Harvard Catalyst Profiles

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David Earl Heppner, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F32HL129706 (HEPPNER, DAVID E.) Jul 1, 2016 - Oct 31, 2017
    Investigations of Redox-dependent Processes of the Airway Epithelium
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jones SM, Heppner DE, Vu K, Kosman DJ, Solomon EI. Rapid Decay of the Native Intermediate in the Metallooxidase Fet3p Enables Controlled FeII Oxidation for Efficient Metabolism. J Am Chem Soc. 2020 06 03; 142(22):10087-10101. PMID: 32379440.
    Citations:    Fields:    
  2. Heppner DE, Günther M, Wittlinger F, Laufer SA, Eck MJ. Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors. J Med Chem. 2020 04 23; 63(8):4293-4305. PMID: 32243152.
    Citations:    Fields:    Translation:AnimalsCells
  3. Xiao H, Jedrychowski MP, Schweppe DK, Huttlin EL, Yu Q, Heppner DE, Li J, Long J, Mills EL, Szpyt J, He Z, Du G, Garrity R, Reddy A, Vaites LP, Paulo JA, Zhang T, Gray NS, Gygi SP, Chouchani ET. A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 03 05; 180(5):968-983.e24. PMID: 32109415.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  4. Dustin CM, Heppner DE, Lin MJ, van der Vliet A. Redox regulation of tyrosine kinase signalling: more than meets the eye. J Biochem. 2020 Feb 01; 167(2):151-163. PMID: 31599960.
    Citations: 3     Fields:    Translation:HumansCells
  5. De Clercq DJH, Heppner DE, To C, Jang J, Park E, Yun CH, Mushajiang M, Shin BH, Gero TW, Scott DA, Jänne PA, Eck MJ, Gray NS. Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors. ACS Med Chem Lett. 2019 Nov 14; 10(11):1549-1553. PMID: 31749909.
    Citations: 1     
  6. Heppner DE, Beyett TS, Eck MJ. A driving test for oncogenic mutations. J Biol Chem. 2019 06 14; 294(24):9390-9391. PMID: 31201242.
    Citations:    Fields:    Translation:HumansCells
  7. To C, Jang J, Chen T, Park E, Mushajiang M, De Clercq DJH, Xu M, Wang S, Cameron MD, Heppner DE, Shin BH, Gero TW, Yang A, Dahlberg SE, Wong KK, Eck MJ, Gray NS, Jänne PA. Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discov. 2019 07; 9(7):926-943. PMID: 31092401.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  8. Little AC, Hristova M, van Lith L, Schiffers C, Dustin CM, Habibovic A, Danyal K, Heppner DE, Lin MJ, van der Velden J, Janssen-Heininger YM, van der Vliet A. Dysregulated Redox Regulation Contributes to Nuclear EGFR Localization and Pathogenicity in Lung Cancer. Sci Rep. 2019 03 19; 9(1):4844. PMID: 30890751.
    Citations: 3     Fields:    Translation:HumansCells
  9. Chamberlain N, Korwin-Mihavics BR, Nakada EM, Bruno SR, Heppner DE, Chapman DG, Hoffman SM, van der Vliet A, Suratt BT, Dienz O, Alcorn JF, Anathy V. Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics. Redox Biol. 2019 04; 22:101129. PMID: 30735910.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Heppner DE, Dustin CM, Liao C, Hristova M, Veith C, Little AC, Ahlers BA, White SL, Deng B, Lam YW, Li J, van der Vliet A. Direct cysteine sulfenylation drives activation of the Src kinase. Nat Commun. 2018 10 30; 9(1):4522. PMID: 30375386.
    Citations: 13     Fields:    Translation:HumansCells
  11. van der Vliet A, Danyal K, Heppner DE. Dual oxidase: a novel therapeutic target in allergic disease. Br J Pharmacol. 2018 05; 175(9):1401-1418. PMID: 29405261.
    Citations: 6     Fields:    Translation:HumansAnimals
  12. Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdándi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A. Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling? Redox Biol. 2018 04; 14:379-385. PMID: 29054072.
    Citations: 11     Fields:    Translation:HumansCells
  13. Little AC, Sulovari A, Danyal K, Heppner DE, Seward DJ, van der Vliet A. Paradoxical roles of dual oxidases in cancer biology. Free Radic Biol Med. 2017 09; 110:117-132. PMID: 28578013.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  14. Heppner DE, Janssen-Heininger YMW, van der Vliet A. The role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies. Arch Biochem Biophys. 2017 02 15; 616:40-46. PMID: 28126370.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  15. Habibovic A, Hristova M, Heppner DE, Danyal K, Ather JL, Janssen-Heininger YM, Irvin CG, Poynter ME, Lundblad LK, Dixon AE, Geiszt M, van der Vliet A. DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma. JCI Insight. 2016 Nov 03; 1(18):e88811. PMID: 27812543.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  16. Heppner DE, Hristova M, Dustin CM, Danyal K, Habibovic A, van der Vliet A. The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling. J Biol Chem. 2016 10 28; 291(44):23282-23293. PMID: 27650496.
    Citations: 16     Fields:    Translation:AnimalsCells
  17. Danyal K, de Jong W, O'Brien E, Bauer RA, Heppner DE, Little AC, Hristova M, Habibovic A, van der Vliet A. Acrolein and thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR. . 2016 11 01; 311(5):L913-L923. PMID: 27612966.
    Citations:    Translation:HumansAnimalsCells
  18. Heppner DE, van der Vliet A. Redox-dependent regulation of epidermal growth factor receptor signaling. Redox Biol. 2016 08; 8:24-7. PMID: 26722841.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  19. Heppner DE, Kjaergaard CH, Solomon EI. Mechanism of the reduction of the native intermediate in the multicopper oxidases: insights into rapid intramolecular electron transfer in turnover. J Am Chem Soc. 2014 Dec 24; 136(51):17788-801. PMID: 25490729.
    Citations: 10     Fields:    Translation:AnimalsCells
  20. Solomon EI, Heppner DE, Johnston EM, Ginsbach JW, Cirera J, Qayyum M, Kieber-Emmons MT, Kjaergaard CH, Hadt RG, Tian L. Copper active sites in biology. Chem Rev. 2014 Apr 09; 114(7):3659-853. PMID: 24588098.
    Citations: 163     Fields:    Translation:Cells
  21. Heppner DE, Kjaergaard CH, Solomon EI. Molecular origin of rapid versus slow intramolecular electron transfer in the catalytic cycle of the multicopper oxidases. J Am Chem Soc. 2013 Aug 21; 135(33):12212-5. PMID: 23902255.
    Citations: 11     Fields:    Translation:Cells
  22. Solomon EI, Ginsbach JW, Heppner DE, Kieber-Emmons MT, Kjaergaard CH, Smeets PJ, Tian L, Woertink JS. Copper dioxygen (bio)inorganic chemistry. Faraday Discuss. 2011; 148:11-39; discussion 97-108. PMID: 21322475.
    Citations: 32     Fields:    Translation:Cells
  23. Op't Holt BT, Vance MA, Mirica LM, Heppner DE, Stack TD, Solomon EI. Reaction coordinate of a functional model of tyrosinase: spectroscopic and computational characterization. J Am Chem Soc. 2009 May 13; 131(18):6421-38. PMID: 19368383.
    Citations: 16     Fields:    
  24. Lewin JL, Heppner DE, Cramer CJ. Validation of density functional modeling protocols on experimental bis(mu-oxo)/mu-eta2:eta2-peroxo dicopper equilibria. J Biol Inorg Chem. 2007 Nov; 12(8):1221-34. PMID: 17710449.
    Citations: 7     Fields:    
  25. Heppner DE, Gherman BF, Tolman WB, Cramer CJ. Can an ancillary ligand lead to a thermodynamically stable end-on 1 : 1 Cu-O2 adduct supported by a beta-diketiminate ligand? Dalton Trans. 2006 Oct 28; (40):4773-82. PMID: 17033702.
    Citations: 2     Fields:    Translation:Cells
  26. Gherman BF, Heppner DE, Tolman WB, Cramer CJ. Models for dioxygen activation by the CuB site of dopamine beta-monooxygenase and peptidylglycine alpha-hydroxylating monooxygenase. J Biol Inorg Chem. 2006 Mar; 11(2):197-205. PMID: 16344970.
    Citations: 10     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.