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Viorel Simion, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Simion V, Zhou H, Pierce JB, Yang D, Haemmig S, Tesmenitsky Y, Sukhova G, Stone PH, Libby P, Feinberg MW. LncRNA VINAS regulates atherosclerosis by modulating NF-?B and MAPK signaling. JCI Insight. 2020 Nov 05; 5(21). PMID: 33021969.
    Citations:    Fields:    
  2. Simion V, Henriet E, Juric V, Aquino R, Loussouarn C, Laurent Y, Martin F, Midoux P, Garcion E, Pichon C, Baril P. Intracellular trafficking and functional monitoring of miRNA delivery in glioblastoma using lipopolyplexes and the miRNA-ON RILES reporter system. J Control Release. 2020 Nov 10; 327:429-443. PMID: 32853728.
    Citations:    Fields:    
  3. Haemmig S, Yang D, Sun X, Das D, Ghaffari S, Molinaro R, Chen L, Deng Y, Freeman D, Moullan N, Tesmenitsky Y, Wara AKMK, Simion V, Shvartz E, Lee JF, Yang T, Sukova G, Marto JA, Stone PH, Lee WL, Auwerx J, Libby P, Feinberg MW. Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence. Sci Transl Med. 2020 02 19; 12(531). PMID: 32075942.
    Citations: 2     Fields:    
  4. Constantinescu CA, Fuior EV, Rebleanu D, Deleanu M, Simion V, Voicu G, Escriou V, Manduteanu I, Simionescu M, Calin M. Targeted Transfection Using PEGylated Cationic Liposomes Directed Towards P-Selectin Increases siRNA Delivery into Activated Endothelial Cells. Pharmaceutics. 2019 Jan 21; 11(1). PMID: 30669699.
    Citations: 4     
  5. Haemmig S, Simion V, Feinberg MW. Long Non-Coding RNAs in Vascular Inflammation. Front Cardiovasc Med. 2018; 5:22. PMID: 29662883.
    Citations: 4     
  6. Simion V, Haemmig S, Feinberg MW. LncRNAs in vascular biology and disease. Vascul Pharmacol. 2019 03; 114:145-156. PMID: 29425892.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  7. Haemmig S, Simion V, Yang D, Deng Y, Feinberg MW. Long noncoding RNAs in cardiovascular disease, diagnosis, and therapy. Curr Opin Cardiol. 2017 11; 32(6):776-783. PMID: 28786864.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  8. Simion V, Sobilo J, Clemoncon R, Natkunarajah S, Ezzine S, Abdallah F, Lerondel S, Pichon C, Baril P. Positive radionuclide imaging of miRNA expression using RILES and the human sodium iodide symporter as reporter gene is feasible and supports a protective role of miRNA-23a in response to muscular atrophy. PLoS One. 2017; 12(5):e0177492. PMID: 28493972.
    Citations:    Fields:    Translation:HumansAnimalsCells
  9. Simion V, Nadim WD, Benedetti H, Pichon C, Morisset-Lopez S, Baril P. Pharmacomodulation of microRNA Expression in Neurocognitive Diseases: Obstacles and Future Opportunities. Curr Neuropharmacol. 2017; 15(2):276-290. PMID: 27397479.
    Citations: 2     Fields:    Translation:HumansAnimals
  10. Nadim WD, Simion V, Benedetti H, Pichon C, Baril P, Morisset-Lopez S. MicroRNAs in Neurocognitive Dysfunctions: New Molecular Targets for Pharmacological Treatments? Curr Neuropharmacol. 2017; 15(2):260-275. PMID: 27396304.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  11. Simion V, Constantinescu CA, Stan D, Deleanu M, Tucureanu MM, Butoi E, Manduteanu I, Simionescu M, Calin M. P-Selectin Targeted Dexamethasone-Loaded Lipid Nanoemulsions: A Novel Therapy to Reduce Vascular Inflammation. Mediators Inflamm. 2016; 2016:1625149. PMID: 27703301.
    Citations: 4     Fields:    Translation:Animals
  12. Simion V, Stan D, Constantinescu CA, Deleanu M, Dragan E, Tucureanu MM, Gan AM, Butoi E, Constantin A, Manduteanu I, Simionescu M, Calin M. Conjugation of curcumin-loaded lipid nanoemulsions with cell-penetrating peptides increases their cellular uptake and enhances the anti-inflammatory effects in endothelial cells. J Pharm Pharmacol. 2016 Feb; 68(2):195-207. PMID: 26748549.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  13. Uritu CM, Varganici CD, Ursu L, Coroaba A, Nicolescu A, Dascalu AI, Peptanariu D, Stan D, Constantinescu CA, Simion V, Calin M, Maier SS, Pinteala M, Barboiu M. Hybrid fullerene conjugates as vectors for DNA cell-delivery. J Mater Chem B. 2015 Mar 28; 3(12):2433-2446. PMID: 32262120.
    Citations: 3     Fields:    
  14. Calin M, Stan D, Schlesinger M, Simion V, Deleanu M, Constantinescu CA, Gan AM, Pirvulescu MM, Butoi E, Manduteanu I, Bota M, Enachescu M, Borsig L, Bendas G, Simionescu M. VCAM-1 directed target-sensitive liposomes carrying CCR2 antagonists bind to activated endothelium and reduce adhesion and transmigration of monocytes. Eur J Pharm Biopharm. 2015 Jan; 89:18-29. PMID: 25438248.
    Citations: 6     Fields:    Translation:HumansCells
  15. Gan AM, Butoi E, Manea A, Pirvulescu MM, Stan D, Simion V, Calin M, Simionescu M, Manduteanu I. Functional analysis of the fractalkine gene promoter in human aortic smooth muscle cells exposed to proinflammatory conditions. FEBS J. 2014 Sep; 281(17):3869-81. PMID: 25040843.
    Citations: 2     Fields:    Translation:HumansCells
  16. Pirvulescu MM, Gan AM, Stan D, Simion V, Calin M, Butoi E, Manduteanu I. Subendothelial resistin enhances monocyte transmigration in a co-culture of human endothelial and smooth muscle cells by mechanisms involving fractalkine, MCP-1 and activation of TLR4 and Gi/o proteins signaling. Int J Biochem Cell Biol. 2014 May; 50:29-37. PMID: 24508784.
    Citations: 12     Fields:    Translation:HumansCells
  17. Gan AM, Pirvulescu MM, Stan D, Simion V, Calin M, Manduteanu I, Butoi E. Monocytes and smooth muscle cells cross-talk activates STAT3 and induces resistin and reactive oxygen species production [corrected]. J Cell Biochem. 2013 Oct; 114(10):2273-83. PMID: 23606279.
    Citations: 6     Fields:    Translation:HumansCells
  18. Calin M, Stan D, Simion V. Stem cell regenerative potential combined with nanotechnology and tissue engineering for myocardial regeneration. Curr Stem Cell Res Ther. 2013 Jul; 8(4):292-303. PMID: 23547964.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  19. Gan AM, Butoi ED, Manea A, Simion V, Stan D, Parvulescu MM, Calin M, Manduteanu I, Simionescu M. Inflammatory effects of resistin on human smooth muscle cells: up-regulation of fractalkine and its receptor, CX3CR1 expression by TLR4 and Gi-protein pathways. Cell Tissue Res. 2013 Jan; 351(1):161-74. PMID: 23086480.
    Citations: 13     Fields:    Translation:HumansCells
  20. Pirvulescu M, Manduteanu I, Gan AM, Stan D, Simion V, Butoi E, Calin M, Simionescu M. A novel pro-inflammatory mechanism of action of resistin in human endothelial cells: up-regulation of SOCS3 expression through STAT3 activation. Biochem Biophys Res Commun. 2012 Jun 01; 422(2):321-6. PMID: 22575502.
    Citations: 6     Fields:    Translation:HumansCells
  21. Pirvulescu MM, Gan AM, Stan D, Simion V, Calin M, Butoi E, Tirgoviste CI, Manduteanu I. Curcumin and a Morus alba extract reduce pro-inflammatory effects of resistin in human endothelial cells. Phytother Res. 2011 Dec; 25(12):1737-42. PMID: 21442673.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  22. Stan D, Calin M, Manduteanu I, Pirvulescu M, Gan AM, Butoi ED, Simion V, Simionescu M. High glucose induces enhanced expression of resistin in human U937 monocyte-like cell line by MAPK- and NF-kB-dependent mechanisms; the modulating effect of insulin. Cell Tissue Res. 2011 Feb; 343(2):379-87. PMID: 21153665.
    Citations: 10     Fields:    Translation:HumansCells
  23. Manduteanu I, Pirvulescu M, Gan AM, Stan D, Simion V, Dragomir E, Calin M, Manea A, Simionescu M. Similar effects of resistin and high glucose on P-selectin and fractalkine expression and monocyte adhesion in human endothelial cells. Biochem Biophys Res Commun. 2010 Jan 15; 391(3):1443-8. PMID: 20034466.
    Citations: 14     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.