Harvard Catalyst Profiles

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Kenneth Marc Kaye, M.D.



The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI150575 (KAYE, KENNETH M) Apr 1, 2020 - Mar 31, 2025
    Genetic and Biochemical Studies of KSHV LANA
    Role: Principal Investigator
  2. R01DE024971 (DEMIRCI, UTKAN) Sep 3, 2015 - Jun 30, 2021
    Platform technology for detection of cancer-associated viruses in HIV patients
    Role: Co-Principal Investigator
  3. R01DE025208 (KAYE, KENNETH M) Apr 1, 2015 - Mar 31, 2026
    KSHV latent infection replication
    Role: Principal Investigator
  4. R21NS067638 (KAYE, KENNETH M) Sep 27, 2010 - Aug 31, 2012
    Inhibitors of Kaposi???s Sarcoma Herpesvirus
    Role: Principal Investigator
  5. R21NS061738 (KAYE, KENNETH M) Sep 30, 2007 - Aug 31, 2010
    Chemical Probes of Kaposi's Sarcoma Herpesvirus Latent Infection
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hatabu H, Kaye KM, Christiani DC. Reply to: Novel Insight into Pulmonary Fibrosis and Long Covid. Am J Respir Crit Care Med. 2023 Feb 02. PMID: 36731064.
    Citations:    Fields:    
  2. Hatabu H, Kaye KM, Christiani DC. Viral Infection, Pulmonary Fibrosis, and Long Covid. Am J Respir Crit Care Med. 2022 Dec 05. PMID: 36470237.
    Citations:    Fields:    
  3. Wada N, Li Y, Hino T, Gagne S, Valtchinov VI, Gay E, Nishino M, Madore B, Guttmann CRG, Bond S, Ishigami K, Hunninghake GM, Levy BD, Kaye KM, Christiani DC, Hatabu H. COVID-19 Vaccination reduced pneumonia severity. Eur J Radiol Open. 2022; 9:100456. PMID: 36386765; PMCID: PMC9650570.
    Citations: 1     
  4. Tan M, Li S, Juillard F, Chitas R, Custódio TF, Xue H, Szymula A, Sun Q, Liu B, Álvarez ÁL, Chen S, Huang J, Simas JP, McVey CE, Kaye KM. MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res. 2021 12 16; 49(22):12895-12911. PMID: 34850113; PMCID: PMC8682764.
    Citations:    Fields:    Translation:HumansCells
  5. Lee SM, Kaye KM, Slack FJ. Cellular microRNA-127-3p suppresses oncogenic herpesvirus-induced transformation and tumorigenesis via down-regulation of SKP2. Proc Natl Acad Sci U S A. 2021 11 09; 118(45). PMID: 34725152; PMCID: PMC8609319.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Wang C, Zhang L, Ke L, Ding W, Jiang S, Li D, Narita Y, Hou I, Liang J, Li S, Xiao H, Gottwein E, Kaye KM, Teng M, Zhao B. Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors. Nat Commun. 2020 12 09; 11(1):6318. PMID: 33298918; PMCID: PMC7726151.
    Citations: 7     Fields:    Translation:HumansCells
  7. Juillard F, de Miranda MP, Li S, Franco A, Seixas AF, Liu B, Álvarez ÁL, Tan M, Szymula A, Kaye KM, Simas JP. KSHV LANA acetylation-selective acidic domain reader sequence mediates virus persistence. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22443-22451. PMID: 32820070.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  8. Slevin MK, Wollison BM, Powers W, Burns RT, Patel N, Ducar MD, Starrett GJ, Garcia EP, Manning DK, Cheng J, Hanna GJ, Kaye KM, Van Hummelen P, Nag A, Thorner AR, DeCaprio JA, MacConaill LE. ViroPanel: Hybrid Capture and Massively Parallel Sequencing for Simultaneous Detection and Profiling of Oncogenic Virus Infection and Tumor Genome. J Mol Diagn. 2020 04; 22(4):476-487. PMID: 32068070.
    Citations: 4     Fields:    Translation:Humans
  9. Gong J, Meyerowitz EA, Isidro RA, Kaye KM. Primary cytomegalovirus infection with invasive disease in a patient with inflammatory bowel disease. BMJ Case Rep. 2019 Sep 30; 12(9). PMID: 31570344.
    Citations: 1     Fields:    Translation:Humans
  10. Juillard F, De León Vázquez E, Tan M, Li S, Kaye KM. Kaposi's Sarcoma-Associated Herpesvirus LANA-Adjacent Regions with Distinct Functions in Episome Segregation or Maintenance. J Virol. 2019 03 15; 93(6). PMID: 30626680; PMCID: PMC6401465.
    Citations: 2     Fields:    Translation:HumansCells
  11. Zhang F, Liang D, Lin X, Zou Z, Sun R, Wang X, Liang X, Kaye KM, Lan K. NDRG1 facilitates the replication and persistence of Kaposi's sarcoma-associated herpesvirus by interacting with the DNA polymerase clamp PCNA. PLoS Pathog. 2019 02; 15(2):e1007628. PMID: 30811506; PMCID: PMC6411202.
    Citations: 4     Fields:    Translation:HumansCells
  12. Pires de Miranda M, Quendera AP, McVey CE, Kaye KM, Simas JP. In Vivo Persistence of Chimeric Virus after Substitution of the Kaposi's Sarcoma-Associated Herpesvirus LANA DNA Binding Domain with That of Murid Herpesvirus 4. J Virol. 2018 11 01; 92(21). PMID: 30111565; PMCID: PMC6189500.
    Citations: 7     Fields:    Translation:AnimalsCells
  13. Habison AC, de Miranda MP, Beauchemin C, Tan M, Cerqueira SA, Correia B, Ponnusamy R, Usherwood EJ, McVey CE, Simas JP, Kaye KM. Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA. PLoS Pathog. 2017 Sep; 13(9):e1006555. PMID: 28910389; PMCID: PMC5599060.
    Citations: 11     Fields:    Translation:AnimalsCells
  14. Nayar U, Sadek J, Reichel J, Hernandez-Hopkins D, Akar G, Barelli PJ, Sahai MA, Zhou H, Totonchy J, Jayabalan D, Niesvizky R, Guasparri I, Hassane D, Liu Y, Sei S, Shoemaker RH, Warren JD, Elemento O, Kaye KM, Cesarman E. Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies. J Clin Invest. 2017 Jun 01; 127(6):2066-2080. PMID: 28504647; PMCID: PMC5451239.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  15. El Assal R, Gurkan UA, Chen P, Juillard F, Tocchio A, Chinnasamy T, Beauchemin C, Unluisler S, Canikyan S, Holman A, Srivatsa S, Kaye KM, Demirci U. 3-D Microwell Array System for Culturing Virus Infected Tumor Cells. Sci Rep. 2016 12 22; 6:39144. PMID: 28004818; PMCID: PMC5177905.
    Citations: 11     Fields:    Translation:HumansCells
  16. Liang J, Zhou H, Gerdt C, Tan M, Colson T, Kaye KM, Kieff E, Zhao B. Epstein-Barr virus super-enhancer eRNAs are essential for MYC oncogene expression and lymphoblast proliferation. Proc Natl Acad Sci U S A. 2016 12 06; 113(49):14121-14126. PMID: 27864512; PMCID: PMC5150416.
    Citations: 45     Fields:    Translation:HumansCells
  17. Cerqueira SA, Tan M, Li S, Juillard F, McVey CE, Kaye KM, Simas JP. Latency-Associated Nuclear Antigen E3 Ubiquitin Ligase Activity Impacts Gammaherpesvirus-Driven Germinal Center B Cell Proliferation. J Virol. 2016 09 01; 90(17):7667-83. PMID: 27307564; PMCID: PMC4988161.
    Citations: 3     Fields:    Translation:AnimalsCells
  18. Juillard F, Tan M, Li S, Kaye KM. Kaposi's Sarcoma Herpesvirus Genome Persistence. Front Microbiol. 2016; 7:1149. PMID: 27570517; PMCID: PMC4982378.
    Citations: 22     
  19. Safavieh M, Khetani S, Juillard F, Kaul V, Kanakasabapathy MK, Kaye KM, Shafiee H. Electrical response of a B lymphoma cell line latently infected with Kaposi's sarcoma herpesvirus. Biosens Bioelectron. 2016 Jun 15; 80:230-236. PMID: 26851580.
    Citations: 2     Fields:    Translation:HumansCells
  20. Ponnusamy R, Petoukhov MV, Correia B, Custodio TF, Juillard F, Tan M, Pires de Miranda M, Carrondo MA, Simas JP, Kaye KM, Svergun DI, McVey CE. KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA. Nucleic Acids Res. 2015 Nov 16; 43(20):10039-54. PMID: 26424851; PMCID: PMC4787769.
    Citations: 13     Fields:    Translation:Cells
  21. Li S, Tan M, Juillard F, Ponnusamy R, Correia B, Simas JP, Carrondo MA, McVey CE, Kaye KM. The Kaposi Sarcoma Herpesvirus Latency-associated Nuclear Antigen DNA Binding Domain Dorsal Positive Electrostatic Patch Facilitates DNA Replication and Episome Persistence. J Biol Chem. 2015 Nov 20; 290(47):28084-28096. PMID: 26420481.
    Citations: 4     Fields:    Translation:HumansCells
  22. Inci F, Filippini C, Baday M, Ozen MO, Calamak S, Durmus NG, Wang S, Hanhauser E, Hobbs KS, Juillard F, Kuang PP, Vetter ML, Carocci M, Yamamoto HS, Takagi Y, Yildiz UH, Akin D, Wesemann DR, Singhal A, Yang PL, Nibert ML, Fichorova RN, Lau DT, Henrich TJ, Kaye KM, Schachter SC, Kuritzkes DR, Steinmetz LM, Gambhir SS, Davis RW, Demirci U. Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4354-63. PMID: 26195743; PMCID: PMC4538635.
    Citations: 20     Fields:    Translation:HumansCells
  23. Shafiee H, Kanakasabapathy MK, Juillard F, Keser M, Sadasivam M, Yuksekkaya M, Hanhauser E, Henrich TJ, Kuritzkes DR, Kaye KM, Demirci U. Printed Flexible Plastic Microchip for Viral Load Measurement through Quantitative Detection of Viruses in Plasma and Saliva. Sci Rep. 2015 Jun 05; 5:9919. PMID: 26046668.
    Citations: 14     Fields:    Translation:HumansCells
  24. Hu Z, Blackman MA, Kaye KM, Usherwood EJ. Functional heterogeneity in the CD4+ T cell response to murine ?-herpesvirus 68. J Immunol. 2015 Mar 15; 194(6):2746-56. PMID: 25662997; PMCID: PMC4355211.
    Citations: 19     Fields:    Translation:AnimalsCells
  25. Sun Q, Tsurimoto T, Juillard F, Li L, Li S, De León Vázquez E, Chen S, Kaye K. Kaposi's sarcoma-associated herpesvirus LANA recruits the DNA polymerase clamp loader to mediate efficient replication and virus persistence. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):11816-21. PMID: 25071216.
    Citations: 30     Fields:    Translation:HumansCells
  26. Beauchemin C, Moerke NJ, Faloon P, Kaye KM. Assay Development and High-Throughput Screening for Inhibitors of Kaposi's Sarcoma-Associated Herpesvirus N-Terminal Latency-Associated Nuclear Antigen Binding to Nucleosomes. J Biomol Screen. 2014 Jul; 19(6):947-58. PMID: 24518064.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  27. De León Vázquez E, Juillard F, Rosner B, Kaye KM. A short sequence immediately upstream of the internal repeat elements is critical for KSHV LANA mediated DNA replication and impacts episome persistence. Virology. 2014 Jan 05; 448:344-55. PMID: 24314665.
    Citations: 7     Fields:    Translation:HumansCells
  28. Correia B, Cerqueira SA, Beauchemin C, Pires de Miranda M, Li S, Ponnusamy R, Rodrigues L, Schneider TR, Carrondo MA, Kaye KM, Simas JP, McVey CE. Crystal structure of the gamma-2 herpesvirus LANA DNA binding domain identifies charged surface residues which impact viral latency. PLoS Pathog. 2013; 9(10):e1003673. PMID: 24146618.
    Citations: 23     Fields:    Translation:Cells
  29. Vázquez Ede L, Carey VJ, Kaye KM. Identification of Kaposi's sarcoma-associated herpesvirus LANA regions important for episome segregation, replication, and persistence. J Virol. 2013 Nov; 87(22):12270-83. PMID: 24006437.
    Citations: 16     Fields:    Translation:HumansCells
  30. Rodrigues L, Popov N, Kaye KM, Simas JP. Stabilization of Myc through heterotypic poly-ubiquitination by mLANA is critical for ?-herpesvirus lymphoproliferation. PLoS Pathog. 2013; 9(8):e1003554. PMID: 23950719.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  31. Dheekollu J, Chen HS, Kaye KM, Lieberman PM. Timeless-dependent DNA replication-coupled recombination promotes Kaposi's Sarcoma-associated herpesvirus episome maintenance and terminal repeat stability. J Virol. 2013 Apr; 87(7):3699-709. PMID: 23325691.
    Citations: 23     Fields:    Translation:HumansCells
  32. Habison AC, Beauchemin C, Simas JP, Usherwood EJ, Kaye KM. Murine gammaherpesvirus 68 LANA acts on terminal repeat DNA to mediate episome persistence. J Virol. 2012 Nov; 86(21):11863-76. PMID: 22915819.
    Citations: 22     Fields:    Translation:AnimalsCells
  33. Ballestas ME, Kaye KM. The latency-associated nuclear antigen, a multifunctional protein central to Kaposi's sarcoma-associated herpesvirus latency. Future Microbiol. 2011 Dec; 6(12):1399-413. PMID: 22122438.
    Citations: 57     Fields:    Translation:HumansCells
  34. Bazan JA, Martin SI, Kaye KM. Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime. Med Clin North Am. 2011 Jul; 95(4):743-60, viii. PMID: 21679790.
    Citations: 4     Fields:    
  35. De León Vázquez E, Kaye KM. The internal Kaposi's sarcoma-associated herpesvirus LANA regions exert a critical role on episome persistence. J Virol. 2011 Aug; 85(15):7622-33. PMID: 21593163.
    Citations: 27     Fields:    Translation:HumansCells
  36. De León Vázquez E, Kaye KM. Rapid and quantitative assessment of KSHV LANA-mediated DNA replication. Arch Virol. 2011 Aug; 156(8):1323-33. PMID: 21472413.
    Citations: 9     Fields:    Translation:HumansCells
  37. Bazan JA, Martin SI, Kaye KM. Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime. Infect Dis Clin North Am. 2009 Dec; 23(4):983-96, ix. PMID: 19909894.
    Citations: 7     Fields:    Translation:HumansCells
  38. Kelley-Clarke B, De Leon-Vazquez E, Slain K, Barbera AJ, Kaye KM. Role of Kaposi's sarcoma-associated herpesvirus C-terminal LANA chromosome binding in episome persistence. J Virol. 2009 May; 83(9):4326-37. PMID: 19225000.
    Citations: 30     Fields:    Translation:HumansCells
  39. Barbera AJ, Kaye KM. KSHV LANA's expanding bag of tricks. Blood. 2008 May 01; 111(9):4425-6. PMID: 18441240.
    Citations: 2     Fields:    
  40. Chodaparambil JV, Barbera AJ, Lu X, Kaye KM, Hansen JC, Luger K. A charged and contoured surface on the nucleosome regulates chromatin compaction. Nat Struct Mol Biol. 2007 Nov; 14(11):1105-7. PMID: 17965723; PMCID: PMC2366819.
    Citations: 56     Fields:    Translation:HumansCells
  41. Bihl F, Narayan M, Chisholm JV, Henry LM, Suscovich TJ, Brown EE, Welzel TM, Kaufmann DE, Zaman TM, Dollard S, Martin JN, Wang F, Scadden DT, Kaye KM, Brander C. Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes. J Virol. 2007 May; 81(9):4904-8. PMID: 17329344; PMCID: PMC1900166.
    Citations: 14     Fields:    Translation:HumansCells
  42. Kelley-Clarke B, Ballestas ME, Srinivasan V, Barbera AJ, Komatsu T, Harris TA, Kazanjian M, Kaye KM. Determination of Kaposi's sarcoma-associated herpesvirus C-terminal latency-associated nuclear antigen residues mediating chromosome association and DNA binding. J Virol. 2007 Apr; 81(8):4348-56. PMID: 17287261; PMCID: PMC1866165.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  43. Kelley-Clarke B, Ballestas ME, Komatsu T, Kaye KM. Kaposi's sarcoma herpesvirus C-terminal LANA concentrates at pericentromeric and peri-telomeric regions of a subset of mitotic chromosomes. Virology. 2007 Jan 20; 357(2):149-57. PMID: 16979209.
    Citations: 35     Fields:    Translation:HumansCells
  44. You J, Srinivasan V, Denis GV, Harrington WJ, Ballestas ME, Kaye KM, Howley PM. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes. J Virol. 2006 Sep; 80(18):8909-19. PMID: 16940503; PMCID: PMC1563901.
    Citations: 96     Fields:    Translation:HumansCells
  45. Barbera AJ, Chodaparambil JV, Kelley-Clarke B, Luger K, Kaye KM. Kaposi's sarcoma-associated herpesvirus LANA hitches a ride on the chromosome. Cell Cycle. 2006 May; 5(10):1048-52. PMID: 16721045.
    Citations: 33     Fields:    Translation:Cells
  46. Barbera AJ, Chodaparambil JV, Kelley-Clarke B, Joukov V, Walter JC, Luger K, Kaye KM. The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA. Science. 2006 Feb 10; 311(5762):856-61. PMID: 16469929.
    Citations: 281     Fields:    Translation:HumansAnimalsCells
  47. Srinivasan V, Komatsu T, Ballestas ME, Kaye KM. Definition of sequence requirements for latency-associated nuclear antigen 1 binding to Kaposi's sarcoma-associated herpesvirus DNA. J Virol. 2004 Dec; 78(24):14033-8. PMID: 15564510; PMCID: PMC533900.
    Citations: 22     Fields:    Translation:HumansCells
  48. Martin SI, Kaye KM. Beta-lactam antibiotics: newer formulations and newer agents. Infect Dis Clin North Am. 2004 Sep; 18(3):603-19, ix. PMID: 15308278.
    Citations: 4     Fields:    Translation:Humans
  49. Komatsu T, Ballestas ME, Barbera AJ, Kelley-Clarke B, Kaye KM. KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistence. Virology. 2004 Feb 20; 319(2):225-36. PMID: 14980483.
    Citations: 49     Fields:    Translation:AnimalsCells
  50. Barbera AJ, Ballestas ME, Kaye KM. The Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 N terminus is essential for chromosome association, DNA replication, and episome persistence. J Virol. 2004 Jan; 78(1):294-301. PMID: 14671111; PMCID: PMC303411.
    Citations: 73     Fields:    Translation:HumansCells
  51. Li H, Komatsu T, Dezube BJ, Kaye KM. The Kaposi's sarcoma-associated herpesvirus K12 transcript from a primary effusion lymphoma contains complex repeat elements, is spliced, and initiates from a novel promoter. J Virol. 2002 Dec; 76(23):11880-8. PMID: 12414930; PMCID: PMC136876.
    Citations: 39     Fields:    Translation:HumansCells
  52. Komatsu T, Ballestas ME, Barbera AJ, Kaye KM. The KSHV latency-associated nuclear antigen: a multifunctional protein. Front Biosci. 2002 Mar 01; 7:d726-30. PMID: 11861213.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  53. Ballestas ME, Kaye KM. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA. J Virol. 2001 Apr; 75(7):3250-8. PMID: 11238851; PMCID: PMC114118.
    Citations: 148     Fields:    Translation:Cells
  54. Komatsu T, Barbera AJ, Ballestas ME, Kaye KM. The Kaposi' s sarcoma-associated herpesvirus latency-associated nuclear antigen. Viral Immunol. 2001; 14(4):311-7. PMID: 11792061.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  55. Fisman DN, Kaye KM. Once-daily dosing of aminoglycoside antibiotics. Infect Dis Clin North Am. 2000 Jun; 14(2):475-87. PMID: 10829267.
    Citations: 4     Fields:    Translation:Humans
  56. Kaye KM, Izumi KM, Li H, Johannsen E, Davidson D, Longnecker R, Kieff E. An Epstein-Barr virus that expresses only the first 231 LMP1 amino acids efficiently initiates primary B-lymphocyte growth transformation. J Virol. 1999 Dec; 73(12):10525-30. PMID: 10559372; PMCID: PMC113109.
    Citations: 33     Fields:    Translation:HumansCells
  57. Lee H, Choi JK, Li M, Kaye K, Kieff E, Jung JU. Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP. J Virol. 1999 May; 73(5):3913-9. PMID: 10196286; PMCID: PMC104169.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  58. Ballestas ME, Chatis PA, Kaye KM. Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science. 1999 Apr 23; 284(5414):641-4. PMID: 10213686.
    Citations: 361     Fields:    Translation:HumansCells
  59. Jones D, Ballestas ME, Kaye KM, Gulizia JM, Winters GL, Fletcher J, Scadden DT, Aster JC. Primary-effusion lymphoma and Kaposi's sarcoma in a cardiac-transplant recipient. N Engl J Med. 1998 Aug 13; 339(7):444-9. PMID: 9700178.
    Citations: 40     Fields:    Translation:HumansCells
  60. Eliopoulos AG, Stack M, Dawson CW, Kaye KM, Hodgkin L, Sihota S, Rowe M, Young LS. Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway involving TNF receptor-associated factors. Oncogene. 1997 Jun 19; 14(24):2899-916. PMID: 9205097.
    Citations: 90     Fields:    Translation:HumansCells
  61. Izumi KM, Kaye KM, Kieff ED. The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1447-52. PMID: 9037073; PMCID: PMC19811.
    Citations: 88     Fields:    Translation:Cells
  62. Devergne O, Hatzivassiliou E, Izumi KM, Kaye KM, Kleijnen MF, Kieff E, Mosialos G. Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-kappaB activation. Mol Cell Biol. 1996 Dec; 16(12):7098-108. PMID: 8943365.
    Citations: 158     Fields:    Translation:HumansCells
  63. Ansieau S, Scheffrahn I, Mosialos G, Brand H, Duyster J, Kaye K, Harada J, Dougall B, Hübinger G, Kieff E, Herrmann F, Leutz A, Gruss HJ. Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14053-8. PMID: 8943059; PMCID: PMC19493.
    Citations: 16     Fields:    Translation:HumansCells
  64. Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G. Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. Proc Natl Acad Sci U S A. 1996 Oct 01; 93(20):11085-90. PMID: 8855313; PMCID: PMC38288.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  65. Kaye ET, Kaye KM. Topical antibacterial agents. Infect Dis Clin North Am. 1995 Sep; 9(3):547-59. PMID: 7490432.
    Citations:    Fields:    Translation:Humans
  66. Zuckerman JM, Kaye KM. The newer macrolides. Azithromycin and clarithromycin. Infect Dis Clin North Am. 1995 Sep; 9(3):731-45. PMID: 7490441.
    Citations: 7     Fields:    Translation:Humans
  67. Kaye KM, Izumi KM, Mosialos G, Kieff E. The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues. J Virol. 1995 Feb; 69(2):675-83. PMID: 7815530; PMCID: PMC188628.
    Citations: 63     Fields:    Translation:HumansCells
  68. Izumi KM, Kaye KM, Kieff ED. Epstein-Barr virus recombinant molecular genetic analysis of the LMP1 amino-terminal cytoplasmic domain reveals a probable structural role, with no component essential for primary B-lymphocyte growth transformation. J Virol. 1994 Jul; 68(7):4369-76. PMID: 8207810; PMCID: PMC236360.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  69. Kaye KM, Izumi KM, Kieff E. Epstein-Barr virus latent membrane protein 1 is essential for B-lymphocyte growth transformation. Proc Natl Acad Sci U S A. 1993 Oct 01; 90(19):9150-4. PMID: 8415670; PMCID: PMC47519.
    Citations: 314     Fields:    Translation:HumansCells
  70. Kaye KM, Macone A, Kazanjian PH. Catheter infection caused by Methylobacterium in immunocompromised hosts: report of three cases and review of the literature. Clin Infect Dis. 1992 May; 14(5):1010-4. PMID: 1600002.
    Citations: 13     Fields:    Translation:HumansCells
  71. Kaye KM, McKusick KA, Eagle KA. Pulmonary embolism masquerading as coronary insufficiency: clues to the diagnosis by exercise-thallium stress test. Am Heart J. 1989 May; 117(5):1169-71. PMID: 2523637.
    Citations:    Fields:    Translation:Humans
  72. Kaye KM, Spriggs DR, Bassel-Duby R, Fields BN, Tyler KL. Genetic basis for altered pathogenesis of an immune-selected antigenic variant of reovirus type 3 (Dearing). J Virol. 1986 Jul; 59(1):90-7. PMID: 3012122; PMCID: PMC253042.
    Citations: 27     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.