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Xiying Qu, Ph.D.


Ludong University , ChinaBachelor06/2000Biology
Guandong Medical University, ChinaMaster06/2003Biochemistry and Molecular Biology
Wuhan University, ChinaPh.D.06/2010Biomedical Sciences
Fudan University, China08/2015Genetics
University of Pittsburgh, USA12/2016Molecular Image
Excellent Post Doctoral Fellow
MGH Annual Research Fellows Poster Celebration Award

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zeng Y, Li B, Liang Y, Reeves PM, Qu X, Ran C, Liu Q, Callahan MV, Sluder AE, Gelfand JA, Chen H, Poznansky MC. Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunosuppression in the tumor microenvironment. FASEB J. 2019 May; 33(5):6596-6608. PMID: 30802149.
  2. Ji H, Lu P, Liu B, Qu X, Wang Y, Jiang Z, Yang X, Zhong Y, Yang H, Pan H, Zhao L, Xu J, Lu H, Zhu H. Zinc-Finger Nucleases Induced by HIV-1 Tat Excise HIV-1 from the Host Genome in Infected and Latently Infected Cells. Mol Ther Nucleic Acids. 2018 Sep 07; 12:67-74. PMID: 30195798.
  3. Li B, Zeng Y, Reeves PM, Ran C, Liu Q, Qu X, Liang Y, Liu Z, Yuan J, Leblanc PR, Ye Z, Sluder AE, Gelfand JA, Brauns TA, Chen H, Poznansky MC. AMD3100 Augments the Efficacy of Mesothelin-Targeted, Immune-Activating VIC-008 in Mesothelioma by Modulating Intratumoral Immunosuppression. Cancer Immunol Res. 2018 05; 6(5):539-551. PMID: 29511032.
    Citations: 3     Fields:    
  4. Li T, Zhang J, Zhang J, Zhang N, Zeng Y, Tang S, Tao Z, Qu X, Jia J, Zhu W, Sun X, Chen H. Nicotine-enhanced stemness and epithelial-mesenchymal transition of human umbilical cord mesenchymal stem cells promote tumor formation and growth in nude mice. Oncotarget. 2018 Jan 02; 9(1):591-606. PMID: 29416638.
    Citations:    Fields:    
  5. Wang P, Lu P, Qu X, Shen Y, Zeng H, Zhu X, Zhu Y, Li X, Wu H, Xu J, Lu H, Ma Z, Zhu H. Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui. Sci Rep. 2017 08 25; 7(1):9451. PMID: 28842560.
  6. Yin C, Zhang T, Qu X, Zhang Y, Putatunda R, Xiao X, Li F, Xiao W, Zhao H, Dai S, Qin X, Mo X, Young WB, Khalili K, Hu W. In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models. Mol Ther. 2017 05 03; 25(5):1168-1186. PMID: 28366764.
  7. Deng J, Qu X, Lu P, Yang X, Zhu Y, Ji H, Wang Y, Jiang Z, Li X, Zhong Y, Yang H, Pan H, Young WB, Zhu H. Specific and Stable Suppression of HIV Provirus Expression In Vitro by Chimeric Zinc Finger DNA Methyltransferase 1. Mol Ther Nucleic Acids. 2017 Mar 17; 6:233-242. PMID: 28325289.
  8. Lu P, Qu X, Shen Y, Jiang Z, Wang P, Zeng H, Ji H, Deng J, Yang X, Li X, Lu H, Zhu H. The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb. Sci Rep. 2016 Apr 12; 6:24100. PMID: 27067814.
  9. Ji H, Jiang Z, Lu P, Ma L, Li C, Pan H, Fu Z, Qu X, Wang P, Deng J, Yang X, Wang J, Zhu H. Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter. Mol Ther. 2016 Mar; 24(3):508-21. PMID: 26775808.
  10. Wang P, Qu X, Zhou X, Shen Y, Ji H, Fu Z, Deng J, Lu P, Yu W, Lu H, Zhu H. Two cellular microRNAs, miR-196b and miR-1290, contribute to HIV-1 latency. Virology. 2015 Dec; 486:228-38. PMID: 26469550.
  11. Wang X, Wang P, Fu Z, Ji H, Qu X, Zeng H, Zhu X, Deng J, Lu P, Zha S, Song Z, Zhu H. Designed transcription activator-like effector proteins efficiently induced the expression of latent HIV-1 in latently infected cells. AIDS Res Hum Retroviruses. 2015 Jan; 31(1):98-106. PMID: 25403229.
  12. Zeng H, Liu S, Wang P, Qu X, Ji H, Wang X, Zhu X, Song Z, Yang X, Ma Z, Zhu H. Dilazep synergistically reactivates latent HIV-1 in latently infected cells. Mol Biol Rep. 2014 Nov; 41(11):7697-704. PMID: 25091947.
  13. Qu X, Wang P, Ding D, Wang X, Zhang G, Zhou X, Liu L, Zhu X, Zeng H, Zhu H. Zinc finger nuclease: a new approach for excising HIV-1 proviral DNA from infected human T cells. Mol Biol Rep. 2014 Sep; 41(9):5819-27. PMID: 24973878.
  14. Zhu X, Liu S, Wang P, Qu X, Wang X, Zeng H, Chen H, Zhu H. Oxaliplatin antagonizes HIV-1 latency by activating NF-?B without causing global T cell activation. Biochem Biophys Res Commun. 2014 Jul 18; 450(1):202-7. PMID: 24878527.
    Citations: 1     Fields:    Translation:HumansCells
  15. Wang P, Qu X, Wang X, Liu L, Zhu X, Zeng H, Zhu H. As2O3 synergistically reactivate latent HIV-1 by induction of NF-?B. Antiviral Res. 2013 Dec; 100(3):688-97. PMID: 24416773.
  16. Qu X, Wang P, Ding D, Li L, Wang H, Ma L, Zhou X, Liu S, Lin S, Wang X, Zhang G, Liu S, Liu L, Wang J, Zhang F, Lu D, Zhu H. Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells. Nucleic Acids Res. 2013 Sep; 41(16):7771-82. PMID: 23804764.
  17. Ding D, Qu X, Li L, Zhou X, Liu S, Lin S, Wang P, Liu S, Kong C, Wang X, Liu L, Zhu H. Involvement of histone methyltransferase GLP in HIV-1 latency through catalysis of H3K9 dimethylation. Virology. 2013 Jun 05; 440(2):182-9. PMID: 23541084.
  18. Pender-Cudlip MC, Krag KJ, Martini D, Yu J, Guidi A, Skinner SS, Zhang Y, Qu X, He C, Xu Y, Qian SY, Kang JX. Delta-6-desaturase activity and arachidonic acid synthesis are increased in human breast cancer tissue. Cancer Sci. 2013 Jun; 104(6):760-4. PMID: 23414387.
    Citations: 11     Fields:    Translation:Humans
  19. Qu X, Ying H, Wang X, Kong C, Zhou X, Wang P, Zhu H. Histone deacetylase inhibitor MC1293 induces latent HIV-1 reactivation by histone modification in vitro latency cell lines. Curr HIV Res. 2013 Jan; 11(1):24-9. PMID: 23092175.
  20. Ying H, Zhang Y, Zhou X, Qu X, Wang P, Liu S, Lu D, Zhu H. Selective histonedeacetylase inhibitor M344 intervenes in HIV-1 latency through increasing histone acetylation and activation of NF-kappaB. PLoS One. 2012; 7(11):e48832. PMID: 23166597.
  21. He C, Qu X, Wan J, Rong R, Huang L, Cai C, Zhou K, Gu Y, Qian SY, Kang JX. Inhibiting delta-6 desaturase activity suppresses tumor growth in mice. PLoS One. 2012; 7(10):e47567. PMID: 23112819.
    Citations: 5     Fields:    Translation:AnimalsCells
  22. Qu X, Zhou X, Zhou K, Xie X, Tian Y. New mutation in the MYOC gene and its association with primary open-angle glaucoma in a Chinese family. Mol Biol Rep. 2010 Jan; 37(1):255-61. PMID: 19688280.
    Citations: 2     Fields:    Translation:HumansCells
  23. He C, Qu X, Cui L, Wang J, Kang JX. Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11370-5. PMID: 19549874.
    Citations: 50     Fields:    Translation:AnimalsCells
  24. Xie X, Zhou X, Qu X, Wen J, Tian Y, Zheng F. Two novel myocilin mutations in a Chinese family with primary open-angle glaucoma. Mol Vis. 2008 Sep 05; 14:1666-72. PMID: 18776955.
  25. Cai CL, Zhou X, Zhao L, Yao XJ, Tu JC, Zheng F, Qu XY. Optical detection of plasma chitotriosidase activity in healthy Chinese children using fluorescence spectrophotometry. Clin Chim Acta. 2007 Apr; 379(1-2):134-8. PMID: 17300771.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.