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Amjad Shehadah, M.D.

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Biography
The National Institutes of HealthFellowship
Henry Ford HospitalResidency

Overview

Mentoring
Available: 10/01/19, Expires: 09/30/20

In this project, the student will participate in basic research to study the role of epigenetic mechanisms (histone acetylation) in an animal model of stroke. The student will have the opportunity to learn about microsurgical animal models of stroke, brain tissue processing, histological assessment and image analysis. It is expected that by the end of the project, the student will be able to present data as a scientific poster.


Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Matheson R, Chida K, Lu H, Clendaniel V, Fisher M, Thomas A, Lo EH, Selim M, Shehadah A. Neuroprotective Effects of Selective Inhibition of Histone Deacetylase 3 in Experimental Stroke. Transl Stroke Res. 2020 Feb 03. PMID: 32016769.
    Citations:    
  2. Kassis H, Shehadah A, Chopp M, Zhang ZG. Epigenetics in Stroke Recovery. Genes (Basel). 2017 Feb 27; 8(3). PMID: 28264471.
    Citations: 2     
  3. Shehadah A, Franklin GM, Benson RT. Global disparities in stroke and why we should care. Neurology. 2016 08 02; 87(5):450-1. PMID: 27371491.
    Citations: 1     Fields:    Translation:Humans
  4. Kassis H, Shehadah A, Li C, Zhang Y, Cui Y, Roberts C, Sadry N, Liu X, Chopp M, Zhang ZG. Class IIa histone deacetylases affect neuronal remodeling and functional outcome after stroke. Neurochem Int. 2016 06; 96:24-31. PMID: 27103167.
    Citations: 4     Fields:    Translation:AnimalsCells
  5. Kassis H, Shehadah A, Chopp M, Roberts C, Zhang ZG. Stroke Induces Nuclear Shuttling of Histone Deacetylase 4. Stroke. 2015 Jul; 46(7):1909-15. PMID: 25967576.
    Citations: 6     Fields:    Translation:AnimalsCells
  6. Kassis H, Chopp M, Liu XS, Shehadah A, Roberts C, Zhang ZG. Histone deacetylase expression in white matter oligodendrocytes after stroke. Neurochem Int. 2014 Nov; 77:17-23. PMID: 24657831.
    Citations: 9     Fields:    Translation:AnimalsCells
  7. Shehadah A, Chen J, Pal A, He S, Zeitlin A, Cui X, Zacharek A, Cui Y, Roberts C, Lu M, Hariri R, Chopp M. Human placenta-derived adherent cell treatment of experimental stroke promotes functional recovery after stroke in young adult and older rats. PLoS One. 2014; 9(1):e86621. PMID: 24466174.
    Citations: 10     Fields:    Translation:HumansAnimals
  8. Shehadah A, Chen J, Kramer B, Zacharek A, Cui Y, Roberts C, Lu M, Chopp M. Efficacy of single and multiple injections of human umbilical tissue-derived cells following experimental stroke in rats. PLoS One. 2013; 8(1):e54083. PMID: 23342081.
    Citations: 4     Fields:    Translation:HumansAnimals
  9. Chen J, Shehadah A, Pal A, Zacharek A, Cui X, Cui Y, Roberts C, Lu M, Zeitlin A, Hariri R, Chopp M. Neuroprotective effect of human placenta-derived cell treatment of stroke in rats. Cell Transplant. 2013; 22(5):871-9. PMID: 22469567.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  10. Cui X, Chopp M, Zacharek A, Dai J, Zhang C, Yan T, Ning R, Roberts C, Shehadah A, Kuzmin-Nichols N, Sanberg CD, Chen J. Combination treatment of stroke with sub-therapeutic doses of Simvastatin and human umbilical cord blood cells enhances vascular remodeling and improves functional outcome. Neuroscience. 2012 Dec 27; 227:223-31. PMID: 23041512.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  11. Cui X, Chopp M, Shehadah A, Zacharek A, Kuzmin-Nichols N, Sanberg CD, Dai J, Zhang C, Ueno Y, Roberts C, Chen J. Therapeutic benefit of treatment of stroke with simvastatin and human umbilical cord blood cells: neurogenesis, synaptic plasticity, and axon growth. Cell Transplant. 2012; 21(5):845-56. PMID: 22405262.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  12. Ye X, Chopp M, Cui X, Zacharek A, Cui Y, Yan T, Shehadah A, Roberts C, Liu X, Lu M, Chen J. Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats. Exp Neurol. 2011 Dec; 232(2):299-308. PMID: 21963653.
    Citations: 20     Fields:    Translation:Animals
  13. Shehadah A, Chen J, Cui Y, Zhang L, Roberts C, Lu M, Chopp M. Combination treatment with low-dose Niaspan and tissue plasminogen activator provides neuroprotection after embolic stroke in rats. J Neurol Sci. 2011 Oct 15; 309(1-2):96-101. PMID: 21802695.
    Citations: 3     Fields:    Translation:Animals
  14. Shehadah A, Chen J, Zacharek A, Cui Y, Ion M, Roberts C, Kapke A, Chopp M. Niaspan treatment induces neuroprotection after stroke. Neurobiol Dis. 2010 Oct; 40(1):277-83. PMID: 20554037.
    Citations: 18     Fields:    Translation:Animals
  15. Shehadah A, Chen J, Cui X, Roberts C, Lu M, Chopp M. Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome. J Neurol Sci. 2010 Jul 15; 294(1-2):107-11. PMID: 20451219.
    Citations: 11     Fields:    Translation:AnimalsCells
  16. Zacharek A, Shehadah A, Chen J, Cui X, Roberts C, Lu M, Chopp M. Comparison of bone marrow stromal cells derived from stroke and normal rats for stroke treatment. Stroke. 2010 Mar; 41(3):524-30. PMID: 20056925.
    Citations: 28     Fields:    Translation:AnimalsCells
  17. Chen J, Zacharek A, Cui X, Shehadah A, Jiang H, Roberts C, Lu M, Chopp M. Treatment of stroke with a synthetic liver X receptor agonist, TO901317, promotes synaptic plasticity and axonal regeneration in mice. J Cereb Blood Flow Metab. 2010 Jan; 30(1):102-9. PMID: 19724285.
    Citations: 17     Fields:    Translation:AnimalsCells
  18. Chen J, Cui X, Zacharek A, Ding GL, Shehadah A, Jiang Q, Lu M, Chopp M. Niaspan treatment increases tumor necrosis factor-alpha-converting enzyme and promotes arteriogenesis after stroke. J Cereb Blood Flow Metab. 2009 May; 29(5):911-20. PMID: 19223914.
    Citations: 11     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.