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Haobo Li, Ph.D.


2021 - 2023
Career Development Award
BCVS Melvin L. Marcus Early Career Investigator Award Finalist
2017 - 2019
Postdoctoral fellowship
Faculty Research Output Award
Graduate Student Scientist Award
YS and Christabel Lung Postgraduate Scholarship
Resident Abstract Awards Finalist
Runner-up in Graduate Student Best Abstract Competition
2011 - 2015
Postgraduate scholarship

Exercise, heart failure, aging, and non-coding RNA

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AG077040 (Li, Haobo) Apr 15, 2022 - Mar 31, 2024
    A Long Noncoding RNA SALTe Links Heart Failure to Alzheimer's Disease
    Role: Principal Investigator
  2. 20CDA35310184 (Li, Haobo) Jan 1, 2021 - Dec 31, 2023
    American Heart Association
    Long Noncoding RNA lncExACT1 in Cardiac Response to Exercise
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li H, Trager LE, Liu X, Hastings MH, Xiao C, Guerra J, To S, Li G, Yeri A, Rodosthenous R, Silverman MG, Das S, Ambardekar AV, Bristow MR, González-Rosa JM, Rosenzweig A. lncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth. Circulation. 2022 04 19; 145(16):1218-1233. PMID: 35114812; PMCID: PMC9056949.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  2. Li H, Rosenzweig A. Understanding Heart Failure With Preserved Ejection Fraction in a Diabetic Way. JACC Basic Transl Sci. 2021 Feb; 6(2):100-102. PMID: 33688851.
  3. Li H, Hastings MH, Rosenzweig A. Exercise Training in Diabetes: Start Earlier or Exercise Harder. Circ Res. 2020 11 06; 127(11):1401-1403. PMID: 33151799.
    Citations:    Fields:    Translation:Humans
  4. Yao W, Han X, Ge M, Chen C, Xiao X, Li H, Hei Z. N6-methyladenosine (m6A) methylation in ischemia-reperfusion injury. Cell Death Dis. 2020 06 24; 11(6):478. PMID: 32581252.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  5. Roh JD, Houstis N, Yu A, Chang B, Yeri A, Li H, Hobson R, Lerchenmüller C, Vujic A, Chaudhari V, Damilano F, Platt C, Zlotoff D, Lee RT, Shah R, Jerosch-Herold M, Rosenzweig A. Exercise training reverses cardiac aging phenotypes associated with heart failure with preserved ejection fraction in male mice. Aging Cell. 2020 06; 19(6):e13159. PMID: 32441410.
    Citations: 19     Fields:    Translation:HumansAnimals
  6. Zhu Q, Li H, Xie X, Chen X, Kosuru R, Li S, Lian Q, Cheung CW, Irwin MG, Ge RS, Xia Z. Adiponectin Facilitates Postconditioning Cardioprotection through Both AMPK-Dependent Nuclear and AMPK-Independent Mitochondrial STAT3 Activation. Oxid Med Cell Longev. 2020; 2020:4253457. PMID: 32190173.
    Citations: 7     Fields:    Translation:AnimalsCells
  7. Li H, Hastings MH, Rhee J, Trager LE, Roh JD, Rosenzweig A. Targeting Age-Related Pathways in Heart Failure. Circ Res. 2020 02 14; 126(4):533-551. PMID: 32078451.
    Citations: 32     Fields:    Translation:HumansCells
  8. Yao W, Guo A, Han X, Wu S, Chen C, Luo C, Li H, Li S, Hei Z. Aerosol inhalation of a hydrogen-rich solution restored septic renal function. Aging (Albany NY). 2019 12 16; 11(24):12097-12113. PMID: 31841441.
    Citations: 10     Fields:    Translation:AnimalsCells
  9. Yao W, Han X, Guan Y, Guan J, Wu S, Chen C, Li H, Hei Z. Neutrophil Elastase Inhibitors Suppress Oxidative Stress in Lung during Liver Transplantation. Oxid Med Cell Longev. 2019; 2019:7323986. PMID: 31871555; PMCID: PMC6906808.
    Citations: 5     Fields:    Translation:Animals
  10. Yao W, Tai LW, Liu Y, Hei Z, Li H. Oxidative Stress and Inflammation Interaction in Ischemia Reperfusion Injury: Role of Programmed Cell Death. Oxid Med Cell Longev. 2019; 2019:6780816. PMID: 31089413; PMCID: PMC6476075.
    Citations: 6     Fields:    Translation:HumansAnimals
  11. Wang TT, Shi MM, Liao XL, Li YQ, Yuan HX, Li Y, Liu X, Ning DS, Peng YM, Yang F, Mo ZW, Jiang YM, Xu YQ, Li H, Wang M, Ou ZJ, Xia Z, Ou JS. Overexpression of inducible nitric oxide synthase in the diabetic heart compromises ischemic postconditioning. J Mol Cell Cardiol. 2019 04; 129:144-153. PMID: 30797815.
    Citations: 4     Fields:    Translation:AnimalsCells
  12. Xie X, Yan D, Li H, Zhu Q, Li J, Fang YP, Cheung CW, Irwin MG, Xia Z, Lian Q. Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats. J Diabetes Res. 2018; 2018:6254340. PMID: 30186875.
    Citations: 7     Fields:    Translation:AnimalsCells
  13. Li H, Xia Z, Chen Y, Qi D, Zheng H. Mechanism and Therapies of Oxidative Stress-Mediated Cell Death in Ischemia Reperfusion Injury. Oxid Med Cell Longev. 2018; 2018:2910643. PMID: 30034574.
    Citations: 19     Fields:    Translation:HumansAnimals
  14. Tai LW, Pan Z, Sun L, Li H, Gu P, Wong SSC, Chung SK, Cheung CW. Suppression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1-ETAR-NFAT5 Signaling in a Rat Model of Neuropathic Pain. Neuroscience. 2018 08 01; 384:139-151. PMID: 29847776.
    Citations: 5     Fields:    Translation:AnimalsCells
  15. Wu Q, Wang T, Chen S, Zhou Q, Li H, Hu N, Feng Y, Dong N, Yao S, Xia Z. Cardiac protective effects of remote ischaemic preconditioning in children undergoing tetralogy of fallot repair surgery: a randomized controlled trial. Eur Heart J. 2018 03 21; 39(12):1028-1037. PMID: 28329231; PMCID: PMC6018784.
    Citations: 23     Fields:    Translation:Humans
  16. Wang C, Li H, Wang S, Mao X, Yan D, Wong SS, Xia Z, Irwin MG. Repeated Non-Invasive Limb Ischemic Preconditioning Confers Cardioprotection Through PKC-?/STAT3 Signaling in Diabetic Rats. Cell Physiol Biochem. 2018; 45(5):2107-2121. PMID: 29533954.
    Citations: 12     Fields:    Translation:AnimalsCells
  17. Deng F, Wang S, Zhang L, Xie X, Cai S, Li H, Xie GL, Miao HL, Yang C, Liu X, Xia Z. Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia. Cell Physiol Biochem. 2017; 44(1):279-292. PMID: 29130958.
    Citations: 16     Fields:    Translation:AnimalsCells
  18. Gao S, Zhan L, Yang Z, Shi R, Li H, Xia Z, Yuan S, Wu QP, Wang T, Yao S. Remote Limb Ischaemic Postconditioning Protects Against Myocardial Ischaemia/Reperfusion Injury in Mice: Activation of JAK/STAT3-Mediated Nrf2-Antioxidant Signalling. Cell Physiol Biochem. 2017; 43(3):1140-1151. PMID: 28977786.
    Citations: 12     Fields:    Translation:AnimalsCells
  19. Wang L, Zhu Q, Lu A, Liu X, Zhang L, Xu C, Liu X, Li H, Yang T. Sodium butyrate suppresses angiotensin II-induced hypertension by inhibition of renal (pro)renin receptor and intrarenal renin-angiotensin system. J Hypertens. 2017 09; 35(9):1899-1908. PMID: 28509726.
    Citations: 53     Fields:    Translation:Animals
  20. Ge M, Yao W, Yuan D, Zhou S, Chen X, Zhang Y, Li H, Xia Z, Hei Z. Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia-reperfusion injury. Cell Death Dis. 2017 06 01; 8(6):e2841. PMID: 28569786.
    Citations: 33     Fields:    Translation:AnimalsCells
  21. Yao W, Li H, Luo G, Li X, Chen C, Yuan D, Chi X, Xia Z, Hei Z. SERPINB1 ameliorates acute lung injury in liver transplantation through ERK1/2-mediated STAT3-dependent HO-1 induction. Free Radic Biol Med. 2017 07; 108:542-553. PMID: 28427999.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  22. Yao W, Li H, Han X, Chen C, Zhang Y, Tai WL, Xia Z, Hei Z. MG53 anchored by dysferlin to cell membrane reduces hepatocyte apoptosis which induced by ischaemia/reperfusion injury in vivo and in vitro. J Cell Mol Med. 2017 10; 21(10):2503-2513. PMID: 28401647; PMCID: PMC5618678.
    Citations: 19     Fields:    Translation:AnimalsCells
  23. Wang S, Wang C, Yan F, Wang T, He Y, Li H, Xia Z, Zhang Z. N-Acetylcysteine Attenuates Diabetic Myocardial Ischemia Reperfusion Injury through Inhibiting Excessive Autophagy. Mediators Inflamm. 2017; 2017:9257291. PMID: 28265179; PMCID: PMC5317145.
    Citations: 27     Fields:    Translation:AnimalsCells
  24. Pang L, Cai Y, Tang EH, Yan D, Kosuru R, Li H, Irwin MG, Ma H, Xia Z. Cox-2 Inhibition Protects against Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Akt-Dependent Enhancement of iNOS Expression. Oxid Med Cell Longev. 2016; 2016:3453059. PMID: 27795807.
    Citations: 23     Fields:    Translation:Cells
  25. Gao S, Zhu Y, Li H, Xia Z, Wu Q, Yao S, Wang T, Yuan S. Remote ischemic postconditioning protects against renal ischemia/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)/PTEN/Akt signaling pathway mediated anti-oxidation and anti-inflammation. Int Immunopharmacol. 2016 Sep; 38:395-401. PMID: 27355132.
    Citations: 18     Fields:    Translation:AnimalsCells
  26. Han X, Yao W, Liu Z, Li H, Zhang ZJ, Hei Z, Xia Z. Lipoxin A4 Preconditioning Attenuates Intestinal Ischemia Reperfusion Injury through Keap1/Nrf2 Pathway in a Lipoxin A4 Receptor Independent Manner. Oxid Med Cell Longev. 2016; 2016:9303606. PMID: 27375835.
    Citations: 28     Fields:    Translation:Animals
  27. Wang L, Wang T, Li H, Liu Q, Zhang Z, Xie W, Feng Y, Socorburam T, Wu G, Xia Z, Wu Q. Receptor Interacting Protein 3-Mediated Necroptosis Promotes Lipopolysaccharide-Induced Inflammation and Acute Respiratory Distress Syndrome in Mice. PLoS One. 2016; 11(5):e0155723. PMID: 27195494; PMCID: PMC4873150.
    Citations: 36     Fields:    Translation:AnimalsCells
  28. Gao S, Yang Z, Shi R, Xu D, Li H, Xia Z, Wu QP, Yao S, Wang T, Yuan S. Diabetes blocks the cardioprotective effects of sevoflurane postconditioning by impairing Nrf2/Brg1/HO-1 signaling. Eur J Pharmacol. 2016 May 15; 779:111-21. PMID: 26973173.
    Citations: 20     Fields:    Translation:AnimalsCells
  29. Kandula V, Kosuru R, Li H, Yan D, Zhu Q, Lian Q, Ge RS, Xia Z, Irwin MG. Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy. Cardiovasc Diabetol. 2016 Mar 08; 15:44. PMID: 26956801.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  30. Wang Y, Li H, Huang H, Liu S, Mao X, Wang S, Wong SS, Xia Z, Irwin MG. Cardioprotection from emulsified isoflurane postconditioning is lost in rats with streptozotocin-induced diabetes due to the impairment of Brg1/Nrf2/STAT3 signalling. Clin Sci (Lond). 2016 05 01; 130(10):801-12. PMID: 26846682.
    Citations: 8     Fields:    Translation:AnimalsCells
  31. Zhao W, Liu Z, Yu X, Lai L, Li H, Liu Z, Li L, Jiang S, Xia Z, Xu SY. iTRAQ proteomics analysis reveals that PI3K is highly associated with bupivacaine-induced neurotoxicity pathways. Proteomics. 2016 Feb; 16(4):564-75. PMID: 26621341.
    Citations: 14     Fields:    Translation:HumansCells
  32. Li H, Yao W, Liu Z, Xu A, Huang Y, Ma XL, Irwin MG, Xia Z. Hyperglycemia Abrogates Ischemic Postconditioning Cardioprotection by Impairing AdipoR1/Caveolin-3/STAT3 Signaling in Diabetic Rats. Diabetes. 2016 04; 65(4):942-55. PMID: 26718505.
    Citations: 38     Fields:    Translation:AnimalsCells
  33. Lin J, Wang T, Li Y, Wang M, Li H, Irwin MG, Xia Z. N-Acetylcysteine Restores Sevoflurane Postconditioning Cardioprotection against Myocardial Ischemia-Reperfusion Injury in Diabetic Rats. J Diabetes Res. 2016; 2016:9213034. PMID: 26783539.
    Citations: 11     Fields:    Translation:AnimalsCells
  34. Liu Y, Jin J, Qiao S, Lei S, Liao S, Ge ZD, Li H, Wong GT, Irwin MG, Xia Z. Inhibition of PKCß2 overexpression ameliorates myocardial ischaemia/reperfusion injury in diabetic rats via restoring caveolin-3/Akt signaling. Clin Sci (Lond). 2015 Aug; 129(4):331-44. PMID: 25849791.
    Citations: 20     Fields:    Translation:AnimalsCells
  35. Tian Y, Li H, Liu P, Xu JM, Irwin MG, Xia Z, Tian G. Captopril Pretreatment Produces an Additive Cardioprotection to Isoflurane Preconditioning in Attenuating Myocardial Ischemia Reperfusion Injury in Rabbits and in Humans. Mediators Inflamm. 2015; 2015:819232. PMID: 26273143; PMCID: PMC4530291.
    Citations: 12     Fields:    Translation:HumansAnimals
  36. Xia R, Xu J, Yin H, Wu H, Xia Z, Zhou D, Xia ZY, Zhang L, Li H, Xiao X. Intravenous Infusion of Dexmedetomidine Combined Isoflurane Inhalation Reduces Oxidative Stress and Potentiates Hypoxia Pulmonary Vasoconstriction during One-Lung Ventilation in Patients. Mediators Inflamm. 2015; 2015:238041. PMID: 26273134; PMCID: PMC4529970.
    Citations: 11     Fields:    Translation:Humans
  37. Gan X, Xing D, Su G, Li S, Luo C, Irwin MG, Xia Z, Li H, Hei Z. Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation. Oxid Med Cell Longev. 2015; 2015:167014. PMID: 26246867.
    Citations: 18     Fields:    Translation:AnimalsCells
  38. Zhou M, Bao Y, Li H, Pan Y, Shu L, Xia Z, Wu D, Lam KS, Vanhoutte PM, Xu A, Jia W, Hoo RL. Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction. Clin Sci (Lond). 2015 Oct; 129(7):547-59. PMID: 26186740.
    Citations: 22     Fields:    Translation:Animals
  39. Li S, Xu J, Yao W, Li H, Liu Q, Xiao F, Irwin MG, Xia Z, Ruan W. Sevoflurane pretreatment attenuates TNF-a-induced human endothelial cell dysfunction through activating eNOS/NO pathway. Biochem Biophys Res Commun. 2015 May 08; 460(3):879-86. PMID: 25838201.
    Citations: 12     Fields:    
  40. Li H, Yao W, Irwin MG, Wang T, Wang S, Zhang L, Xia Z. Adiponectin ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction by concomitantly activating Nrf2 and Brg1. Free Radic Biol Med. 2015 Jul; 84:311-321. PMID: 25795513.
    Citations: 43     Fields:    Translation:AnimalsCells
  41. Luo C, Yuan D, Li X, Yao W, Luo G, Chi X, Li H, Irwin MG, Xia Z, Hei Z. Propofol attenuated acute kidney injury after orthotopic liver transplantation via inhibiting gap junction composed of connexin 32. Anesthesiology. 2015 Jan; 122(1):72-86. PMID: 25254904.
    Citations: 27     Fields:    Translation:AnimalsCells
  42. Xu J, Li H, Irwin MG, Xia ZY, Mao X, Lei S, Wong GT, Hung V, Cheung CW, Fang X, Clanachan AS, Xia Z. Propofol ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction via heme oxygenase-1/signal transducer and activator of transcription 3 signaling pathway in rats. Crit Care Med. 2014 Aug; 42(8):e583-94. PMID: 24810525.
    Citations: 16     Fields:    Translation:AnimalsCells
  43. Li H, Liu Z, Wang J, Wong GT, Cheung CW, Zhang L, Chen C, Xia Z, Irwin MG. Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats. Cardiovasc Diabetol. 2013 Sep 17; 12:133. PMID: 24041262.
    Citations: 41     Fields:    Translation:AnimalsCells
  44. Wang T, Mao X, Li H, Qiao S, Xu A, Wang J, Lei S, Liu Z, Ng KF, Wong GT, Vanhoutte PM, Irwin MG, Xia Z. N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes. Free Radic Biol Med. 2013 Oct; 63:291-303. PMID: 23747931.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  45. Lei S, Li H, Xu J, Liu Y, Gao X, Wang J, Ng KF, Lau WB, Ma XL, Rodrigues B, Irwin MG, Xia Z. Hyperglycemia-induced protein kinase C ß2 activation induces diastolic cardiac dysfunction in diabetic rats by impairing caveolin-3 expression and Akt/eNOS signaling. Diabetes. 2013 Jul; 62(7):2318-28. PMID: 23474486; PMCID: PMC3712061.
    Citations: 53     Fields:    Translation:AnimalsCells
  46. Han C, Wen X, Zheng Q, Li H. Effect of starvation on activities and mRNA expression of lipoprotein lipase and hormone-sensitive lipase in tilapia (Oreochromis niloticus x O. areus). Fish Physiol Biochem. 2011 Mar; 37(1):113-22. PMID: 20706869.
    Citations: 6     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.