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Ian Roman Rifkin, Ph.D., M.B.,B.Ch.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI130199 (RIFKIN, IAN R) Sep 22, 2017 - Aug 31, 2022
    NIH/NIAID
    The Role of Interferon Regulatory Factor 5 in the Pathogenesis of SLE
    Role: Principal Investigator
  2. K08DK002597 (RIFKIN, IAN R) Aug 1, 1998 - Jun 30, 2004
    NIH/NIDDK
    PATHOGENIC AUTOREACTIVE T CELLS IN MURINE AUTOIMMUNITY
    Role: Principal Investigator
  3. T32DK007053 (RIFKIN, IAN R) Jul 1, 1975 - Jun 30, 2020
    NIH/NIDDK
    Research Training in Nephrology
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lee J, Zhang J, Chung YJ, Kim JH, Kook CM, González-Navajas JM, Herdman DS, Nürnberg B, Insel PA, Corr M, Mo JH, Tao A, Yasuda K, Rifkin IR, Broide DH, Sciammas R, Webster NJ, Raz E. Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses. Elife. 2020 Feb 04; 9. PMID: 32014112.
    Citations:    
  2. Lyle C, Richards S, Yasuda K, Napoleon MA, Walker J, Arinze N, Belghasem M, Vellard I, Yin W, Ravid JD, Zavaro E, Amraei R, Francis J, Phatak U, Rifkin IR, Rahimi N, Chitalia VC. c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth. Sci Rep. 2019 12 27; 9(1):20257. PMID: 31882749.
    Citations:    
  3. Rifkin IR, Bonegio RG. Editorial: Podocytes as Active Participants in Lupus Nephritis. Arthritis Rheumatol. 2017 08; 69(8):1517-1520. PMID: 28544537.
    Citations:    Fields:    
  4. Choo MK, Sano Y, Kim C, Yasuda K, Li XD, Lin X, Stenzel-Poore M, Alexopoulou L, Ghosh S, Latz E, Rifkin IR, Chen ZJ, Stewart GC, Chong H, Park JM. TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects. J Exp Med. 2017 05 01; 214(5):1297-1311. PMID: 28400473.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Das A, Heesters BA, Bialas A, O'Flynn J, Rifkin IR, Ochando J, Mittereder N, Carlesso G, Herbst R, Carroll MC. Follicular Dendritic Cell Activation by TLR Ligands Promotes Autoreactive B Cell Responses. Immunity. 2017 01 17; 46(1):106-119. PMID: 28099860.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  6. Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR. Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model. Arthritis Rheumatol. 2015 Dec; 67(12):3146-57. PMID: 26315890.
    Citations: 8     Fields:    Translation:AnimalsCells
  7. Aprahamian TR, Zhong X, Amir S, Binder CJ, Chiang LK, Al-Riyami L, Gharakhanian R, Harnett MM, Harnett W, Rifkin IR. The immunomodulatory parasitic worm product ES-62 reduces lupus-associated accelerated atherosclerosis in a mouse model. Int J Parasitol. 2015 Mar; 45(4):203-7. PMID: 25666929.
    Citations: 6     Fields:    Translation:AnimalsCells
  8. Watkins AA, Yasuda K, Wilson GE, Aprahamian T, Xie Y, Maganto-Garcia E, Shukla P, Oberlander L, Laskow B, Menn-Josephy H, Wu Y, Duffau P, Fried SK, Lichtman AH, Bonegio RG, Rifkin IR. IRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosis. J Immunol. 2015 Feb 15; 194(4):1467-79. PMID: 25595782.
    Citations: 8     Fields:    Translation:Animals
  9. Mathes AL, Rice L, Affandi AJ, DiMarzio M, Rifkin IR, Stifano G, Christmann RB, Lafyatis R. CpGB DNA activates dermal macrophages and specifically recruits inflammatory monocytes into the skin. Exp Dermatol. 2015 Feb; 24(2):133-9. PMID: 25425469.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Tan Y, Watkins AA, Freeman BB, Meyers JA, Rifkin IR, Lerner A. Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells. J Immunol. 2015 Jan 01; 194(1):101-12. PMID: 25416804.
    Citations: 5     Fields:    Translation:HumansCells
  11. Ericson JA, Duffau P, Yasuda K, Ortiz-Lopez A, Rothamel K, Rifkin IR, Monach PA. Gene expression during the generation and activation of mouse neutrophils: implication of novel functional and regulatory pathways. PLoS One. 2014; 9(10):e108553. PMID: 25279834.
    Citations: 10     Fields:    Translation:AnimalsCells
  12. Yasuda K, Watkins AA, Kochar GS, Wilson GE, Laskow B, Richez C, Bonegio RG, Rifkin IR. Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2. PLoS One. 2014; 9(7):e103478. PMID: 25076492.
    Citations: 6     Fields:    Translation:AnimalsCells
  13. Aprahamian TR, Bonegio RG, Weitzner Z, Gharakhanian R, Rifkin IR. Peroxisome proliferator-activated receptor gamma agonists in the prevention and treatment of murine systemic lupus erythematosus. Immunology. 2014 Jul; 142(3):363-73. PMID: 24456224.
    Citations: 5     Fields:    Translation:Animals
  14. Watkins AA, Bonegio RG, Rifkin IR. Evaluating the role of nucleic acid antigens in murine models of systemic lupus erythematosus. Methods Mol Biol. 2014; 1169:143-58. PMID: 24957237.
    Citations: 1     Fields:    Translation:Animals
  15. Richez C, Richards RJ, Duffau P, Weitzner Z, Andry CD, Rifkin IR, Aprahamian T. The effect of mycophenolate mofetil on disease development in the gld.apoE (-/-) mouse model of accelerated atherosclerosis and systemic lupus erythematosus. PLoS One. 2013; 8(4):e61042. PMID: 23577189.
    Citations: 6     Fields:    Translation:HumansAnimals
  16. Yasuda K, Nündel K, Watkins AA, Dhawan T, Bonegio RG, Ubellacker JM, Marshak-Rothstein A, Rifkin IR. Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2. Int Immunol. 2013 May; 25(5):295-306. PMID: 23291967.
    Citations: 16     Fields:    Translation:AnimalsCells
  17. Richez C, Blanco P, Rifkin I, Moreau JF, Schaeverbeke T. Role for toll-like receptors in autoimmune disease: the example of systemic lupus erythematosus. Joint Bone Spine. 2011 Mar; 78(2):124-30. PMID: 20961794.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  18. Richez C, Barnetche T, Miceli-Richard C, Blanco P, Moreau JF, Rifkin I, Schaeverbeke T. Role for interferon regulatory factors in autoimmunity. Joint Bone Spine. 2010 Dec; 77(6):525-31. PMID: 20863736.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  19. Farina GA, York MR, Di Marzio M, Collins CA, Meller S, Homey B, Rifkin IR, Marshak-Rothstein A, Radstake TR, Lafyatis R. Poly(I:C) drives type I IFN- and TGFß-mediated inflammation and dermal fibrosis simulating altered gene expression in systemic sclerosis. J Invest Dermatol. 2010 Nov; 130(11):2583-93. PMID: 20613770.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  20. Richez C, Yasuda K, Bonegio RG, Watkins AA, Aprahamian T, Busto P, Richards RJ, Liu CL, Cheung R, Utz PJ, Marshak-Rothstein A, Rifkin IR. IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus. J Immunol. 2010 Jan 15; 184(2):796-806. PMID: 20007534.
    Citations: 38     Fields:    Translation:Animals
  21. Yasuda K, Richez C, Uccellini MB, Richards RJ, Bonegio RG, Akira S, Monestier M, Corley RB, Viglianti GA, Marshak-Rothstein A, Rifkin IR. Requirement for DNA CpG content in TLR9-dependent dendritic cell activation induced by DNA-containing immune complexes. J Immunol. 2009 Sep 01; 183(5):3109-17. PMID: 19648272.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  22. Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009 Aug 01; 183(3):1569-76. PMID: 19587008.
    Citations: 46     Fields:    Translation:AnimalsCells
  23. Lenert P, Yasuda K, Busconi L, Nelson P, Fleenor C, Ratnabalasuriar RS, Nagy PL, Ashman RF, Rifkin IR, Marshak-Rothstein A. DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo. Arthritis Res Ther. 2009; 11(3):R79. PMID: 19476613.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  24. Richez C, Yasuda K, Watkins AA, Akira S, Lafyatis R, van Seventer JM, Rifkin IR. TLR4 ligands induce IFN-alpha production by mouse conventional dendritic cells and human monocytes after IFN-beta priming. J Immunol. 2009 Jan 15; 182(2):820-8. PMID: 19124725.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  25. Aprahamian T, Bonegio RG, Richez C, Yasuda K, Chiang LK, Sato K, Walsh K, Rifkin IR. The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol. 2009 Jan 01; 182(1):340-6. PMID: 19109165.
    Citations: 35     Fields:    Translation:Animals
  26. Yasuda K, Richez C, Maciaszek JW, Agrawal N, Akira S, Marshak-Rothstein A, Rifkin IR. Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production. J Immunol. 2007 Jun 01; 178(11):6876-85. PMID: 17513736.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  27. Marshak-Rothstein A, Rifkin IR. Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol. 2007; 25:419-41. PMID: 17378763.
    Citations: 125     Fields:    Translation:HumansAnimals
  28. Bijol V, Agrawal N, Abernethy VE, Rifkin IR, Nosé V, Rennke HG. A 57-year-old woman with recently diagnosed SLE, proteinuria, and microhematuria. Am J Kidney Dis. 2006 Dec; 48(6):1004-8. PMID: 17162159.
    Citations: 1     Fields:    Translation:Humans
  29. Aprahamian T, Bonegio R, Rizzo J, Perlman H, Lefer DJ, Rifkin IR, Walsh K. Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model. J Immunol. 2006 Sep 01; 177(5):3028-34. PMID: 16920939.
    Citations: 30     Fields:    Translation:AnimalsCells
  30. Beaudette-Zlatanova BC, Ling T, Shlomchik MJ, Marshak-Rothstein A, Rifkin IR. B cells and dendritic cells from V kappa 8 light chain transgenic mice activate MRL-lpr/gld CD4+ T cells. J Immunol. 2006 Jul 01; 177(1):45-52. PMID: 16785497.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  31. Agrawal N, Chiang LK, Rifkin IR. Lupus nephritis. Semin Nephrol. 2006 Mar; 26(2):95-104. PMID: 16530602.
    Citations: 4     Fields:    Translation:Humans
  32. Busconi L, Lau CM, Tabor AS, Uccellini MB, Ruhe Z, Akira S, Viglianti GA, Rifkin IR, Marshak-Rothstein A. DNA and RNA autoantigens as autoadjuvants. J Endotoxin Res. 2006; 12(6):379-84. PMID: 17254393.
    Citations: 6     Fields:    Translation:AnimalsCells
  33. Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, Christensen SR, Shlomchik MJ, Viglianti GA, Rifkin IR, Marshak-Rothstein A. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med. 2005 Nov 07; 202(9):1171-7. PMID: 16260486.
    Citations: 254     Fields:    Translation:AnimalsCells
  34. Rifkin IR, Leadbetter EA, Busconi L, Viglianti G, Marshak-Rothstein A. Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol Rev. 2005 Apr; 204:27-42. PMID: 15790348.
    Citations: 116     Fields:    Translation:HumansAnimals
  35. Marshak-Rothstein A, Busconi L, Rifkin IR, Viglianti GA. The stimulation of Toll-like receptors by nuclear antigens: a link between apoptosis and autoimmunity. Rheum Dis Clin North Am. 2004 Aug; 30(3):559-74, ix. PMID: 15261341.
    Citations: 3     Fields:    Translation:HumansCells
  36. Boulé MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J Exp Med. 2004 Jun 21; 199(12):1631-40. PMID: 15197227.
    Citations: 160     Fields:    Translation:AnimalsCells
  37. Aprahamian T, Rifkin I, Bonegio R, Hugel B, Freyssinet JM, Sato K, Castellot JJ, Walsh K. Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J Exp Med. 2004 Apr 19; 199(8):1121-31. PMID: 15096538.
    Citations: 53     Fields:    Translation:AnimalsCells
  38. Marshak-Rothstein A, Busconi L, Lau CM, Tabor AS, Leadbetter EA, Akira S, Krieg AM, Lipford GB, Viglianti GA, Rifkin IR. Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells. J Endotoxin Res. 2004; 10(4):247-51. PMID: 15373969.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  39. Rifkin IR, Marshak-Rothstein A. T-bet: the Toll-bridge to class-switch recombination? Nat Immunol. 2003 Jul; 4(7):650-2. PMID: 12830144.
    Citations: 6     Fields:    Translation:HumansCells
  40. Leadbetter EA, Rifkin IR, Marshak-Rothstein A. Toll-like receptors and activation of autoreactive B cells. Curr Dir Autoimmun. 2003; 6:105-22. PMID: 12408049.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  41. Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 2002 Apr 11; 416(6881):603-7. PMID: 11948342.
    Citations: 521     Fields:    Translation:AnimalsCells
  42. Rifkin IR, Leadbetter EA, Beaudette BC, Kiani C, Monestier M, Shlomchik MJ, Marshak-Rothstein A. Immune complexes present in the sera of autoimmune mice activate rheumatoid factor B cells. J Immunol. 2000 Aug 01; 165(3):1626-33. PMID: 10903773.
    Citations: 17     Fields:    Translation:AnimalsCells
  43. Zhu B, Beaudette BC, Rifkin IR, Marshak-Rothstein A. Double mutant MRL-lpr/lpr-gld/gld cells fail to trigger lpr-graft-versus-host disease in syngeneic wild-type recipient mice, but can induce wild-type B cells to make autoantibody. Eur J Immunol. 2000 Jun; 30(6):1778-84. PMID: 10898516.
    Citations: 3     Fields:    Translation:AnimalsCells
  44. Rifkin IR, Marshak-Rothstein A. Fas and Fas ligand in autoimmunity. Curr Dir Autoimmun. 1999; 1:31-55. PMID: 11791447.
    Citations: 1     Fields:    Translation:HumansCells
  45. Rifkin IR, Channavajhala PL, Kiefer HL, Carmack AJ, Landesman-Bollag E, Beaudette BC, Jersky B, Salant DJ, Ju ST, Marshak-Rothstein A, Seldin DC. Acceleration of lpr lymphoproliferative and autoimmune disease by transgenic protein kinase CK2 alpha. J Immunol. 1998 Nov 15; 161(10):5164-70. PMID: 9820486.
    Citations: 7     Fields:    Translation:AnimalsCells
  46. McHugh S, Deighton J, Rifkin I, Ewan P. Kinetics and functional implications of Th1 and Th2 cytokine production following activation of peripheral blood mononuclear cells in primary culture. Eur J Immunol. 1996 Jun; 26(6):1260-5. PMID: 8647202.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  47. McHugh SM, Rifkin IR, Deighton J, Wilson AB, Lachmann PJ, Lockwood CM, Ewan PW. The immunosuppressive drug thalidomide induces T helper cell type 2 (Th2) and concomitantly inhibits Th1 cytokine production in mitogen- and antigen-stimulated human peripheral blood mononuclear cell cultures. Clin Exp Immunol. 1995 Feb; 99(2):160-7. PMID: 7851006.
    Citations: 21     Fields:    Translation:HumansCells
  48. Lai KN, Leung JC, Rifkin I, Lockwood CM. Effect of anti-neutrophil cytoplasm autoantibodies on the intracellular calcium concentration of human neutrophils. Lab Invest. 1994 Feb; 70(2):152-62. PMID: 7908069.
    Citations: 6     Fields:    Translation:HumansCells
  49. Parsons V, Baldwin D, Moniz C, Marsden J, Ball E, Rifkin I. Successful control of hyperparathyroidism in patients on continuous ambulatory peritoneal dialysis using magnesium carbonate and calcium carbonate as phosphate binders. Nephron. 1993; 63(4):379-83. PMID: 8459870.
    Citations: 6     Fields:    Translation:Humans
  50. Keogan MT, Rifkin I, Ronda N, Lockwood CM, Brown DL. Anti-neutrophil cytoplasm antibodies (ANCA) increase neutrophil adhesion to cultured human endothelium. Adv Exp Med Biol. 1993; 336:115-9. PMID: 7905228.
    Citations: 4     Fields:    Translation:HumansCells
  51. Maheshwari HG, Rifkin I, Butler J, Norman M. Growth hormone binding protein in patients with renal failure. Acta Endocrinol (Copenh). 1992 Dec; 127(6):485-8. PMID: 1492536.
    Citations: 4     Fields:    Translation:Humans
  52. Deane C, Cowan N, Giles J, Walters H, Rifkin I, Severn A, Parsons V. Arteriovenous fistulas in renal transplants: color Doppler ultrasound observations. Urol Radiol. 1992; 13(4):211-7. PMID: 1598744.
    Citations: 2     Fields:    Translation:Humans
  53. Bateman AM, Larner AJ, McCartney SA, Rifkin IR. Rhabdomyolysis associated with lithium-induced hyperosmolal state. Nephrol Dial Transplant. 1991; 6(3):203-5. PMID: 1907725.
    Citations: 2     Fields:    Translation:HumansCells
  54. Sacks LV, Rifkin IR. Mirror image arrangement of the abdominal organs with a left-sided morphologically normal heart. Br Heart J. 1987 Nov; 58(5):534-6. PMID: 3676045.
    Citations: 2     Fields:    Translation:Humans
  55. Weiss G, O'Byrne M, Hochman JA, Goldsmith LT, Rifkin I, Steinetz BG. Secretion of progesterone and relaxin by the humancorpus luteum at midpregnancy and at term. Obstet Gynecol. 1977 Dec; 50(6):679-81. PMID: 927758.
    Citations: 5     Fields:    Translation:Humans
  56. Weiss G, Rifkin I, Atkinson LE. Induction of ovulation in premenarchial rhesus monkeys with human gonadotropins. Biol Reprod. 1976 May; 14(4):401-4. PMID: 819046.
    Citations:    Fields:    Translation:Animals
  57. Weiss G, Rifkin I. Progesterone and estrogen secretion by puerperal human ovaries. Obstet Gynecol. 1975 Nov; 46(5):557-9. PMID: 1196558.
    Citations: 2     Fields:    Translation:Humans
  58. Rifkin I, Nachtigall LE, Beckman EM. Amenorrhea following use of oral contraceptives. Am J Obstet Gynecol. 1972 Jun 01; 113(3):420-32. PMID: 4678381.
    Citations: 1     Fields:    Translation:Humans
  59. SENGER FL, WARRES HL, RIFKIN I. Penicillin in propylene glycol; a preliminary report. J Urol. 1946 Jan; 55:138-42. PMID: 21009433.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.