Harvard Catalyst Profiles

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Mark Blaser, Ph.D.

Title
Institution
Department
Address

Biography
education and training
University of TorontoPh.D12/2016Biomedical Engineering
McGill UniversityB.Eng.06/2009Chemical and Biomedical Engineering

Overview
overview
Dr. Mark Blaser obtained his Bachelor of Engineering (Chemical Engineering – Minor in Biomedical Engineering, 2009) from McGill University. He completed his Ph.D (Biomedical Engineering, 2016) at the University of Toronto in the laboratory of Professor Craig Simmons, where he was a CIHR Frederick Banting and Charles Best Canada Graduate Scholar. During his Ph.D, he also spent time as a Michael Smith Visiting Scholar at the University of California - Irvine with Professor Arash Kheradvar. His doctoral dissertation was titled “The Role of C-type Natriuretic Peptide Signaling in Aortic Valve Disease”, and won the 2017 John Leyerle-CIFAR Prize for the best interdisciplinary research at the University of Toronto.

Mark joined the CICS in 2017 as a postdoctoral research fellow in Professor Elena Aikawa’s research group. He is working to identify insights into and treatments for calcific aortic valve disease, particularly in the context of congenital valve malformations that drive accelerated valvular pathogenesis.
keywords

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Blaser MC, Kraler S, Lüscher TF, Aikawa E. Network-Guided Multiomic Mapping of Aortic Valve Calcification. Arterioscler Thromb Vasc Biol. 2023 03; 43(3):417-426. PMID: 36727519; PMCID: PMC9975082.
    Citations:    Fields:    Translation:Humans
  2. Decano JL, Iwamoto Y, Goto S, Lee JY, Matamalas JT, Halu A, Blaser M, Lee LH, Pieper B, Chelvanambi S, Silva-Nicolau J, Bartoli-Leonard F, Higashi H, Shibata H, Vyas P, Wang J, Gostjeva E, Body SC, Singh SA, Aikawa M, Aikawa E. A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling. Cell Rep. 2022 04 12; 39(2):110685. PMID: 35417712.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Passos LSA, Jha PK, Becker-Greene D, Blaser MC, Romero D, Lupieri A, Sukhova GK, Libby P, Singh SA, Dutra WO, Aikawa M, Levine RA, Nunes MCP, Aikawa E. Prothymosin Alpha: A Novel Contributor to Estradiol Receptor Alpha-Mediated CD8+ T-Cell Pathogenic Responses and Recognition of Type 1 Collagen in Rheumatic Heart Valve Disease. Circulation. 2022 02 15; 145(7):531-548. PMID: 35157519; PMCID: PMC8869797.
    Citations: 2     Fields:    Translation:HumansCells
  4. Kraler S, Blaser MC, Aikawa E, Camici GG, Lüscher TF. Calcific aortic valve disease: from molecular and cellular mechanisms to medical therapy. Eur Heart J. 2022 02 12; 43(7):683-697. PMID: 34849696; PMCID: PMC8843796.
    Citations: 7     Fields:    Translation:HumansCells
  5. Blaser MC, Kraler S, Lüscher TF, Aikawa E. Multi-Omics Approaches to Define Calcific Aortic Valve Disease Pathogenesis. Circ Res. 2021 04 30; 128(9):1371-1397. PMID: 33914608; PMCID: PMC8095729.
    Citations: 7     Fields:    Translation:HumansCells
  6. Kraler S, Wenzl FA, Akhmedov A, Blaser MC, Aikawa E, Lüscher TF. ApoA-I mimetics improve aortic stenosis-associated left-ventricular diastolic dysfunction but fail to benefit rabbit models with normal aortic valves. Int J Cardiol. 2021 06 01; 332:159-161. PMID: 33626387.
    Citations:    Fields:    Translation:Animals
  7. Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 02; 7(6). PMID: 33547080; PMCID: PMC7864581.
    Citations: 10     Fields:    
  8. Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E. ApoC-III is a novel inducer of calcification in human aortic valves. J Biol Chem. 2021 Jan-Jun; 296:100193. PMID: 33334888.
    Citations: 7     Fields:    Translation:HumansCells
  9. Aikawa E, Blaser MC. 2020 Jeffrey M. Hoeg Award Lecture: Calcifying Extracellular Vesicles as Building Blocks of Microcalcifications in Cardiovascular Disorders. Arterioscler Thromb Vasc Biol. 2021 01; 41(1):117-127. PMID: 33115271.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  10. Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E. Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis. Sci Adv. 2020 09; 6(38). PMID: 32938681; PMCID: PMC7494353.
    Citations: 24     Fields:    
  11. Kawakami R, Katsuki S, Travers R, Romero DC, Becker-Greene D, Passos LSA, Higashi H, Blaser MC, Sukhova GK, Buttigieg J, Kopriva D, Schmidt AM, Anderson DG, Singh SA, Cardoso L, Weinbaum S, Libby P, Aikawa M, Croce K, Aikawa E. S100A9-RAGE Axis Accelerates Formation of Macrophage-Mediated Extracellular Vesicle Microcalcification in Diabetes Mellitus. Arterioscler Thromb Vasc Biol. 2020 08; 40(8):1838-1853. PMID: 32460581.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  12. Goto S, Rogers MA, Blaser MC, Higashi H, Lee LH, Schlotter F, Body SC, Aikawa M, Singh SA, Aikawa E. Standardization of Human Calcific Aortic Valve Disease in vitro Modeling Reveals Passage-Dependent Calcification. Front Cardiovasc Med. 2019; 6:49. PMID: 31041314; PMCID: PMC6476921.
    Citations: 13     
  13. Blaser MC, Aikawa E. Differential miRNA Loading Underpins Dual Harmful and Protective Roles for Extracellular Vesicles in Atherogenesis. Circ Res. 2019 02 15; 124(4):467-469. PMID: 30763209.
    Citations: 9     Fields:    Translation:HumansCells
  14. Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E. 18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images. Circ Cardiovasc Imaging. 2019 01; 12(1):e007835. PMID: 30642216; PMCID: PMC6338081.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  15. Blaser MC, Aikawa E. Roles and Regulation of Extracellular Vesicles in Cardiovascular Mineral Metabolism. Front Cardiovasc Med. 2018; 5:187. PMID: 30622949; PMCID: PMC6308298.
    Citations: 33     
  16. Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E. Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease. Circulation. 2018 07 24; 138(4):377-393. PMID: 29588317; PMCID: PMC6160370.
    Citations: 72     Fields:    Translation:HumansCells
  17. van der Valk DC, van der Ven CFT, Blaser MC, Grolman JM, Wu PJ, Fenton OS, Lee LH, Tibbitt MW, Andresen JL, Wen JR, Ha AH, Buffolo F, van Mil A, Bouten CVC, Body SC, Mooney DJ, Sluijter JPG, Aikawa M, Hjortnaes J, Langer R, Aikawa E. Engineering a 3D-Bioprinted Model of Human Heart Valve Disease Using Nanoindentation-Based Biomechanics. Nanomaterials (Basel). 2018 May 03; 8(5). PMID: 29751516; PMCID: PMC5977310.
    Citations: 26     
  18. Blaser MC, Wei K, Adams RLE, Zhou YQ, Caruso LL, Mirzaei Z, Lam AY, Tam RKK, Zhang H, Heximer SP, Henkelman RM, Simmons CA. Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice. Circ Res. 2018 02 02; 122(3):405-416. PMID: 29273600.
    Citations: 21     Fields:    Translation:AnimalsCells
  19. Hutcheson JD, Blaser MC, Aikawa E. Giving Calcification Its Due: Recognition of a Diverse Disease: A First Attempt to Standardize the Field. Circ Res. 2017 01 20; 120(2):270-273. PMID: 28104767; PMCID: PMC5260841.
    Citations: 22     Fields:    Translation:HumansAnimals
  20. Parvin Nejad S, Blaser MC, Santerre JP, Caldarone CA, Simmons CA. Biomechanical conditioning of tissue engineered heart valves: Too much of a good thing? Adv Drug Deliv Rev. 2016 Jan 15; 96:161-75. PMID: 26555371.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  21. Hannan JL, Cheung GL, Blaser MC, Pang JJ, Pang SC, Webb RC, Adams MA. Characterization of the vasculature supplying the genital tissues in female rats. J Sex Med. 2012 Jan; 9(1):136-47. PMID: 22023507.
    Citations: 2     Fields:    Translation:Animals
  22. Sider KL, Blaser MC, Simmons CA. Animal models of calcific aortic valve disease. Int J Inflam. 2011; 2011:364310. PMID: 21826258.
    Citations: 48     
  23. Yip CY, Blaser MC, Mirzaei Z, Zhong X, Simmons CA. Inhibition of pathological differentiation of valvular interstitial cells by C-type natriuretic peptide. Arterioscler Thromb Vasc Biol. 2011 Aug; 31(8):1881-9. PMID: 21617139.
    Citations: 26     Fields:    Translation:AnimalsCells
  24. Hannan JL, Blaser MC, Pang JJ, Adams SM, Pang SC, Adams MA. Impact of hypertension, aging, and antihypertensive treatment on the morphology of the pudendal artery. J Sex Med. 2011 Apr; 8(4):1027-38. PMID: 21284829.
    Citations: 8     Fields:    Translation:Animals
  25. Hannan JL, Blaser MC, Oldfield L, Pang JJ, Adams SM, Pang SC, Adams MA. Morphological and functional evidence for the contribution of the pudendal artery in aging-induced erectile dysfunction. J Sex Med. 2010 Oct; 7(10):3373-84. PMID: 20584117.
    Citations: 11     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.