Harvard Catalyst Profiles

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Akul Y Mehta, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Stavenhagen K, Mehta AY, Laan L, Gao C, Heimburg-Molinaro J, van Die I, Cummings RD. N-glycosylation of mannose receptor (CD206) regulates glycan binding by C-type lectin domains. J Biol Chem. 2022 Oct 13; 298(12):102591. PMID: 36244450; PMCID: PMC9672410.
    Citations:    Fields:    
  2. Nielsen MA, Juul-Madsen K, Stegmayr J, Gao C, Mehta AY, Greisen SR, Kragstrup TW, Hvid M, Vorup-Jensen T, Cummings RD, Leffler H, Deleuran BW. Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB. Front Immunol. 2022; 13:915890. PMID: 35812455; PMCID: PMC9263355.
    Citations:    Fields:    Translation:HumansCells
  3. Gao C, Stavenhagen K, Eckmair B, McKitrick TR, Mehta AY, Matsumoto Y, McQuillan AM, Hanes MS, Eris D, Baker KJ, Jia N, Wei M, Heimburg-Molinaro J, Ernst B, Cummings RD. Differential recognition of oligomannose isomers by glycan-binding proteins involved in innate and adaptive immunity. Sci Adv. 2021 06; 7(24). PMID: 34108208; PMCID: PMC8189592.
    Citations: 3     Fields:    
  4. Stavenhagen K, Laan LC, Gao C, Mehta AY, Heimburg-Molinaro J, Glickman JN, van Die I, Cummings RD. Tumor cells express pauci- and oligomannosidic N-glycans in glycoproteins recognized by the mannose receptor (CD206). Cell Mol Life Sci. 2021 Jul; 78(14):5569-5585. PMID: 34089345.
    Citations: 3     Fields:    Translation:HumansCells
  5. Luetscher RND, McKitrick TR, Gao C, Mehta AY, McQuillan AM, Kardish R, Boligan KF, Song X, Lu L, Heimburg-Molinaro J, von Gunten S, Alter G, Cummings RD. Unique repertoire of anti-carbohydrate antibodies in individual human serum. Sci Rep. 2020 09 22; 10(1):15436. PMID: 32963315.
    Citations: 7     Fields:    Translation:HumansAnimals
  6. Mehta AY, Heimburg-Molinaro J, Cummings RD. Tools for generating and analyzing glycan microarray data. Beilstein J Org Chem. 2020; 16:2260-2271. PMID: 32983270.
    Citations: 3     
  7. Mehta AY, Veeraiah RKH, Dutta S, Goth CK, Hanes MS, Gao C, Stavenhagen K, Kardish R, Matsumoto Y, Heimburg-Molinaro J, Boyce M, Pohl NLB, Cummings RD. Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries. Cell Chem Biol. 2020 09 17; 27(9):1207-1219.e9. PMID: 32610041.
    Citations: 1     Fields:    Translation:Cells
  8. Mehta AY, Cummings RD. GlycoGlyph: a glycan visualizing, drawing and naming application. Bioinformatics. 2020 06 01; 36(11):3613-3614. PMID: 32170934.
    Citations: 14     Fields:    
  9. Cao Y, Park SJ, Mehta AY, Cummings RD, Im W. GlyMDB: Glycan Microarray Database and analysis toolset. Bioinformatics. 2020 04 15; 36(8):2438-2442. PMID: 31841142.
    Citations: 8     Fields:    Translation:Cells
  10. Mehta AY, Heimburg-Molinaro J, Cummings RD, Goth CK. Emerging patterns of tyrosine sulfation and O-glycosylation cross-talk and co-localization. Curr Opin Struct Biol. 2020 06; 62:102-111. PMID: 31927217.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  11. Byrd-Leotis L, Gao C, Jia N, Mehta AY, Trost J, Cummings SF, Heimburg-Molinaro J, Cummings RD, Steinhauer DA. Antigenic Pressure on H3N2 Influenza Virus Drift Strains Imposes Constraints on Binding to Sialylated Receptors but Not Phosphorylated Glycans. J Virol. 2019 11 15; 93(22). PMID: 31484755.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  12. Wei M, McKitrick TR, Mehta AY, Gao C, Jia N, McQuillan AM, Heimburg-Molinaro J, Sun L, Cummings RD. Novel Reversible Fluorescent Glycan Linker for Functional Glycomics. Bioconjug Chem. 2019 11 20; 30(11):2897-2908. PMID: 31600064.
    Citations: 6     Fields:    Translation:HumansCells
  13. Mehta AY, Cummings RD. GLAD: GLycan Array Dashboard, a visual analytics tool for glycan microarrays. Bioinformatics. 2019 09 15; 35(18):3536-3537. PMID: 30715201.
    Citations: 14     Fields:    Translation:Animals
  14. Mangrum JB, Mehta AY, Alabbas AB, Desai UR, Hawkridge AM. Comparative analysis of INLIGHT™-labeled enzymatically depolymerized heparin by reverse-phase chromatography and high-performance mass spectrometry. Anal Bioanal Chem. 2017 Jan; 409(2):499-509. PMID: 27888308.
    Citations: 2     Fields:    Translation:Cells
  15. Verespy S, Mehta AY, Afosah D, Al-Horani RA, Desai UR. Allosteric Partial Inhibition of Monomeric Proteases. Sulfated Coumarins Induce Regulation, not just Inhibition, of Thrombin. Sci Rep. 2016 Apr 07; 6:24043. PMID: 27053426.
    Citations: 14     Fields:    Translation:HumansCells
  16. Mehta AY, Mohammed BM, Martin EJ, Brophy DF, Gailani D, Desai UR. Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Iba-binding and heparin-binding site of thrombin. J Thromb Haemost. 2016 Apr; 14(4):828-38. PMID: 26748875; PMCID: PMC4828251.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  17. Xu GG, Deshpande TM, Ghatge MS, Mehta AY, Omar AS, Ahmed MH, Venitz J, Abdulmalik O, Zhang Y, Safo MK. Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Prodrugs as Drug Candidates for the Treatment of Ischemic Disorders: Insights into NO-Releasing Prodrug Biotransformation and Hemoglobin-NO Biochemistry. Biochemistry. 2015 Dec 15; 54(49):7178-92. PMID: 26582149.
    Citations: 3     Fields:    Translation:HumansCells
  18. Boothello RS, Sarkar A, Tran VM, Nguyen TK, Sankaranarayanan NV, Mehta AY, Alabbas A, Brown S, Rossi A, Joice AC, Mencio CP, Quintero MV, Kuberan B, Desai UR. Chemoenzymatically prepared heparan sulfate containing rare 2-O-sulfonated glucuronic acid residues. ACS Chem Biol. 2015 Jun 19; 10(6):1485-94. PMID: 25742429.
    Citations: 11     Fields:    Translation:Cells
  19. Mehta AY, Desai UR. Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2. Biochem Biophys Res Commun. 2014 Sep 26; 452(3):813-6. PMID: 25201728.
    Citations: 7     Fields:    Translation:Cells
  20. Argade MD, Mehta AY, Sarkar A, Desai UR. Allosteric inhibition of human factor XIa: discovery of monosulfated benzofurans as a class of promising inhibitors. J Med Chem. 2014 Apr 24; 57(8):3559-69. PMID: 24666186.
    Citations: 9     Fields:    Translation:HumansCells
  21. Mehta AY, Thakkar JN, Mohammed BM, Martin EJ, Brophy DF, Kishimoto T, Desai UR. Targeting the GPIba binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effects. J Med Chem. 2014 Apr 10; 57(7):3030-9. PMID: 24635452.
    Citations: 8     Fields:    Translation:HumansCells
  22. Mehta AY, Jin Y, Desai UR. An update on recent patents on thrombin inhibitors (2010 - 2013). Expert Opin Ther Pat. 2014 Jan; 24(1):47-67. PMID: 24099091.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  23. Sidhu PS, Abdel Aziz MH, Sarkar A, Mehta AY, Zhou Q, Desai UR. Designing allosteric regulators of thrombin. Exosite 2 features multiple subsites that can be targeted by sulfated small molecules for inducing inhibition. J Med Chem. 2013 Jun 27; 56(12):5059-70. PMID: 23718540.
    Citations: 25     Fields:    Translation:HumansCells
  24. Al-Horani RA, Ponnusamy P, Mehta AY, Gailani D, Desai UR. Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa. J Med Chem. 2013 Feb 14; 56(3):867-78. PMID: 23316863.
    Citations: 36     Fields:    Translation:Cells
  25. Al-Horani RA, Mehta AY, Desai UR. Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold. Eur J Med Chem. 2012 Aug; 54:771-83. PMID: 22770607.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  26. Sidhu PS, Liang A, Mehta AY, Abdel Aziz MH, Zhou Q, Desai UR. Rational design of potent, small, synthetic allosteric inhibitors of thrombin. J Med Chem. 2011 Aug 11; 54(15):5522-31. PMID: 21714536.
    Citations: 23     Fields:    Translation:HumansCells
  27. Desai BJ, Boothello RS, Mehta AY, Scarsdale JN, Wright HT, Desai UR. Interaction of thrombin with sucrose octasulfate. Biochemistry. 2011 Aug 16; 50(32):6973-82. PMID: 21736375.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.