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profileVeronica Len Massey, M.D.

TitleInstructor in Anaesthesia, Part-time
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia
AddressMgh
55 Fruit St
Boston MA 02114
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hudson SV, Dolin CE, Poole LG, Massey VL, Wilkey D, Beier JI, Merchant ML, Frieboes HB, Arteel GE. Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins. Sci Rep. 2017 Sep 29; 7(1):12444. PMID: 28963535.
    View in: PubMed
  2. Poole LG, Massey VL, Siow DL, Torres-Gonzáles E, Warner NL, Luyendyk JP, Ritzenthaler JD, Roman J, Arteel GE. Plasminogen Activator Inhibitor-1 Is Critical in Alcohol-Enhanced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol. 2017 Sep; 57(3):315-323. PMID: 28445073.
    View in: PubMed
  3. Massey VL, Dolin CE, Poole LG, Hudson SV, Siow DL, Brock GN, Merchant ML, Wilkey DW, Arteel GE. The hepatic "matrisome" responds dynamically to injury: Characterization of transitional changes to the extracellular matrix in mice. Hepatology. 2017 Mar; 65(3):969-982. PMID: 28035785.
    View in: PubMed
  4. Massey VL, Beier JI, Ritzenthaler JD, Roman J, Arteel GE. Potential Role of the Gut/Liver/Lung Axis in Alcohol-Induced Tissue Pathology. Biomolecules. 2015 Sep 30; 5(4):2477-503. PMID: 26437442; PMCID: PMC4693244.
  5. Massey VL, Poole LG, Siow DL, Torres E, Warner NL, Schmidt RH, Ritzenthaler JD, Roman J, Arteel GE. Chronic Alcohol Exposure Enhances Lipopolysaccharide-Induced Lung Injury in Mice: Potential Role of Systemic Tumor Necrosis Factor-Alpha. Alcohol Clin Exp Res. 2015 Oct; 39(10):1978-88. PMID: 26380957; PMCID: PMC4804458 [Available on 10/01/16].
  6. Massey VL, Stocke KS, Schmidt RH, Tan M, Ajami N, Neal RE, Petrosino JF, Barve S, Arteel GE. Oligofructose protects against arsenic-induced liver injury in a model of environment/obesity interaction. Toxicol Appl Pharmacol. 2015 May 01; 284(3):304-14. PMID: 25759243; PMCID: PMC4515777.
  7. Schmidt RH, Jokinen JD, Massey VL, Falkner KC, Shi X, Yin X, Zhang X, Beier JI, Arteel GE. Olanzapine activates hepatic mammalian target of rapamycin: new mechanistic insight into metabolic dysregulation with atypical antipsychotic drugs. J Pharmacol Exp Ther. 2013 Oct; 347(1):126-35. PMID: 23926289; PMCID: PMC3781405.
  8. Massey VL, Arteel GE. Acute alcohol-induced liver injury. Front Physiol. 2012; 3:193. PMID: 22701432; PMCID: PMC3372892.
  9. Xu D, Ballou DP, Massey V. Studies of the mechanism of phenol hydroxylase: mutants Tyr289Phe, Asp54Asn, and Arg281Met. Biochemistry. 2001 Oct 16; 40(41):12369-78. PMID: 11591156.
    View in: PubMed
  10. Ortiz-Maldonado M, Aeschliman SM, Ballou DP, Massey V. Synergistic interactions of multiple mutations on catalysis during the hydroxylation reaction of p-hydroxybenzoate hydroxylase: studies of the Lys297Met, Asn300Asp, and Tyr385Phe mutants reconstituted with 8-Cl-flavin. Biochemistry. 2001 Jul 31; 40(30):8705-16. PMID: 11467930.
    View in: PubMed
  11. Raibekas AA, Fukui K, Massey V. Design and properties of human D-amino acid oxidase with covalently attached flavin. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3089-93. PMID: 10716694; PMCID: PMC16197.
  12. Ortiz-Maldonado M, Gatti D, Ballou DP, Massey V. Structure-function correlations of the reaction of reduced nicotinamide analogues with p-hydroxybenzoate hydroxylase substituted with a series of 8-substituted flavins. Biochemistry. 1999 Dec 14; 38(50):16636-47. PMID: 10600126.
    View in: PubMed
  13. Xu D, Kohli RM, Massey V. The role of threonine 37 in flavin reactivity of the old yellow enzyme. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3556-61. PMID: 10097075; PMCID: PMC22332.
  14. Brown BJ, Deng Z, Karplus PA, Massey V. On the active site of Old Yellow Enzyme. Role of histidine 191 and asparagine 194. J Biol Chem. 1998 Dec 04; 273(49):32753-62. PMID: 9830019.
    View in: PubMed
  15. Palfey BA, Ballou DP, Massey V. Flavin conformational changes in the catalytic cycle of p-hydroxybenzoate hydroxylase substituted with 6-azido- and 6-aminoflavin adenine dinucleotide. Biochemistry. 1997 Dec 16; 36(50):15713-23. PMID: 9398300.
    View in: PubMed
  16. Chaiyen P, Brissette P, Ballou DP, Massey V. Reaction of 2-methyl-3-hydroxypyridine-5-carboxylic acid (MHPC) oxygenase with N-methyl-5-hydroxynicotinic acid: studies on the mode of binding, and protonation status of the substrate. Biochemistry. 1997 Nov 11; 36(45):13856-64. PMID: 9374863.
    View in: PubMed
  17. Sun W, Williams CH, Massey V. The role of glycine 99 in L-lactate monooxygenase from Mycobacterium smegmatis. J Biol Chem. 1997 Oct 24; 272(43):27065-76. PMID: 9341146.
    View in: PubMed
  18. Chaiyen P, Brissette P, Ballou DP, Massey V. Thermodynamics and reduction kinetics properties of 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase. Biochemistry. 1997 Mar 04; 36(9):2612-21. PMID: 9054568.
    View in: PubMed
  19. Benson TE, Walsh CT, Massey V. Kinetic characterization of wild-type and S229A mutant MurB: evidence for the role of Ser 229 as a general acid. Biochemistry. 1997 Jan 28; 36(4):796-805. PMID: 9020777.
    View in: PubMed
  20. Sun W, Williams CH, Massey V. Site-directed mutagenesis of glycine 99 to alanine in L-lactate monooxygenase from Mycobacterium smegmatis. J Biol Chem. 1996 Jul 19; 271(29):17226-33. PMID: 8663383.
    View in: PubMed
  21. Tedeschi G, Deng PS, Chen HH, Forrest GL, Massey V, Chen S. A site-directed mutagenesis study at Lys-113 of NAD(P)H:quinone-acceptor oxidoreductase: an involvement of Lys-113 in the binding of the flavin adenine dinucleotide prosthetic group. Arch Biochem Biophys. 1995 Aug 01; 321(1):76-82. PMID: 7639539.
    View in: PubMed
  22. Vaz AD, Chakraborty S, Massey V. Old Yellow enzyme: aromatization of cyclic enones and the mechanism of a novel dismutation reaction. Biochemistry. 1995 Apr 04; 34(13):4246-56. PMID: 7703238.
    View in: PubMed
  23. Niino YS, Chakraborty S, Brown BJ, Massey V. A new old yellow enzyme of Saccharomyces cerevisiae. J Biol Chem. 1995 Feb 03; 270(5):1983-91. PMID: 7836424.
    View in: PubMed
  24. Müh U, Williams CH, Massey V. Lactate monooxygenase. III. Additive contributions of active site residues to catalytic efficiency and stabilization of an anionic transition state. J Biol Chem. 1994 Mar 18; 269(11):7994-8000. PMID: 8132520.
    View in: PubMed
  25. Müh U, Williams CH, Massey V. Lactate monooxygenase. II. Site-directed mutagenesis of the postulated active site base histidine 290. J Biol Chem. 1994 Mar 18; 269(11):7989-93. PMID: 8132519.
    View in: PubMed
  26. Müh U, Massey V, Williams CH. Lactate monooxygenase. I. Expression of the mycobacterial gene in Escherichia coli and site-directed mutagenesis of lysine 266. J Biol Chem. 1994 Mar 18; 269(11):7982-8. PMID: 8132518.
    View in: PubMed
  27. Palfey BA, Entsch B, Ballou DP, Massey V. Changes in the catalytic properties of p-hydroxybenzoate hydroxylase caused by the mutation Asn300Asp. Biochemistry. 1994 Feb 15; 33(6):1545-54. PMID: 8312275.
    View in: PubMed
  28. Maeda-Yorita K, Russell GC, Guest JR, Massey V, Williams CH. Properties of lipoamide dehydrogenase altered by site-directed mutagenesis at a key residue (I184Y) in the pyridine nucleotide binding domain. Biochemistry. 1991 Dec 24; 30(51):11788-95. PMID: 1751496.
    View in: PubMed
  29. Entsch B, Palfey BA, Ballou DP, Massey V. Catalytic function of tyrosine residues in para-hydroxybenzoate hydroxylase as determined by the study of site-directed mutants. J Biol Chem. 1991 Sep 15; 266(26):17341-9. PMID: 1910043.
    View in: PubMed
  30. Miller SM, Massey V, Williams CH, Ballou DP, Walsh CT. Communication between the active sites in dimeric mercuric ion reductase: an alternating sites hypothesis for catalysis. Biochemistry. 1991 Mar 12; 30(10):2600-12. PMID: 2001350.
    View in: PubMed
  31. Taylor MG, Massey V. Decay of the 4a-hydroxy-FAD intermediate of phenol hydroxylase. J Biol Chem. 1990 Aug 15; 265(23):13687-94. PMID: 2380181.
    View in: PubMed
  32. Miller SM, Massey V, Ballou D, Williams CH, Distefano MD, Moore MJ, Walsh CT. Use of a site-directed triple mutant to trap intermediates: demonstration that the flavin C(4a)-thiol adduct and reduced flavin are kinetically competent intermediates in mercuric ion reductase. Biochemistry. 1990 Mar 20; 29(11):2831-41. PMID: 2189497.
    View in: PubMed
  33. Einarsdottir GH, Stankovich MT, Powlowski J, Ballou DP, Massey V. Regulation of oxidation-reduction potentials of anthranilate hydroxylase from Trichosporon cutaneum by substrate and effector binding. Biochemistry. 1989 May 16; 28(10):4161-8. PMID: 2765477.
    View in: PubMed
  34. Miller SM, Moore MJ, Massey V, Williams CH, Distefano MD, Ballou DP, Walsh CT. Evidence for the participation of Cys558 and Cys559 at the active site of mercuric reductase. Biochemistry. 1989 Feb 07; 28(3):1194-205. PMID: 2653437.
    View in: PubMed
  35. Gumucio JJ, May M, Dvorak C, Chianale J, Massey V. The isolation of functionally heterogeneous hepatocytes of the proximal and distal half of the liver acinus in the rat. Hepatology. 1986 Sep-Oct; 6(5):932-44. PMID: 3019862.
    View in: PubMed
  36. Miller SM, Ballou DP, Massey V, Williams CH, Walsh CT. Two-electron reduced mercuric reductase binds Hg(II) to the active site dithiol but does not catalyze Hg(II) reduction. J Biol Chem. 1986 Jun 25; 261(18):8081-4. PMID: 3522563.
    View in: PubMed
  37. Ghisla S, Thorpe C, Massey V. Mechanistic studies with general acyl-CoA dehydrogenase and butyryl-CoA dehydrogenase: evidence for the transfer of the beta-hydrogen to the flavin N(5)-position as a hydride. Biochemistry. 1984 Jul 03; 23(14):3154-61. PMID: 6466635.
    View in: PubMed
  38. Entsch B, Husain M, Ballou DP, Massey V, Walsh C. Oxygen reactivity of p-hydroxybenzoate hydroxylase containing 1-deaza-FAD. J Biol Chem. 1980 Feb 25; 255(4):1420-9. PMID: 6766449.
    View in: PubMed
  39. Schonbrunn A, Abeles RH, Walsh CT, Ghisla S, Ogata H, Massey V. The structure of the covalent flavin adduct formed between lactate oxidase and the suicide substrate 2-hydroxy-3-butynoate. Biochemistry. 1976 May 04; 15(9):1798-807. PMID: 1268196.
    View in: PubMed
  40. Ghisla S, Ogata H, Massey V, Schonbrunn A, Abeles RH, Walsh CT. Kinetic studies on the inactivation of L-lactate oxidase by [the acetylenic suicide substrate] 2-hydroxy-3-butynoate. Biochemistry. 1976 May 04; 15(9):1791-7. PMID: 1268195.
    View in: PubMed
  41. Walsh C, Lockridge O, Massey V, Abeles R. Studies on the mechanism of action of the flavoenzyme lactate oxidase. Oxidation and elimination with beta-chlorolactate. J Biol Chem. 1973 Oct 25; 248(20):7049-54. PMID: 4147556.
    View in: PubMed
  42. Walsh CT, Krodel E, Massey V, Abeles RH. Studies on the elimination reaction of D-amino acid oxidase with -amino- -chlorobutyrate. Further evidence for abstraction of substrate -hydrogen as a proton. J Biol Chem. 1973 Mar 25; 248(6):1946-55. PMID: 4144104.
    View in: PubMed
  43. Walsh CT, Schonbrunn A, Lockridge O, Massey V, Abeles RH. Inactivation of a flavoprotein, lactate oxidase, by an acetylenic substrate. J Biol Chem. 1972 Sep 25; 247(18):6004-6. PMID: 5057095.
    View in: PubMed
  44. Spector T, Massey V. Studies on the effector specificity of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. J Biol Chem. 1972 Jul 25; 247(14):4679-87. PMID: 4402938.
    View in: PubMed
  45. Howell LG, Massey V. A non-substrate effector of p-hydroxybenzoate hydroxylase. Biochem Biophys Res Commun. 1970 Aug 24; 40(4):887-93. PMID: 4395604.
    View in: PubMed
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