Harvard Catalyst Profiles

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Amjad Shehadah, M.D.

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Biography
education and training
The National Institutes of HealthFellowship
Henry Ford HospitalResidency

Overview

Mentoring
current student opportunities
Available: 01/01/23, Expires: 01/01/24

Using in vivo and in vitro models of stroke and advanced molecular biology techniques, our laboratory focuses on investigating molecular mechanisms that regulate cell injury and recovery processes after stroke. Posttranslational modifications to chromatin have profound effects on gene expression and thus provide a multifaceted mechanism for regulation. Our recent research has focused on histone deacetylases (HDACs), a superfamily of enzymes that remove acetyl groups from histones and suppress transcription. The student will participate in our ongoing research on the role of HDAC3 in ischemic stroke. Under my mentorship, the student will learn to analyze behavioral tests, calculate infarct volume, and quantify immunostaining and WB. The student will also participate in the in vitro experiment using different cell types including neurons, astrocytes, microglia, and endothelial cells


Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AG055559 (SHEHADAH, AMJAD) Jan 22, 2021 - May 31, 2023
    NIH
    Role of Tau Conformations in Vascular Contribution to Cognitive Impairment and Dementia
    Role Description: Co-PI

Bibliographic
selected publications
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© 2023 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.