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Johan K. E. Spetz, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Langen B, Vorontsov E, Spetz J, Swanpalmer J, Sihlbom C, Helou K, Forssell-Aronsson E. Age and sex effects across the blood proteome after ionizing radiation exposure can bias biomarker screening and risk assessment. Sci Rep. 2022 Apr 29; 12(1):7000. PMID: 35487913.
    Citations:    Fields:    Translation:AnimalsPHPublic Health
  2. Larsson M, Rudqvist NP, Spetz J, Parris TZ, Langen B, Helou K, Forssell-Aronsson E. Age-related long-term response in rat thyroid tissue and plasma after internal low dose exposure to 131I. Sci Rep. 2022 02 08; 12(1):2107. PMID: 35136135.
    Citations:    Fields:    Translation:Animals
  3. Romiani A, Spetz J, Shubbar E, Lind DE, Hallberg B, Palmer RH, Forssell-Aronsson E. Neuroblastoma xenograft models demonstrate the therapeutic potential of 177Lu-octreotate. BMC Cancer. 2021 Aug 25; 21(1):950. PMID: 34433438.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  4. Inde Z, Croker BA, Yapp C, Joshi GN, Spetz J, Fraser C, Qin X, Xu L, Deskin B, Ghelfi E, Webb G, Carlin AF, Zhu YP, Leibel SL, Garretson AF, Clark AE, Duran JM, Pretorius V, Crotty-Alexander LE, Li C, Lee JC, Sodhi C, Hackam DJ, Sun X, Hata AN, Kobzik L, Miller J, Park JA, Brownfield D, Jia H, Sarosiek KA. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity. Sci Adv. 2021 08; 7(34). PMID: 34407940.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  5. Daniels VW, Zoeller JJ, van Gastel N, McQueeney KE, Parvin S, Potter DS, Fell GG, Ferreira VG, Yilma B, Gupta R, Spetz J, Bhola PD, Endress JE, Harris IS, Carrilho E, Sarosiek KA, Scadden DT, Brugge JS, Letai A. Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics. Sci Signal. 2021 06 08; 14(686). PMID: 34103421.
    Citations: 1     Fields:    Translation:HumansCells
  6. Larsson M, Rudqvist N, Spetz J, Shubbar E, Parris TZ, Langen B, Helou K, Forssell-Aronsson E. Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure. PLoS One. 2020; 15(12):e0244098. PMID: 33382739.
    Citations: 3     Fields:    Translation:AnimalsCells
  7. Andersson CK, Elvborn M, Spetz JKE, Langen B, Forssell-Aronsson EB. Biodistribution of 131I in mice is influenced by circadian variations. Sci Rep. 2020 09 23; 10(1):15541. PMID: 32968085.
    Citations:    Fields:    Translation:Animals
  8. Inde Z, Yapp C, Joshi GN, Spetz J, Fraser C, Deskin B, Ghelfi E, Sodhi C, Hackam D, Kobzik L, Croker B, Brownfield D, Jia H, Sarosiek KA. Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity. bioRxiv. 2020 Sep 13. PMID: 32935109.
    Citations:    
  9. Sandblom V, Spetz J, Shubbar E, Montelius M, Ståhl I, Swanpalmer J, Nilsson O, Forssell-Aronsson E. Increased therapeutic effect on medullary thyroid cancer using a combination of radiation and tyrosine kinase inhibitors. PLoS One. 2020; 15(5):e0233720. PMID: 32459817.
    Citations:    Fields:    Translation:HumansAnimals
  10. Spetz J, Galluzzi L. Preface: Life through death-Key role of cellular suicide for colonial and organismal homeostasis. Int Rev Cell Mol Biol. 2020; 351:xi-xv. PMID: 32247583.
    Citations:    Fields:    Translation:HumansAnimals
  11. Spetz J, Galluzzi L. Preface: Life through death-Key role of cellular suicide for colonial and organismal homeostasis. Int Rev Cell Mol Biol. 2020; 352:xi-xv. PMID: 32334819.
    Citations:    Fields:    Translation:HumansAnimals
  12. Spetz J, Galluzzi L. Preface: Life through death-Key role of cellular suicide for colonial and organismal homeostasis. Int Rev Cell Mol Biol. 2020; 353:ix-xiii. PMID: 32381180.
    Citations:    Fields:    Translation:HumansAnimals
  13. Sandblom V, Spetz J, Shubbar E, Montelius M, Ståhl I, Swanpalmer J, Nilsson O, Forssell-Aronsson E. Gemcitabine potentiates the anti-tumour effect of radiation on medullary thyroid cancer. PLoS One. 2019; 14(11):e0225260. PMID: 31725814.
    Citations: 4     Fields:    Translation:HumansAnimals
  14. Spetz J, Langen B, Rudqvist NP, Parris TZ, Shubbar E, Dalmo J, Wängberg B, Nilsson O, Helou K, Forssell-Aronsson E. Transcriptional effects of 177Lu-octreotate therapy using a priming treatment schedule on GOT1 tumor in nude mice. EJNMMI Res. 2019 Mar 20; 9(1):28. PMID: 30895393.
    Citations: 2     
  15. Montelius M, Jalnefjord O, Spetz J, Nilsson O, Forssell-Aronsson E, Ljungberg M. Multiparametric MR for non-invasive evaluation of tumour tissue histological characteristics after radionuclide therapy. NMR Biomed. 2019 03; 32(3):e4060. PMID: 30693592.
    Citations: 5     Fields:    Translation:Animals
  16. Spetz J, Presser AG, Sarosiek KA. T Cells and Regulated Cell Death: Kill or Be Killed. Int Rev Cell Mol Biol. 2019; 342:27-71. PMID: 30635093.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  17. Langen B, Rudqvist N, Spetz J, Helou K, Forssell-Aronsson E. Deconvolution of expression microarray data reveals 131I-induced responses otherwise undetected in thyroid tissue. PLoS One. 2018; 13(7):e0197911. PMID: 30001320.
    Citations: 3     Fields:    Translation:AnimalsCells
  18. Spetz J, Moslehi J, Sarosiek K. Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment. Curr Treat Options Cardiovasc Med. 2018 Mar 20; 20(4):31. PMID: 29556748.
    Citations: 22     
  19. Spetz J, Rudqvist N, Langen B, Parris TZ, Dalmo J, Schüler E, Wängberg B, Nilsson O, Helou K, Forssell-Aronsson E. Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu[Lu]-octreotate therapy. Nucl Med Biol. 2018 05; 60:11-18. PMID: 29502008.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Montelius M, Spetz J, Jalnefjord O, Berger E, Nilsson O, Ljungberg M, Forssell-Aronsson E. Identification of Potential MR-Derived Biomarkers for Tumor Tissue Response to 177Lu-Octreotate Therapy in an Animal Model of Small Intestine Neuroendocrine Tumor. Transl Oncol. 2018 Apr; 11(2):193-204. PMID: 29331677.
    Citations: 6     
  21. Spetz J, Langen B, Rudqvist N, Parris TZ, Helou K, Nilsson O, Forssell-Aronsson E. Hedgehog inhibitor sonidegib potentiates 177Lu-octreotate therapy of GOT1 human small intestine neuroendocrine tumors in nude mice. BMC Cancer. 2017 Aug 08; 17(1):528. PMID: 28789624.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  22. Rudqvist N, Spetz J, Schüler E, Parris TZ, Langen B, Helou K, Forssell-Aronsson E. Transcriptional response to 131I exposure of rat thyroid gland. PLoS One. 2017; 12(2):e0171797. PMID: 28222107.
    Citations: 7     Fields:    Translation:AnimalsCells
  23. Dalmo J, Spetz J, Montelius M, Langen B, Arvidsson Y, Johansson H, Parris TZ, Helou K, Wängberg B, Nilsson O, Ljungberg M, Forssell-Aronsson E. Priming increases the anti-tumor effect and therapeutic window of 177Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1. EJNMMI Res. 2017 Dec; 7(1):6. PMID: 28097640.
    Citations: 12     
  24. Langen B, Rudqvist N, Spetz J, Swanpalmer J, Helou K, Forssell-Aronsson E. Non-targeted transcriptomic effects upon thyroid irradiation: similarity between in-field and out-of-field responses varies with tissue type. Sci Rep. 2016 10 25; 6:30738. PMID: 27779251.
    Citations: 4     Fields:    Translation:Animals
  25. Rudqvist N, Spetz J, Schüler E, Langen B, Parris TZ, Helou K, Forssell-Aronsson E. Gene expression signature in mouse thyroid tissue after (131)I and (211)At exposure. EJNMMI Res. 2015 Dec; 5(1):59. PMID: 26492889.
    Citations: 10     
  26. Rudqvist N, Spetz J, Schüler E, Parris TZ, Langen B, Helou K, Forssell-Aronsson E. Transcriptional Response in Mouse Thyroid Tissue after 211At Administration: Effects of Absorbed Dose, Initial Dose-Rate and Time after Administration. PLoS One. 2015; 10(7):e0131686. PMID: 26177204.
    Citations: 7     Fields:    Translation:Animals
  27. Langen B, Rudqvist N, Parris TZ, Schüler E, Spetz J, Helou K, Forssell-Aronsson E. Transcriptional response in normal mouse tissues after i.v. (211)At administration - response related to absorbed dose, dose rate, and time. EJNMMI Res. 2015; 5:1. PMID: 25853007.
    Citations: 10     
  28. Schüler E, Rudqvist N, Parris TZ, Langen B, Spetz J, Helou K, Forssell-Aronsson E. Time- and dose rate-related effects of internal (177)Lu exposure on gene expression in mouse kidney tissue. Nucl Med Biol. 2014 Nov-Dec; 41(10):825-32. PMID: 25156037.
    Citations: 15     Fields:    Translation:HumansAnimals
  29. Spetz J, Rudqvist N, Forssell-Aronsson E. Biodistribution and dosimetry of free 211At, 125I- and 131I- in rats. Cancer Biother Radiopharm. 2013 Nov; 28(9):657-64. PMID: 23789969.
    Citations: 29     Fields:    Translation:Animals
  30. Forssell-Aronsson E, Spetz J, Ahlman H. Radionuclide therapy via SSTR: future aspects from experimental animal studies. Neuroendocrinology. 2013; 97(1):86-98. PMID: 22572526.
    Citations: 13     Fields:    Translation:Animals
  31. Dalmo J, Rudqvist N, Spetz J, Laverman P, Nilsson O, Ahlman H, Forssell-Aronsson E. Biodistribution of 177Lu-octreotate and 111In-minigastrin in female nude mice transplanted with human medullary thyroid carcinoma GOT2. Oncol Rep. 2012 Jan; 27(1):174-81. PMID: 21993546.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.