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Colette Cywes-Bentley, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pons S, Frapy E, Sereme Y, Gaultier C, Lebreton F, Kropec A, Danilchanka O, Schlemmer L, Schrimpf C, Allain M, Angoulvant F, Lecuyer H, Bonacorsi S, Aschard H, Sokol H, Cywes-Bentley C, Mekalanos JJ, Guillard T, Pier GB, Roux D, Skurnik D. A high-throughput sequencing approach identifies immunotherapeutic targets for bacterial meningitis in neonates. EBioMedicine. 2023 Feb; 88:104439. PMID: 36709579; PMCID: PMC9900374.
    Citations:    Fields:    Translation:AnimalsCells
  2. Waltmann A, Duncan JA, Pier GB, Cywes-Bentley C, Cohen MS, Hobbs MM. Experimental Urethral Infection with Neisseria gonorrhoeae. Curr Top Microbiol Immunol. 2022 Mar 05. PMID: 35246736; PMCID: PMC9441470.
    Citations:    Fields:    
  3. Taus NS, Cywes-Bentley C, Johnson WC, Pier GB, Fry LM, Mousel MR, Ueti MW. Immunization against a Conserved Surface Polysaccharide Stimulates Bovine Antibodies with Opsonic Killing Activity but Does Not Protect against Babesia bovis Challenge. Pathogens. 2021 Dec 09; 10(12). PMID: 34959553.
  4. Kahn SK, Cywes-Bentley C, Blodgett GP, Canaday NM, Turner-Garcia CE, Flores-Ahlschwede P, Metcalfe LL, Nevill M, Vinacur M, Sutter PJ, Meyer SC, Bordin AI, Pier GB, Cohen ND. Randomized, controlled trial comparing Rhodococcus equi and poly-N-acetyl glucosamine hyperimmune plasma to prevent R?equi pneumonia in foals. J Vet Intern Med. 2021 Nov; 35(6):2912-2919. PMID: 34738651.
    Citations: 2     Fields:    Translation:AnimalsCells
  5. Kahn SK, Cywes-Bentley C, Blodgett GP, Canaday NM, Turner-Garcia CE, Vinacur M, Cortez-Ramirez SC, Sutter PJ, Meyer SC, Bordin AI, Vlock DR, Pier GB, Cohen ND. Antibody activities in hyperimmune plasma against the Rhodococcus equi virulence -associated protein A or poly-N-acetyl glucosamine are associated with protection of foals against rhodococcal pneumonia. PLoS One. 2021; 16(8):e0250133. PMID: 34437551.
    Citations:    Fields:    Translation:AnimalsCells
  6. Cohen ND, Kahn SK, Cywes-Bentley C, Ramirez-Cortez S, Schuckert AE, Vinacur M, Bordin AI, Pier GB. Serum Antibody Activity against Poly-N-Acetyl Glucosamine (PNAG), but Not PNAG Vaccination Status, Is Associated with Protecting Newborn Foals against Intrabronchial Infection with Rhodococcus equi. Microbiol Spectr. 2021 09 03; 9(1):e0063821. PMID: 34319137; PMCID: PMC8552712.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  7. Cohen ND, Cywes-Bentley C, Kahn SM, Bordin AI, Bray JM, Wehmeyer SG, Pier GB. Vaccination of yearling horses against poly-N-acetyl glucosamine fails to protect against infection with Streptococcus equi subspecies equi. PLoS One. 2020; 15(10):e0240479. PMID: 33057397; PMCID: PMC7561144.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  8. D'Gama JD, Ma Z, Zhang H, Liu X, Fan H, Morris ERA, Cohen ND, Cywes-Bentley C, Pier GB, Waldor MK. A Conserved Streptococcal Virulence Regulator Controls the Expression of a Distinct Class of M-Like Proteins. mBio. 2019 10 22; 10(5). PMID: 31641092.
    Citations: 3     Fields:    Translation:AnimalsCells
  9. Hülsdünker J, Thomas OS, Haring E, Unger S, Gonzalo Núñez N, Tugues S, Gao Z, Duquesne S, Cywes-Bentley C, Oyardi O, Kirschnek S, Schmitt-Graeff A, Pabst O, Koenecke C, Duyster J, Apostolova P, Blaser MJ, Becher B, Pier GB, Häcker G, Zeiser R. Immunization against poly-N-acetylglucosamine reduces neutrophil activation and GVHD while sparing microbial diversity. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20700-20706. PMID: 31527267; PMCID: PMC6789638.
    Citations: 11     Fields:    Translation:AnimalsCells
  10. Folmar CN, Cywes-Bentley C, Bordin AI, Rocha JN, Bray JM, Kahn SK, Schuckert AE, Pier GB, Cohen ND. In vitro evaluation of complement deposition and opsonophagocytic killing of Rhodococcus equi mediated by poly-N-acetyl glucosamine hyperimmune plasma compared to commercial plasma products. J Vet Intern Med. 2019 May; 33(3):1493-1499. PMID: 31034109.
    Citations: 5     Fields:    Translation:AnimalsCells
  11. Ramos Y, Rocha J, Hael AL, van Gestel J, Vlamakis H, Cywes-Bentley C, Cubillos-Ruiz JR, Pier GB, Gilmore MS, Kolter R, Morales DK. PolyGlcNAc-containing exopolymers enable surface penetration by non-motile Enterococcus faecalis. PLoS Pathog. 2019 02; 15(2):e1007571. PMID: 30742693; PMCID: PMC6386517.
    Citations: 14     Fields:    Translation:HumansCells
  12. Rocha JN, Dangott LJ, Mwangi W, Alaniz RC, Bordin AI, Cywes-Bentley C, Lawhon SD, Pillai SD, Bray JM, Pier GB, Cohen ND. PNAG-specific equine IgG1 mediates significantly greater opsonization and killing of Prescottella equi (formerly Rhodococcus equi) than does IgG4/7. Vaccine. 2019 02 21; 37(9):1142-1150. PMID: 30691984.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Cywes-Bentley C, Rocha JN, Bordin AI, Vinacur M, Rehman S, Zaidi TS, Meyer M, Anthony S, Lambert M, Vlock DR, Giguère S, Cohen ND, Pier GB. Antibody to Poly-N-acetyl glucosamine provides protection against intracellular pathogens: Mechanism of action and validation in horse foals challenged with Rhodococcus equi. PLoS Pathog. 2018 07; 14(7):e1007160. PMID: 30024986; PMCID: PMC6053243.
    Citations: 14     Fields:    Translation:AnimalsCells
  14. Stevenson TC, Cywes-Bentley C, Moeller TD, Weyant KB, Putnam D, Chang YF, Jones BD, Pier GB, DeLisa MP. Immunization with outer membrane vesicles displaying conserved surface polysaccharide antigen elicits broadly antimicrobial antibodies. Proc Natl Acad Sci U S A. 2018 04 03; 115(14):E3106-E3115. PMID: 29555731; PMCID: PMC5889644.
    Citations: 30     Fields:    Translation:AnimalsCellsPHPublic Health
  15. Soliman C, Walduck AK, Yuriev E, Richards JS, Cywes-Bentley C, Pier GB, Ramsland PA. Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine. J Biol Chem. 2018 04 06; 293(14):5079-5089. PMID: 29449370.
    Citations: 11     Fields:    Translation:HumansCells
  16. Skurnik D, Cywes-Bentley C, Pier GB. The exceptionally broad-based potential of active and passive vaccination targeting the conserved microbial surface polysaccharide PNAG. Expert Rev Vaccines. 2016 08; 15(8):1041-53. PMID: 26918288.
    Citations: 17     Fields:    Translation:HumansAnimalsPHPublic Health
  17. Skurnik D, Roux D, Pons S, Guillard T, Lu X, Cywes-Bentley C, Pier GB. Extended-spectrum antibodies protective against carbapenemase-producing Enterobacteriaceae. J Antimicrob Chemother. 2016 Apr; 71(4):927-35. PMID: 26747103; PMCID: PMC4790622.
    Citations: 9     Fields:    Translation:AnimalsCells
  18. Skurnik D, Clermont O, Guillard T, Launay A, Danilchanka O, Pons S, Diancourt L, Lebreton F, Kadlec K, Roux D, Jiang D, Dion S, Aschard H, Denamur M, Cywes-Bentley C, Schwarz S, Tenaillon O, Andremont A, Picard B, Mekalanos J, Brisse S, Denamur E. Emergence of Antimicrobial-Resistant Escherichia coli of Animal Origin Spreading in Humans. Mol Biol Evol. 2016 Apr; 33(4):898-914. PMID: 26613786; PMCID: PMC5013867.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  19. Gauguet S, D'Ortona S, Ahnger-Pier K, Duan B, Surana NK, Lu R, Cywes-Bentley C, Gadjeva M, Shan Q, Priebe GP, Pier GB. Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia. Infect Immun. 2015 Oct; 83(10):4003-14. PMID: 26216419; PMCID: PMC4567647.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  20. Roux D, Cywes-Bentley C, Zhang YF, Pons S, Konkol M, Kearns DB, Little DJ, Howell PL, Skurnik D, Pier GB. Identification of Poly-N-acetylglucosamine as a Major Polysaccharide Component of the Bacillus subtilis Biofilm Matrix. J Biol Chem. 2015 Jul 31; 290(31):19261-72. PMID: 26078454.
    Citations: 39     Fields:    Translation:HumansCells
  21. Boyle-Vavra S, Li X, Alam MT, Read TD, Sieth J, Cywes-Bentley C, Dobbins G, David MZ, Kumar N, Eells SJ, Miller LG, Boxrud DJ, Chambers HF, Lynfield R, Lee JC, Daum RS. USA300 and USA500 clonal lineages of Staphylococcus aureus do not produce a capsular polysaccharide due to conserved mutations in the cap5 locus. mBio. 2015 Apr 07; 6(2). PMID: 25852165.
    Citations: 42     Fields:    Translation:HumansCells
  22. Zaidi T, Zaidi T, Cywes-Bentley C, Lu R, Priebe GP, Pier GB. Microbiota-driven immune cellular maturation is essential for antibody-mediated adaptive immunity to Staphylococcus aureus infection in the eye. Infect Immun. 2014 Aug; 82(8):3483-91. PMID: 24914214.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  23. Lu X, Skurnik D, Pozzi C, Roux D, Cywes-Bentley C, Ritchie JM, Munera D, Gening ML, Tsvetkov YE, Nifantiev NE, Waldor MK, Pier GB. A Poly-N-acetylglucosamine-Shiga toxin broad-spectrum conjugate vaccine for Shiga toxin-producing Escherichia coli. mBio. 2014 Mar 25; 5(2):e00974-14. PMID: 24667709.
    Citations: 8     Fields:    Translation:AnimalsCells
  24. Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, Deoliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier GB. Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2209-18. PMID: 23716675.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  25. Maira-Litrán T, Bentancor LV, Bozkurt-Guzel C, O'Malley JM, Cywes-Bentley C, Pier GB. Synthesis and evaluation of a conjugate vaccine composed of Staphylococcus aureus poly-N-acetyl-glucosamine and clumping factor A. PLoS One. 2012; 7(9):e43813. PMID: 22970144.
    Citations: 15     Fields:    Translation:AnimalsCells
  26. Yoong P, Cywes-Bentley C, Pier GB. Poly-N-acetylglucosamine expression by wild-type Yersinia pestis is maximal at mammalian, not flea, temperatures. mBio. 2012; 3(4):e00217-12. PMID: 22893384.
    Citations: 8     Fields:    Translation:AnimalsCells
  27. Skurnik D, Davis MR, Benedetti D, Moravec KL, Cywes-Bentley C, Roux D, Traficante DC, Walsh RL, Maira-Litràn T, Cassidy SK, Hermos CR, Martin TR, Thakkallapalli EL, Vargas SO, McAdam AJ, Lieberman TD, Kishony R, Lipuma JJ, Pier GB, Goldberg JB, Priebe GP. Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection. J Infect Dis. 2012 Jun; 205(11):1709-18. PMID: 22448004; PMCID: PMC3415848.
    Citations: 20     Fields:    Translation:AnimalsCells
  28. Risley AL, Loughman A, Cywes-Bentley C, Foster TJ, Lee JC. Capsular polysaccharide masks clumping factor A-mediated adherence of Staphylococcus aureus to fibrinogen and platelets. J Infect Dis. 2007 Sep 15; 196(6):919-27. PMID: 17703424.
    Citations: 17     Fields:    Translation:HumansCells
  29. Zaleski KJ, Kolodka T, Cywes-Bentley C, McLoughlin RM, Delaney ML, Charlton BT, Johnson W, Tzianabos AO. Hyaluronic acid binding peptides prevent experimental staphylococcal wound infection. Antimicrob Agents Chemother. 2006 Nov; 50(11):3856-60. PMID: 17065624; PMCID: PMC1635204.
    Citations: 9     Fields:    Translation:AnimalsCells
  30. Sitkiewicz I, Nagiec MJ, Sumby P, Butler SD, Cywes-Bentley C, Musser JM. Emergence of a bacterial clone with enhanced virulence by acquisition of a phage encoding a secreted phospholipase A2. Proc Natl Acad Sci U S A. 2006 Oct 24; 103(43):16009-14. PMID: 17043230; PMCID: PMC1635118.
    Citations: 30     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  31. Levy O, Zarember KA, Roy RM, Cywes C, Godowski PJ, Wessels MR. Selective impairment of TLR-mediated innate immunity in human newborns: neonatal blood plasma reduces monocyte TNF-alpha induction by bacterial lipopeptides, lipopolysaccharide, and imiquimod, but preserves the response to R-848. J Immunol. 2004 Oct 01; 173(7):4627-34. PMID: 15383597.
    Citations: 139     Fields:    Translation:HumansCells
  32. Levy O, Jean-Jacques RM, Cywes C, Sisson RB, Zarember KA, Godowski PJ, Christianson JL, Guttormsen HK, Carroll MC, Nicholson-Weller A, Wessels MR. Critical role of the complement system in group B streptococcus-induced tumor necrosis factor alpha release. Infect Immun. 2003 Nov; 71(11):6344-53. PMID: 14573654.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  33. Sierig G, Cywes C, Wessels MR, Ashbaugh CD. Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorly encapsulated group a streptococci. Infect Immun. 2003 Jan; 71(1):446-55. PMID: 12496195.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  34. Bricker AL, Cywes C, Ashbaugh CD, Wessels MR. NAD+-glycohydrolase acts as an intracellular toxin to enhance the extracellular survival of group A streptococci. Mol Microbiol. 2002 Apr; 44(1):257-69. PMID: 11967084.
    Citations: 68     Fields:    Translation:HumansCells
  35. Cywes C, Wessels MR. Group A Streptococcus tissue invasion by CD44-mediated cell signalling. Nature. 2001 Dec 06; 414(6864):648-52. PMID: 11740562.
    Citations: 74     Fields:    Translation:HumansCells
  36. Gryllos I, Cywes C, Shearer MH, Cary M, Kennedy RC, Wessels MR. Regulation of capsule gene expression by group A Streptococcus during pharyngeal colonization and invasive infection. Mol Microbiol. 2001 Oct; 42(1):61-74. PMID: 11679067.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  37. Cywes C, Stamenkovic I, Wessels MR. CD44 as a receptor for colonization of the pharynx by group A Streptococcus. J Clin Invest. 2000 Oct; 106(8):995-1002. PMID: 11032859; PMCID: PMC314343.
    Citations: 44     Fields:    Translation:AnimalsCells
  38. Tzianabos AO, Russell PR, Onderdonk AB, Gibson FC, Cywes C, Chan M, Finberg RW, Kasper DL. IL-2 mediates protection against abscess formation in an experimental model of sepsis. J Immunol. 1999 Jul 15; 163(2):893-7. PMID: 10395684.
    Citations: 21     Fields:    Translation:AnimalsCells
  39. Schrager HM, Albertí S, Cywes C, Dougherty GJ, Wessels MR. Hyaluronic acid capsule modulates M protein-mediated adherence and acts as a ligand for attachment of group A Streptococcus to CD44 on human keratinocytes. J Clin Invest. 1998 Apr 15; 101(8):1708-16. PMID: 9541502; PMCID: PMC508753.
    Citations: 60     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.