. J Gerontol A Biol Sci Med Sci. 2015 Jun; 70(6):694-5. PMID: 25838548.
    Citations: 3     Fields:    Translation:HumansAnimals
  16. Kane AE, Hilmer SN, Boyer D, Gavin K, Nines D, Howlett SE, de Cabo R, Mitchell SJ. Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index. J Gerontol A Biol Sci Med Sci. 2016 Mar; 71(3):333-9. PMID: 25711530.
    Citations: 19     Fields:    Translation:Animals
  17. Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R. SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell. 2014 Oct; 13(5):787-96. PMID: 24931715.
    Citations: 34     Fields:    Translation:HumansAnimals
  18. Mitchell SJ, Martin-Montalvo A, Mercken EM, Palacios HH, Ward TM, Abulwerdi G, Minor RK, Vlasuk GP, Ellis JL, Sinclair DA, Dawson J, Allison DB, Zhang Y, Becker KG, Bernier M, de Cabo R. The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. Cell Rep. 2014 Mar 13; 6(5):836-43. PMID: 24582957.
    Citations: 82     Fields:    Translation:AnimalsCells
  19. Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R. Metformin improves healthspan and lifespan in mice. Nat Commun. 2013; 4:2192. PMID: 23900241.
    Citations: 210     Fields:    Translation:AnimalsCells
  20. Kane A, Mitchell SJ, Carroll PR, Matthews S, Hilmer SN. Characteristics of older and younger patients with suspected paracetamol toxicity. Australas J Ageing. 2012 Sep; 31(3):190-3. PMID: 22950592.
  21. Mitchell SJ, Kane AE, Hilmer SN. Age-related changes in the hepatic pharmacology and toxicology of paracetamol. Curr Gerontol Geriatr Res. 2011; 2011:624156. PMID: 21765826.
    Citations: 11     
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.