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Shan Hai Siddiqi, M.D.

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Biography
Washington University, St. LouisResidency06/2017Psychiatry
University of Sydney, AustraliaMBBS05/2013Medicine
Harvard Medical School (MGH/McLean Hospital), BostonFellowship06/2018Behavioral Neurology & Neuropsychiatry
Harvard Medical School (Berenson-Allen Center for Noninvasive Brain Stimulation), BostonFellowship06/2019Neuromodulation
2019
Stanley Cobb Research Award
2019
HMS Mysell Award
2019
CTMSS Top Abstract Award
2018
ANPA Young Investigator Award
2017
ANPA Clinical Neuroscience Trainee Award
2017
Eli Robins Award
2017
ISEN Trainee Abstract Award
2016
JPP Resident Paper Award
2015
Gene Rubin Award

Overview
The brain has long remained enigmatic because it has been difficult to study direct cause-effect relationships in such a complex dynamic system. At the microscopic level, the neuroscience community has made major strides with optogenetics, which allows us to study the direct effects of stimulating specific nerves in a living organism. At the large scale, we are just starting to learn how to study causality in brain systems by pairing functional imaging with targeted neuromodulation. This allows us to study the direct effects of stimulating specific brain regions.

My research is focused on developing better methods for individualizing these neuromodulatory treatments based on functional MRI (fMRI) and clinical phenomenology. During residency, I was involved in several projects to investigate predictors of response to brain stimulation based on both clinical factors and computational analysis of brain imaging data. This culminated in a randomized-controlled trial of transcranial magnetic stimulation (TMS) targeted with individualized brain network mapping for depression associated with traumatic brain injury, which is now being scaled up into multiple larger trials in the military system.

Since arriving in Boston, I have been working with Dr. Michael Fox to develop better computational methods for using brain stimulation to explain human behavior. We are working on developing better understandings of human emotional networks via novel approaches to looking at data acquired from functional MRI, TMS, deep brain stimulation, and brain lesions. We hope that this will help us discover new ways to individualize brain stimulation treatments based on patient-specific symptoms and imaging findings.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Siddiqi SH, Trapp NT, Shahim P, Hacker CD, Laumann TO, Kandala S, Carter AR, Brody DL. Individualized Connectome-Targeted Transcranial Magnetic Stimulation for Neuropsychiatric Sequelae of Repetitive Traumatic Brain Injury in a Retired NFL Player. Journal of Neuropsychiatry and Clinical Neurosciences. 2019. View Publication.
  2. Siddiqi SH, Trapp NT, Shahim P, Hacker CD, Laumann TO, Kandala S, Carter AR, Brody DL. Individualized Connectome-Targeted Transcranial Magnetic Stimulation for Neuropsychiatric Sequelae of Repetitive Traumatic Brain Injury in a Retired NFL Player. J Neuropsychiatry Clin Neurosci. 2019 Apr 03; appineuropsych18100230. PMID: 30945588.
    Citations:    
  3. Cristancho P, Trapp NT, Siddiqi SH, Dixon D, Miller JP, Lenze EJ. Crossover to Bilateral Repetitive Transcranial Magnetic Stimulation: A Potential Strategy When Patients Are Not Responding to Unilateral Left-Sided High-Frequency Repetitive Transcranial Magnetic Stimulation. J ECT. 2019 03; 35(1):3-5. PMID: 29877963.
    Citations:    Fields:    
  4. Siddiqi SH, Trapp NT, Hacker CD, Laumann TO, Kandala S, Hong X, Trillo L, Shahim P, Leuthardt EC, Carter AR, Brody DL. Repetitive Transcranial Magnetic Stimulation with Resting-State Network Targeting for Treatment-Resistant Depression in Traumatic Brain Injury: A Randomized, Controlled, Double-Blinded Pilot Study. J Neurotrauma. 2019 Apr 15; 36(8):1361-1374. PMID: 30381997.
    Citations:    Fields:    
  5. Siddiqi SH, Chockalingam R, Cloninger CR, Lenze EJ, Cristancho P. Use of the Temperament and Character Inventory to Predict Response to Repetitive Transcranial Magnetic Stimulation for Major Depression. J Psychiatr Pract. 2016 05; 22(3):193-202. PMID: 27123799.
    Citations: 1     Fields:    Translation:Humans
  6. Siddiqi SH, Abraham NK, Geiger CL, Karimi M, Perlmutter JS, Black KJ. The Human Experience with Intravenous Levodopa. Front Pharmacol. 2015; 6:307. PMID: 26779024.
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  7. Siddiqi SH, Black KJ, Womer FY. Impact of a structured review session on medical student psychiatry subject examination performance. F1000Res. 2015; 4:897. PMID: 26594347.
    Citations:    
  8. Siddiqi SH, Creech ML, Black KJ. Orthostatic stability with intravenous levodopa. PeerJ. 2015; 3:e1198. PMID: 26336641.
    Citations: 1     
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.