Harvard Catalyst Profiles

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Tyler Steven Brown, M.D.

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  1. 1K08AI166125-01A1 (Tyler Brown) Aug 2, 2022
    NIH/NAID
    Geographic origins and dispersal of drug-resistant M. tuberculosis in South Africa: Advancing strategies for early detection
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Brown T, de Salazar Munoz PM, Bhatia A, Bunda B, Williams EK, Bor D, Miller JS, Mohareb A, Thierauf J, Yang W, Villalba J, Naranbai V, Garcia Beltran W, Miller TE, Kress D, Stelljes K, Johnson K, Larremore D, Lennerz J, Iafrate AJ, Balsari S, Buckee C, Grad Y. Geographically skewed recruitment and COVID-19 seroprevalence estimates: a cross-sectional serosurveillance study and mathematical modelling analysis. BMJ Open. 2023 03 07; 13(3):e061840. PMID: 36882240; PMCID: PMC10008195.
    Citations:    Fields:    Translation:HumansCells
  2. Brown TS, Robinson DA, Buckee CO, Mathema B. Connecting the dots: understanding how human mobility shapes TB epidemics. Trends Microbiol. 2022 11; 30(11):1036-1044. PMID: 35597716.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  3. Brown TS, Arogbokun O, Buckee CO, Chang HH. Distinguishing gene flow between malaria parasite populations. PLoS Genet. 2021 12; 17(12):e1009335. PMID: 34928954; PMCID: PMC8726502.
    Citations: 1     Fields:    Translation:HumansAnimals
  4. Brown TS, Eldholm V, Brynildsrud O, Osnes M, Levy N, Stimson J, Colijn C, Alexandru S, Noroc E, Ciobanu N, Crudu V, Cohen T, Mathema B. Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova. Microb Genom. 2021 08; 7(8). PMID: 34431762; PMCID: PMC8549355.
    Citations: 2     Fields:    Translation:HumansCells
  5. Salje H, Wesolowski A, Brown TS, Kiang MV, Berry IM, Lefrancq N, Fernandez S, Jarman RG, Ruchusatsawat K, Iamsirithaworn S, Vandepitte WP, Suntarattiwong P, Read JM, Klungthong C, Thaisomboonsuk B, Engø-Monsen K, Buckee C, Cauchemez S, Cummings DAT. Reconstructing unseen transmission events to infer dengue dynamics from viral sequences. Nat Commun. 2021 03 22; 12(1):1810. PMID: 33753725; PMCID: PMC7985522.
    Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  6. Brown TS, Engø-Monsen K, Kiang MV, Mahmud AS, Maude RJ, Buckee CO. The impact of mobility network properties on predicted epidemic dynamics in Dhaka and Bangkok. Epidemics. 2021 06; 35:100441. PMID: 33667878.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  7. Brown TS, Dubowski K, Plitt M, Falci L, Lee E, Huynh M, Furuya Y, Vora NM. Erroneous Reporting of Deaths Attributed to Pneumonia and Influenza at 2 New York City Teaching Hospitals, 2013-2014. Public Health Rep. 2020 Nov/Dec; 135(6):796-804. PMID: 33031711; PMCID: PMC7649996.
    Citations: 2     Fields:    Translation:Humans
  8. Brown TS, Walensky RP. Serosurveillance and the COVID-19 Epidemic in the US: Undetected, Uncertain, and Out of Control. JAMA. 2020 08 25; 324(8):749-751. PMID: 32692350.
    Citations: 18     Fields:    Translation:HumansCellsPHPublic Health
  9. Nelson KN, Gandhi NR, Mathema B, Lopman BA, Brust JCM, Auld SC, Ismail N, Omar SV, Brown TS, Allana S, Campbell A, Moodley P, Mlisana K, Shah NS, Jenness SM. Modeling Missing Cases and Transmission Links in Networks of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa. Am J Epidemiol. 2020 07 01; 189(7):735-745. PMID: 32242216.
    Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
  10. Brown TS, Challagundla L, Baugh EH, Omar SV, Mustaev A, Auld SC, Shah NS, Kreiswirth BN, Brust JCM, Nelson KN, Narechania A, Kurepina N, Mlisana K, Bonneau R, Eldholm V, Ismail N, Kolokotronis SO, Robinson DA, Gandhi NR, Mathema B. Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa. Proc Natl Acad Sci U S A. 2019 11 12; 116(46):23284-23291. PMID: 31659018; PMCID: PMC6859317.
    Citations: 10     Fields:    Translation:HumansCells
  11. O'Donnell MR, Larsen MH, Brown TS, Jain P, Munsamy V, Wolf A, Uccellini L, Karim F, de Oliveira T, Mathema B, Jacobs WR, Pym A. Early Detection of Emergent Extensively Drug-Resistant Tuberculosis by Flow Cytometry-Based Phenotyping and Whole-Genome Sequencing. Antimicrob Agents Chemother. 2019 04; 63(4). PMID: 30670422; PMCID: PMC6437479.
    Citations: 9     Fields:    Translation:HumansCells
  12. Yuengling KA, Padayatchi N, Wolf A, Mathema B, Brown T, Horsburgh CR, O'Donnell MR. Effect of Antiretroviral Therapy on Treatment Outcomes in a Prospective Study of Extensively Drug-Resistant Tuberculosis (XDR-TB) HIV Coinfection Treatment in KwaZulu-Natal, South Africa. J Acquir Immune Defic Syndr. 2018 12 01; 79(4):474-480. PMID: 30212394; PMCID: PMC6203657.
    Citations: 8     Fields:    Translation:HumansCells
  13. Nelson KN, Shah NS, Mathema B, Ismail N, Brust JCM, Brown TS, Auld SC, Omar SV, Morris N, Campbell A, Allana S, Moodley P, Mlisana K, Gandhi NR. Spatial Patterns of Extensively Drug-Resistant Tuberculosis Transmission in KwaZulu-Natal, South Africa. J Infect Dis. 2018 11 05; 218(12):1964-1973. PMID: 29961879; PMCID: PMC6217717.
    Citations: 14     Fields:    Translation:HumansCells
  14. Auld SC, Shah NS, Mathema B, Brown TS, Ismail N, Omar SV, Brust JCM, Nelson KN, Allana S, Campbell A, Mlisana K, Moodley P, Gandhi NR. Extensively drug-resistant tuberculosis in South Africa: genomic evidence supporting transmission in communities. Eur Respir J. 2018 10; 52(4). PMID: 30115614; PMCID: PMC6195447.
    Citations: 13     Fields:    Translation:HumansCells
  15. Brynildsrud OB, Pepperell CS, Suffys P, Grandjean L, Monteserin J, Debech N, Bohlin J, Alfsnes K, Pettersson JO, Kirkeleite I, Fandinho F, da Silva MA, Perdigao J, Portugal I, Viveiros M, Clark T, Caws M, Dunstan S, Thai PVK, Lopez B, Ritacco V, Kitchen A, Brown TS, van Soolingen D, O'Neill MB, Holt KE, Feil EJ, Mathema B, Balloux F, Eldholm V. Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation. Sci Adv. 2018 10; 4(10):eaat5869. PMID: 30345355.
    Citations: 56     Fields:    Translation:HumansCells
  16. Shah NS, Auld SC, Brust JC, Mathema B, Ismail N, Moodley P, Mlisana K, Allana S, Campbell A, Mthiyane T, Morris N, Mpangase P, van der Meulen H, Omar SV, Brown TS, Narechania A, Shaskina E, Kapwata T, Kreiswirth B, Gandhi NR. Transmission of Extensively Drug-Resistant Tuberculosis in South Africa. N Engl J Med. 2017 01 19; 376(3):243-253. PMID: 28099825; PMCID: PMC5330208.
    Citations: 120     Fields:    Translation:HumansCells
  17. Brown TS, Narechania A, Walker JR, Planet PJ, Bifani PJ, Kolokotronis SO, Kreiswirth BN, Mathema B. Genomic epidemiology of Lineage 4 Mycobacterium tuberculosis subpopulations in New York City and New Jersey, 1999-2009. BMC Genomics. 2016 11 21; 17(1):947. PMID: 27871225.
    Citations: 8     Fields:    Translation:HumansCells
  18. Brown TS, Jacob CG, Silva JC, Takala-Harrison S, Djimdé A, Dondorp AM, Fukuda M, Noedl H, Nyunt MM, Kyaw MP, Mayxay M, Hien TT, Plowe CV, Cummings MP. Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype. Infect Genet Evol. 2015 Mar; 30:318-322. PMID: 25514047.
    Citations: 13     Fields:    Translation:HumansAnimals
  19. Takala-Harrison S, Jacob CG, Arze C, Cummings MP, Silva JC, Dondorp AM, Fukuda MM, Hien TT, Mayxay M, Noedl H, Nosten F, Kyaw MP, Nhien NT, Imwong M, Bethell D, Se Y, Lon C, Tyner SD, Saunders DL, Ariey F, Mercereau-Puijalon O, Menard D, Newton PN, Khanthavong M, Hongvanthong B, Starzengruber P, Fuehrer HP, Swoboda P, Khan WA, Phyo AP, Nyunt MM, Nyunt MH, Brown TS, Adams M, Pepin CS, Bailey J, Tan JC, Ferdig MT, Clark TG, Miotto O, MacInnis B, Kwiatkowski DP, White NJ, Ringwald P, Plowe CV. Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia. J Infect Dis. 2015 Mar 01; 211(5):670-9. PMID: 25180241; PMCID: PMC4334802.
    Citations: 234     Fields:    Translation:HumansAnimals
  20. Brown T, Smith LS, Oo EK, Shawng K, Lee TJ, Sullivan D, Beyrer C, Richards AK. Molecular surveillance for drug-resistant Plasmodium falciparum in clinical and subclinical populations from three border regions of Burma/Myanmar: cross-sectional data and a systematic review of resistance studies. Malar J. 2012 Sep 19; 11:333. PMID: 22992214.
    Citations: 13     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.