Harvard Catalyst Profiles

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Pedro Brugarolas, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS120139 (BRUGAROLAS, PEDRO) Sep 30, 2020 - May 31, 2022
    NIH
    Development of a PET radioligand for alpha2delta-1 receptors to visualize and quantify neuropathic pain mechanisms neuropathic pain mechanisms
    Role: Principal Investigator
  2. R01NS114066 (BRUGAROLAS, PEDRO) Dec 15, 2019 - Nov 30, 2024
    NIH
    Can [18F]3F4AP detect brain demyelination? Evaluation of novel PET tracer in nonhuman primates and humans
    Role: Principal Investigator
  3. R00EB020075 (BRUGAROLAS, PEDRO) Sep 1, 2017 - Jun 30, 2021
    NIH
    New tools for imaging: diagnostics based on therapeutics
    Role: Principal Investigator
  4. K99EB020075 (BRUGAROLAS, PEDRO) Jul 1, 2015 - Jun 30, 2017
    NIH
    New tools for imaging: diagnostics based on therapeutics
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Guehl NJ, Neelamegam R, Zhou YP, Moon SH, Dhaynaut M, El Fakhri G, Normandin MD, Brugarolas P. Radiochemical Synthesis and Evaluation in Non-Human Primates of 3-[11C]methoxy-4-aminopyridine: A Novel PET Tracer for Imaging Potassium Channels in the CNS. ACS Chem Neurosci. 2021 02 17; 12(4):756-765. PMID: 33539063.
    Citations:    Fields:    Translation:Animals
  2. Shoup TM, Griciuc A, Normandin MD, Quinti L, Walsh LV, Dhaynaut M, Moon SH, Guehl NJ, Brugarolas P, Elmaleh DR, Fakhri GE, Tanzi RE. Evaluation of Fluorinated Cromolyn Derivatives as Potential Therapeutics for Alzheimer's Disease. J Alzheimers Dis. 2021; 80(2):775-786. PMID: 33579853.
    Citations: 1     Fields:    
  3. Guehl NJ, Ramos-Torres KM, Linnman C, Moon SH, Dhaynaut M, Wilks MQ, Han PK, Ma C, Neelamegam R, Zhou YP, Popko B, Correia JA, Reich DS, Fakhri GE, Herscovitch P, Normandin MD, Brugarolas P. Evaluation of the potassium channel tracer [18F]3F4AP in rhesus macaques. J Cereb Blood Flow Metab. 2021 07; 41(7):1721-1733. PMID: 33090071.
    Citations: 2     Fields:    Translation:Animals
  4. Foxley S, Wildenberg G, Sampathkumar V, Karczmar GS, Brugarolas P, Kasthuri N. Sensitivity to myelin using model-free analysis of the water resonance line-shape in postmortem mouse brain. Magn Reson Med. 2021 02; 85(2):667-677. PMID: 32783262.
    Citations:    Fields:    Translation:AnimalsCells
  5. Ramos-Torres KM, Zhou YP, Yang BY, Guehl NJ, Sung-Hyun M, Telu S, Normandin MD, Pike VW, Brugarolas P. Syntheses of [11C]2- and [11C]3-trifluoromethyl-4-aminopyridine: potential PET radioligands for demyelinating diseases. RSC Med Chem. 2020 Oct 01; 11(10):1161-1167. PMID: 33479620.
    Citations:    
  6. Brugarolas P, Comstock J, Dick DW, Ellmer T, Engle JW, Lapi SE, Liang SH, Parent EE, Kishore Pillarsetty NV, Selivanova S, Sun X, Vavere A, Scott PJH. Fifty Years of Radiopharmaceuticals. J Nucl Med Technol. 2020 06; 48(Suppl 1):34S-39S. PMID: 32605944.
    Citations: 1     Fields:    Translation:Humans
  7. Rodríguez-Rangel S, Bravin AD, Ramos-Torres KM, Brugarolas P, Sánchez-Rodríguez JE. Structure-activity relationship studies of four novel 4-aminopyridine K+ channel blockers. Sci Rep. 2020 01 09; 10(1):52. PMID: 31919372.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Elbaz B, Aaker JD, Isaac S, Kolarzyk A, Brugarolas P, Eden A, Popko B. Phosphorylation State of ZFP24 Controls Oligodendrocyte Differentiation. Cell Rep. 2018 05 22; 23(8):2254-2263. PMID: 29791837.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. Brugarolas P, Sánchez-Rodríguez JE, Tsai HM, Basuli F, Cheng SH, Zhang X, Caprariello AV, Lacroix JJ, Freifelder R, Murali D, DeJesus O, Miller RH, Swenson RE, Chen CT, Herscovitch P, Reich DS, Bezanilla F, Popko B. Development of a PET radioligand for potassium channels to image CNS demyelination. Sci Rep. 2018 01 12; 8(1):607. PMID: 29330383.
    Citations: 11     Fields:    Translation:HumansAnimals
  10. Brugarolas P, Reich DS, Popko B. Detecting Demyelination by PET: The Lesion as Imaging Target. Mol Imaging. 2018 Jan-Dec; 17:1536012118785471. PMID: 30039728.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  11. Basuli F, Zhang X, Brugarolas P, Reich DS, Swenson RE. An efficient new method for the synthesis of 3-[18 F]fluoro-4-aminopyridine via Yamada-Curtius rearrangement. J Labelled Comp Radiopharm. 2018 02; 61(2):112-117. PMID: 28870001.
    Citations: 6     Fields:    
  12. Brugarolas P, Bhuiyan M, Kucharski A, Freifelder R. Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases. J Vis Exp. 2017 05 29; (123). PMID: 28605366.
    Citations: 3     Fields:    Translation:Humans
  13. Brugarolas P, Freifelder R, Cheng SH, DeJesus O. Synthesis of meta-substituted [(18)F]3-fluoro-4-aminopyridine via direct radiofluorination of pyridine N-oxides. Chem Commun (Camb). 2016 06 04; 52(44):7150-2. PMID: 27216991.
    Citations: 7     Fields:    Translation:Cells
  14. Way SW, Podojil JR, Clayton BL, Zaremba A, Collins TL, Kunjamma RB, Robinson AP, Brugarolas P, Miller RH, Miller SD, Popko B. Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic. Nat Commun. 2015 Mar 13; 6:6532. PMID: 25766071.
    Citations: 43     Fields:    Translation:AnimalsCells
  15. Brugarolas P, Popko B. Remyelination therapy goes to trial for multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 2014 Aug; 1(2):e26. PMID: 25340076.
    Citations: 7     Fields:    
  16. Ji Q, Zhang L, Jones MB, Sun F, Deng X, Liang H, Cho H, Brugarolas P, Gao YN, Peterson SN, Lan L, Bae T, He C. Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proc Natl Acad Sci U S A. 2013 Mar 26; 110(13):5010-5. PMID: 23479646.
    Citations: 13     Fields:    Translation:HumansCells
  17. Brugarolas P, Movahedzadeh F, Wang Y, Zhang N, Bartek IL, Gao YN, Voskuil MI, Franzblau SG, He C. The oxidation-sensing regulator (MosR) is a new redox-dependent transcription factor in Mycobacterium tuberculosis. J Biol Chem. 2012 Nov 02; 287(45):37703-12. PMID: 22992749.
    Citations: 21     Fields:    Translation:Cells
  18. Aryal BP, Brugarolas P, He C. Binding of ReO4(-) with an engineered MoO4(2-)-binding protein: towards a new approach in radiopharmaceutical applications. J Biol Inorg Chem. 2012 Jan; 17(1):97-106. PMID: 21861186.
    Citations: 3     Fields:    Translation:Cells
  19. Brugarolas P, Duguid EM, Zhang W, Poor CB, He C. Structural and biochemical characterization of N5-carboxyaminoimidazole ribonucleotide synthetase and N5-carboxyaminoimidazole ribonucleotide mutase from Staphylococcus aureus. Acta Crystallogr D Biol Crystallogr. 2011 Aug; 67(Pt 8):707-15. PMID: 21795812.
    Citations: 4     Fields:    Translation:HumansCells
  20. Chen PR, Brugarolas P, He C. Redox signaling in human pathogens. Antioxid Redox Signal. 2011 Mar 15; 14(6):1107-18. PMID: 20578795.
    Citations: 25     Fields:    Translation:HumansCells
  21. J. García-Martínez, P. Brugarolas, S. Domínguez-Domínguez. Ordered circular mesoporosity induced by phospholipids. Microporous and Mesoporous Materials. 2007; 100(1-3):63-69. View Publication.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.