Harvard Catalyst Profiles

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Hassan A Khalil, M.D.

Title
Institution
Department
Address

Biography
University of Texas at Houston, Houston, TXMD05/2010Medicine
University of California, Los Angeles, Los Angeles, CA05/2017General Surgery
Brigham & Women's Hospital, Boston, MA06/2018Thoracic Surgery

Mentoring
Available: 12/01/22, Expires: 12/01/23

Esophageal and bowel anastomotic leaks are devastating complications after surgery. Our lab studies how vacuum (in the form of microdeformation) affects healing of intestinal anastomotic healing in an animal model, but in vitro model would be helpful. A creative student investigator can initiate an in vitro model system to study microdeformation in my laboratory. The role will include learning how to grow and sustain chick embryos in culture, and potentially some cell culture work. The student will have an opportunity to learn immunofluorescence, microscopy, and quantitative PCR.

Available: 12/01/22, Expires: 11/01/23

Classically, lung cancer has been known to metastasize via lymphatic or hematogenous spread. A more recently discovered metastatic pathway is spread through air spaces, possibly related to tumor discohesion and implantation of tumor cells away from the primary tumor. My laboratory investigates this mode of spread via histology, high resolution X-ray imaging, and other methods. It's an exciting field with little known and great potential for discovery. The role will include working with a clinical database, using statistical methods, and analyzing advanced imaging data including histology and high-resolution X-rays.


Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vesvoranan O, Liu BS, Zheng Y, Wagner WL, Sutlive J, Chen Z, Khalil HA, Ackermann M, Mentzer SJ. Active Loading of Pectin Hydrogels for Targeted Drug Delivery. Polymers (Basel). 2022 Dec 26; 15(1). PMID: 36616442; PMCID: PMC9824191.
    Citations:    
  2. Liu BS, Valenzuela CD, Mentzer KL, Wagner WL, Khalil HA, Chen Z, Ackermann M, Mentzer SJ. Topography of pleural epithelial structure enabled by en face isolation and machine learning. J Cell Physiol. 2023 Jan; 238(1):274-284. PMID: 36502471; PMCID: PMC9845181.
    Citations:    Fields:    
  3. Liao MW, Liu BS, Sutlive J, Wagner WL, Khalil HA, Chen Z, Ackermann M, Mentzer SJ. Kinetics of Pectin Biopolymer Facial Erosion Characterized by Fluorescent Tracer Microfluidics. Polymers (Basel). 2022 Sep 19; 14(18). PMID: 36146055; PMCID: PMC9501333.
    Citations: 1     
  4. Belyayev LA, Foroushani SM, Wiener DC, Branch-Elliman W, Marshall MB, Khalil HA. Bronchopleural fistula due to cavitary pneumonia after SARS-CoV-2 infection treated with open thoracostomy. J Surg Case Rep. 2022 Apr; 2022(4):rjac076. PMID: 35422997; PMCID: PMC9004406.
    Citations:    
  5. Polhemus EL, Dolan DP, Lee DN, Khalil HA, White AA, Swanson SJ. How I do it: Multiport video-assisted thoracoscopic surgery of the right middle lobe for non-small cell lung cancer: Right middle lobectomy in 12 steps. JTCVS Tech. 2022 Aug; 14:130-135. PMID: 35967230; PMCID: PMC9366233.
    Citations:    
  6. Pierce AF, Liu BS, Liao M, Wagner WL, Khalil HA, Chen Z, Ackermann M, Mentzer SJ. Optical and Mechanical Properties of Self-Repairing Pectin Biopolymers. Polymers (Basel). 2022 Mar 26; 14(7). PMID: 35406219; PMCID: PMC9002866.
    Citations:    
  7. Zheng Y, Pierce AF, Wagner WL, Khalil HA, Chen Z, Servais AB, Ackermann M, Mentzer SJ. Functional Adhesion of Pectin Biopolymers to the Lung Visceral Pleura. Polymers (Basel). 2021 Sep 02; 13(17). PMID: 34503016; PMCID: PMC8433721.
    Citations: 2     
  8. Zheng Y, Pierce AF, Wagner WL, Khalil HA, Chen Z, Funaya C, Ackermann M, Mentzer SJ. Biomaterial-Assisted Anastomotic Healing: Serosal Adhesion of Pectin Films. Polymers (Basel). 2021 Aug 21; 13(16). PMID: 34451349; PMCID: PMC8401717.
    Citations: 2     
  9. Khalil HA, Marshall MB. 10 Commandments of Robotic Segmentectomy. Innovations (Phila). 2021 Mar-Apr; 16(2):127-131. PMID: 33829926.
    Citations:    Fields:    Translation:Humans
  10. Kandilis A, Iniguez CB, Khalil H, Mazzola E, Jaklitsch MT, Swanson SJ, Bueno R, Wee JO. Residual lymph node disease and mortality following neoadjuvant chemoradiation and curative esophagectomy for distal esophageal adenocarcinoma. JTCVS Open. 2021; 5:135-147. View Publication.
  11. Scott A, Olack B, Rouch JD, Khalil HA, Kokubun BA, Lei NY, Wang J, Solorzano S, Lewis M, Dunn JCY, Stelzner MG, Niland JC, Martín MG. Comparison of Surgical and Cadaveric Intestine as a Source of Crypt Culture in Humans. Cell Transplant. 2020 Jan-Dec; 29:963689720903709. PMID: 32907378; PMCID: PMC7784595.
    Citations:    Fields:    Translation:Humans
  12. Khalil HA, Hong SN, Rouch JD, Scott A, Cho Y, Wang J, Lewis MS, Martin MG, Dunn JCY, Stelzner MG. Intestinal epithelial replacement by transplantation of cultured murine and human cells into the small intestine. PLoS One. 2019; 14(5):e0216326. PMID: 31150401; PMCID: PMC6544206.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  13. Kobayashi M, Khalil HA, Lei NY, Wang Q, Wang K, Wu BM, Dunn JCY. Bioengineering functional smooth muscle with spontaneous rhythmic contraction in vitro. Sci Rep. 2018 09 10; 8(1):13544. PMID: 30202095.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  14. Scott A, Rouch JD, Jabaji Z, Khalil HA, Solorzano S, Lewis M, Martín MG, Stelzner MG, Dunn JC. Long-term renewable human intestinal epithelial stem cells as monolayers: A potential for clinical use. J Pediatr Surg. 2016 Jun; 51(6):995-1000. PMID: 26995514; PMCID: PMC4921284.
    Citations: 17     Fields:    Translation:HumansCells
  15. Khalil HA, Lei NY, Brinkley G, Scott A, Wang J, Kar UK, Jabaji ZB, Lewis M, Martín MG, Dunn JC, Stelzner MG. A novel culture system for adult porcine intestinal crypts. Cell Tissue Res. 2016 07; 365(1):123-34. PMID: 26928041; PMCID: PMC4919165.
    Citations: 32     Fields:    Translation:AnimalsCells
  16. Khalil HA, Kobayashi M, Rana P, Wagner JP, Scott A, Yoo J, Dunn JC. Mouse model of endoscopically ablated enteric nervous system. J Surg Res. 2016 Jan; 200(1):117-21. PMID: 26299595.
    Citations: 4     Fields:    Translation:Animals
  17. Khalil HA, Lei NY, Nie W, Lewis MS, Stelzner MG, Martín MG, Dunn JC, Yoo J. Primary Myofibroblasts Maintain Short-Term Viability following Submucosal Injection in Syngeneic, Immune-Competent Mice Utilizing Murine Colonoscopy. PLoS One. 2015; 10(5):e0127258. PMID: 26016485; PMCID: PMC4445916.
    Citations: 2     Fields:    Translation:AnimalsCells
  18. Wagner JP, Sullins VF, Khalil HA, Dunn JC. A durable model of Hirschsprung's colon. J Pediatr Surg. 2014 Dec; 49(12):1804-8. PMID: 25487488; PMCID: PMC4261142.
    Citations: 2     Fields:    Translation:Animals
  19. Jabaji Z, Brinkley GJ, Khalil HA, Sears CM, Lei NY, Lewis M, Stelzner M, Martín MG, Dunn JC. Type I collagen as an extracellular matrix for the in vitro growth of human small intestinal epithelium. PLoS One. 2014; 9(9):e107814. PMID: 25222024; PMCID: PMC4164635.
    Citations: 43     Fields:    Translation:HumansCells
  20. Larson ES, Khalil HA, Lin AY, Russell M, Ardehali A, Ross D, Yoo J. Diverticulitis occurs early after lung transplantation. J Surg Res. 2014 Aug; 190(2):667-71. PMID: 24912859.
    Citations: 7     Fields:    Translation:Humans
  21. Lei NY, Jabaji Z, Wang J, Joshi VS, Brinkley GJ, Khalil H, Wang F, Jaroszewicz A, Pellegrini M, Li L, Lewis M, Stelzner M, Dunn JC, Martín MG. Intestinal subepithelial myofibroblasts support the growth of intestinal epithelial stem cells. PLoS One. 2014; 9(1):e84651. PMID: 24400106; PMCID: PMC3882257.
    Citations: 56     Fields:    Translation:AnimalsCells
  22. Khalil H, Nie W, Edwards RA, Yoo J. Isolation of primary myofibroblasts from mouse and human colon tissue. J Vis Exp. 2013 Oct 12; (80). PMID: 24145735.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  23. Khalil HA, Yoo J. Colorectal emergencies: perforated diverticulitis (operative and nonoperative management). J Gastrointest Surg. 2014 Apr; 18(4):865-8. PMID: 24072684.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  24. Khalil HA, Kerr DT, Schusterman MA, Cohn WE, Frazier OH, Radovancevic B. Induced pulsation of a continuous-flow total artificial heart in a mock circulatory system. J Heart Lung Transplant. 2010 May; 29(5):568-73. PMID: 20153967.
    Citations: 4     Fields:    Translation:Humans
  25. Frazier OH, Khalil HA, Benkowski RJ, Cohn WE. Optimization of axial-pump pressure sensitivity for a continuous-flow total artificial heart. J Heart Lung Transplant. 2010 Jun; 29(6):687-91. PMID: 20133164.
    Citations: 8     Fields:    Translation:Humans
  26. Khalil HA, Hanafy AM, Saleh SY, Medan MS. Comparative changes in the serum concentrations of inhibin-B, prolactin, gonadotropins and steroid hormones at different reproductive States in domestic Turkey hens. J Reprod Dev. 2009 Oct; 55(5):523-8. PMID: 19602848.
    Citations: 1     Fields:    Translation:Animals
  27. Khalil HA, Metcalfe RW, Kleis SJ, Lee EL, Gilbert NL, Kerr DT, Frazier OH, Cohn WE. Flow visualization techniques in a mock ventricle supported by a nonpulsatile left ventricular assist device. ASAIO J. 2009 Jul-Aug; 55(4):323-7. PMID: 19512887.
    Citations: 1     Fields:    Translation:Humans
  28. Tuzun E, Oliveira E, Narin C, Khalil H, Jimenez-Quevedo P, Perin E, Silva G. Correlation of ischemic area and coronary flow with ameroid size in a porcine model. J Surg Res. 2010 Nov; 164(1):38-42. PMID: 19577254.
    Citations: 10     Fields:    Translation:Animals
  29. Khalil HA, Kerr DT, Franchek MA, Metcalfe RW, Benkowski RJ, Cohn WE, Tuzun E, Radovancevic B, Frazier OH, Kadipasaoglu KA. Continuous flow total artificial heart: modeling and feedback control in a mock circulatory system. ASAIO J. 2008 May-Jun; 54(3):249-55. PMID: 18496274.
    Citations: 3     Fields:    Translation:HumansAnimals
  30. Khalil HA, Cohn WE, Metcalfe RW, Frazier OH. Preload sensitivity of the Jarvik 2000 and HeartMate II left ventricular assist devices. ASAIO J. 2008 May-Jun; 54(3):245-8. PMID: 18496273.
    Citations: 9     Fields:    Translation:Humans
  31. Mullapudi S, Pullan L, Bishop OT, Khalil H, Stoops JK, Beckmann R, Kloetzel PM, Krüger E, Penczek PA. Rearrangement of the 16S precursor subunits is essential for the formation of the active 20S proteasome. Biophys J. 2004 Dec; 87(6):4098-105. PMID: 15361411; PMCID: PMC1304918.
    Citations: 2     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.