Harvard Catalyst Profiles

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Jason Hunt Maley, M.D.

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Hospital of the University of Pennsylvania06/2016Internal Medicine
Hospital of the University of Pennsylvania06/2016Healthcare Leadership in Quality Track
University of Pennsylvania06/2017Chief Medical Resident
Harvard Combined Fellowship, Massachusetts General Hospital, Beth Israel Deaconess Medical Center06/2020Pulmonary and Critical Care Medicine
Harvard T.H. Chan School of Public HealthMS11/2021Epidemiology
BIDMC Outstanding Fellow Teaching Award
2019 - 2021
Charles A King Trust Postdoctoral Research Fellowship
Penn Inaugural Richard P. Shannon, MD Resident Award for Leadership in Quality and Safety

Research Locations:
BIDMC Center for Healthcare Delivery Science
MIT Institute for Medical Engineering and Science

Director, BIDMC Critical Illness and COVID-19 Survivorship Program
Director, Quality, Pulmonary, Critical Care, and Sleep Medicine
Co-Chair, American Academy of Physical Medicine and Rehabilitation PASC Collaborative

Currently my work focuses on recovery and long-term outcomes for patients and families after critical illness and COVID-19, including long COVID, also referred to as post-acute sequelae of SARS-CoV-2 infection (PASC). I am engaged in both research and clinical work to develop better approaches to help these patients regain their quality of life.

I am also involved in work to improving the value and humanism in healthcare delivered to people experiencing critical illness, chronic illness, and those approaching the end of life. Value refers to the outcomes that matter to patients and families, relative to the cost of achieving those outcomes. A portion of my research examines value in the intensive care unit, seeking to understand variation in care, cost, waste, and opportunities to improve the care patients receive by eliminating low-value care. I am also interested in improving the end-of-life experience of patients with serious illness, in particular aligning the care patients receive with their values, and improving the use of palliative rather than intensive therapies at the end of life.

Finally, I collaborate with colleagues to analyze highly detailed intensive care unit data, with the aim of improving the quality, safety, and effectiveness of critical care through machine learning and biomedical engineering applications. Overall, I hope to help develop a smarter, kinder, and more effective healthcare delivery system through my research, medical education efforts, and clinical work.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. Dec 1, 2019 - Nov 30, 2021
    Charles A. King Trust
    A Novel Model of Healthcare Waste and Value in the Intensive Care Unit
    Role: PI

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Maley JH, Sandsmark DK, Trainor A, Bass GD, Dabrowski CL, Magdamo BA, Durkin B, Hayes MM, Schwartzstein RM, Stevens JP, Kaplan LJ, Mikkelsen ME, Lane-Fall MB. Six-Month Impairment in Cognition, Mental Health, and Physical Function Following COVID-19-Associated Respiratory Failure. Crit Care Explor. 2022 Apr; 4(4):e0673. PMID: 35372848.
  2. Danesh V, Boehm LM, Eaton TL, Arroliga AC, Mayer KP, Kesler SR, Bakhru RN, Baram M, Bellinghausen AL, Biehl M, Dangayach NS, Goldstein NM, Hoehn KS, Islam M, Jagpal S, Johnson AB, Jolley SE, Kloos JA, Mahoney EJ, Maley JH, Martin SF, McSparron JI, Mery M, Saft H, Santhosh L, Schwab K, Villalba D, Sevin CM, Montgomery AA. Characteristics of Post-ICU and Post-COVID Recovery Clinics in 29 U.S. Health Systems. Crit Care Explor. 2022 Mar; 4(3):e0658. PMID: 35291316.
  3. Maley JH, Alba GA, Barry JT, Bartels MN, Fleming TK, Oleson CV, Rydberg L, Sampsel S, Silver JK, Sipes S, Verduzco-Gutierrez M, Wood J, Zibrak JD, Whiteson J. Multi-disciplinary collaborative consensus guidance statement on the assessment and treatment of breathing discomfort and respiratory sequelae in patients with post-acute sequelae of SARS-CoV-2 infection (PASC). PM R. 2022 01; 14(1):77-95. PMID: 34902224.
    Citations:    Fields:    Translation:HumansCells
  4. Anesi GL, Maley JH. Pandemic Situation Report: Perspectives on COVID-19 Surges, Case Trajectories, and Viral Variants. Society of Critical Care Medicine: Critical Connections. 2021. View Publication.
  5. Herrera JE, Niehaus WN, Whiteson J, Azola A, Baratta JM, Fleming TK, Kim SY, Naqvi H, Sampsel S, Silver JK, Gutierrez MV, Maley JH, Herman E, Abramoff B. Response to letter to the editor regarding "Multi-Disciplinary collaborative consensus guidance statement on the assessment and treatment of fatigue in patients with Post-Acute sequelae of SARS-CoV-2 infection (PASC)". PM R. 2021 12; 13(12):1439-1440. PMID: 34617402.
    Citations:    Fields:    Translation:HumansCells
  6. Mantena S, Arévalo AR, Maley JH, da Silva Vieira SM, Mateo-Collado R, da Costa Sousa JM, Celi LA. Predicting hypoglycemia in critically Ill patients using machine learning and electronic health records. J Clin Monit Comput. 2021 Oct 04. PMID: 34606005.
    Citations:    Fields:    
  7. Herrera JE, Niehaus WN, Whiteson J, Azola A, Baratta JM, Fleming TK, Kim SY, Naqvi H, Sampsel S, Silver JK, Gutierrez MV, Maley J, Herman E, Abramoff B. Multidisciplinary collaborative consensus guidance statement on the assessment and treatment of fatigue in postacute sequelae of SARS-CoV-2 infection (PASC) patients. PM R. 2021 09; 13(9):1027-1043. PMID: 34346558.
    Citations: 3     Fields:    Translation:HumansCells
  8. Maley JH, Sampsel S, Abramoff BA, Herman E, Neerukonda KV, Mikkelsen ME. Consensus methodology for the development of postacute sequelae of SARS-CoV-2 guidance statements. PM R. 2021 09; 13(9):1021-1026. PMID: 34240583.
    Citations: 2     Fields:    Translation:HumansCells
  9. Rubin J, Sclafani A, Helland TL, Sharma A, Maley JH, Peck TJ, Wallwork RS, Bolster MB, Berigei S, Colson YL, Selig MK, Mino-Kenudson M, Hariri LP. Pulmonary Hemosiderosis with Calcification Associated with IgA Nephropathy. Am J Respir Crit Care Med. 2021 07 15; 204(2):e24-e25. PMID: 33626295.
    Citations:    Fields:    Translation:Humans
  10. LaSalvia E Maley JH Keshavan MS. Psychiatric Times. Developing a Collaborative Approach to Post-Acute Sequelae of SARS-CoV-2 Infection. 2021; 38(7). View Publication.
  11. Maley JH, Mikkelsen ME. The Intersection of Health and Critical Illness: Preservation and Restoration. Am J Respir Crit Care Med. 2021 06 15; 203(12):1451-1453. PMID: 33636093.
    Citations:    Fields:    Translation:Humans
  12. Maley JH, Mikkelsen ME. Improving Critical Care Survivorship (eds. Haines, McPeake, Sevin). A PICS Free Future. 2021.
  13. Robles Arévalo A, Maley JH, Baker L, da Silva Vieira SM, da Costa Sousa JM, Finkelstein S, Mateo-Collado R, Raffa JD, Celi LA, DeMichele F. Data-driven curation process for describing the blood glucose management in the intensive care unit. Sci Data. 2021 03 10; 8(1):80. PMID: 33692359.
    Citations:    Fields:    Translation:Humans
  14. Baedorf Kassis E, Schaefer MS, Maley JH, Hoenig B, Loo Y, Hayes MM, Moskowitz A, Talmor D. Transpulmonary pressure measurements and lung mechanics in patients with early ARDS and SARS-CoV-2. J Crit Care. 2021 06; 63:106-112. PMID: 33676795.
    Citations: 5     Fields:    Translation:HumansCells
  15. Maley JH, Law AC, Stevens JP. Evidence and Our Daily Risk Trade-offs in the Care of Critically Ill Patients. Am J Respir Crit Care Med. 2020 12 01; 202(11):1493-1494. PMID: 32777189.
    Citations:    Fields:    Translation:Humans
  16. Ziehr DR, Alladina J, Petri CR, Maley JH, Moskowitz A, Medoff BD, Hibbert KA, Thompson BT, Hardin CC. Reply to Yaroshetskiy et al.: Acute Respiratory Distress Syndrome in COVID-19: Do All These Patients Definitely Require Intubation and Mechanical Ventilation? Am J Respir Crit Care Med. 2020 11 15; 202(10):1481-1482. PMID: 32809839.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  17. Maley JH, Anesi GL. Watchful Waiting in the ICU? Considerations for the Allocation of ICU Resources. Am J Respir Crit Care Med. 2020 11 15; 202(10):1332-1333. PMID: 32755485.
    Citations: 2     Fields:    Translation:Humans
  18. Chivukula RR, Maley JH, Dudzinski DM, Hibbert K, Hardin CC. Evidence-Based Management of the Critically Ill Adult With SARS-CoV-2 Infection. J Intensive Care Med. 2021 Jan; 36(1):18-41. PMID: 33111601.
    Citations: 4     Fields:    Translation:Humans
  19. Hariri LP, North CM, Shih AR, Israel RA, Maley JH, Villalba JA, Vinarsky V, Rubin J, Okin DA, Sclafani A, Alladina JW, Griffith JW, Gillette MA, Raz Y, Richards CJ, Wong AK, Ly A, Hung YP, Chivukula RR, Petri CR, Calhoun TF, Brenner LN, Hibbert KA, Medoff BD, Hardin CC, Stone JR, Mino-Kenudson M. Lung Histopathology in Coronavirus Disease 2019 as Compared With Severe Acute Respiratory Sydrome and H1N1 Influenza: A Systematic Review. Chest. 2021 01; 159(1):73-84. PMID: 33038391.
    Citations: 49     Fields:    Translation:HumansCells
  20. Maley JH, Wanis KN, Young JG, Celi LA. Mortality prediction models, causal effects, and end-of-life decision making in the intensive care unit. BMJ Health Care Inform. 2020 Oct; 27(3). PMID: 33106330.
    Citations: 1     Fields:    Translation:Humans
  21. Maley JH, Stevens JP. Low-Value Diagnostic Imaging in the Intensive Care Unit: A Teachable Moment. JAMA Intern Med. 2020 10 01; 180(10):1368-1369. PMID: 32730564.
    Citations: 1     Fields:    Translation:Humans
  22. Theodore M, Maley JH, O’Donnell WJ. Pocket Medicine High-Yield Board Review (Sabatine). Pulmonary and Critical Care. 2020.
  23. Maley JH, Winkler T, Hardin CC. Heterogeneity of Acute Respiratory Distress Syndrome in COVID-19: "Typical" or Not? Am J Respir Crit Care Med. 2020 08 15; 202(4):618-619. PMID: 32579019.
    Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
  24. Maley JH, Worsham CM, Landon BE, Stevens JP. Association between Palliative Care and End-of-Life Resource Use for Older Adults Hospitalized with Septic Shock. Ann Am Thorac Soc. 2020 08; 17(8):974-979. PMID: 32275846.
    Citations: 1     Fields:    Translation:Humans
  25. Ziehr DR, Alladina J, Petri CR, Maley JH, Moskowitz A, Medoff BD, Hibbert KA, Thompson BT, Hardin CC. Reply to Epelbaum: Standards and Stereotypes in COVID-19. Am J Respir Crit Care Med. 2020 08 01; 202(3):470-471. PMID: 32510977.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  26. Baker L, Maley JH, Arévalo A, DeMichele F, Mateo-Collado R, Finkelstein S, Celi LA. Real-world characterization of blood glucose control and insulin use in the intensive care unit. Sci Rep. 2020 07 01; 10(1):10718. PMID: 32612144.
    Citations: 5     Fields:    Translation:Humans
  27. Maley JH, Landon BE, Stevens JP. Regional Variation in Use of End-of-Life Care at Hospitals, Intensive Care Units, and Hospices Among Older Adults With Chronic Illness in the US, 2010 to 2016. JAMA Netw Open. 2020 07 01; 3(7):e2010810. PMID: 32692369.
    Citations:    Fields:    Translation:Humans
  28. Petri CR, Brenner LN, Calhoun TF, Chivukula RR, Maley JH, Vinarsky V, Dudzinski DM, Hardin CC. The Fast Literature Assessment and Review (FLARE) Initiative. A Collaborative Effort for Timely Literature Appraisal during the Coronavirus Disease Pandemic. ATS Sch. 2020 Jun 29; 1(2):186-193. PMID: 33870283.
    Citations: 4     
  29. Maley JH, Petri CR, Brenner LN, Chivukula RR, Calhoun TF, Vinarsky V, Hardin CC. Anticoagulation, immortality, and observations of COVID-19. Res Pract Thromb Haemost. 2020 Jul; 4(5):674-676. PMID: 32685874.
    Citations: 1     
  30. Ziehr DR, Alladina J, Petri CR, Maley JH, Moskowitz A, Medoff BD, Hibbert KA, Thompson BT, Hardin CC. Respiratory Pathophysiology of Mechanically Ventilated Patients with COVID-19: A Cohort Study. Am J Respir Crit Care Med. 2020 06 15; 201(12):1560-1564. PMID: 32348678.
    Citations: 171     Fields:    Translation:HumansCellsPHPublic Health
  31. Petri CR, Brenner LN, Calhoun TF, Chivukula RR, Maley JH, Vinarsky V, Dudzinski DM, and Hardin CC . The FLARE Initiative: A collaborative effort for timely literature appraisal during the COVID-19 pandemic. ATS Scholar. 2020. View Publication.
  32. Maley JH, Stevens JP. Evidence-Based Critical Care (eds. Hyzy and McSparron). Ventilator-Associated Pneumonia. 2020.
  33. Maley JH, Mikkelsen ME. Evidence-Based Critical Care (eds. Hyzy and McSparron). Post-Intensive Care Syndrome. 2020.
  34. Maley JH, Thompson BT. Evidence-Based Practice of Critical Care 3rd Edition (Deutschman and Neligan). What are the Berlin criteria for ARDS? Have they been useful?. 2019.
  35. Maley JH, Mikkelsen ME. Evidence-Based Practice of Critical Care 3rd Edition (Deutschman and Neligan). What happens to ICU survivors after they leave the ICU?. 2019.
  36. Maley, JH, Hibbert, KA. Critical Care Medicine Review (eds. Sonny, Bittner, Horvath, Berg). 2019.
  37. Theodore M, Maley JH, O’Donnell WJ. Pocket Medicine 7th Edition (Sabatine). Pulmonary and Critical Care. 2019.
  38. Maley JH, Stevens JP. Post-ICU Care: If You Build It, Will They Come… and How Do You Build It? Crit Care Med. 2019 09; 47(9):1269-1270. PMID: 31415311.
    Citations:    Fields:    Translation:Humans
  39. Maley JH, Thompson BT. Embracing the Heterogeneity of ARDS. Chest. 2019 03; 155(3):453-455. PMID: 30846060.
    Citations: 3     Fields:    Translation:Humans
  40. McPeake J, Veith J, Maley JH, Mikkelsen ME. Acute Respiratory Failure as a Precursor for Post-Intensive Care Syndrome. Clinical Pulmonary Medicine. 2019; 1(26):18-23.
  41. Maley JH, Dannheim K, Kooistra T, Hallowell RW. A Man with a Decade of Persistent Pulmonary Opacities. Ann Am Thorac Soc. 2018 11; 15(11):1344-1348. PMID: 30382779.
    Citations:    Fields:    Translation:Humans
  42. Maley JH. Hemoptysis or Hematemesis?-The Importance of Professional Medical Interpretation: A Teachable Moment. JAMA Intern Med. 2018 06 01; 178(6):841-842. PMID: 29582083.
    Citations:    Fields:    Translation:Humans
  43. Maley JH, Rogan J, Mikkelsen ME. Families in the Intensive Care Unit: Understanding, Engaging, and Supporting (Giora Netzer). Post-intensive Care Syndrome - Family. 2018.
  44. Jason H Maley, Mark E Mikkelsen . Evidence Based Critical Care: A Case Study Approach. Editor: Robert C Hyzy. Chapter: The Post-Intensive Care Syndrome. 2017.
  45. Maley JH, Brewster I, Mayoral I, Siruckova R, Adams S, McGraw KA, Piech AA, Detsky M, Mikkelsen ME. Resilience in Survivors of Critical Illness in the Context of the Survivors' Experience and Recovery. Ann Am Thorac Soc. 2016 08; 13(8):1351-60. PMID: 27159794.
    Citations: 30     Fields:    Translation:Humans
  46. Maley JH, Mikkelsen ME. Short-term Gains with Long-term Consequences: The Evolving Story of Sepsis Survivorship. Clin Chest Med. 2016 06; 37(2):367-80. PMID: 27229651.
    Citations: 15     Fields:    Translation:Humans
  47. Jason H Maley. Approach to Hypotension. In: A Resident-led Nocturnal Curriculum, Golbus JR, Murphy, KM, Manly DA and Bellini L (Ed), AAMC iCollaborative. 2015. View Publication.
  48. Maley JH, Gaieski D, Mikkelsen ME. Early Recognition: The rate limiting step to quality care for severe sepsis patients in the emergency department. Journal of Clinical Outcomes Management. 2015; 22(5).
  49. Kumar AD, Shah MK, Maley JH, Evron J, Gyftopoulos A, Miller C. Preparing to take the USMLE Step 1: a survey on medical students' self-reported study habits. Postgrad Med J. 2015 May; 91(1075):257-61. PMID: 25910497.
    Citations: 10     Fields:    Translation:Humans
  50. Maley JH, Mikkelsen ME. Sepsis survivorship: how can we promote a culture of resilience? Crit Care Med. 2015 Feb; 43(2):479-81. PMID: 25599473.
    Citations: 2     Fields:    Translation:Humans
  51. Maley JH, Kiskis EC. Acute renal failure following treatment of a common culture contaminant: a teachable moment. JAMA Intern Med. 2014 Dec; 174(12):1890-1. PMID: 25330095.
    Citations:    Fields:    Translation:HumansCells
  52. Maley JH. History lessons. Ann Intern Med. 2013 Nov 19; 159(10):715-6. PMID: 24247677.
    Citations:    Fields:    Translation:Humans
  53. Kahn MJ, Maley JH, Lasker GF, Kadowitz PJ. Updated role of nitric oxide in disorders of erythrocyte function. Cardiovasc Hematol Disord Drug Targets. 2013 Mar 01; 13(1):83-7. PMID: 23534951.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  54. Lasker GF, Maley JH, Pankey EA, Kadowitz PJ. Targeting soluble guanylate cyclase for the treatment of pulmonary hypertension. Expert Rev Respir Med. 2011 Apr; 5(2):153-61. PMID: 21510726.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  55. Maley JH, Lasker GF, Kadowitz PJ. Nitric oxide and disorders of the erythrocyte: emerging roles and therapeutic targets. Cardiovasc Hematol Disord Drug Targets. 2010 Dec 01; 10(4):284-91. PMID: 21067512.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  56. Maley JH, Alvernia JE, Valle EP, Richardson D. Deep brain stimulation of the orbitofrontal projections for the treatment of intermittent explosive disorder. Neurosurg Focus. 2010 Aug; 29(2):E11. PMID: 20672913.
    Citations: 2     Fields:    Translation:Humans
  57. Alvernia JE, Sindou MP, Dang ND, Maley JH, Mertens P. Percutaneous approach to the foramen ovale: an anatomical study of the extracranial trajectory with the incorrect trajectories to be avoided. Acta Neurochir (Wien). 2010 Jun; 152(6):1043-53. PMID: 20140745.
    Citations: 7     Fields:    Translation:Humans
  58. Lasker GF, Maley JH, Kadowitz PJ. A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction. Adv Pharmacol Sci. 2010; 2010. PMID: 21152267.
    Citations: 10     
  59. Farrell CJ, Zaupa C, Barnard Z, Maley J, Martuza RL, Rabkin SD, Curry WT. Combination immunotherapy for tumors via sequential intratumoral injections of oncolytic herpes simplex virus 1 and immature dendritic cells. Clin Cancer Res. 2008 Dec 01; 14(23):7711-6. PMID: 19047097.
    Citations: 15     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.