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Gengyang Yuan, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yuan G, Dhaynaut M, Guehl NJ, Neelamegam R, Moon SH, Qu X, Poutiainen P, Afshar S, Fakhri GE, Normandin MD, Brownell AL. PET imaging studies to investigate functional expression of mGluR2 using [11C]mG2P001. J Cereb Blood Flow Metab. 2022 Sep 28; 271678X221130387. PMID: 36172629.
    Citations:    Fields:    
  2. Yuan G, Dhaynaut M, Guehl NJ, Afshar S, Huynh D, Moon SH, Iyengar SM, Jain MK, Pickett JE, Kang HJ, Ondrechen MJ, El Fakhri G, Normandin MD, Brownell AL. Design, Synthesis, and Characterization of [18F]mG2P026 as a High-Contrast PET Imaging Ligand for Metabotropic Glutamate Receptor 2. J Med Chem. 2022 07 28; 65(14):9939-9954. PMID: 35802702; PMCID: PMC9434700.
    Citations:    Fields:    Translation:Animals
  3. Bai P, Liu Y, Xu Y, Striar R, Yuan G, Afshar S, Langan AG, Rattray AK, Wang C. Synthesis and characterization of a new Positron emission tomography probe for orexin 2 receptors neuroimaging. Bioorg Chem. 2022 06; 123:105779. PMID: 35397430; PMCID: PMC9050936.
    Citations:    Fields:    Translation:Animals
  4. Yuan G, Dhaynaut M, Lan Y, Guehl NJ, Huynh D, Iyengar SM, Afshar S, Jain MK, Pickett JE, Kang HJ, Wang H, Moon SH, Ondrechen MJ, Wang C, Shoup TM, El Fakhri G, Normandin MD, Brownell AL. Synthesis and Characterization of 5-(2-Fluoro-4-[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2. J Med Chem. 2022 02 10; 65(3):2593-2609. PMID: 35089713; PMCID: PMC9434702.
    Citations:    Fields:    Translation:Animals
  5. Afshar S, Lule S, Yuan G, Qu X, Pan C, Whalen M, Brownell AL, Mody M. Longitudinal PET studies of mGluR5 in FXS using an FMR1 knockout mouse model. Transl Neurosci. 2022 Jan 01; 13(1):80-92. PMID: 35582646; PMCID: PMC9055256.
  6. Bai P, Lan Y, Patnaik D, Wang H, Liu Y, Chen Z, Yuan G, Afshar S, Striar R, Zagaroli JS, Tocci DR, Langan AG, Haggarty SJ, Wang C. Design, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins. J Med Chem. 2021 10 14; 64(19):14745-14756. PMID: 34549949.
    Citations:    Fields:    Translation:AnimalsCells
  7. Bai P, Lan Y, Wang H, Liu Y, Striar R, Yuan G, Afshar S, Zagaroli JS, Tocci DR, Langan AG, Wang C. Synthesis and Characterization of a Positron Emission Tomography Imaging Probe Selectively Targeting the Second Bromodomain of Bromodomain Protein BRD4. Bioconjug Chem. 2021 08 18; 32(8):1711-1718. PMID: 34139120.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Yuan G, Guehl NJ, Zheng B, Qu X, Moon SH, Dhaynaut M, Shoup TM, Afshar S, Kang HJ, Zhang Z, El Fakhri G, Normandin MD, Brownell AL. Synthesis and Characterization of [18F]JNJ-46356479 as the First 18F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2. Mol Imaging Biol. 2021 08; 23(4):527-536. PMID: 33559035; PMCID: PMC8277681.
    Citations: 1     Fields:    Translation:Animals
  9. Xu Y, Xu Y, Blevins H, Lan Y, Liu Y, Yuan G, Striar R, Zagaroli JS, Tocci DR, Langan AG, Zhang C, Zhang S, Wang C. Discovery of carbon-11 labeled sulfonamide derivative: A PET tracer for imaging brain NLRP3 inflammasome. Bioorg Med Chem Lett. 2021 02 15; 34:127777. PMID: 33418063; PMCID: PMC8785901.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. Yuan G, Qu X, Zheng B, Neelamegam R, Afshar S, Iyengar S, Pan C, Wang J, Kang HJ, Ondrechen MJ, Poutiainen P, El Fakhri G, Zhang Z, Brownell AL. Design, Synthesis, and Characterization of Benzimidazole Derivatives as Positron Emission Tomography Imaging Ligands for Metabotropic Glutamate Receptor 2. J Med Chem. 2020 10 22; 63(20):12060-12072. PMID: 32981322.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Yuan G, Shoup TM, Moon SH, Brownell AL. A concise method for fully automated radiosyntheses of [18F]JNJ-46356479 and [18F]FITM via Cu-mediated 18F-fluorination of organoboranes. RSC Adv. 2020 Jul 02; 10(42):25223-25227. PMID: 33014351; PMCID: PMC7497470.
    Citations: 2     
  12. Chen Z, Wang X, Yang X, Xu Y, Yang Y, Wang H, Li T, Bai P, Yuan G, Chen H, Yang J, Fiedler SA, Striar R, Bernales DR, Koegel RE, Cao Q, Ran C, Xiang B, Li H, Wang C. Imaging assisted evaluation of antitumor efficacy of a new histone deacetylase inhibitor in the castration-resistant prostate cancer. Eur J Nucl Med Mol Imaging. 2021 01; 48(1):53-66. PMID: 32592040.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Wang J, Qu X, Shoup TM, Yuan G, Afshar S, Pan C, Zhu A, Choi JK, Kang HJ, Poutiainen P, El Fakhri G, Zhang Z, Brownell AL. Synthesis and Characterization of Fluorine-18-Labeled N-(4-Chloro-3-((fluoromethyl-d2)thio)phenyl)picolinamide for Imaging of mGluR4 in Brain. J Med Chem. 2020 03 26; 63(6):3381-3389. PMID: 32081008.
    Citations:    Fields:    Translation:AnimalsCells
  14. Lan Y, Bai P, Chen Z, Neelamegam R, Placzek MS, Wang H, Fiedler SA, Yang J, Yuan G, Qu X, Schmidt HR, Song J, Normandin MD, Ran C, Wang C. Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET). Acta Pharm Sin B. 2019 Nov; 9(6):1204-1215. PMID: 31867166; PMCID: PMC6900558.
    Citations: 7     
  15. Cheng R, Mori W, Ma L, Alhouayek M, Hatori A, Zhang Y, Ogasawara D, Yuan G, Chen Z, Zhang X, Shi H, Yamasaki T, Xie L, Kumata K, Fujinaga M, Nagai Y, Minamimoto T, Svensson M, Wang L, Du Y, Ondrechen MJ, Vasdev N, Cravatt BF, Fowler C, Zhang MR, Liang SH. In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies. J Med Chem. 2018 03 22; 61(6):2278-2291. PMID: 29481079; PMCID: PMC5966020.
    Citations: 13     Fields:    Translation:Animals
  16. Ranasinghe N, Mongeau E, Yuan G, Minden Z, Waldron S, Patrick C, Fouad F, Kappera S, Jones GB. Flow and Microwave Induced Pellizzari Reactions: Synthesis of Heterocyclic Analogues of the Benzoxazepine Antipsychotic Agents Loxapine and JL-13. Advances in Chemistry. 2017. View Publication.
  17. Yuan G, Jankins TC, Patrick CG, Philbrook P, Sears O, Hatfield S, Sitkovsky M, Vasdev N, Liang SH, Ondrechen MJ, Pollastri MP, Jones GB. Fluorinated Adenosine A2A Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics. Int J Med Chem. 2017; 2017:4852537. PMID: 29201461; PMCID: PMC5671725.
    Citations: 4     
  18. Mongeau E, Yuan G, Minden Z, Waldron S, Booth R, Felsing D, Ondrechen MJ, Jones GB. Homology Modeling Inspired Synthesis of 5-HT2A Receptor Inhibitors: A Diazepine Analogue of the Atypical Antipsychotic JL13. Cent Nerv Syst Agents Med Chem. 2017; 17(3):239-244. PMID: 28462720.
    Citations:    Fields:    Translation:HumansCells
  19. Yuan G, Wang F, Stephenson NA, Wang L, Rotstein BH, Vasdev N, Tang P, Liang SH. Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C-H activation. Chem Commun (Camb). 2016 12 20; 53(1):126-129. PMID: 27917423; PMCID: PMC5179041.
    Citations: 1     Fields:    Translation:Cells
  20. Yuan G, Jones GB, Vasdev N, Liang SH. Radiosynthesis and preliminary PET evaluation of (18)F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile for imaging AMPA receptors. Bioorg Med Chem Lett. 2016 10 01; 26(19):4857-4860. PMID: 27546294; PMCID: PMC5018461.
    Citations: 5     Fields:    Translation:Animals
  21. Yuan G, Gedeon NG, Jankins TC, Jones GB. Novel approaches for targeting the adenosine A2A receptor. Expert Opin Drug Discov. 2015 Jan; 10(1):63-80. PMID: 25311639.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  22. Yuan G, Jones GB. Towards next generation adenosine A(2A) receptor antagonists. Curr Med Chem. 2014; 21(34):3918-35. PMID: 25174927.
    Citations: 3     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.