Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

HMS faculty, help us improve the algorithms in Profiles by uploading your CV!

Alexander Matthew Holtz, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F31NS081806 (HOLTZ, ALEXANDER MATTHEW) Jan 1, 2014 - Dec 31, 2014
    PTCH2-Mediated Antagonism of Hedgehog Signaling During Vertebrate Neural Patterni
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Holtz AM, Harrington AW, McNamara ER, Kielian A, Soul JS, Martinez-Ojeda M, Levy PT. Expanding the phenotypic spectrum of Mabry Syndrome with novel PIGO gene variants associated with hyperphosphatasia, intractable epilepsy, and complex gastrointestinal and urogenital malformations. Eur J Med Genet. 2020 Apr; 63(4):103802. PMID: 31698102.
    Citations: 1     Fields:    Translation:Humans
  2. Cardenas V, DiPaola F, Adams SD, Holtz AM, Ahmad A. Acute Liver Failure Secondary to Neuroblastoma Amplified Sequence Deficiency. J Pediatr. 2017 07; 186:179-182. PMID: 28410752.
    Citations: 3     Fields:    Translation:Humans
  3. Holtz AM, Griffiths SC, Davis SJ, Bishop B, Siebold C, Allen BL. Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function. J Cell Biol. 2015 Jun 08; 209(5):739-57. PMID: 26056142; PMCID: PMC4460154.
    Citations: 18     Fields:    Translation:AnimalsCells
  4. Song JY, Holtz AM, Pinskey JM, Allen BL. Distinct structural requirements for CDON and BOC in the promotion of Hedgehog signaling. Dev Biol. 2015 Jun 15; 402(2):239-52. PMID: 25848697; PMCID: PMC4450140.
    Citations: 8     Fields:    Translation:AnimalsCells
  5. Mathew E, Zhang Y, Holtz AM, Kane KT, Song JY, Allen BL, Pasca di Magliano M. Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling. Cell Rep. 2014 Oct 23; 9(2):484-94. PMID: 25310976.
    Citations: 49     Fields:    Translation:AnimalsCells
  6. Camp D, Haitian He B, Li S, Althaus IW, Holtz AM, Allen BL, Charron F, van Meyel DJ. Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligand. Development. 2014 Oct; 141(20):3879-88. PMID: 25231763.
    Citations: 3     Fields:    Translation:AnimalsCells
  7. Mathew E, Collins MA, Fernandez-Barrena MG, Holtz AM, Yan W, Hogan JO, Tata Z, Allen BL, Fernandez-Zapico ME, di Magliano MP. The transcription factor GLI1 modulates the inflammatory response during pancreatic tissue remodeling. J Biol Chem. 2014 Oct 03; 289(40):27727-43. PMID: 25104358.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  8. Holtz AM, Peterson KA, Nishi Y, Morin S, Song JY, Charron F, McMahon AP, Allen BL. Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development. 2013 Aug; 140(16):3423-34. PMID: 23900540.
    Citations: 42     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Holtz's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (74)
Co-Authors (6)
Similar People (60)
Same Department 
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.