Harvard Catalyst Profiles

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Peter R Chai, M.D.

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Biography
Brown University, Providence, RIBA2006History of Art and Architecture
Brown University, Providence, RIMMS2007Artificial Organs, Biomaterials and Cellular Technology
Alpert Medical School at Brown University, Providence, RIMD2010Medicine
Rhode Island Hospital/Brown University, Providence, RI2014Emergency Medicine
University of Massachusetts Medical School, Worcester, MA2016Medical Toxicology

Overview
Our lab focuses on how technologies can change the spaces and methods in which we deliver healthcare. The main foci center around the use of ingestible electronic systems to detect changes in disease through biometric monitoring and real-time medication adherence events, technologies that improve the collection and display of health information to providers and patients for collaborative care, population-level technologies to measure exposure to pharmaceuticals, bioweapons and disease, and investigations into the application of pharmacotherapy to modulate anxiety, pain and mental health. We work with a wide network of collaborators from the Koch Institute for Integrated Cancer Research at MIT, the Petrie Flom Center for Biotechnology, Bioethics and Health Law Policy at Harvard Law School, The Fenway Institute and Dana Farber Cancer Institute.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R44DA051106 (MATUS GARCIA, MARIANA G) Apr 15, 2020 - Mar 31, 2021
    NIH/NIDA
    A novel robotic wastewater analysis system to quantify opioid exposure and treatment in residential communities
    Role: Co-Principal Investigator
  2. (Chai, Peter) Jan 15, 2020 - Jan 15, 2021
    E-ink Holdings
    Addressing patient experience with virtual white boards
    Role Description: The goal of this study is to understand design factors associated with electronic ink-based virtual white boards to improve patient/clinician communication and patient satisfaction in the emergency department.
    Role: Principal Investigator
  3. (Chai, Peter) Oct 15, 2019 - Oct 15, 2020
    Brigham Care Redesign Incubator Program (BCRISP)
    Deployment of Virtual Windows to Address Emergency Department Patient Satisfaction and Delirium
    Role Description: The major goal of this project is to deploy and understand the impact of natural lighting delivered via a virtual window on patient satisfaction in the emergency department.
    Role: Principal Investigator
  4. PCMS-CSV-G10BWH-2018-10290 (Peter Chai) Oct 1, 2018 - Dec 31, 2019
    Philips Biosensing
    Feasibility and Acceptability of wireless biometric monitoring using a novel wearable sensor
    Role Description: This grant investigates the operational barriers and usability of a novel wireless biosensor that collects real-time biometric data in emergency department patients.
    Role: Principal Investigator
  5. ISR-17-10189 (Peter Chai) Oct 1, 2018 - Oct 1, 2019
    Gilead Sciences
    Feasibility and Acceptability of Digital Pills to Monitor PrEP adherence in MSM with Substance Abuse (DigiPrEP)
    Role Description: This grant investigates the use of digital pills to measure real-time PrEP adherence in MSM with substance use disorders.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Spinelli MA, Haberer JE, Chai PR, Castillo-Mancilla J, Anderson PL, Gandhi M. Approaches to Objectively Measure Antiretroviral Medication Adherence and Drive Adherence Interventions. Curr HIV/AIDS Rep. 2020 Aug; 17(4):301-314. PMID: 32424549.
    Citations:    
  2. DeLuca MA, Chai PR, Goralnick E, Erickson TB. Five Decades of Global Chemical Terror Attacks: Data Analysis to Inform Training and Preparedness. Disaster Med Public Health Prep. 2020 Jul 24; 1-12. PMID: 32703327.
    Citations:    
  3. Wu F, Zhang J, Xiao A, Gu X, Lee WL, Armas F, Kauffman K, Hanage W, Matus M, Ghaeli N, Endo N, Duvallet C, Poyet M, Moniz K, Washburne AD, Erickson TB, Chai PR, Thompson J, Alm EJ. SARS-CoV-2 Titers in Wastewater Are Higher than Expected from Clinically Confirmed Cases. mSystems. 2020 Jul 21; 5(4). PMID: 32694130.
    Citations:    
  4. Byrne JD, Wentworth AJ, Chai PR, Huang HW, Babaee S, Li C, Becker SL, Tov C, Min S, Traverso G. Injection Molded Autoclavable, Scalable, Conformable (iMASC) system for aerosol-based protection: a prospective single-arm feasibility study. BMJ Open. 2020 07 07; 10(7):e039120. PMID: 32641368.
    Citations:    
  5. Wu F, Xiao A, Zhang J, Moniz K, Endo N, Armas F, Bonneau R, Brown MA, Bushman M, Chai PR, Duvallet C, Erickson TB, Foppe K, Ghaeli N, Gu X, Hanage WP, Huang KH, Lee WL, Matus M, McElroy KA, Nagler J, Rhode SF, Santillana M, Tucker JA, Wuertz S, Zhao S, Thompson J, Alm EJ. SARS-CoV-2 titers in wastewater foreshadow dynamics and clinical presentation of new COVID-19 cases. medRxiv. 2020 Jun 23. PMID: 32607521.
    Citations:    
  6. Chai PR, Ferro EG, Kirshenbaum JM, Hayes BD, Culbreth SE, Boyer EW, Erickson TB. Intentional Hydroxychloroquine Overdose Treated with High-Dose Diazepam: an Increasing Concern in the COVID-19 Pandemic. J Med Toxicol. 2020 07; 16(3):314-320. PMID: 32514696.
    Citations:    
  7. Chai PR, Schwartz E, Hasdianda MA, Azizoddin DR, Kikut A, Jambaulikar GD, Edwards RR, Boyer EW, Schreiber KL. A Brief Music App to Address Pain in the Emergency Department: Prospective Study. J Med Internet Res. 2020 May 20; 22(5):e18537. PMID: 32432550.
    Citations:    
  8. Erickson TB, Chai PR, Boyer EW. Chloroquine, hydroxychloroquine and COVID-19. Toxicol Commun. 2020; 4(1):40-42. PMID: 32457932.
    Citations:    
  9. Neumann NR, Chai PR, Wood DM, Greller HA, Mycyk MB. Medical Toxicology and COVID-19: Our Role in a Pandemic. J Med Toxicol. 2020 07; 16(3):245-247. PMID: 32356251.
    Citations:    
  10. Chai PR, Gale JY, Patton ME, Schwartz E, Jambaulikar GD, Wade Taylor S, Edwards RR, Boyer EW, Schreiber KL. The Impact of Music on Nociceptive Processing. Pain Med. 2020 Apr 26. PMID: 32337605.
    Citations:    
  11. Lai JT, Chapman BP, Carreiro SP, Babu KM, Boyer EW, Chai PR. Understanding Naloxone Uptake from an Emergency Department Distribution Program Using a Low-Energy Bluetooth Real-time Location System. J Med Toxicol. 2020 Apr 06. PMID: 32253630.
    Citations:    
  12. Chary MA, Chai PR. Tweetchats, Disseminating Information, and Sparking Further Scientific Discussion with Social Media. J Med Toxicol. 2020 04; 16(2):109-111. PMID: 32096006.
    Citations:    
  13. Chai PR, Carreiro S, Chapman BP, Boyer EW, O'Laughlin KN. Federal Funding in Emergency Medicine: Demographics and Perspectives of Awardees. West J Emerg Med. 2020 Feb 24; 21(2):304-312. PMID: 32191187.
    Citations:    
  14. Endo N, Ghaeli N, Duvallet C, Foppe K, Erickson TB, Matus M, Chai PR. Rapid Assessment of Opioid Exposure and Treatment in Cities Through Robotic Collection and Chemical Analysis of Wastewater. J Med Toxicol. 2020 04; 16(2):195-203. PMID: 31919800.
    Citations:    
  15. Chenworth M, Perrone J, Love JS, Greller HA, Sarker A, Chai PR. Buprenorphine Initiation in the Emergency Department: a Thematic Content Analysis of a #firesidetox Tweetchat. J Med Toxicol. 2020 Jul; 16(3):262-268. PMID: 31898154.
    Citations:    
  16. Bruccoleri RE, Demeter BL, Chai PR, Burns MM. Massive lamotrigine and bupropion overdose resulting in status epilepticus without cardiovascular collapse. Toxicol Commun. 2019; 3(1):102-105. PMID: 31984304.
    Citations:    
  17. Jaffe TA, Boyer EW, Erickson TB, Studley H, Hayes BD, Chai PR. Acute and delayed toxicity from co-ingestion of methylene chloride and methanol. Toxicol Commun. 2019; 3(1):79-84. PMID: 31745533.
    Citations:    
  18. Lazaridou A, Koulouris A, Dorado K, Chai P, Edwards RR, Schreiber KL. The Impact of a Daily Yoga Program for Women with Fibromyalgia. Int J Yoga. 2019 Sep-Dec; 12(3):206-217. PMID: 31543629.
    Citations:    
  19. Nwanaji-Enwerem JC, Cardenas A, Chai PR, Weisskopf MG, Baccarelli AA, Boyer EW. Relationships of Long-Term Smoking and Moist Snuff Consumption With a DNA Methylation Age Relevant Smoking Index: An Analysis in Buccal Cells. Nicotine Tob Res. 2019 08 19; 21(9):1267-1273. PMID: 30053132.
    Citations:    Fields:    
  20. Chai PR, Zhang H, Jambaulikar GD, Boyer EW, Shrestha L, Kitmitto L, Wickner PG, Salmasian H, Landman AB. An Internet of Things Buttons to Measure and Respond to Restroom Cleanliness in a Hospital Setting: Descriptive Study. J Med Internet Res. 2019 06 19; 21(6):e13588. PMID: 31219046.
    Citations:    
  21. Chai PR, Pereira LM, Jambaulikar GD, Carrico AW, O'Cleirigh C, Mayer KH, Boyer EW. Short Communication: Bioequivalence of Tenofovir Component of Tenofovir/Rilpivirine/Emtricitabine in Digital Pills. AIDS Res Hum Retroviruses. 2019 04; 35(4):361-363. PMID: 30693811.
    Citations:    Fields:    
  22. Chai PR, Schreiber KL, Taylor SW, Jambaulikar GD, Kikut A, Hasdianda MA, Boyer EW. The Feasibility and Acceptability of a Smartphone-Based Music Intervention for Acute Pain. Proc Annu Hawaii Int Conf Syst Sci. 2019 Jan 08; 2019:3917-3925. PMID: 30700971.
    Citations:    
  23. Toce MS, Chai PR, Burns MM, Boyer EW. Pharmacologic Treatment of Opioid Use Disorder: a Review of Pharmacotherapy, Adjuncts, and Toxicity. J Med Toxicol. 2018 12; 14(4):306-322. PMID: 30377951.
    Citations:    Fields:    
  24. Jin H, Ogunbajo A, Mimiaga MJ, Duncan DT, Boyer E, Chai P, Dilworth SE, Carrico AW. Over the influence: The HIV care continuum among methamphetamine-using men who have sex with men. Drug Alcohol Depend. 2018 11 01; 192:125-128. PMID: 30248558.
    Citations:    Fields:    
  25. Chai PR, Carreiro S, Carey JL, Boyle KL, Chapman BP, Boyer EW. Faculty member writing groups support productivity. Clin Teach. 2019 12; 16(6):565-569. PMID: 30256535.
    Citations:    Fields:    
  26. Chai PR, Zhang H, Baugh CW, Jambaulikar GD, McCabe JC, Gorman JM, Boyer EW, Landman A. Internet of Things Buttons for Real-Time Notifications in Hospital Operations: Proposal for Hospital Implementation. J Med Internet Res. 2018 08 10; 20(8):e251. PMID: 30097420.
    Citations:    Fields:    
  27. Chai PR, Hayes BD, Erickson TB, Boyer EW. Novichok agents: a historical, current, and toxicological perspective. Toxicol Commun. 2018; 2(1):45-48. PMID: 30003185.
    Citations:    
  28. Chai PR, Ruha AM, Wong KE, Monette DL, Spyres MB, Lapoint J, Greller H, Mycyk MB. The Virtual Toxicology Journal Club: the Dissemination and Discussion of Noteworthy Manuscripts Using Twitter. J Med Toxicol. 2018 09; 14(3):212-217. PMID: 29926389.
    Citations:    Fields:    
  29. Ouchi K, Lindvall C, Chai PR, Boyer EW. Machine Learning to Predict, Detect, and Intervene Older Adults Vulnerable for Adverse Drug Events in the Emergency Department. J Med Toxicol. 2018 09; 14(3):248-252. PMID: 29858745.
    Citations:    Fields:    
  30. Carreiro S, Chai PR, Carey J, Lai J, Smelson D, Boyer EW. mHealth for the Detection and Intervention in Adolescent and Young Adult Substance Use Disorder. Curr Addict Rep. 2018 Jun; 5(2):110-119. PMID: 30148037.
    Citations: 1     
  31. Broach J, Hart A, Griswold M, Lai J, Boyer EW, Skolnik AB, Chai PR. Usability and Reliability of Smart Glasses for Secondary Triage During Mass Casualty Incidents. Proc Annu Hawaii Int Conf Syst Sci. 2018 Jan 03; 2018:1416-1422. PMID: 29398976.
    Citations:    
  32. Lai JT, Chapman BP, Boyle KL, Boyer EW, Chai PR. Low-energy Bluetooth for detecting real-world penetrance of bystander naloxone kits: a pilot study. Proc Annu Hawaii Int Conf Syst Sci. 2018 Jan 03; 2018:3253-3258. PMID: 29416443.
    Citations:    
  33. Carey JL, Carreiro S, Chapman B, Nader N, Chai PR, Pagoto S, Jake-Schoffman DE. SoMe and Self Harm: The use of social media in depressed and suicidal youth. Proc Annu Hawaii Int Conf Syst Sci. 2018; 2018:3314-3319. PMID: 31723338.
    Citations:    
  34. Chai PR, Carreiro S, Innes BJ, Chapman B, Schreiber KL, Edwards RR, Carrico AW, Boyer EW. Oxycodone Ingestion Patterns in Acute Fracture Pain With Digital Pills. Anesth Analg. 2017 12; 125(6):2105-2112. PMID: 29189367.
    Citations:    Fields:    Translation:Humans
  35. Griswold MK, Chai PR, Krotulski AJ, Friscia M, Chapman BP, Varma N, Boyer EW, Logan BK, Babu KM. A Novel Oral Fluid Assay (LC-QTOF-MS) for the Detection of Fentanyl and Clandestine Opioids in Oral Fluid After Reported Heroin Overdose. J Med Toxicol. 2017 Dec; 13(4):287-292. PMID: 28971325.
    Citations:    Fields:    Translation:HumansPHPublic Health
  36. Chai PR, Boyer EW, Al-Nahhas H, Erickson TB. Toxic chemical weapons of assassination and warfare: nerve agents VX and sarin. Toxicol Commun. 2017; 1(1):21-23. PMID: 29974075.
    Citations: 1     
  37. Griswold MK, Chai PR, Krotulski AJ, Friscia M, Chapman B, Boyer EW, Logan BK, Babu KM. Self-identification of nonpharmaceutical fentanyl exposure following heroin overdose. Clin Toxicol (Phila). 2018 Jan; 56(1):37-42. PMID: 28681615.
    Citations:    Fields:    Translation:Humans
  38. Chai PR, Carreiro S, Ranney ML, Karanam K, Ahtisaari M, Edwards R, Schreiber KL, Ben-Ghaly L, Erickson TB, Boyer EW. Music as an Adjunct to Opioid-Based Analgesia. J Med Toxicol. 2017 Sep; 13(3):249-254. PMID: 28646359.
    Citations: 1     Fields:    Translation:Humans
  39. Griswold MK, Nordberg A, Babu KM, Boyer EW, Chai PR. Accidental copper sulfate toxicity after flame colorant ingestion. Clin Toxicol (Phila). 2017 09; 55(8):943-945. PMID: 28594239.
    Citations:    Fields:    
  40. Chai PR, Bonney C, Blohm E, Boyer EW, Babu KM. Canagliflozin-associated diabetic ketoacidosis: a case report. Toxicol Commun. 2017; 1(1):2-5. PMID: 29978156.
    Citations:    
  41. Carreiro S, Chai PR, Carey J, Chapman B, Boyer EW. Integrating Personalized Technology in Toxicology: Sensors, Smart Glass, and Social Media Applications in Toxicology Research. J Med Toxicol. 2017 06; 13(2):166-172. PMID: 28405896.
    Citations: 2     Fields:    Translation:Humans
  42. Chai PR, Carreiro S, Innes BJ, Rosen RK, O'Cleirigh C, Mayer KH, Boyer EW. Digital Pills to Measure Opioid Ingestion Patterns in Emergency Department Patients With Acute Fracture Pain: A Pilot Study. J Med Internet Res. 2017 01 13; 19(1):e19. PMID: 28087496.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  43. Carey JL, Nader N, Chai PR, Carreiro S, Griswold MK, Boyle KL. Drugs and Medical Devices: Adverse Events and the Impact on Women's Health. Clin Ther. 2017 Jan; 39(1):10-22. PMID: 28069260.
    Citations:    Fields:    Translation:Humans
  44. Hart A, Chai PR, Griswold MK, Lai JT, Boyer EW, Broach J. Acceptability and perceived utility of drone technology among emergency medical service responders and incident commanders for mass casualty incident management. Am J Disaster Med. 2017; 12(4):261-265. PMID: 29468628.
    Citations:    Fields:    Translation:Humans
  45. Skolnik AB, Chai PR, Dameff C, Gerkin R, Monas J, Padilla-Jones A, Curry S. Teletoxicology: Patient Assessment Using Wearable Audiovisual Streaming Technology. J Med Toxicol. 2016 12; 12(4):358-364. PMID: 27381429.
    Citations: 3     Fields:    Translation:Humans
  46. Chai PR. Wearable Devices and Biosensing: Future Frontiers. J Med Toxicol. 2016 12; 12(4):332-334. PMID: 27352082.
    Citations: 2     Fields:    Translation:Humans
  47. Chai PR, Hack JB. Intravenous lipid emulsion in the resuscitation of cocaine-induced cardiovascular arrest in a rat model. Am J Emerg Med. 2016 Aug; 34(8):1452-4. PMID: 27142757.
    Citations: 2     Fields:    Translation:Animals
  48. Chai PR, Rosen RK, Boyer EW. Ingestible Biosensors for Real-Time Medical Adherence Monitoring: MyTMed. Proc Annu Hawaii Int Conf Syst Sci. 2016 Jan; 2016:3416-3423. PMID: 27182206.
    Citations: 4     
  49. Chai PR, Castillo-Mancilla J, Buffkin E, Darling C, Rosen RK, Horvath KJ, Boudreaux ED, Robbins GK, Hibberd PL, Boyer EW. Utilizing an Ingestible Biosensor to Assess Real-Time Medication Adherence. J Med Toxicol. 2015 Dec; 11(4):439-44. PMID: 26245878.
    Citations: 7     Fields:    Translation:Humans
  50. Chai PR. Enriching the Toxicology Experience through Twitter. J Med Toxicol. 2015 Dec; 11(4):385-7. PMID: 26493395.
    Citations: 1     Fields:    Translation:Humans
  51. Chai PR, Babu KM, Boyer EW. The Feasibility and Acceptability of Google Glass for Teletoxicology Consults. J Med Toxicol. 2015 Sep; 11(3):283-7. PMID: 26245879.
    Citations: 8     Fields:    Translation:Humans
  52. Chai PR, Wu RY, Ranney ML, Bird J, Chai S, Zink B, Porter PS. Feasibility and Acceptability of Google Glass for Emergency Department Dermatology Consultations. JAMA Dermatol. 2015 Jul; 151(7):794-6. PMID: 25874898.
    Citations: 10     Fields:    Translation:Humans
  53. Chai PR, Wu RY, Ranney ML, Porter PS, Babu KM, Boyer EW. The virtual toxicology service: wearable head-mounted devices for medical toxicology. J Med Toxicol. 2014 Dec; 10(4):382-7. PMID: 25135308.
    Citations: 6     Fields:    Translation:Humans
  54. Chai P, Babu K. Toxin-induced coagulopathy. Emerg Med Clin North Am. 2014 Feb; 32(1):53-78. PMID: 24275169.
    Citations:    Fields:    Translation:Humans
  55. Chai PR, Bastan W, Machan J, Hack JB, Babu KM. Levamisole exposure and hematologic indices in cocaine users. Acad Emerg Med. 2011 Nov; 18(11):1141-7. PMID: 22092895.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  56. Ranney ML, Mello MJ, Baird JB, Chai PR, Clark MA. Correlates of motorcycle helmet use among recent graduates of a motorcycle training course. Accid Anal Prev. 2010 Nov; 42(6):2057-62. PMID: 20728662.
    Citations: 4     Fields:    Translation:Humans
  57. Rago AP, Chai PR, Morgan JR. Encapsulated arrays of self-assembled microtissues: an alternative to spherical microcapsules. Tissue Eng Part A. 2009 Feb; 15(2):387-95. PMID: 19193131.
    Citations: 9     Fields:    Translation:HumansCells
  58. Rago AP, Napolitano AP, Dean DM, Chai PR, Morgan JR. Miniaturization of an Anoikis assay using non-adhesive micromolded hydrogels. Cytotechnology. 2008 Feb; 56(2):81-90. PMID: 19002845.
    Citations: 2     Fields:    
  59. Napolitano AP, Chai P, Dean DM, Morgan JR. Dynamics of the self-assembly of complex cellular aggregates on micromolded nonadhesive hydrogels. Tissue Eng. 2007 Aug; 13(8):2087-94. PMID: 17518713.
    Citations: 54     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.