Harvard Catalyst Profiles

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Luis Eduardo Fonseca-Ornelas, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ramalingam N, Jin SX, Moors TE, Fonseca-Ornelas L, Shimanaka K, Lei S, Cam HP, Watson AH, Brontesi L, Ding L, Hacibaloglu DY, Jiang H, Choi SJ, Kanter E, Liu L, Bartels T, Nuber S, Sulzer D, Mosharov EV, Chen WV, Li S, Selkoe DJ, Dettmer U. Dynamic physiological a-synuclein S129 phosphorylation is driven by neuronal activity. NPJ Parkinsons Dis. 2023 Jan 16; 9(1):4. PMID: 36646701; PMCID: PMC9842642.
    Citations:    
  2. Fonseca-Ornelas L, Stricker JMS, Soriano-Cruz S, Weykopf B, Dettmer U, Muratore CR, Scherzer CR, Selkoe DJ. Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous a-synuclein in human neurons. NPJ Parkinsons Dis. 2022 Sep 16; 8(1):118. PMID: 36114228; PMCID: PMC9481630.
    Citations:    
  3. Fonseca-Ornelas L, Viennet T, Rovere M, Jiang H, Liu L, Nuber S, Ericsson M, Arthanari H, Selkoe DJ. Altered conformation of a-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease. Cell Rep. 2021 07 06; 36(1):109333. PMID: 34233191; PMCID: PMC8552450.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  4. Rovere M, Powers AE, Jiang H, Pitino JC, Fonseca-Ornelas L, Patel DS, Achille A, Langen R, Varkey J, Bartels T. E46K-like a-synuclein mutants increase lipid interactions and disrupt membrane selectivity. J Biol Chem. 2019 06 21; 294(25):9799-9812. PMID: 31048377.
    Citations: 20     Fields:    Translation:HumansCells
  5. Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MAS, Villar-Piqué A, Szego É, Lopes da Fonseca T, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kügler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF. Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein. Hum Mol Genet. 2019 01 01; 28(1):31-50. PMID: 30219847.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  6. Rovere M, Sanderson JB, Fonseca-Ornelas L, Patel DS, Bartels T. Refolding of helical soluble a-synuclein through transient interaction with lipid interfaces. FEBS Lett. 2018 05; 592(9):1464-1472. PMID: 29633780.
    Citations: 20     Fields:    Translation:HumansCells
  7. Fonseca-Ornelas L, Schmidt C, Camacho-Zarco AR, Fernandez CO, Becker S, Zweckstetter M. Small-Molecule-Induced Soluble Oligomers of a-Synuclein with Helical Structure. Chemistry. 2017 Sep 21; 23(53):13010-13014. PMID: 28763125.
    Citations: 5     Fields:    Translation:Cells
  8. de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF. Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biol. 2017 04; 15(4):e1002601. PMID: 28379951; PMCID: PMC5381757.
    Citations: 1     Fields:    
  9. de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biol. 2017 03; 15(3):e2000374. PMID: 28257421; PMCID: PMC5336201.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  10. Villar-Piqué A, Lopes da Fonseca T, Sant'Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF. Environmental and genetic factors support the dissociation between a-synuclein aggregation and toxicity. Proc Natl Acad Sci U S A. 2016 10 18; 113(42):E6506-E6515. PMID: 27708160; PMCID: PMC5081623.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  11. Fonseca-Ornelas L, Zweckstetter M. The protonation state of histidine 111 regulates the aggregation of the evolutionary most conserved region of the human prion protein. Protein Sci. 2016 08; 25(8):1563-7. PMID: 27184108; PMCID: PMC4972213.
    Citations:    Fields:    Translation:HumansCells
  12. Tatenhorst L, Eckermann K, Dambeck V, Fonseca-Ornelas L, Walle H, Lopes da Fonseca T, Koch JC, Becker S, Tönges L, Bähr M, Outeiro TF, Zweckstetter M, Lingor P. Fasudil attenuates aggregation of a-synuclein in models of Parkinson's disease. Acta Neuropathol Commun. 2016 Apr 22; 4:39. PMID: 27101974.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  13. Fonseca-Ornelas L, Eisbach SE, Paulat M, Giller K, Fernández CO, Outeiro TF, Becker S, Zweckstetter M. Small molecule-mediated stabilization of vesicle-associated helical a-synuclein inhibits pathogenic misfolding and aggregation. Nat Commun. 2014 Dec 19; 5:5857. PMID: 25524885.
    Citations: 41     Fields:    Translation:HumansCells
  14. Skora L, Fonseca-Ornelas L, Hofele RV, Riedel D, Giller K, Watzlawik J, Schulz-Schaeffer WJ, Urlaub H, Becker S, Zweckstetter M. Burial of the polymorphic residue 129 in amyloid fibrils of prion stop mutants. J Biol Chem. 2013 Feb 01; 288(5):2994-3002. PMID: 23209282.
    Citations: 12     Fields:    Translation:HumansCells
  15. Hernández-Vargas R, Fonseca-Ornelas L, López-González I, Riesgo-Escovar J, Zurita M, Reynaud E. Synphilin suppresses a-synuclein neurotoxicity in a Parkinson's disease Drosophila model. Genesis. 2011 May; 49(5):392-402. PMID: 21584925.
    Citations: 11     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.