Harvard Catalyst Profiles

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Carmen Unzu, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Unzu C, Planet E, Brandenberg N, Fusil F, Cassano M, Perez-Vargas J, Friedli M, Cosset FL, Lutolf MP, Wildhaber BE, Trono D. Pharmacological Induction of a Progenitor State for the Efficient Expansion of Primary Human Hepatocytes. Hepatology. 2019 05; 69(5):2214-2231. PMID: 30549291.
    Citations:    Fields:    
  2. Unzu C, Friedli M, Bosman A, Jaconi ME, Wildhaber BE, Rougemont AL. Human Hepatocyte-Derived Induced Pluripotent Stem Cells: MYC Expression, Similarities to Human Germ Cell Tumors, and Safety Issues. Stem Cells Int. 2016; 2016:4370142. PMID: 26880963.
  3. Unzu C, Melero I, Hervás-Stubbs S, Sampedro A, Mancheño U, Morales-Kastresana A, Serrano-Mendioroz I, de Salamanca RE, Benito A, Fontanellas A. Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression. Gene Ther. 2015 Nov; 22(11):856-65. PMID: 26125605.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Friedli M, Turelli P, Kapopoulou A, Rauwel B, Castro-Díaz N, Rowe HM, Ecco G, Unzu C, Planet E, Lombardo A, Mangeat B, Wildhaber BE, Naldini L, Trono D. Loss of transcriptional control over endogenous retroelements during reprogramming to pluripotency. Genome Res. 2014 Aug; 24(8):1251-9. PMID: 24879558.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  5. Unzu C, Melero I, Morales-Kastresana A, Sampedro A, Serrano-Mendioroz I, Azpilikueta A, Ochoa MC, Dubrot J, Martínez-Ansó E, Fontanellas A. Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus. PLoS One. 2014; 9(1):e85432. PMID: 24465560.
    Citations: 3     Fields:    Translation:AnimalsCells
  6. Pañeda A, Lopez-Franco E, Kaeppel C, Unzu C, Gil-Royo AG, D'Avola D, Beattie SG, Olagüe C, Ferrero R, Sampedro A, Mauleon I, Hermening S, Salmon F, Benito A, Gavira JJ, Cornet ME, del Mar Municio M, von Kalle C, Petry H, Prieto J, Schmidt M, Fontanellas A, González-Aseguinolaza G. Safety and liver transduction efficacy of rAAV5-cohPBGD in nonhuman primates: a potential therapy for acute intermittent porphyria. Hum Gene Ther. 2013 Dec; 24(12):1007-17. PMID: 24070415.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  7. Unzu C, Sampedro A, Mauleón I, González-Aparicio M, Enríquez de Salamanca R, Prieto J, Aragón T, Fontanellas A. Helper-dependent adenoviral liver gene therapy protects against induced attacks and corrects protein folding stress in acute intermittent porphyria mice. Hum Mol Genet. 2013 Jul 15; 22(14):2929-40. PMID: 23562909.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  8. Unzu C, Hervás-Stubbs S, Sampedro A, Mauleón I, Mancheño U, Alfaro C, de Salamanca RE, Benito A, Beattie SG, Petry H, Prieto J, Melero I, Fontanellas A. Transient and intensive pharmacological immunosuppression fails to improve AAV-based liver gene transfer in non-human primates. J Transl Med. 2012 Jun 15; 10:122. PMID: 22704060.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  9. Unzu C, Sampedro A, Sardh E, Mauleón I, Enríquez de Salamanca R, Prieto J, Salido E, Harper P, Fontanellas A. Renal failure affects the enzymatic activities of the three first steps in hepatic heme biosynthesis in the acute intermittent porphyria mouse. PLoS One. 2012; 7(3):e32978. PMID: 22412963.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. Unzu C, Sampedro A, Mauleón I, Alegre M, Beattie SG, de Salamanca RE, Snapper J, Twisk J, Petry H, González-Aseguinolaza G, Artieda J, Rodríguez-Pena MS, Prieto J, Fontanellas A. Sustained enzymatic correction by rAAV-mediated liver gene therapy protects against induced motor neuropathy in acute porphyria mice. Mol Ther. 2011 Feb; 19(2):243-50. PMID: 20877347.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  11. Fontanellas A, Hervás-Stubbs S, Mauleón I, Dubrot J, Mancheño U, Collantes M, Sampedro A, Unzu C, Alfaro C, Palazón A, Smerdou C, Benito A, Prieto J, Peñuelas I, Melero I. Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates. Mol Ther. 2010 Apr; 18(4):754-65. PMID: 20087317.
    Citations: 12     Fields:    Translation:AnimalsCells
  12. Unzu C, Sampedro A, Mauleón I, Vanrell L, Dubrot J, de Salamanca RE, González-Aseguinolaza G, Melero I, Prieto J, Fontanellas A. Porphobilinogen deaminase over-expression in hepatocytes, but not in erythrocytes, prevents accumulation of toxic porphyrin precursors in a mouse model of acute intermittent porphyria. J Hepatol. 2010 Mar; 52(3):417-24. PMID: 19815305.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  13. Berasain C, Sampedro A, Mauleón I, Goñi S, Latasa MU, Matscheko N, García-Bravo M, Unzu C, Corrales FJ, Enríquez de Salamanca R, Prieto J, Avila MA, Fontanellas A. Epidermal growth factor receptor ligands in murine models for erythropoietic protoporphyria: potential novel players in the progression of liver injury. Cell Mol Biol (Noisy-le-grand). 2009 Feb 16; 55(1):29-37. PMID: 19267999.
    Citations: 2     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.