Harvard Catalyst Profiles

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Jake June-Koo Lee, Ph.D., M.D.

Title
Institution
Department
Address

Biography
Seoul National University College of Medicine, South KoreaM.D.02/2008Medicine
Seoul National University Hospital, South Korea02/2013Residency of Internal Medicine
Seoul National University College of Medicine, South KoreaM.S.02/2013Molecular Oncology
Korea Advanced Institute of Science and Technology, South KoreaPh.D.02/2017Medical Science and Engineering (Cancer Genomics)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jung M, Kim S, Lee JK, Yoon SO, Park HS, Hong SW, Park WS, Kim JE, Kim J, Keam B, Kim HJ, Kang HJ, Kim DW, Jung KC, Kim YT, Heo DS, Kim TM, Jeon YK. Clinicopathological and Preclinical Findings of NUT Carcinoma: A Multicenter Study. Oncologist. 2019 Jan 29. PMID: 30696721.
    Citations:    
  2. Lee JH, Lee JE, Kahng JY, Kim SH, Park JS, Yoon SJ, Um JY, Kim WK, Lee JK, Park J, Kim EH, Lee JH, Lee JH, Chung WS, Ju YS, Park SH, Chang JH, Kang SG, Lee JH. Human glioblastoma arises from subventricular zone cells with low-level driver mutations. Nature. 2018 Aug; 560(7717):243-247. PMID: 30069053.
    Citations: 1     Fields:    
  3. Lee J, Lee AJ, Lee JK, Park J, Kwon Y, Park S, Chun H, Ju YS, Hong D. Mutalisk: a web-based somatic MUTation AnaLyIS toolKit for genomic, transcriptional and epigenomic signatures. Nucleic Acids Res. 2018 Jul 02; 46(W1):W102-W108. PMID: 29790943.
    Citations:    Fields:    
  4. Lee JK, Lee J, Kim S, Kim S, Youk J, Park S, An Y, Keam B, Kim DW, Heo DS, Kim YT, Kim JS, Kim SH, Lee JS, Lee SH, Park K, Ku JL, Jeon YK, Chung DH, Park PJ, Kim J, Kim TM, Ju YS. Clonal History and Genetic Predictors of Transformation Into Small-Cell Carcinomas From Lung Adenocarcinomas. J Clin Oncol. 2017 Sep 10; 35(26):3065-3074. PMID: 28498782.
    Citations: 21     Fields:    Translation:Humans
  5. Lee JK, Louzada S, An Y, Kim SY, Kim S, Youk J, Park S, Koo SH, Keam B, Jeon YK, Ku JL, Yang F, Kim TM, Ju YS. Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma. Ann Oncol. 2017 04 01; 28(4):890-897. PMID: 28203693.
    Citations: 1     Fields:    Translation:HumansCells
  6. Lee SH, Lee JK, Ahn MJ, Kim DW, Sun JM, Keam B, Kim TM, Heo DS, Ahn JS, Choi YL, Min HS, Jeon YK, Park K. Vandetanib in pretreated patients with advanced non-small cell lung cancer-harboring RET rearrangement: a phase II clinical trial. Ann Oncol. 2017 02 01; 28(2):292-297. PMID: 27803005.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  7. Lee SH, Lee JK. Two recent phase 2 trials of vandetanib in RET-rearranged NSCLC. Lancet Respir Med. 2017 02; 5(2):e10. PMID: 28145234.
    Citations:    Fields:    Translation:Humans
  8. Lee JK, Choi YL, Kwon M, Park PJ. Mechanisms and Consequences of Cancer Genome Instability: Lessons from Genome Sequencing Studies. Annu Rev Pathol. 2016 05 23; 11:283-312. PMID: 26907526.
    Citations: 10     Fields:    Translation:Humans
  9. Kim MH, Kim J, Hong H, Lee SH, Lee JK, Jung E, Kim J. Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation. EMBO J. 2016 Mar 01; 35(5):462-78. PMID: 26668268; PMCID: PMC4772854.
    Citations: 26     Fields:    Translation:HumansCells
  10. Kim J, Jo H, Hong H, Kim MH, Kim JM, Lee JK, Heo WD, Kim J. Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking. Nat Commun. 2015 Apr 07; 6:6781. PMID: 25849865.
    Citations: 31     Fields:    Translation:HumansCells
  11. Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, Buhay C, Kang H, Kim SC, Fahey CC, Hacker KE, Bhanot G, Gordenin DA, Chu A, Gunaratne PH, Biehl M, Seth S, Kaipparettu BA, Bristow CA, Donehower LA, Wallen EM, Smith AB, Tickoo SK, Tamboli P, Reuter V, Schmidt LS, Hsieh JJ, Choueiri TK, Hakimi AA, Chin L, Meyerson M, Kucherlapati R, Park WY, Robertson AG, Laird PW, Henske EP, Kwiatkowski DJ, Park PJ, Morgan M, Shuch B, Muzny D, Wheeler DA, Linehan WM, Gibbs RA, Rathmell WK, Creighton CJ. The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer Cell. 2014 Sep 08; 26(3):319-330. PMID: 25155756; PMCID: PMC4160352.
    Citations: 133     Fields:    Translation:HumansCells
  12. An AR, Lee JK, Yun YH, Heo DS. Terminal cancer patients' and their primary caregivers' attitudes toward hospice/palliative care and their effects on actual utilization: A prospective cohort study. Palliat Med. 2014 Jul; 28(7):976-985. PMID: 24781817.
    Citations: 3     Fields:    
  13. Lee JK, Hahn S, Kim DW, Suh KJ, Keam B, Kim TM, Lee SH, Heo DS. Epidermal growth factor receptor tyrosine kinase inhibitors vs conventional chemotherapy in non-small cell lung cancer harboring wild-type epidermal growth factor receptor: a meta-analysis. JAMA. 2014 Apr 09; 311(14):1430-7. PMID: 24715074.
    Citations: 42     Fields:    Translation:Humans
  14. Lee JK, Yun YH, An AR, Heo DS, Park BW, Cho CH, Kim S, Lee DH, Lee SN, Lee ES, Kang JH, Kim SY, Lee JL, Lee CG, Lim YK, Kim S, Choi JS, Jeong HS, Chun M. The Understanding of Terminal Cancer and Its Relationship with Attitudes toward End-of-Life Care Issues. Med Decis Making. 2014 08; 34(6):720-30. PMID: 23975503.
    Citations: 3     Fields:    Translation:Humans
  15. Lee JK, Shin JY, Kim S, Lee S, Park C, Kim JY, Koh Y, Keam B, Min HS, Kim TM, Jeon YK, Kim DW, Chung DH, Heo DS, Lee SH, Kim JI. Primary resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with non-small-cell lung cancer harboring TKI-sensitive EGFR mutations: an exploratory study. Ann Oncol. 2013 Aug; 24(8):2080-7. PMID: 23559152.
    Citations: 34     Fields:    Translation:HumansCells
  16. Choi H, Paeng JC, Kim DW, Lee JK, Park CM, Kang KW, Chung JK, Lee DS. Metabolic and metastatic characteristics of ALK-rearranged lung adenocarcinoma on FDG PET/CT. Lung Cancer. 2013 Mar; 79(3):242-7. PMID: 23261227.
    Citations: 10     Fields:    Translation:Humans
  17. Seo JS, Ju YS, Lee WC, Shin JY, Lee JK, Bleazard T, Lee J, Jung YJ, Kim JO, Shin JY, Yu SB, Kim J, Lee ER, Kang CH, Park IK, Rhee H, Lee SH, Kim JI, Kang JH, Kim YT. The transcriptional landscape and mutational profile of lung adenocarcinoma. Genome Res. 2012 Nov; 22(11):2109-19. PMID: 22975805; PMCID: PMC3483540.
    Citations: 166     Fields:    Translation:HumansCells
  18. Lee JK, Keam B, An AR, Kim TM, Lee SH, Kim DW, Heo DS. Surrogate decision-making in Korean patients with advanced cancer: a longitudinal study. Support Care Cancer. 2013 Jan; 21(1):183-90. PMID: 22644263.
    Citations: 6     Fields:    Translation:Humans
  19. Lee JK, Kim TM, Koh Y, Lee SH, Kim DW, Jeon YK, Chung DH, Yang SC, Kim YT, Kim YW, Heo DS, Bang YJ. Differential sensitivities to tyrosine kinase inhibitors in NSCLC harboring EGFR mutation and ALK translocation. Lung Cancer. 2012 Aug; 77(2):460-3. PMID: 22622260.
    Citations: 21     Fields:    Translation:HumansCells
  20. Park HS, Lee JK, Kim DW, Kulig K, Kim TM, Lee SH, Jeon YK, Chung DH, Heo DS. Immunohistochemical screening for anaplastic lymphoma kinase (ALK) rearrangement in advanced non-small cell lung cancer patients. Lung Cancer. 2012 Aug; 77(2):288-92. PMID: 22465695.
    Citations: 31     Fields:    Translation:Humans
  21. Lee JK, Park HS, Kim DW, Kulig K, Kim TM, Lee SH, Jeon YK, Chung DH, Heo DS, Kim WH, Bang YJ. Comparative analyses of overall survival in patients with anaplastic lymphoma kinase-positive and matched wild-type advanced nonsmall cell lung cancer. Cancer. 2012 Jul 15; 118(14):3579-86. PMID: 22086654.
    Citations: 15     Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.