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Shan Hai Siddiqi, M.D.

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Biography
Washington University, St. LouisResidency06/2017Psychiatry
University of Sydney, AustraliaMBBS05/2013Medicine
Harvard Medical School (MGH/McLean Hospital), BostonFellowship06/2018Behavioral Neurology & Neuropsychiatry
Harvard Medical School (Berenson-Allen Center for Noninvasive Brain Stimulation), BostonFellowship06/2019Neuromodulation
2021
SoBP Rising Star
2022
SoBP Early Career Travel Award
2020
ANPA Career Development Award
2020 - 2022
NARSAD Young Investigator Award
2019
Stanley Cobb Research Award
2019
HMS Mysell Award
2019
CTMSS Top Abstract Award
2018
ANPA Young Investigator Award
2017
ANPA Clinical Neuroscience Trainee Award
2017
Eli Robins Award
2017
ISEN Trainee Abstract Award
2016
JPP Resident Paper Award
2015
Gene Rubin Award

Overview
We use causal techniques to map the brain circuitry of neuropsychiatric disorders, with the goal of identifying treatment targets for therapeutic brain stimulation. Currently, we are working on different approaches to personalize these treatment targets based on patient-specific symptoms, comorbidities, and brain connectivity. This primarily involves computational analyses of brain imaging data, but we are also now starting to translate these results into real-world clinical trials.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K23MH121657 (Shan Siddiqi)
    National Institute of Mental Health
    Personalized circuit-based neuromodulation targets for depression

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Joutsa J, Moussawi K, Siddiqi SH, Abdolahi A, Drew W, Cohen AL, Ross TJ, Deshpande HU, Wang HZ, Bruss J, Stein EA, Volkow ND, Grafman JH, van Wijngaarden E, Boes AD, Fox MD. Brain lesions disrupting addiction map to a common human brain circuit. Nat Med. 2022 06; 28(6):1249-1255. PMID: 35697842; PMCID: PMC9205767.
    Citations:    Fields:    Translation:Humans
  2. Siddiqi SH, Taylor JJ, Horn A, Fox MD. Bringing Human Brain Connectomics to Clinical Practice in Psychiatry. Biol Psychiatry. 2022 May 26. PMID: 35868885.
    Citations:    Fields:    
  3. Bryant BR, Richey LN, Jahed S, Heinzerling A, Stevens DA, Pace BD, Tsai J, Bray MJC, Esagoff AI, Adkins J, Cohen I, Narapareddy BR, Rodriguez CP, Jones MB, Roper C, Goldwaser EL, Lobner K, Siddiqi S, Sair HI, Lauterbach M, Luna LP, Peters ME, Trapp NT. Behavioral and Emotional Dyscontrol Following Traumatic Brain Injury: A Systematic Review of Neuroimaging and Electrophysiological Correlates. J Acad Consult Liaison Psychiatry. 2022 Nov-Dec; 63(6):579-598. PMID: 35618223.
    Citations:    Fields:    
  4. Trapp NT, Martyna MR, Siddiqi SH, Bajestan SN. The Neuropsychiatric Approach to the Assessment of Patients in Neurology. Semin Neurol. 2022 04; 42(2):88-106. PMID: 35477181; PMCID: PMC9177704.
    Citations:    Fields:    Translation:Humans
  5. Siddiqi SH, Kording KP, Parvizi J, Fox MD. Causal mapping of human brain function. Nat Rev Neurosci. 2022 06; 23(6):361-375. PMID: 35444305; PMCID: PMC9387758.
    Citations:    Fields:    Translation:Humans
  6. Singh NM, Harrod JB, Subramanian S, Robinson M, Chang K, Cetin-Karayumak S, Dalca AV, Eickhoff S, Fox M, Franke L, Golland P, Haehn D, Iglesias JE, O'Donnell LJ, Ou Y, Rathi Y, Siddiqi SH, Sun H, Westover MB, Whitfield-Gabrieli S, Gollub RL. How Machine Learning is Powering Neuroimaging to Improve Brain Health. Neuroinformatics. 2022 Oct; 20(4):943-964. PMID: 35347570; PMCID: PMC9515245.
    Citations:    Fields:    
  7. Mollica A, Greben R, Oriuwa C, Siddiqi SH, Burke MJ. Neuromodulation Treatments for Mild Traumatic Brain Injury and Post-concussive Symptoms. Curr Neurol Neurosci Rep. 2022 03; 22(3):171-181. PMID: 35175543.
    Citations:    Fields:    Translation:Humans
  8. Mir-Moghtadaei A, Siddiqi SH, Mir-Moghtadaei K, Blumberger DM, Vila-Rodriguez F, Daskalakis ZJ, Fox MD, Downar J. Updated scalp heuristics for localizing the dorsolateral prefrontal cortex based on convergent evidence of lesion and brain stimulation studies in depression. Brain Stimul. 2022 Mar-Apr; 15(2):291-295. PMID: 35085817.
    Citations:    Fields:    
  9. Siddiqi SH, Haddad N, Fox MD. Circuit-Targeted Neuromodulation for Anhedonia. Curr Top Behav Neurosci. 2022; 58:515-535. PMID: 35604569.
    Citations: 1     Fields:    
  10. Hollunder B, Rajamani N, Siddiqi SH, Finke C, Kühn AA, Mayberg HS, Fox MD, Neudorfer C, Horn A. Toward personalized medicine in connectomic deep brain stimulation. Prog Neurobiol. 2022 03; 210:102211. PMID: 34958874.
    Citations: 1     Fields:    Translation:Humans
  11. Taylor JJ, Siddiqi SH, Fox MD. Coordinate Network Mapping: An Emerging Approach for Morphometric Meta-Analysis. Am J Psychiatry. 2021 12; 178(12):1080-1081. PMID: 34855450.
    Citations:    Fields:    Translation:Humans
  12. Siddiqi SH, Schaper FLWVJ, Horn A, Hsu J, Padmanabhan JL, Brodtmann A, Cash RFH, Corbetta M, Choi KS, Dougherty DD, Egorova N, Fitzgerald PB, George MS, Gozzi SA, Irmen F, Kuhn AA, Johnson KA, Naidech AM, Pascual-Leone A, Phan TG, Rouhl RPW, Taylor SF, Voss JL, Zalesky A, Grafman JH, Mayberg HS, Fox MD. Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease. Nat Hum Behav. 2021 12; 5(12):1707-1716. PMID: 34239076; PMCID: PMC8688172.
    Citations: 10     Fields:    Translation:Humans
  13. Ferguson MA, Schaper FLWVJ, Cohen A, Siddiqi S, Merrill SM, Nielsen JA, Grafman J, Urgesi C, Fabbro F, Fox MD. A Neural Circuit for Spirituality and Religiosity Derived From Patients With Brain Lesions. Biol Psychiatry. 2022 02 15; 91(4):380-388. PMID: 34454698; PMCID: PMC8714871.
    Citations: 1     Fields:    Translation:Humans
  14. Siddiqi SH, Weigand A, Pascual-Leone A, Fox MD. Identification of Personalized Transcranial Magnetic Stimulation Targets Based on Subgenual Cingulate Connectivity: An Independent Replication. Biol Psychiatry. 2021 11 15; 90(10):e55-e56. PMID: 33820629.
    Citations: 4     Fields:    
  15. Yip AG, Ressler KJ, Rodriguez-Villa F, Siddiqi SH, Seiner SJ. Treatment Outcomes of Electroconvulsive Therapy for Depressed Patients With and Without Borderline Personality Disorder: A Retrospective Cohort Study. J Clin Psychiatry. 2021 01 19; 82(2). PMID: 33471448.
    Citations: 1     Fields:    Translation:Humans
  16. Lehmann AE, Raquib AR, Siddiqi SH, Meier J, Durand ML, Gray ST, Holbrook EH. Prophylactic antibiotics after endoscopic sinus surgery for chronic rhinosinusitis: a randomized, double-blind, placebo-controlled noninferiority clinical trial. Int Forum Allergy Rhinol. 2021 07; 11(7):1047-1055. PMID: 33340285.
    Citations: 2     Fields:    Translation:Humans
  17. Ward HB, Yip A, Siddiqui R, Morales OG, Seiner SJ, Siddiqi SH. Borderline personality traits do not influence response to TMS. J Affect Disord. 2021 02 15; 281:834-838. PMID: 33229022.
    Citations: 1     Fields:    Translation:Humans
  18. Herrold AA, Siddiqi SH, Livengood SL, Bender Pape TL, Higgins JP, Adamson MM, Leung A, Raij T. Customizing TMS Applications in Traumatic Brain Injury Using Neuroimaging. J Head Trauma Rehabil. 2020 Nov-Dec; 35(6):401-411. PMID: 33165153.
    Citations:    Fields:    Translation:Humans
  19. Oberman LM, Exley S, Philip NS, Siddiqi SH, Adamson MM, Brody DL. Use of Repetitive Transcranial Magnetic Stimulation in the Treatment of Neuropsychiatric and Neurocognitive Symptoms Associated With Concussion in Military Populations. J Head Trauma Rehabil. 2020 Nov/Dec; 35(6):388-400. PMID: 33165152; PMCID: PMC7664843.
    Citations: 1     Fields:    Translation:Humans
  20. Cash RFH, Weigand A, Zalesky A, Siddiqi SH, Downar J, Fitzgerald PB, Fox MD. Using Brain Imaging to Improve Spatial Targeting of Transcranial Magnetic Stimulation for Depression. Biol Psychiatry. 2021 11 15; 90(10):689-700. PMID: 32800379.
    Citations: 24     Fields:    Translation:Humans
  21. Siddiqi SH, Taylor SF, Cooke D, Pascual-Leone A, George MS, Fox MD. Distinct Symptom-Specific Treatment Targets for Circuit-Based Neuromodulation. Am J Psychiatry. 2020 05 01; 177(5):435-446. PMID: 32160765; PMCID: PMC8396109.
    Citations: 40     Fields:    Translation:Humans
  22. Padmanabhan JL, Cooke D, Joutsa J, Siddiqi SH, Ferguson M, Darby RR, Soussand L, Horn A, Kim NY, Voss JL, Naidech AM, Brodtmann A, Egorova N, Gozzi S, Phan TG, Corbetta M, Grafman J, Fox MD. A Human Depression Circuit Derived From Focal Brain Lesions. Biol Psychiatry. 2019 11 15; 86(10):749-758. PMID: 31561861.
    Citations: 44     Fields:    Translation:Humans
  23. Siddiqi SH, Trapp NT, Shahim P, Hacker CD, Laumann TO, Kandala S, Carter AR, Brody DL. Individualized Connectome-Targeted Transcranial Magnetic Stimulation for Neuropsychiatric Sequelae of Repetitive Traumatic Brain Injury in a Retired NFL Player. Journal of Neuropsychiatry and Clinical Neurosciences. 2019. View Publication.
  24. Siddiqi SH, Trapp NT, Shahim P, Hacker CD, Laumann TO, Kandala S, Carter AR, Brody DL. Individualized Connectome-Targeted Transcranial Magnetic Stimulation for Neuropsychiatric Sequelae of Repetitive Traumatic Brain Injury in a Retired NFL Player. J Neuropsychiatry Clin Neurosci. 2019; 31(3):254-263. PMID: 30945588.
    Citations: 5     Fields:    Translation:Humans
  25. Cristancho P, Trapp NT, Siddiqi SH, Dixon D, Miller JP, Lenze EJ. Crossover to Bilateral Repetitive Transcranial Magnetic Stimulation: A Potential Strategy When Patients Are Not Responding to Unilateral Left-Sided High-Frequency Repetitive Transcranial Magnetic Stimulation. J ECT. 2019 03; 35(1):3-5. PMID: 29877963.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  26. Siddiqi SH, Trapp NT, Hacker CD, Laumann TO, Kandala S, Hong X, Trillo L, Shahim P, Leuthardt EC, Carter AR, Brody DL. Repetitive Transcranial Magnetic Stimulation with Resting-State Network Targeting for Treatment-Resistant Depression in Traumatic Brain Injury: A Randomized, Controlled, Double-Blinded Pilot Study. J Neurotrauma. 2019 04 15; 36(8):1361-1374. PMID: 30381997; PMCID: PMC6909726.
    Citations: 15     Fields:    Translation:Humans
  27. Siddiqi SH, Chockalingam R, Cloninger CR, Lenze EJ, Cristancho P. Use of the Temperament and Character Inventory to Predict Response to Repetitive Transcranial Magnetic Stimulation for Major Depression. J Psychiatr Pract. 2016 05; 22(3):193-202. PMID: 27123799.
    Citations: 7     Fields:    Translation:Humans
  28. Siddiqi SH, Abraham NK, Geiger CL, Karimi M, Perlmutter JS, Black KJ. The Human Experience with Intravenous Levodopa. Front Pharmacol. 2015; 6:307. PMID: 26779024; PMCID: PMC4701937.
    Citations: 3     
  29. Siddiqi SH, Black KJ, Womer FY. Impact of a structured review session on medical student psychiatry subject examination performance. F1000Res. 2015; 4:897. PMID: 26594347.
    Citations:    Fields:    
  30. Siddiqi SH, Creech ML, Black KJ. Orthostatic stability with intravenous levodopa. PeerJ. 2015; 3:e1198. PMID: 26336641.
    Citations: 1     
  31. Witebsky FG, Keiser JF, Conville PS, Bryan R, Park CH, Walker R, Siddiqi SH. Comparison of BACTEC 13A medium and Du Pont isolator for detection of mycobacteremia. J Clin Microbiol. 1988 Aug; 26(8):1501-5. PMID: 3170713.
    Citations: 12     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.