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Pedro Lopes Da Frota Moreira, Ph.D.

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Université Montpellier 2, FrancePh.D.Medical Robotics
Federal University of Rio de Janeiro, BrazilM.Sc.Electrical Eng.


Available: 10/01/23, Expires: 01/31/24

Focal therapies have emerged as minimally invasive alternatives for localized prostate cancer (PCa), particularly in low-risk patients with unifocal disease and those with post-radiation recurrence. These treatments selectively target and destroy the diseased area while preserving surrounding healthy tissues. Cryoablation, in particular, requires optimal cryo-needle placement to ensure effective tumor ablation while minimizing damage to adjacent structures. However, accurately predicting the shape of the freezing isotherm presents a significant challenge due to various patient-specific factors, such as proximity to heat sources and unique thermal properties of the prostatic tissue and its surroundings. Insufficient planning and execution have been linked to many patients experiencing tumor recurrence following focal therapy. Consequently, there is an urgent need for an advanced and precise solution to overcome these limitations and improve patient outcomes. This project aims to develop and implement a clinically ready planning software for focal cryoablation. This project will amplify the benefits of employing MRI guidance in focal therapy, not only for cryoablation, but we also expect to extend the software to other ablation modalities. The student will integrate the current algorithm into the clinical workflow used in MRI-guided focal cryoablation and evaluate our algorithm using retrospective data of 60 patients who underwent prostate cryoablation in our department, correlating intraprocedural images with clinical outcomes.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 129717 (Pedro Moreira) Oct 1, 2023 - Sep 30, 2024
    Department of Radiology (BWH)
    Advanced data-driven planning for focal therapy of prostate cancer
    Role: PI
  2. R43EB032676 (PARK, JESUNG) Sep 23, 2021 - Sep 22, 2022
    Smart Multi-grid Template for Focal Therapy of Prostate Cancer
    Role: Co-Investigator
  3. R01CA235134 (TOKUDA, JUNICHI) Aug 1, 2019 - Jul 31, 2022
    Adaptive Percutaneous Prostate Interventions using Sensorized Needle
    Role: Co-Investigator
  4. R44CA224853 (PARK, JESUNG) Jul 3, 2018 - Aug 31, 2021
    Smart template for prostate biopsy guidance
    Role: Co-Investigator
  5. R01EB020667 (TOKUDA, JUNICHI) Jul 1, 2015 - Jan 31, 2025
    OpenIGTLink: a network communication interface for closed-loop image-guided interventions
    Role: Co-Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.