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Veronica Len Massey, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Massey VL, Qin L, Cabezas J, Caballeria J, Sancho-Bru P, Bataller R, Crews FT. TLR7-let-7 Signaling Contributes to Ethanol-Induced Hepatic Inflammatory Response in Mice and in Alcoholic Hepatitis. Alcohol Clin Exp Res. 2018 Nov; 42(11):2107-2122. PMID: 30103265.
    Citations:    Fields:    
  2. Chen Y, Ouyang X, Hoque R, Garcia-Martinez I, Yousaf MN, Tonack S, Offermanns S, Dubuquoy L, Louvet A, Mathurin P, Massey V, Schnabl B, Bataller RA, Mehal WZ. ß-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway. J Hepatol. 2018 09; 69(3):687-696. PMID: 29705237.
    Citations:    Fields:    
  3. Hudson SV, Dolin CE, Poole LG, Massey VL, Wilkey D, Beier JI, Merchant ML, Frieboes HB, Arteel GE. Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins. Sci Rep. 2017 09 29; 7(1):12444. PMID: 28963535.
    Citations: 1     Fields:    
  4. Poole LG, Massey VL, Siow DL, Torres-Gonzáles E, Warner NL, Luyendyk JP, Ritzenthaler JD, Roman J, Arteel GE. Plasminogen Activator Inhibitor-1 Is Critical in Alcohol-Enhanced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol. 2017 09; 57(3):315-323. PMID: 28445073.
    Citations:    Fields:    Translation:AnimalsCells
  5. Massey V, Cabezas J, Bataller R. Epigenetics in Liver Fibrosis. Semin Liver Dis. 2017 08; 37(3):219-230. PMID: 28847033.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Massey VL, Dolin CE, Poole LG, Hudson SV, Siow DL, Brock GN, Merchant ML, Wilkey DW, Arteel GE. The hepatic "matrisome" responds dynamically to injury: Characterization of transitional changes to the extracellular matrix in mice. Hepatology. 2017 03; 65(3):969-982. PMID: 28035785.
    Citations: 2     Fields:    Translation:AnimalsCells
  7. Massey VL, Beier JI, Ritzenthaler JD, Roman J, Arteel GE. Potential Role of the Gut/Liver/Lung Axis in Alcohol-Induced Tissue Pathology. Biomolecules. 2015 Sep 30; 5(4):2477-503. PMID: 26437442.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  8. Massey VL, Poole LG, Siow DL, Torres E, Warner NL, Schmidt RH, Ritzenthaler JD, Roman J, Arteel GE. Chronic Alcohol Exposure Enhances Lipopolysaccharide-Induced Lung Injury in Mice: Potential Role of Systemic Tumor Necrosis Factor-Alpha. Alcohol Clin Exp Res. 2015 Oct; 39(10):1978-88. PMID: 26380957.
    Citations: 5     Fields:    Translation:Animals
  9. Massey VL, Stocke KS, Schmidt RH, Tan M, Ajami N, Neal RE, Petrosino JF, Barve S, Arteel GE. Oligofructose protects against arsenic-induced liver injury in a model of environment/obesity interaction. Toxicol Appl Pharmacol. 2015 May 01; 284(3):304-14. PMID: 25759243.
    Citations: 5     Fields:    Translation:Animals
  10. Schmidt RH, Jokinen JD, Massey VL, Falkner KC, Shi X, Yin X, Zhang X, Beier JI, Arteel GE. Olanzapine activates hepatic mammalian target of rapamycin: new mechanistic insight into metabolic dysregulation with atypical antipsychotic drugs. J Pharmacol Exp Ther. 2013 Oct; 347(1):126-35. PMID: 23926289.
    Citations: 9     Fields:    Translation:Animals
  11. Massey VL, Arteel GE. Acute alcohol-induced liver injury. Front Physiol. 2012; 3:193. PMID: 22701432.
    Citations: 17     
  12. Xu D, Ballou DP, Massey V. Studies of the mechanism of phenol hydroxylase: mutants Tyr289Phe, Asp54Asn, and Arg281Met. Biochemistry. 2001 Oct 16; 40(41):12369-78. PMID: 11591156.
    Citations: 5     Fields:    Translation:AnimalsCells
  13. Sheng D, Ballou DP, Massey V. Mechanistic studies of cyclohexanone monooxygenase: chemical properties of intermediates involved in catalysis. Biochemistry. 2001 Sep 18; 40(37):11156-67. PMID: 11551214.
  14. Ortiz-Maldonado M, Aeschliman SM, Ballou DP, Massey V. Synergistic interactions of multiple mutations on catalysis during the hydroxylation reaction of p-hydroxybenzoate hydroxylase: studies of the Lys297Met, Asn300Asp, and Tyr385Phe mutants reconstituted with 8-Cl-flavin. Biochemistry. 2001 Jul 31; 40(30):8705-16. PMID: 11467930.
    Citations:    Fields:    Translation:Cells
  15. Ortiz-Maldonado M, Ballou DP, Massey V. A rate-limiting conformational change of the flavin in p-hydroxybenzoate hydroxylase is necessary for ligand exchange and catalysis: studies with 8-mercapto- and 8-hydroxy-flavins. Biochemistry. 2001 Jan 30; 40(4):1091-101. PMID: 11170433.
  16. Raibekas AA, Fukui K, Massey V. Design and properties of human D-amino acid oxidase with covalently attached flavin. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3089-93. PMID: 10716694.
    Citations: 4     Fields:    Translation:HumansCells
  17. Ortiz-Maldonado M, Gatti D, Ballou DP, Massey V. Structure-function correlations of the reaction of reduced nicotinamide analogues with p-hydroxybenzoate hydroxylase substituted with a series of 8-substituted flavins. Biochemistry. 1999 Dec 14; 38(50):16636-47. PMID: 10600126.
    Citations: 6     Fields:    Translation:Cells
  18. Sanders SA, Williams CH, Massey V. The roles of two amino acid residues in the active site of L-lactate monooxygenase. Mutation of arginine 187 to methionine and histidine 240 to glutamine. J Biol Chem. 1999 Aug 06; 274(32):22289-95. PMID: 10428797.
    Citations: 1     Fields:    Translation:Cells
  19. Xu D, Kohli RM, Massey V. The role of threonine 37 in flavin reactivity of the old yellow enzyme. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3556-61. PMID: 10097075.
    Citations: 10     Fields:    Translation:Cells
  20. Brown BJ, Deng Z, Karplus PA, Massey V. On the active site of Old Yellow Enzyme. Role of histidine 191 and asparagine 194. J Biol Chem. 1998 Dec 04; 273(49):32753-62. PMID: 9830019.
    Citations: 22     Fields:    Translation:Cells
  21. Palfey BA, Ballou DP, Massey V. Flavin conformational changes in the catalytic cycle of p-hydroxybenzoate hydroxylase substituted with 6-azido- and 6-aminoflavin adenine dinucleotide. Biochemistry. 1997 Dec 16; 36(50):15713-23. PMID: 9398300.
    Citations: 3     Fields:    Translation:Cells
  22. Chaiyen P, Brissette P, Ballou DP, Massey V. Reaction of 2-methyl-3-hydroxypyridine-5-carboxylic acid (MHPC) oxygenase with N-methyl-5-hydroxynicotinic acid: studies on the mode of binding, and protonation status of the substrate. Biochemistry. 1997 Nov 11; 36(45):13856-64. PMID: 9374863.
    Citations: 6     Fields:    Translation:Cells
  23. Sun W, Williams CH, Massey V. The role of glycine 99 in L-lactate monooxygenase from Mycobacterium smegmatis. J Biol Chem. 1997 Oct 24; 272(43):27065-76. PMID: 9341146.
    Citations: 2     Fields:    Translation:Cells
  24. Chaiyen P, Brissette P, Ballou DP, Massey V. Thermodynamics and reduction kinetics properties of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase. Biochemistry. 1997 Mar 04; 36(9):2612-21. PMID: 9054568.
    Citations: 8     Fields:    Translation:Cells
  25. Benson TE, Walsh CT, Massey V. Kinetic characterization of wild-type and S229A mutant MurB: evidence for the role of Ser 229 as a general acid. Biochemistry. 1997 Jan 28; 36(4):796-805. PMID: 9020777.
    Citations: 6     Fields:    Translation:Cells
  26. Sun W, Williams CH, Massey V. Site-directed mutagenesis of glycine 99 to alanine in L-lactate monooxygenase from Mycobacterium smegmatis. J Biol Chem. 1996 Jul 19; 271(29):17226-33. PMID: 8663383.
    Citations: 3     Fields:    Translation:Cells
  27. Tedeschi G, Deng PS, Chen HH, Forrest GL, Massey V, Chen S. A site-directed mutagenesis study at Lys-113 of NAD(P)H:quinone-acceptor oxidoreductase: an involvement of Lys-113 in the binding of the flavin adenine dinucleotide prosthetic group. Arch Biochem Biophys. 1995 Aug 01; 321(1):76-82. PMID: 7639539.
    Citations: 1     Fields:    Translation:Cells
  28. Vaz AD, Chakraborty S, Massey V. Old Yellow enzyme: aromatization of cyclic enones and the mechanism of a novel dismutation reaction. Biochemistry. 1995 Apr 04; 34(13):4246-56. PMID: 7703238.
    Citations: 24     Fields:    Translation:Cells
  29. Niino YS, Chakraborty S, Brown BJ, Massey V. A new old yellow enzyme of Saccharomyces cerevisiae. J Biol Chem. 1995 Feb 03; 270(5):1983-91. PMID: 7836424.
    Citations: 20     Fields:    Translation:AnimalsCells
  30. Tedeschi G, Chen S, Massey V. DT-diaphorase. Redox potential, steady-state, and rapid reaction studies. J Biol Chem. 1995 Jan 20; 270(3):1198-204. PMID: 7836380.
  31. Müh U, Williams CH, Massey V. Lactate monooxygenase. III. Additive contributions of active site residues to catalytic efficiency and stabilization of an anionic transition state. J Biol Chem. 1994 Mar 18; 269(11):7994-8000. PMID: 8132520.
    Citations: 3     Fields:    Translation:Cells
  32. Müh U, Williams CH, Massey V. Lactate monooxygenase. II. Site-directed mutagenesis of the postulated active site base histidine 290. J Biol Chem. 1994 Mar 18; 269(11):7989-93. PMID: 8132519.
    Citations: 6     Fields:    Translation:Cells
  33. Müh U, Massey V, Williams CH. Lactate monooxygenase. I. Expression of the mycobacterial gene in Escherichia coli and site-directed mutagenesis of lysine 266. J Biol Chem. 1994 Mar 18; 269(11):7982-8. PMID: 8132518.
    Citations: 5     Fields:    Translation:Cells
  34. Palfey BA, Entsch B, Ballou DP, Massey V. Changes in the catalytic properties of p-hydroxybenzoate hydroxylase caused by the mutation Asn300Asp. Biochemistry. 1994 Feb 15; 33(6):1545-54. PMID: 8312275.
    Citations: 5     Fields:    Translation:Cells
  35. Maeda-Yorita K, Russell GC, Guest JR, Massey V, Williams CH. Properties of lipoamide dehydrogenase altered by site-directed mutagenesis at a key residue (I184Y) in the pyridine nucleotide binding domain. Biochemistry. 1991 Dec 24; 30(51):11788-95. PMID: 1751496.
    Citations: 3     Fields:    Translation:Cells
  36. Entsch B, Palfey BA, Ballou DP, Massey V. Catalytic function of tyrosine residues in para-hydroxybenzoate hydroxylase as determined by the study of site-directed mutants. J Biol Chem. 1991 Sep 15; 266(26):17341-9. PMID: 1910043.
    Citations: 10     Fields:    Translation:Cells
  37. Miller SM, Massey V, Williams CH, Ballou DP, Walsh CT. Communication between the active sites in dimeric mercuric ion reductase: an alternating sites hypothesis for catalysis. Biochemistry. 1991 Mar 12; 30(10):2600-12. PMID: 2001350.
    Citations: 7     Fields:    Translation:Cells
  38. Taylor MG, Massey V. Decay of the 4a-hydroxy-FAD intermediate of phenol hydroxylase. J Biol Chem. 1990 Aug 15; 265(23):13687-94. PMID: 2380181.
    Citations: 3     Fields:    Translation:AnimalsCells
  39. Miller SM, Massey V, Ballou D, Williams CH, Distefano MD, Moore MJ, Walsh CT. Use of a site-directed triple mutant to trap intermediates: demonstration that the flavin C(4a)-thiol adduct and reduced flavin are kinetically competent intermediates in mercuric ion reductase. Biochemistry. 1990 Mar 20; 29(11):2831-41. PMID: 2189497.
    Citations: 17     Fields:    Translation:Cells
  40. Einarsdottir GH, Stankovich MT, Powlowski J, Ballou DP, Massey V. Regulation of oxidation-reduction potentials of anthranilate hydroxylase from Trichosporon cutaneum by substrate and effector binding. Biochemistry. 1989 May 16; 28(10):4161-8. PMID: 2765477.
    Citations: 1     Fields:    Translation:AnimalsCells
  41. Powlowski J, Massey V, Ballou DP. Reactions of anthranilate hydroxylase with salicylate, a nonhydroxylated substrate analogue. Steady state and rapid reaction kinetics. J Biol Chem. 1989 Apr 05; 264(10):5606-12. PMID: 2925623.
  42. Miller SM, Moore MJ, Massey V, Williams CH, Distefano MD, Ballou DP, Walsh CT. Evidence for the participation of Cys558 and Cys559 at the active site of mercuric reductase. Biochemistry. 1989 Feb 07; 28(3):1194-205. PMID: 2653437.
    Citations: 15     Fields:    Translation:Cells
  43. Schopfer LM, Massey V, Ghisla S, Thorpe C. Oxidation-reduction of general acyl-CoA dehydrogenase by the butyryl-CoA/crotonyl-CoA couple. A new investigation of the rapid reaction kinetics. Biochemistry. 1988 Aug 23; 27(17):6599-611. PMID: 3219356.
    Citations: 10     Fields:    Translation:AnimalsCells
  44. Gumucio JJ, May M, Dvorak C, Chianale J, Massey V. The isolation of functionally heterogeneous hepatocytes of the proximal and distal half of the liver acinus in the rat. Hepatology. 1986 Sep-Oct; 6(5):932-44. PMID: 3019862.
    Citations: 10     Fields:    Translation:Animals
  45. Miller SM, Ballou DP, Massey V, Williams CH, Walsh CT. Two-electron reduced mercuric reductase binds Hg(II) to the active site dithiol but does not catalyze Hg(II) reduction. J Biol Chem. 1986 Jun 25; 261(18):8081-4. PMID: 3522563.
    Citations: 2     Fields:    Translation:Cells
  46. Ghisla S, Thorpe C, Massey V. Mechanistic studies with general acyl-CoA dehydrogenase and butyryl-CoA dehydrogenase: evidence for the transfer of the beta-hydrogen to the flavin N(5)-position as a hydride. Biochemistry. 1984 Jul 03; 23(14):3154-61. PMID: 6466635.
    Citations: 13     Fields:    Translation:Animals
  47. Detmer K, Schopfer LM, Massey V. Reactions of 1-deaza-FAD-substituted phenol hydroxylase and melilotate hydroxylase. J Biol Chem. 1984 Feb 10; 259(3):1532-8. PMID: 6693423.
  48. Morpeth FF, Massey V. Metal binding to D-lactate dehydrogenase. Biochemistry. 1982 Mar 16; 21(6):1318-23. PMID: 7074089.
  49. Husain M, Entsch B, Ballou DP, Massey V, Chapman PJ. Fluoride elimination from substrates in hydroxylation reactions catalyzed by p-hydroxybenzoate hydroxylase. J Biol Chem. 1980 May 10; 255(9):4189-97. PMID: 6768750.
    Citations: 16     Fields:    Translation:Cells
  50. Entsch B, Husain M, Ballou DP, Massey V, Walsh C. Oxygen reactivity of p-hydroxybenzoate hydroxylase containing 1-deaza-FAD. J Biol Chem. 1980 Feb 25; 255(4):1420-9. PMID: 6766449.
    Citations: 6     Fields:    Translation:Cells
  51. Husain M, Massey V. Kinetic studies on the reaction of p-hydroxybenzoate hydroxylase. Agreement of steady state and rapid reaction data. J Biol Chem. 1979 Jul 25; 254(14):6657-66. PMID: 36402.
  52. Husain M, Schopfer LM, Massey V. P-Hydroxybenzoate hydroxylase and melilotate hydroxylase. Methods Enzymol. 1978; 53:543-58. PMID: 30879.
  53. Schonbrunn A, Abeles RH, Walsh CT, Ghisla S, Ogata H, Massey V. The structure of the covalent flavin adduct formed between lactate oxidase and the suicide substrate 2-hydroxy-3-butynoate. Biochemistry. 1976 May 04; 15(9):1798-807. PMID: 1268196.
    Citations: 4     Fields:    Translation:Cells
  54. Ghisla S, Ogata H, Massey V, Schonbrunn A, Abeles RH, Walsh CT. Kinetic studies on the inactivation of L-lactate oxidase by [the acetylenic suicide substrate] 2-hydroxy-3-butynoate. Biochemistry. 1976 May 04; 15(9):1791-7. PMID: 1268195.
    Citations: 4     Fields:    Translation:Cells
  55. Walsh C, Lockridge O, Massey V, Abeles R. Studies on the mechanism of action of the flavoenzyme lactate oxidase. Oxidation and elimination with beta-chlorolactate. J Biol Chem. 1973 Oct 25; 248(20):7049-54. PMID: 4147556.
    Citations: 11     Fields:    Translation:Cells
  56. Walsh CT, Krodel E, Massey V, Abeles RH. Studies on the elimination reaction of D-amino acid oxidase with -amino- -chlorobutyrate. Further evidence for abstraction of substrate -hydrogen as a proton. J Biol Chem. 1973 Mar 25; 248(6):1946-55. PMID: 4144104.
    Citations: 9     Fields:    Translation:AnimalsCells
  57. Spector T, Massey V. p-Hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Reactivity with oxygen. J Biol Chem. 1972 Nov 25; 247(22):7123-7. PMID: 4404745.
  58. Walsh CT, Schonbrunn A, Lockridge O, Massey V, Abeles RH. Inactivation of a flavoprotein, lactate oxidase, by an acetylenic substrate. J Biol Chem. 1972 Sep 25; 247(18):6004-6. PMID: 5057095.
    Citations: 8     Fields:    Translation:Cells
  59. Spector T, Massey V. p-Hydroxybenzoate hydroxylase from Pseudomonas fluorescens. Evidence for an oxygenated flavin intermediate. J Biol Chem. 1972 Sep 10; 247(17):5632-6. PMID: 4403446.
  60. Spector T, Massey V. Studies on the effector specificity of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. J Biol Chem. 1972 Jul 25; 247(14):4679-87. PMID: 4402938.
    Citations: 2     Fields:    Translation:Cells
  61. Howell LG, Spector T, Massey V. Purification and properties of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. J Biol Chem. 1972 Jul 10; 247(13):4340-50. PMID: 4402514.
  62. Howell LG, Massey V. A non-substrate effector of p-hydroxybenzoate hydroxylase. Biochem Biophys Res Commun. 1970 Aug 24; 40(4):887-93. PMID: 4395604.
    Citations: 2     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.