Harvard Catalyst Profiles

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Alexander Gimelbrant, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM114864 (GIMELBRANT, ALEXANDER) Sep 30, 2014 - Aug 31, 2019
    Mechanism and function of autosomal analog of X inactivation
    Role: Principal Investigator
  2. R21MH105745 (GIMELBRANT, ALEXANDER) Sep 5, 2014 - Aug 31, 2016
    Epigenetic loss of heterozygosity in a recurrent neurodevelopmental CNV region
    Role: Principal Investigator
  3. R21HD081675 (GIMELBRANT, ALEXANDER) Aug 15, 2014 - Aug 31, 2016
    Assessing parent-of-origin transcriptional effects in Xenopus laevis
    Role: Principal Investigator
  4. R21CA185000 (GIMELBRANT, ALEXANDER) Apr 17, 2014 - Mar 31, 2016
    (PQD4) Epigenetic loss of heterozygosity as a driver of the cancer field effect
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vinogradova S, Saksena SD, Ward HN, Vigneau S, Gimelbrant AA. MaGIC: a machine learning tool set and web application for monoallelic gene inference from chromatin. BMC Bioinformatics. 2019 Feb 28; 20(1):106. PMID: 30819107.
  2. Hinohara K, Wu HJ, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales SC, Lal-Nag M, Rai G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K. KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance. Cancer Cell. 2019 Feb 11; 35(2):330-332. PMID: 30753830.
  3. Hinohara K, Wu HJ, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales SC, Lal-Nag M, Rai G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K. KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance. Cancer Cell. 2018 12 10; 34(6):939-953.e9. PMID: 30472020.
    Citations:    Fields:    
  4. Vigneau S, Vinogradova S, Savova V, Gimelbrant A. High prevalence of clonal monoallelic expression. Nat Genet. 2018 09; 50(9):1198-1199. PMID: 30082785.
    Citations:    Fields:    
  5. Savova V, Vinogradova S, Pruss D, Gimelbrant AA, Weiss LA. Risk alleles of genes with monoallelic expression are enriched in gain-of-function variants and depleted in loss-of-function variants for neurodevelopmental disorders. Mol Psychiatry. 2017 Dec; 22(12):1785-1794. PMID: 28265118.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Dunford A, Weinstock DM, Savova V, Schumacher SE, Cleary JP, Yoda A, Sullivan TJ, Hess JM, Gimelbrant AA, Beroukhim R, Lawrence MS, Getz G, Lane AA. Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias. Nat Genet. 2017 01; 49(1):10-16. PMID: 27869828.
    Citations: 21     Fields:    Translation:HumansCells
  7. Savova V, Chun S, Sohail M, McCole RB, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA. Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. Nat Genet. 2016 Mar; 48(3):231-237. PMID: 26808112.
    Citations: 11     Fields:    Translation:HumansAnimals
  8. Savova V, Patsenker J, Vigneau S, Gimelbrant AA. dbMAE: the database of autosomal monoallelic expression. Nucleic Acids Res. 2016 Jan 04; 44(D1):D753-6. PMID: 26503248.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  9. Nag A, Vigneau S, Savova V, Zwemer LM, Gimelbrant AA. Chromatin Signature Identifies Monoallelic Gene Expression Across Mammalian Cell Types. G3 (Bethesda). 2015 Jun 18; 5(8):1713-20. PMID: 26092837.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  10. Su Y, Subedee A, Bloushtain-Qimron N, Savova V, Krzystanek M, Li L, Marusyk A, Tabassum DP, Zak A, Flacker MJ, Li M, Lin JJ, Sukumar S, Suzuki H, Long H, Szallasi Z, Gimelbrant A, Maruyama R, Polyak K. Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer. Cell Rep. 2015 Jun 16; 11(10):1549-63. PMID: 26051943.
    Citations: 15     Fields:    Translation:HumansCells
  11. Adegbola AA, Cox GF, Bradshaw EM, Hafler DA, Gimelbrant A, Chess A. Monoallelic expression of the human FOXP2 speech gene. Proc Natl Acad Sci U S A. 2015 Jun 02; 112(22):6848-54. PMID: 25422445.
    Citations: 8     Fields:    Translation:Humans
  12. Hutchinson JN, Fagerness J, Kirby A, Reynolds R, Zak A, Gimelbrant A, Plenge R, Daly M, Chess A, Seddon JM. (Epi)Genetic analyses of age-related macular degeneration: case-control and discordant twin studies. Hum Hered. 2014; 78(2):59-72. PMID: 25033836.
    Citations: 2     Fields:    Translation:HumansCells
  13. Hutchinson JN, Raj T, Fagerness J, Stahl E, Viloria FT, Gimelbrant A, Seddon J, Daly M, Chess A, Plenge R. Allele-specific methylation occurs at genetic variants associated with complex disease. PLoS One. 2014; 9(6):e98464. PMID: 24911414.
    Citations: 10     Fields:    Translation:HumansCells
  14. Nag A, Savova V, Fung HL, Miron A, Yuan GC, Zhang K, Gimelbrant AA. Chromatin signature of widespread monoallelic expression. Elife. 2013 Dec 31; 2:e01256. PMID: 24381246.
    Citations: 26     Fields:    Translation:HumansCells
  15. Savova V, Vigneau S, Gimelbrant AA. Autosomal monoallelic expression: genetics of epigenetic diversity? Curr Opin Genet Dev. 2013 Dec; 23(6):642-8. PMID: 24075575.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  16. Anguera MC, Sadreyev R, Zhang Z, Szanto A, Payer B, Sheridan SD, Kwok S, Haggarty SJ, Sur M, Alvarez J, Gimelbrant A, Mitalipova M, Kirby JE, Lee JT. Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes. Cell Stem Cell. 2012 Jul 06; 11(1):75-90. PMID: 22770242.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  17. Zwemer LM, Zak A, Thompson BR, Kirby A, Daly MJ, Chess A, Gimelbrant AA. Autosomal monoallelic expression in the mouse. Genome Biol. 2012 Feb 20; 13(2):R10. PMID: 22348269.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  18. Zacharek SJ, Fillmore CM, Lau AN, Gludish DW, Chou A, Ho JW, Zamponi R, Gazit R, Bock C, Jäger N, Smith ZD, Kim TM, Saunders AH, Wong J, Lee JH, Roach RR, Rossi DJ, Meissner A, Gimelbrant AA, Park PJ, Kim CF. Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci. Cell Stem Cell. 2011 Sep 02; 9(3):272-81. PMID: 21885022.
    Citations: 53     Fields:    Translation:AnimalsCells
  19. Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, Jaenisch R, Mitalipova M. Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell. 2010 May 28; 141(5):872-83. PMID: 20471072.
    Citations: 153     Fields:    Translation:HumansAnimalsCells
  20. Gimelbrant A, Hutchinson JN, Thompson BR, Chess A. Widespread monoallelic expression on human autosomes. Science. 2007 Nov 16; 318(5853):1136-40. PMID: 18006746.
    Citations: 222     Fields:    Translation:HumansAnimalsCells
  21. Gimelbrant AA, Chess A. An epigenetic state associated with areas of gene duplication. Genome Res. 2006 Jun; 16(6):723-9. PMID: 16687731.
    Citations: 12     Fields:    Translation:AnimalsCells
  22. Gimelbrant AA, Ensminger AW, Qi P, Zucker J, Chess A. Monoallelic expression and asynchronous replication of p120 catenin in mouse and human cells. J Biol Chem. 2005 Jan 14; 280(2):1354-9. PMID: 15522875.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  23. Gimelbrant AA, Skaletsky H, Chess A. Selective pressures on the olfactory receptor repertoire since the human-chimpanzee divergence. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):9019-22. PMID: 15178761.
    Citations: 26     Fields:    Translation:HumansAnimals
  24. Singh N, Ebrahimi FA, Gimelbrant AA, Ensminger AW, Tackett MR, Qi P, Gribnau J, Chess A. Coordination of the random asynchronous replication of autosomal loci. Nat Genet. 2003 Mar; 33(3):339-41. PMID: 12577058.
    Citations: 37     Fields:    Translation:AnimalsCells
  25. Hollins B, Hardin D, Gimelbrant AA, McClintock TS. Olfactory-enriched transcripts are cell-specific markers in the lobster olfactory organ. J Comp Neurol. 2003 Jan 01; 455(1):125-38. PMID: 12455001.
    Citations: 14     Fields:    Translation:AnimalsCells
  26. Gimelbrant AA, Haley SL, McClintock TS. Olfactory receptor trafficking involves conserved regulatory steps. J Biol Chem. 2001 Mar 09; 276(10):7285-90. PMID: 11060288.
    Citations: 25     Fields:    Translation:AnimalsCells
  27. Gimelbrant AA, Stoss TD, Landers TM, McClintock TS. Truncation releases olfactory receptors from the endoplasmic reticulum of heterologous cells. J Neurochem. 1999 Jun; 72(6):2301-11. PMID: 10349839.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  28. Mankad RV, Gimelbrant AA, McClintock TS. Consensus translational initiation sites of marine invertebrate phyla. Biol Bull. 1998 Dec; 195(3):251-4. PMID: 9924770.
    Citations: 2     Fields:    Translation:AnimalsCells
  29. McClintock TS, Landers TM, Gimelbrant AA, Fuller LZ, Jackson BA, Jayawickreme CK, Lerner MR. Functional expression of olfactory-adrenergic receptor chimeras and intracellular retention of heterologously expressed olfactory receptors. Brain Res Mol Brain Res. 1997 Sep; 48(2):270-8. PMID: 9332724.
    Citations: 16     Fields:    Translation:AnimalsCells
  30. Gimelbrant AA, McClintock TS. A nuclear matrix attachment region is highly homologous to a conserved domain of olfactory receptors. J Mol Neurosci. 1997 Aug; 9(1):61-3. PMID: 9356928.
    Citations:    Fields:    Translation:HumansAnimalsCells
  31. Gorodovikova EN, Gimelbrant AA, Senin II, Philippov PP. Recoverin mediates the calcium effect upon rhodopsin phosphorylation and cGMP hydrolysis in bovine retina rod cells. FEBS Lett. 1994 Aug 01; 349(2):187-90. PMID: 8050563.
    Citations: 9     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.