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Shan Hai Siddiqi, M.D.

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Washington University, St. LouisResidency06/2017Psychiatry
University of Sydney, AustraliaMBBS05/2013Medicine
Harvard Medical School (MGH/McLean Hospital), BostonFellowship06/2018Behavioral Neurology & Neuropsychiatry
Harvard Medical School (Berenson-Allen Center for Noninvasive Brain Stimulation), BostonFellowship06/2019Neuromodulation
ANPA Career Development Award
2020 - 2022
NARSAD Young Investigator Award
Stanley Cobb Research Award
HMS Mysell Award
CTMSS Top Abstract Award
ANPA Young Investigator Award
ANPA Clinical Neuroscience Trainee Award
Eli Robins Award
ISEN Trainee Abstract Award
JPP Resident Paper Award
Gene Rubin Award

The brain has long remained enigmatic because it has been difficult to study direct cause-effect relationships in such a complex dynamic system. At the microscopic level, the neuroscience community has made major strides with optogenetics, which allows us to study the direct effects of stimulating specific nerves in a living organism. At the large scale, we are just starting to learn how to study causality in brain systems by pairing functional imaging with targeted neuromodulation. This allows us to study the direct effects of stimulating specific brain regions.

My research is focused on developing better methods for individualizing these neuromodulatory treatments based on functional MRI (fMRI) and clinical phenomenology. During residency, I was involved in several projects to investigate predictors of response to brain stimulation based on both clinical factors and computational analysis of brain imaging data. This culminated in a randomized-controlled trial of transcranial magnetic stimulation (TMS) targeted with individualized brain network mapping for depression associated with traumatic brain injury, which is now being scaled up into multiple larger trials in the military system.

Since arriving in Boston, I have been working with Dr. Michael Fox to develop better computational methods for using brain stimulation to explain human behavior. We are working on developing better understandings of human emotional networks via novel approaches to looking at data acquired from functional MRI, TMS, deep brain stimulation, and brain lesions. We hope that this will help us discover new ways to individualize brain stimulation treatments based on patient-specific symptoms and imaging findings.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K23MH121657 (Shan Siddiqi)
    National Institute of Mental Health
    Personalized circuit-based neuromodulation targets for depression

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Siddiqi SH, Schaper FLWVJ, Horn A, Hsu J, Padmanabhan JL, Brodtmann A, Cash RFH, Corbetta M, Choi KS, Dougherty DD, Egorova N, Fitzgerald PB, George MS, Gozzi SA, Irmen F, Kuhn AA, Johnson KA, Naidech AM, Pascual-Leone A, Phan TG, Rouhl RPW, Taylor SF, Voss JL, Zalesky A, Grafman JH, Mayberg HS, Fox MD. Brain stimulation and brain lesions converge on common causal circuits in neuropsychiatric disease. Nat Hum Behav. 2021 Jul 08. PMID: 34239076.
    Citations: 2     Fields:    
  2. Ferguson MA, Schaper FLWVJ, Cohen A, Siddiqi S, Merrill SM, Nielsen JA, Grafman J, Urgesi C, Fabbro F, Fox MD. A Neural Circuit for Spirituality and Religiosity Derived From Patients With Brain Lesions. Biol Psychiatry. 2021 Jun 29. PMID: 34454698.
    Citations:    Fields:    
  3. Siddiqi SH, Weigand A, Pascual-Leone A, Fox MD. Identification of Personalized Transcranial Magnetic Stimulation Targets Based on Subgenual Cingulate Connectivity: An Independent Replication. Biol Psychiatry. 2021 Apr 02. PMID: 33820629.
    Citations:    Fields:    
  4. Yip AG, Ressler KJ, Rodriguez-Villa F, Siddiqi SH, Seiner SJ. Treatment Outcomes of Electroconvulsive Therapy for Depressed Patients With and Without Borderline Personality Disorder: A Retrospective Cohort Study. J Clin Psychiatry. 2021 01 19; 82(2). PMID: 33471448.
    Citations:    Fields:    Translation:Humans
  5. Lehmann AE, Raquib AR, Siddiqi SH, Meier J, Durand ML, Gray ST, Holbrook EH. Prophylactic antibiotics after endoscopic sinus surgery for chronic rhinosinusitis: a randomized, double-blind, placebo-controlled noninferiority clinical trial. Int Forum Allergy Rhinol. 2021 07; 11(7):1047-1055. PMID: 33340285.
    Citations: 1     Fields:    Translation:Humans
  6. Ward HB, Yip A, Siddiqui R, Morales OG, Seiner SJ, Siddiqi SH. Borderline personality traits do not influence response to TMS. J Affect Disord. 2021 02 15; 281:834-838. PMID: 33229022.
    Citations:    Fields:    Translation:Humans
  7. Herrold AA, Siddiqi SH, Livengood SL, Bender Pape TL, Higgins JP, Adamson MM, Leung A, Raij T. Customizing TMS Applications in Traumatic Brain Injury Using Neuroimaging. J Head Trauma Rehabil. 2020 Nov/Dec; 35(6):401-411. PMID: 33165153.
    Citations:    Fields:    Translation:Humans
  8. Oberman LM, Exley S, Philip NS, Siddiqi SH, Adamson MM, Brody DL. Use of Repetitive Transcranial Magnetic Stimulation in the Treatment of Neuropsychiatric and Neurocognitive Symptoms Associated With Concussion in Military Populations. J Head Trauma Rehabil. 2020 Nov/Dec; 35(6):388-400. PMID: 33165152.
    Citations:    Fields:    Translation:Humans
  9. Cash RFH, Weigand A, Zalesky A, Siddiqi SH, Downar J, Fitzgerald PB, Fox MD. Using Brain Imaging to Improve Spatial Targeting of Transcranial Magnetic Stimulation for Depression. Biol Psychiatry. 2020 Jun 07. PMID: 32800379.
    Citations: 4     Fields:    
  10. Siddiqi SH, Taylor SF, Cooke D, Pascual-Leone A, George MS, Fox MD. Distinct Symptom-Specific Treatment Targets for Circuit-Based Neuromodulation. Am J Psychiatry. 2020 05 01; 177(5):435-446. PMID: 32160765.
    Citations: 18     Fields:    Translation:Humans
  11. Padmanabhan JL, Cooke D, Joutsa J, Siddiqi SH, Ferguson M, Darby RR, Soussand L, Horn A, Kim NY, Voss JL, Naidech AM, Brodtmann A, Egorova N, Gozzi S, Phan TG, Corbetta M, Grafman J, Fox MD. A Human Depression Circuit Derived From Focal Brain Lesions. Biol Psychiatry. 2019 11 15; 86(10):749-758. PMID: 31561861.
    Citations: 26     Fields:    Translation:Humans
  12. Siddiqi SH, Trapp NT, Shahim P, Hacker CD, Laumann TO, Kandala S, Carter AR, Brody DL. Individualized Connectome-Targeted Transcranial Magnetic Stimulation for Neuropsychiatric Sequelae of Repetitive Traumatic Brain Injury in a Retired NFL Player. Journal of Neuropsychiatry and Clinical Neurosciences. 2019. View Publication.
  13. Siddiqi SH, Trapp NT, Shahim P, Hacker CD, Laumann TO, Kandala S, Carter AR, Brody DL. Individualized Connectome-Targeted Transcranial Magnetic Stimulation for Neuropsychiatric Sequelae of Repetitive Traumatic Brain Injury in a Retired NFL Player. J Neuropsychiatry Clin Neurosci. 2019; 31(3):254-263. PMID: 30945588.
    Citations: 3     Fields:    Translation:Humans
  14. Cristancho P, Trapp NT, Siddiqi SH, Dixon D, Miller JP, Lenze EJ. Crossover to Bilateral Repetitive Transcranial Magnetic Stimulation: A Potential Strategy When Patients Are Not Responding to Unilateral Left-Sided High-Frequency Repetitive Transcranial Magnetic Stimulation. J ECT. 2019 03; 35(1):3-5. PMID: 29877963.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  15. Siddiqi SH, Trapp NT, Hacker CD, Laumann TO, Kandala S, Hong X, Trillo L, Shahim P, Leuthardt EC, Carter AR, Brody DL. Repetitive Transcranial Magnetic Stimulation with Resting-State Network Targeting for Treatment-Resistant Depression in Traumatic Brain Injury: A Randomized, Controlled, Double-Blinded Pilot Study. J Neurotrauma. 2019 04 15; 36(8):1361-1374. PMID: 30381997.
    Citations: 10     Fields:    Translation:Humans
  16. Siddiqi SH, Chockalingam R, Cloninger CR, Lenze EJ, Cristancho P. Use of the Temperament and Character Inventory to Predict Response to Repetitive Transcranial Magnetic Stimulation for Major Depression. J Psychiatr Pract. 2016 05; 22(3):193-202. PMID: 27123799.
    Citations: 5     Fields:    Translation:Humans
  17. Siddiqi SH, Abraham NK, Geiger CL, Karimi M, Perlmutter JS, Black KJ. The Human Experience with Intravenous Levodopa. Front Pharmacol. 2015; 6:307. PMID: 26779024.
    Citations: 3     
  18. Siddiqi SH, Black KJ, Womer FY. Impact of a structured review session on medical student psychiatry subject examination performance. F1000Res. 2015; 4:897. PMID: 26594347.
    Citations:    Fields:    
  19. Siddiqi SH, Creech ML, Black KJ. Orthostatic stability with intravenous levodopa. PeerJ. 2015; 3:e1198. PMID: 26336641.
    Citations: 1     
  20. Witebsky FG, Keiser JF, Conville PS, Bryan R, Park CH, Walker R, Siddiqi SH. Comparison of BACTEC 13A medium and Du Pont isolator for detection of mycobacteremia. J Clin Microbiol. 1988 Aug; 26(8):1501-5. PMID: 3170713.
    Citations: 11     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.