Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Bradford Barr Lowell, M.D.,Ph.D.

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Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01DK122976 (LOWELL, BRADFORD B) Sep 17, 2019 - Jun 30, 2024
    NIH/NIDDK
    Leveraging the Rich Genetic Diversity of Vagal Motor Neurons to Decode Brain-to-Gut Communication
    Role: Principal Investigator
  2. R01DK111401 (LOWELL, BRADFORD B) Sep 15, 2016 - Jul 31, 2021
    NIH/NIDDK
    Glutamatergic Neurons in the Arcuate Nucleus (ARC) and Regulation of Satiety
    Role: Principal Investigator
  3. R01DK096010 (LOWELL, BRADFORD B) Jul 1, 2012 - May 31, 2016
    NIH/NIDDK
    AgRP Neuron Activity ? Plasticity, Gene Expression and Excitatory Afferent Control
    Role: Principal Investigator
  4. R01DK089044 (LOWELL, BRADFORD B) Aug 5, 2010 - May 31, 2019
    NIH/NIDDK
    Leptin, GABAergic Neurons and the Feedback / Feedforward Regulation of Energy Balance
    Role: Principal Investigator
  5. R37DK053477 (LOWELL, BRADFORD B) Dec 21, 2009 - Dec 31, 2016
    NIH/NIDDK
    Glucose-Sensing by Neurons: Its Importance and the Role of UCP2
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC. PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 Jun 17; 106(6):1009-1025.e10. PMID: 32302532.
    Citations:    
  2. Hu B, Jin C, Zeng X, Resch JM, Jedrychowski MP, Yang Z, Desai BN, Banks AS, Lowell BB, Mathis D, Spiegelman BM. ?d T cells and adipocyte IL-17RC control fat innervation and thermogenesis. Nature. 2020 02; 578(7796):610-614. PMID: 32076265.
    Citations:    
  3. Livneh Y, Sugden AU, Madara JC, Essner RA, Flores VI, Sugden LA, Resch JM, Lowell BB, Andermann ML. Estimation of Current and Future Physiological States in Insular Cortex. Neuron. 2020 03 18; 105(6):1094-1111.e10. PMID: 31955944.
    Citations:    
  4. Perry RJ, Resch JM, Douglass AM, Madara JC, Rabin-Court A, Kucukdereli H, Wu C, Song JD, Lowell BB, Shulman GI. Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents. Proc Natl Acad Sci U S A. 2019 07 02; 116(27):13670-13679. PMID: 31213533.
    Citations:    
  5. Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. Publisher Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3ß-S100b axis. Nature. 2019 Jun; 570(7760):E32. PMID: 31114060.
    Citations:    
  6. Lowell BB. The Neuroscience of Drives for Food, Water, and Salt. Reply. N Engl J Med. 2019 05 02; 380(18):e33. PMID: 31042849.
    Citations:    
  7. Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. Innervation of thermogenic adipose tissue via a calsyntenin 3ß-S100b axis. Nature. 2019 05; 569(7755):229-235. PMID: 31043739.
    Citations:    
  8. Li MM, Madara JC, Steger JS, Krashes MJ, Balthasar N, Campbell JN, Resch JM, Conley NJ, Garfield AS, Lowell BB. The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits. Neuron. 2019 05 08; 102(3):653-667.e6. PMID: 30879785.
    Citations:    
  9. Lowell BB. New Neuroscience of Homeostasis and Drives for Food, Water, and Salt. N Engl J Med. 2019 01 31; 380(5):459-471. PMID: 30699320.
    Citations:    Fields:    
  10. Ostrowski L, Speiser PW, Accacha S, Altshuler L, Fennoy I, Lowell B, Rapaport R, Rosenfeld W, Shelov SP, Ten S, Rosenbaum M. Demographics and anthropometrics impact benefits of health intervention: data from the Reduce Obesity and Diabetes Project. Obes Sci Pract. 2019 Feb; 5(1):46-58. PMID: 30847225.
    Citations:    
  11. Machado NLS, Abbott SBG, Resch JM, Zhu L, Arrigoni E, Lowell BB, Fuller PM, Fontes MAP, Saper CB. A Glutamatergic Hypothalamomedullary Circuit Mediates Thermogenesis, but Not Heat Conservation, during Stress-Induced Hyperthermia. Curr Biol. 2018 07 23; 28(14):2291-2301.e5. PMID: 30017482.
    Citations: 2     Fields:    
  12. Ross RA, Leon S, Madara JC, Schafer D, Fergani C, Maguire CA, Verstegen AM, Brengle E, Kong D, Herbison AE, Kaiser UB, Lowell BB, Navarro VM. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse. Elife. 2018 06 15; 7. PMID: 29905528.
    Citations:    Fields:    
  13. Todd WD, Fenselau H, Wang JL, Zhang R, Machado NL, Venner A, Broadhurst RY, Kaur S, Lynagh T, Olson DP, Lowell BB, Fuller PM, Saper CB. A hypothalamic circuit for the circadian control of aggression. Nat Neurosci. 2018 05; 21(5):717-724. PMID: 29632359.
    Citations: 1     Fields:    
  14. Resch JM, Fenselau H, Madara JC, Wu C, Campbell JN, Lyubetskaya A, Dawes BA, Tsai LT, Li MM, Livneh Y, Ke Q, Kang PM, Fejes-Tóth G, Náray-Fejes-Tóth A, Geerling JC, Lowell BB. Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling. Neuron. 2017 Sep 27; 96(1):190-206.e7. PMID: 28957668.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Andermann ML, Lowell BB. Toward a Wiring Diagram Understanding of Appetite Control. Neuron. 2017 Aug 16; 95(4):757-778. PMID: 28817798.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  16. Fenselau H, Campbell JN, Verstegen AMJ, Madara JC, Xu J, Shah BP, Resch JM, Yang Z, Mandelblat-Cerf Y, Livneh Y, Lowell BB. Corrigendum: A rapidly acting glutamatergic ARC?PVH satiety circuit postsynaptically regulated by a-MSH. Nat Neurosci. 2017 Jul 26; 20(8):1189. PMID: 28745725.
    Citations:    Fields:    
  17. Livneh Y, Ramesh RN, Burgess CR, Levandowski KM, Madara JC, Fenselau H, Goldey GJ, Diaz VE, Jikomes N, Resch JM, Lowell BB, Andermann ML. Homeostatic circuits selectively gate food cue responses in insular cortex. Nature. 2017 06 29; 546(7660):611-616. PMID: 28614299.
    Citations: 11     Fields:    Translation:AnimalsCells
  18. Cheng L, Duan B, Huang T, Zhang Y, Chen Y, Britz O, Garcia-Campmany L, Ren X, Vong L, Lowell BB, Goulding M, Wang Y, Ma Q. Identification of spinal circuits involved in touch-evoked dynamic mechanical pain. Nat Neurosci. 2017 Jun; 20(6):804-814. PMID: 28436981.
    Citations: 11     Fields:    Translation:AnimalsCells
  19. Mahoney CE, Agostinelli LJ, Brooks JN, Lowell BB, Scammell TE. GABAergic Neurons of the Central Amygdala Promote Cataplexy. J Neurosci. 2017 04 12; 37(15):3995-4006. PMID: 28235898.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Agostinelli LJ, Ferrari LL, Mahoney CE, Mochizuki T, Lowell BB, Arrigoni E, Scammell TE. Descending projections from the basal forebrain to the orexin neurons in mice. J Comp Neurol. 2017 May 01; 525(7):1668-1684. PMID: 27997037.
    Citations: 4     Fields:    Translation:AnimalsCells
  21. Campbell JN, Macosko EZ, Fenselau H, Pers TH, Lyubetskaya A, Tenen D, Goldman M, Verstegen AM, Resch JM, McCarroll SA, Rosen ED, Lowell BB, Tsai LT. A molecular census of arcuate hypothalamus and median eminence cell types. Nat Neurosci. 2017 Mar; 20(3):484-496. PMID: 28166221.
    Citations: 44     Fields:    Translation:AnimalsCells
  22. Tejeda HA, Wu J, Kornspun AR, Pignatelli M, Kashtelyan V, Krashes MJ, Lowell BB, Carlezon WA, Bonci A. Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity. Neuron. 2017 Jan 04; 93(1):147-163. PMID: 28056342.
    Citations: 6     Fields:    Translation:AnimalsCells
  23. Mandelblat-Cerf Y, Kim A, Burgess CR, Subramanian S, Tannous BA, Lowell BB, Andermann ML. Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons. Neuron. 2017 Jan 04; 93(1):57-65. PMID: 27989461.
    Citations: 8     Fields:    Translation:AnimalsCells
  24. Fenselau H, Campbell JN, Verstegen AM, Madara JC, Xu J, Shah BP, Resch JM, Yang Z, Mandelblat-Cerf Y, Livneh Y, Lowell BB. A rapidly acting glutamatergic ARC?PVH satiety circuit postsynaptically regulated by a-MSH. Nat Neurosci. 2017 01; 20(1):42-51. PMID: 27869800.
    Citations: 24     Fields:    Translation:AnimalsCells
  25. Keenan WT, Rupp AC, Ross RA, Somasundaram P, Hiriyanna S, Wu Z, Badea TC, Robinson PR, Lowell BB, Hattar SS. A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction. Elife. 2016 09 26; 5. PMID: 27669145.
    Citations: 9     Fields:    Translation:Cells
  26. Garfield AS, Shah BP, Burgess CR, Li MM, Li C, Steger JS, Madara JC, Campbell JN, Kroeger D, Scammell TE, Tannous BA, Myers MG, Andermann ML, Krashes MJ, Lowell BB. Dynamic GABAergic afferent modulation of AgRP neurons. Nat Neurosci. 2016 12; 19(12):1628-1635. PMID: 27643429.
    Citations: 21     Fields:    Translation:AnimalsCells
  27. Vetrivelan R, Kong D, Ferrari LL, Arrigoni E, Madara JC, Bandaru SS, Lowell BB, Lu J, Saper CB. Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice. Neuroscience. 2016 Nov 12; 336:102-113. PMID: 27595887.
    Citations: 7     Fields:    Translation:AnimalsCells
  28. Burgess CR, Ramesh RN, Sugden AU, Levandowski KM, Minnig MA, Fenselau H, Lowell BB, Andermann ML. Hunger-Dependent Enhancement of Food Cue Responses in Mouse Postrhinal Cortex and Lateral Amygdala. Neuron. 2016 Sep 07; 91(5):1154-1169. PMID: 27523426.
    Citations: 6     Fields:    Translation:Animals
  29. Kong D, Dagon Y, Campbell JN, Guo Y, Yang Z, Yi X, Aryal P, Wellenstein K, Kahn BB, Sabatini BL, Lowell BB. A Postsynaptic AMPK?p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons. Neuron. 2016 07 06; 91(1):25-33. PMID: 27321921.
    Citations: 7     Fields:    Translation:AnimalsCells
  30. Williams EK, Chang RB, Strochlic DE, Umans BD, Lowell BB, Liberles SD. Sensory Neurons that Detect Stretch and Nutrients in the Digestive System. Cell. 2016 Jun 30; 166(1):209-21. PMID: 27238020.
    Citations: 28     Fields:    Translation:AnimalsCells
  31. Kondoh K, Lu Z, Ye X, Olson DP, Lowell BB, Buck LB. A specific area of olfactory cortex involved in stress hormone responses to predator odours. Nature. 2016 Apr 07; 532(7597):103-6. PMID: 27001694.
    Citations: 8     Fields:    Translation:AnimalsCells
  32. Crowley NA, Bloodgood DW, Hardaway JA, Kendra AM, McCall JG, Al-Hasani R, McCall NM, Yu W, Schools ZL, Krashes MJ, Lowell BB, Whistler JL, Bruchas MR, Kash TL. Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. Cell Rep. 2016 Mar 29; 14(12):2774-83. PMID: 26997280.
    Citations: 11     Fields:    Translation:Animals
  33. D'Agostino G, Lyons DJ, Cristiano C, Burke LK, Madara JC, Campbell JN, Garcia AP, Land BB, Lowell BB, Dileone RJ, Heisler LK. Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit. Elife. 2016 03 14; 5. PMID: 26974347.
    Citations: 14     Fields:    Translation:Animals
  34. Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu O, Smith AS, Jain S, Lowell BB, Krashes MJ, Wess J. Corrigendum: Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake. Nat Commun. 2016 Mar 03; 7:11019. PMID: 26936677.
    Citations: 1     Fields:    
  35. Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ. Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress. Elife. 2016 Feb 24; 5:e10031. PMID: 26910012.
    Citations: 3     Fields:    Translation:AnimalsCells
  36. Krashes MJ, Lowell BB, Garfield AS. Melanocortin-4 receptor-regulated energy homeostasis. Nat Neurosci. 2016 Feb; 19(2):206-19. PMID: 26814590.
    Citations: 30     Fields:    Translation:HumansAnimals
  37. Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu O, Smith AS, Jain S, Lowell BB, Krashes MJ, Wess J. Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake. Nat Commun. 2016 Jan 08; 7:10268. PMID: 26743492.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  38. Ferrari LL, Agostinelli LJ, Krashes MJ, Lowell BB, Scammell TE, Arrigoni E. Dynorphin inhibits basal forebrain cholinergic neurons by pre- and postsynaptic mechanisms. J Physiol. 2016 Feb 15; 594(4):1069-85. PMID: 26613645.
    Citations: 3     Fields:    Translation:AnimalsCells
  39. Geerling JC, Kim M, Mahoney CE, Abbott SB, Agostinelli LJ, Garfield AS, Krashes MJ, Lowell BB, Scammell TE. Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 01; 310(1):R41-54. PMID: 26491097.
    Citations: 9     Fields:    Translation:AnimalsCells
  40. Al-Hasani R, McCall JG, Shin G, Gomez AM, Schmitz GP, Bernardi JM, Pyo CO, Park SI, Marcinkiewcz CM, Crowley NA, Krashes MJ, Lowell BB, Kash TL, Rogers JA, Bruchas MR. Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward. Neuron. 2015 Sep 02; 87(5):1063-77. PMID: 26335648.
    Citations: 33     Fields:    Translation:AnimalsCells
  41. Mandelblat-Cerf Y, Ramesh RN, Burgess CR, Patella P, Yang Z, Lowell BB, Andermann ML. Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales. Elife. 2015 Jul 10; 4. PMID: 26159614.
    Citations: 27     Fields:    Translation:AnimalsCells
  42. Garfield AS, Li C, Madara JC, Shah BP, Webber E, Steger JS, Campbell JN, Gavrilova O, Lee CE, Olson DP, Elmquist JK, Tannous BA, Krashes MJ, Lowell BB. A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci. 2015 Jun; 18(6):863-71. PMID: 25915476.
    Citations: 63     Fields:    Translation:AnimalsCells
  43. Pleil KE, Rinker JA, Lowery-Gionta EG, Mazzone CM, McCall NM, Kendra AM, Olson DP, Lowell BB, Grant KA, Thiele TE, Kash TL. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci. 2015 Apr; 18(4):545-52. PMID: 25751534.
    Citations: 39     Fields:    Translation:AnimalsCells
  44. Allison MB, Patterson CM, Krashes MJ, Lowell BB, Myers MG, Olson DP. TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons. Mol Metab. 2015 Apr; 4(4):299-309. PMID: 25830093.
    Citations: 19     Fields:    
  45. Garfield AS, Shah BP, Madara JC, Burke LK, Patterson CM, Flak J, Neve RL, Evans ML, Lowell BB, Myers MG, Heisler LK. A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia. Cell Metab. 2014 Dec 02; 20(6):1030-7. PMID: 25470549.
    Citations: 31     Fields:    Translation:Animals
  46. Saper CB, Lowell BB. The hypothalamus. Curr Biol. 2014 Dec 01; 24(23):R1111-6. PMID: 25465326.
    Citations: 18     Fields:    Translation:HumansAnimals
  47. Duan B, Cheng L, Bourane S, Britz O, Padilla C, Garcia-Campmany L, Krashes M, Knowlton W, Velasquez T, Ren X, Ross S, Lowell BB, Wang Y, Goulding M, Ma Q. Identification of spinal circuits transmitting and gating mechanical pain. Cell. 2014 Dec 04; 159(6):1417-1432. PMID: 25467445.
    Citations: 67     Fields:    Translation:AnimalsCells
  48. do Carmo JM, da Silva AA, Ebaady SE, Sessums PO, Abraham RS, Elmquist JK, Lowell BB, Hall JE. Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation. Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15; 307(12):R1438-47. PMID: 25339680.
    Citations: 9     Fields:    Translation:AnimalsCells
  49. Shah BP, Vong L, Olson DP, Koda S, Krashes MJ, Ye C, Yang Z, Fuller PM, Elmquist JK, Lowell BB. MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13193-8. PMID: 25157144.
    Citations: 32     Fields:    Translation:AnimalsCells
  50. Berglund ED, Liu T, Kong X, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Williams KW, Olson DP, Scherer PE, Lowell BB, Elmquist JK. Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia. Nat Neurosci. 2014 Jul; 17(7):911-3. PMID: 24908101.
    Citations: 33     Fields:    Translation:AnimalsCells
  51. Martin C, Navarro VM, Simavli S, Vong L, Carroll RS, Lowell BB, Kaiser UB. Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. J Neurosci. 2014 Apr 23; 34(17):6047-56. PMID: 24760864.
    Citations: 16     Fields:    Translation:AnimalsCells
  52. Krashes MJ, Shah BP, Madara JC, Olson DP, Strochlic DE, Garfield AS, Vong L, Pei H, Watabe-Uchida M, Uchida N, Liberles SD, Lowell BB. An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014 Mar 13; 507(7491):238-42. PMID: 24487620.
    Citations: 110     Fields:    Translation:AnimalsCells
  53. Xu Y, Wu Z, Sun H, Zhu Y, Kim ER, Lowell BB, Arenkiel BR, Xu Y, Tong Q. Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation. Cell Metab. 2013 Dec 03; 18(6):860-70. PMID: 24315371.
    Citations: 18     Fields:    Translation:AnimalsCells
  54. Garfield AS, Lowell BB. Was it something I ate? Cell Metab. 2013 Dec 03; 18(6):769-70. PMID: 24315365.
    Citations: 1     Fields:    Translation:Animals
  55. Accacha S, Rosenfeld W, Jacobson A, Michel L, Schnurr FJ, Shelov S, Ten S, Boucher-Berry C, Carey DE, Speiser PW, Lowell B, Conroy R, Klein M, Fennoy I, Rapaport R, Rosenbaum M. Plasma advanced glycation end products (AGEs), receptors for AGEs and their correlation with inflammatory markers in middle school-age children. Horm Res Paediatr. 2013; 80(5):318-27. PMID: 24217195.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  56. Krashes MJ, Shah BP, Koda S, Lowell BB. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP. Cell Metab. 2013 Oct 01; 18(4):588-95. PMID: 24093681.
    Citations: 82     Fields:    Translation:AnimalsCells
  57. Fujikawa T, Berglund ED, Patel VR, Ramadori G, Vianna CR, Vong L, Thorel F, Chera S, Herrera PL, Lowell BB, Elmquist JK, Baldi P, Coppari R. Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab. 2013 Sep 03; 18(3):431-44. PMID: 24011077.
    Citations: 38     Fields:    Translation:AnimalsCells
  58. Huang H, Lee SH, Ye C, Lima IS, Oh BC, Lowell BB, Zabolotny JM, Kim YB. ROCK1 in AgRP neurons regulates energy expenditure and locomotor activity in male mice. Endocrinology. 2013 Oct; 154(10):3660-70. PMID: 23885017.
    Citations: 7     Fields:    Translation:AnimalsCells
  59. Xu P, Grueter BA, Britt JK, McDaniel L, Huntington PJ, Hodge R, Tran S, Mason BL, Lee C, Vong L, Lowell BB, Malenka RC, Lutter M, Pieper AA. Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):10759-64. PMID: 23754400.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  60. Allister EM, Robson-Doucette CA, Prentice KJ, Hardy AB, Sultan S, Gaisano HY, Kong D, Gilon P, Herrera PL, Lowell BB, Wheeler MB. UCP2 regulates the glucagon response to fasting and starvation. Diabetes. 2013 May; 62(5):1623-33. PMID: 23434936.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  61. Sohn JW, Harris LE, Berglund ED, Liu T, Vong L, Lowell BB, Balthasar N, Williams KW, Elmquist JK. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell. 2013 Jan 31; 152(3):612-9. PMID: 23374353.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  62. Lou S, Duan B, Vong L, Lowell BB, Ma Q. Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechanoreceptors. J Neurosci. 2013 Jan 16; 33(3):870-82. PMID: 23325226.
    Citations: 43     Fields:    Translation:AnimalsCells
  63. Lee S, Bookout AL, Lee CE, Gautron L, Harper MJ, Elias CF, Lowell BB, Elmquist JK. Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus. J Comp Neurol. 2012 Nov 01; 520(16):3617-32. PMID: 22473294.
    Citations: 10     Fields:    Translation:AnimalsCells
  64. Kong D, Tong Q, Ye C, Koda S, Fuller PM, Krashes MJ, Vong L, Ray RS, Olson DP, Lowell BB. GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell. 2012 Oct 26; 151(3):645-57. PMID: 23101631.
    Citations: 80     Fields:    Translation:AnimalsCells
  65. Wu Z, Xu Y, Zhu Y, Sutton AK, Zhao R, Lowell BB, Olson DP, Tong Q. An obligate role of oxytocin neurons in diet induced energy expenditure. PLoS One. 2012; 7(9):e45167. PMID: 23028821.
    Citations: 40     Fields:    Translation:AnimalsCells
  66. Huang H, Kong D, Byun KH, Ye C, Koda S, Lee DH, Oh BC, Lee SW, Lee B, Zabolotny JM, Kim MS, Bjørbæk C, Lowell BB, Kim YB. Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling. Nat Neurosci. 2012 Oct; 15(10):1391-8. PMID: 22941110.
    Citations: 31     Fields:    Translation:AnimalsCells
  67. Kozorovitskiy Y, Saunders A, Johnson CA, Lowell BB, Sabatini BL. Recurrent network activity drives striatal synaptogenesis. Nature. 2012 May 13; 485(7400):646-50. PMID: 22660328.
    Citations: 48     Fields:    Translation:AnimalsCells
  68. Liu T, Kong D, Shah BP, Ye C, Koda S, Saunders A, Ding JB, Yang Z, Sabatini BL, Lowell BB. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron. 2012 Feb 09; 73(3):511-22. PMID: 22325203.
    Citations: 81     Fields:    Translation:AnimalsCells
  69. Cohen JY, Haesler S, Vong L, Lowell BB, Uchida N. Neuron-type-specific signals for reward and punishment in the ventral tegmental area. Nature. 2012 Jan 18; 482(7383):85-8. PMID: 22258508.
    Citations: 279     Fields:    Translation:AnimalsCells
  70. Li C, Pleil KE, Stamatakis AM, Busan S, Vong L, Lowell BB, Stuber GD, Kash TL. Presynaptic inhibition of gamma-aminobutyric acid release in the bed nucleus of the stria terminalis by kappa opioid receptor signaling. Biol Psychiatry. 2012 Apr 15; 71(8):725-32. PMID: 22225848.
    Citations: 41     Fields:    Translation:AnimalsCells
  71. Krenzer M, Anaclet C, Vetrivelan R, Wang N, Vong L, Lowell BB, Fuller PM, Lu J. Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia. PLoS One. 2011; 6(10):e24998. PMID: 22043278.
    Citations: 33     Fields:    Translation:AnimalsCells
  72. Vong L, Ye C, Yang Z, Choi B, Chua S, Lowell BB. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron. 2011 Jul 14; 71(1):142-54. PMID: 21745644.
    Citations: 268     Fields:    Translation:AnimalsCells
  73. Klöckener T, Hess S, Belgardt BF, Paeger L, Verhagen LA, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P, Brüning JC. High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci. 2011 Jun 05; 14(7):911-8. PMID: 21642975.
    Citations: 79     Fields:    Translation:AnimalsCells
  74. Higley MJ, Gittis AH, Oldenburg IA, Balthasar N, Seal RP, Edwards RH, Lowell BB, Kreitzer AC, Sabatini BL. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One. 2011 Apr 22; 6(4):e19155. PMID: 21544206.
    Citations: 54     Fields:    Translation:AnimalsCells
  75. Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, Maratos-Flier E, Roth BL, Lowell BB. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest. 2011 Apr; 121(4):1424-8. PMID: 21364278.
    Citations: 316     Fields:    Translation:AnimalsCells
  76. Mochizuki T, Arrigoni E, Marcus JN, Clark EL, Yamamoto M, Honer M, Borroni E, Lowell BB, Elmquist JK, Scammell TE. Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4471-6. PMID: 21368172.
    Citations: 47     Fields:    Translation:AnimalsCells
  77. Rossi J, Balthasar N, Olson D, Scott M, Berglund E, Lee CE, Choi MJ, Lauzon D, Lowell BB, Elmquist JK. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab. 2011 Feb 02; 13(2):195-204. PMID: 21284986.
    Citations: 186     Fields:    Translation:AnimalsCells
  78. Liu Y, Abdel Samad O, Zhang L, Duan B, Tong Q, Lopes C, Ji RR, Lowell BB, Ma Q. VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron. 2010 Nov 04; 68(3):543-56. PMID: 21040853.
    Citations: 92     Fields:    Translation:AnimalsCells
  79. Xu Y, Jones JE, Lauzon DA, Anderson JG, Balthasar N, Heisler LK, Zinn AR, Lowell BB, Elmquist JK. A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. J Neurosci. 2010 Nov 03; 30(44):14630-4. PMID: 21048120.
    Citations: 26     Fields:    Translation:Animals
  80. Kong D, Vong L, Parton LE, Ye C, Tong Q, Hu X, Choi B, Brüning JC, Lowell BB. Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab. 2010 Nov 03; 12(5):545-52. PMID: 21035764.
    Citations: 54     Fields:    Translation:AnimalsCells
  81. Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci. 2010 Dec; 13(12):1457-9. PMID: 21037584.
    Citations: 38     Fields:    Translation:AnimalsCells
  82. Irani BG, Donato J, Olson DP, Lowell BB, Sacktor TC, Reyland ME, Tolson KP, Zinn AR, Ueta Y, Sakata I, Zigman JM, Elias CF, Clegg DJ. Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus. Neuroscience. 2010 Nov 10; 170(4):1065-79. PMID: 20691763.
    Citations: 4     Fields:    Translation:AnimalsCells
  83. Xu Y, Hill JW, Fukuda M, Gautron L, Sohn JW, Kim KW, Lee CE, Choi MJ, Lauzon DA, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab. 2010 Jul 07; 12(1):88-95. PMID: 20620998.
    Citations: 49     Fields:    Translation:AnimalsCells
  84. Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab. 2010 Apr 07; 11(4):286-97. PMID: 20374961.
    Citations: 142     Fields:    Translation:AnimalsCells
  85. Olson DP, Pulinilkunnil T, Cline GW, Shulman GI, Lowell BB. Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7598-603. PMID: 20368432.
    Citations: 29     Fields:    Translation:Animals
  86. Hawke Z, Ivanov TR, Bechtold DA, Dhillon H, Lowell BB, Luckman SM. PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling. J Neurosci. 2009 Nov 25; 29(47):14828-35. PMID: 19940178.
    Citations: 28     Fields:    Translation:AnimalsCells
  87. Sakata I, Nakano Y, Osborne-Lawrence S, Rovinsky SA, Lee CE, Perello M, Anderson JG, Coppari R, Xiao G, Lowell BB, Elmquist JK, Zigman JM. Characterization of a novel ghrelin cell reporter mouse. Regul Pept. 2009 Jun 05; 155(1-3):91-8. PMID: 19361544.
    Citations: 37     Fields:    Translation:AnimalsCells
  88. van den Pol AN, Yao Y, Fu LY, Foo K, Huang H, Coppari R, Lowell BB, Broberger C. Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons. J Neurosci. 2009 Apr 08; 29(14):4622-39. PMID: 19357287.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  89. Fukuda M, Jones JE, Olson D, Hill J, Lee CE, Gautron L, Choi M, Zigman JM, Lowell BB, Elmquist JK. Monitoring FoxO1 localization in chemically identified neurons. J Neurosci. 2008 Dec 10; 28(50):13640-8. PMID: 19074037.
    Citations: 39     Fields:    Translation:AnimalsCells
  90. Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron. 2008 Nov 26; 60(4):582-9. PMID: 19038216.
    Citations: 86     Fields:    Translation:Animals
  91. Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci. 2008 Sep; 11(9):998-1000. PMID: 19160495.
    Citations: 192     Fields:    Translation:AnimalsCells
  92. Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci. 2008 Aug 10. PMID: 18690230.
    Citations:    
  93. Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS. Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology. 2008 Nov; 149(11):5654-61. PMID: 18669597.
    Citations: 41     Fields:    Translation:AnimalsCells
  94. Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest. 2008 May; 118(5):1796-805. PMID: 18382766.
    Citations: 146     Fields:    Translation:HumansAnimalsCells
  95. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53. PMID: 18223655.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  96. van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG, Schwartz GJ, Chua SC. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology. 2008 Apr; 149(4):1773-85. PMID: 18162515.
    Citations: 154     Fields:    Translation:Animals
  97. Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature. 2007 Sep 13; 449(7159):228-32. PMID: 17728716.
    Citations: 217     Fields:    Translation:HumansAnimalsCells
  98. Lazarus M, Yoshida K, Coppari R, Bass CE, Mochizuki T, Lowell BB, Saper CB. EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci. 2007 Sep; 10(9):1131-3. PMID: 17676060.
    Citations: 101     Fields:    Translation:AnimalsCells
  99. McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, Lowell BB, Fanselow MS, Wilson MA, Tonegawa S. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science. 2007 Jul 06; 317(5834):94-9. PMID: 17556551.
    Citations: 297     Fields:    Translation:AnimalsCells
  100. Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab. 2007 May; 5(5):383-93. PMID: 17488640.
    Citations: 145     Fields:    Translation:AnimalsCells
  101. Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB. Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab. 2006 Dec; 4(6):453-64. PMID: 17141629.
    Citations: 75     Fields:    Translation:AnimalsCells
  102. Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006 Jul 20; 51(2):239-49. PMID: 16846858.
    Citations: 94     Fields:    Translation:AnimalsCells
  103. Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA, Lowell BB. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab. 2006 Jun; 3(6):417-27. PMID: 16753577.
    Citations: 74     Fields:    Translation:AnimalsCells
  104. Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S, Elmquist JK, Lowell BB. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006 Jan 19; 49(2):191-203. PMID: 16423694.
    Citations: 282     Fields:    Translation:AnimalsCells
  105. Elmquist JK, Coppari R, Balthasar N, Ichinose M, Lowell BB. Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol. 2005 Dec 05; 493(1):63-71. PMID: 16254991.
    Citations: 133     Fields:    Translation:AnimalsCells
  106. Zigman JM, Nakano Y, Coppari R, Balthasar N, Marcus JN, Lee CE, Jones JE, Deysher AE, Waxman AR, White RD, Williams TD, Lachey JL, Seeley RJ, Lowell BB, Elmquist JK. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest. 2005 Dec; 115(12):3564-72. PMID: 16322794.
    Citations: 187     Fields:    Translation:AnimalsCells
  107. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell. 2005 Nov 04; 123(3):493-505. PMID: 16269339.
    Citations: 362     Fields:    Translation:AnimalsCells
  108. Solanes G, Pedraza N, Calvo V, Vidal-Puig A, Lowell BB, Villarroya F. Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region. Biochem J. 2005 Mar 15; 386(Pt 3):505-13. PMID: 15496137.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  109. Krauss S, Zhang CY, Lowell BB. The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol. 2005 Mar; 6(3):248-61. PMID: 15738989.
    Citations: 170     Fields:    Translation:HumansCells
  110. Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science. 2005 Jan 21; 307(5708):384-7. PMID: 15662004.
    Citations: 551     Fields:    Translation:HumansAnimalsCells
  111. Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, Tang V, Liu SM, Ludwig T, Chua SC, Lowell BB, Elmquist JK. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab. 2005 Jan; 1(1):63-72. PMID: 16054045.
    Citations: 164     Fields:    Translation:AnimalsCells
  112. Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004 Oct 01; 119(1):121-35. PMID: 15454086.
    Citations: 433     Fields:    Translation:AnimalsCells
  113. Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB. Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression. J Biol Chem. 2004 Dec 03; 279(49):51049-56. PMID: 15448158.
    Citations: 40     Fields:    Translation:AnimalsCells
  114. Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC, Elmquist JK, Lowell BB. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron. 2004 Jun 24; 42(6):983-91. PMID: 15207242.
    Citations: 341     Fields:    Translation:AnimalsCells
  115. Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest. 2003 Dec; 112(12):1831-42. PMID: 14679178.
    Citations: 84     Fields:    Translation:AnimalsCells
  116. Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, Korsmeyer SJ. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature. 2003 Aug 21; 424(6951):952-6. PMID: 12931191.
    Citations: 186     Fields:    Translation:AnimalsCells
  117. Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell. 2003 Jul; 5(1):73-83. PMID: 12852853.
    Citations: 44     Fields:    Translation:AnimalsCells
  118. Lowell BB, Bachman ES. Beta-Adrenergic receptors, diet-induced thermogenesis, and obesity. J Biol Chem. 2003 Aug 08; 278(32):29385-8. PMID: 12788929.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  119. Nakayama A, Bianco AC, Zhang CY, Lowell BB, Frangioni JV. Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging. Mol Imaging. 2003 01; 2(1):37-49. PMID: 12926236.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  120. Joseph JW, Koshkin V, Zhang CY, Wang J, Lowell BB, Chan CB, Wheeler MB. Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes. 2002 Nov; 51(11):3211-9. PMID: 12401712.
    Citations: 40     Fields:    Translation:AnimalsCells
  121. Boucher J, Castan-Laurell I, Le Lay S, Grujic D, Sibrac D, Krief S, Lafontan M, Lowell BB, Dugail I, Saulnier-Blache JS, Valet P. Human alpha 2A-adrenergic receptor gene expressed in transgenic mouse adipose tissue under the control of its regulatory elements. J Mol Endocrinol. 2002 Oct; 29(2):251-64. PMID: 12370125.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  122. Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature. 2002 Aug 15; 418(6899):797-801. PMID: 12181572.
    Citations: 732     Fields:    Translation:AnimalsCells
  123. Bachman ES, Dhillon H, Zhang CY, Cinti S, Bianco AC, Kobilka BK, Lowell BB. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science. 2002 Aug 02; 297(5582):843-5. PMID: 12161655.
    Citations: 176     Fields:    Translation:AnimalsCells
  124. Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB, Langer R, Folkman MJ. Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10730-5. PMID: 12149466.
    Citations: 190     Fields:    Translation:Animals
  125. Jost P, Fasshauer M, Kahn CR, Benito M, Meyer M, Ott V, Lowell BB, Klein HH, Klein J. Atypical beta-adrenergic effects on insulin signaling and action in beta(3)-adrenoceptor-deficient brown adipocytes. Am J Physiol Endocrinol Metab. 2002 Jul; 283(1):E146-53. PMID: 12067855.
    Citations: 3     Fields:    Translation:AnimalsCells
  126. Baffy G, Zhang CY, Glickman JN, Lowell BB. Obesity-related fatty liver is unchanged in mice deficient for mitochondrial uncoupling protein 2. Hepatology. 2002 Apr; 35(4):753-61. PMID: 11915020.
    Citations: 17     Fields:    Translation:AnimalsCells
  127. Krauss S, Zhang CY, Lowell BB. A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):118-22. PMID: 11756659.
    Citations: 42     Fields:    Translation:AnimalsCells
  128. Dumont LM, Wu CS, Aschkenasi CJ, Elmquist JK, Lowell BB, Mountjoy KG. Mouse melanocortin-4 receptor gene 5'-flanking region imparts cell specific expression in vitro. Mol Cell Endocrinol. 2001 Nov 26; 184(1-2):173-85. PMID: 11694353.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  129. Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell. 2001 Nov; 8(5):971-82. PMID: 11741533.
    Citations: 213     Fields:    Translation:HumansAnimalsCells
  130. Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell. 2001 Jun 15; 105(6):745-55. PMID: 11440717.
    Citations: 188     Fields:    Translation:HumansAnimals
  131. Vianna CR, Hagen T, Zhang CY, Bachman E, Boss O, Gereben B, Moriscot AS, Lowell BB, Bicudo JE, Bianco AC. Cloning and functional characterization of an uncoupling protein homolog in hummingbirds. Physiol Genomics. 2001 Apr 02; 5(3):137-45. PMID: 11285367.
    Citations: 12     Fields:    Translation:AnimalsCells
  132. Cline GW, Vidal-Puig AJ, Dufour S, Cadman KS, Lowell BB, Shulman GI. In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism. J Biol Chem. 2001 Jun 08; 276(23):20240-4. PMID: 11274222.
    Citations: 41     Fields:    Translation:AnimalsCells
  133. Ludwig DS, Tritos NA, Mastaitis JW, Kulkarni R, Kokkotou E, Elmquist J, Lowell B, Flier JS, Maratos-Flier E. Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. J Clin Invest. 2001 Feb; 107(3):379-86. PMID: 11160162.
    Citations: 105     Fields:    Translation:Animals
  134. Huppertz C, Fischer BM, Kim YB, Kotani K, Vidal-Puig A, Slieker LJ, Sloop KW, Lowell BB, Kahn BB. Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism. J Biol Chem. 2001 Apr 20; 276(16):12520-9. PMID: 11278970.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  135. Valet P, Grujic D, Wade J, Ito M, Zingaretti MC, Soloveva V, Ross SR, Graves RA, Cinti S, Lafontan M, Lowell BB. Expression of human alpha 2-adrenergic receptors in adipose tissue of beta 3-adrenergic receptor-deficient mice promotes diet-induced obesity. J Biol Chem. 2000 Nov 03; 275(44):34797-802. PMID: 10948198.
    Citations: 14     Fields:    Translation:HumansAnimals
  136. Ristow M, Pfister MF, Yee AJ, Schubert M, Michael L, Zhang CY, Ueki K, Michael MD, Lowell BB, Kahn CR. Frataxin activates mitochondrial energy conversion and oxidative phosphorylation. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12239-43. PMID: 11035806.
    Citations: 50     Fields:    Translation:AnimalsCells
  137. Hagen T, Lowell BB. Chimeric proteins between UCP1 and UCP3: the middle third of UCP1 is necessary and sufficient for activation by fatty acids. Biochem Biophys Res Commun. 2000 Sep 24; 276(2):642-8. PMID: 11027525.
    Citations: 3     Fields:    Translation:HumansAnimals
  138. Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med. 2000 Aug; 6(8):924-8. PMID: 10932232.
    Citations: 162     Fields:    Translation:HumansAnimalsCells
  139. Splaver A, Silos S, Lowell B, Valenzuela R, Kirsner RS. Case report: pemphigus vulgaris in a patient infected with HIV. AIDS Patient Care STDS. 2000 Jun; 14(6):295-6. PMID: 10897500.
    Citations: 1     Fields:    Translation:Humans
  140. Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R, Muoio DM, Lowell BB. Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem. 2000 May 26; 275(21):16258-66. PMID: 10748196.
    Citations: 134     Fields:    Translation:AnimalsCells
  141. Hagen T, Zhang CY, Vianna CR, Lowell BB. Uncoupling proteins 1 and 3 are regulated differently. Biochemistry. 2000 May 16; 39(19):5845-51. PMID: 10801335.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  142. Lowell BB, Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis. Nature. 2000 Apr 06; 404(6778):652-60. PMID: 10766252.
    Citations: 318     Fields:    Translation:HumansAnimalsCells
  143. Boss O, Hagen T, Lowell BB. Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism. Diabetes. 2000 Feb; 49(2):143-56. PMID: 10868929.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  144. Cohen ML, Bloomquist W, Ito M, Lowell BB. Beta3 receptors mediate relaxation in stomach fundus whereas a fourth beta receptor mediates tachycardia in atria from transgenic beta3 receptor knockout mice. Receptors Channels. 2000; 7(1):17-23. PMID: 10800773.
    Citations: 8     Fields:    Translation:HumansAnimals
  145. Deen D, Karp R, Lowell B. A mini-fellowship in clinical nutrition for primary care physicians. J Cancer Educ. 2000; 15(3):134-6. PMID: 11019758.
    Citations:    Fields:    Translation:Humans
  146. Klein J, Fasshauer M, Ito M, Lowell BB, Benito M, Kahn CR. beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes. J Biol Chem. 1999 Dec 03; 274(49):34795-802. PMID: 10574950.
    Citations: 70     Fields:    Translation:AnimalsCells
  147. Abel ED, Kaulbach HC, Tian R, Hopkins JC, Duffy J, Doetschman T, Minnemann T, Boers ME, Hadro E, Oberste-Berghaus C, Quist W, Lowell BB, Ingwall JS, Kahn BB. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Invest. 1999 Dec; 104(12):1703-14. PMID: 10606624.
    Citations: 100     Fields:    Translation:Animals
  148. Lowell BB. PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function. Cell. 1999 Oct 29; 99(3):239-42. PMID: 10555139.
    Citations: 86     Fields:    Translation:AnimalsCells
  149. Boss O, Bachman E, Vidal-Puig A, Zhang CY, Peroni O, Lowell BB. Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-gamma coactivator-1. Biochem Biophys Res Commun. 1999 Aug 11; 261(3):870-6. PMID: 10441518.
    Citations: 16     Fields:    Translation:Animals
  150. Abel ED, Boers ME, Pazos-Moura C, Moura E, Kaulbach H, Zakaria M, Lowell B, Radovick S, Liberman MC, Wondisford F. Divergent roles for thyroid hormone receptor beta isoforms in the endocrine axis and auditory system. J Clin Invest. 1999 Aug; 104(3):291-300. PMID: 10430610.
    Citations: 40     Fields:    Translation:Animals
  151. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell. 1999 Jul 09; 98(1):115-24. PMID: 10412986.
    Citations: 1028     Fields:    Translation:AnimalsCells
  152. Hagen T, Zhang CY, Slieker LJ, Chung WK, Leibel RL, Lowell BB. Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous expression system. FEBS Lett. 1999 Jul 09; 454(3):201-6. PMID: 10431807.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  153. Lowell BB. Uncoupling protein-3 (UCP3): a mitochondrial carrier in search of a function. Int J Obes Relat Metab Disord. 1999 Jun; 23 Suppl 6:S43-5. PMID: 10454121.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  154. Chung WK, Luke A, Cooper RS, Rotini C, Vidal-Puig A, Rosenbaum M, Gordon D, Leal SM, Caprio S, Goldsmith R, Andreu AL, Bruno C, DiMauro S, Heo M, Lowe WL, Lowell BB, Allison DB, Leibel RL. The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis. Int J Obes Relat Metab Disord. 1999 Jun; 23 Suppl 6:S49-50. PMID: 10454123.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  155. Zhang CY, Hagen T, Mootha VK, Slieker LJ, Lowell BB. Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system. FEBS Lett. 1999 Apr 23; 449(2-3):129-34. PMID: 10338118.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  156. Vidal-Puig A, Rosenbaum M, Considine RC, Leibel RL, Dohm GL, Lowell BB. Effects of obesity and stable weight reduction on UCP2 and UCP3 gene expression in humans. Obes Res. 1999 Mar; 7(2):133-40. PMID: 10102249.
    Citations: 8     Fields:    Translation:HumansCells
  157. Cortright RN, Zheng D, Jones JP, Fluckey JD, DiCarlo SE, Grujic D, Lowell BB, Dohm GL. Regulation of skeletal muscle UCP-2 and UCP-3 gene expression by exercise and denervation. Am J Physiol. 1999 01; 276(1):E217-21. PMID: 9886970.
    Citations: 10     Fields:    Translation:Animals
  158. Shimada M, Tritos NA, Lowell BB, Flier JS, Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 1998 Dec 17; 396(6712):670-4. PMID: 9872314.
    Citations: 189     Fields:    Translation:AnimalsCells
  159. Fletcher DS, Candelore MR, Grujic D, Lowell BB, Luell S, Susulic VS, Macintyre DE. Beta-3 adrenergic receptor agonists cause an increase in gastrointestinal transit time in wild-type mice, but not in mice lacking the beta-3 adrenergic receptor. J Pharmacol Exp Ther. 1998 Nov; 287(2):720-4. PMID: 9808702.
    Citations: 5     Fields:    Translation:Animals
  160. Boyer BB, Barnes BM, Lowell BB, Grujic D. Differential regulation of uncoupling protein gene homologues in multiple tissues of hibernating ground squirrels. Am J Physiol. 1998 10; 275(4):R1232-8. PMID: 9756555.
    Citations: 13     Fields:    Translation:AnimalsCells
  161. Walder K, Norman RA, Hanson RL, Schrauwen P, Neverova M, Jenkinson CP, Easlick J, Warden CH, Pecqueur C, Raimbault S, Ricquier D, Silver MH, Shuldiner AR, Solanes G, Lowell BB, Chung WK, Leibel RL, Pratley R, Ravussin E. Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians. Hum Mol Genet. 1998 Sep; 7(9):1431-5. PMID: 9700198.
    Citations: 46     Fields:    Translation:HumansCells
  162. Ito M, Grujic D, Abel ED, Vidal-Puig A, Susulic VS, Lawitts J, Harper ME, Himms-Hagen J, Strosberg AD, Lowell BB. Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements. Diabetes. 1998 Sep; 47(9):1464-71. PMID: 9726236.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  163. Lowell BB. Adaptive thermogenesis: turning on the heat. Curr Biol. 1998 Jul 16; 8(15):R517-20. PMID: 9705924.
    Citations: 5     Fields:    Translation:AnimalsCells
  164. Lowell BB. Using gene knockout and transgenic techniques to study the physiology and pharmacology of beta3-adrenergic receptors. Endocr J. 1998 Apr; 45 Suppl:S9-13. PMID: 9790223.
    Citations: 2     Fields:    Translation:HumansAnimals
  165. Mantzoros CS, Frederich RC, Qu D, Lowell BB, Maratos-Flier E, Flier JS. Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations. Diabetes. 1998 Feb; 47(2):230-8. PMID: 9519718.
    Citations: 8     Fields:    Translation:AnimalsCells
  166. Hamann A, Flier JS, Lowell BB. Obesity after genetic ablation of brown adipose tissue. Z Ernahrungswiss. 1998; 37 Suppl 1:1-7. PMID: 9558722.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  167. Kim JB, Sarraf P, Wright M, Yao KM, Mueller E, Solanes G, Lowell BB, Spiegelman BM. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J Clin Invest. 1998 Jan 01; 101(1):1-9. PMID: 9421459.
    Citations: 157     Fields:    Translation:AnimalsCells
  168. Solanes G, Vidal-Puig A, Grujic D, Flier JS, Lowell BB. The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. J Biol Chem. 1997 Oct 10; 272(41):25433-6. PMID: 9325252.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  169. Grujic D, Susulic VS, Harper ME, Himms-Hagen J, Cunningham BA, Corkey BE, Lowell BB. Beta3-adrenergic receptors on white and brown adipocytes mediate beta3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. A study using transgenic and gene knockout mice. J Biol Chem. 1997 Jul 11; 272(28):17686-93. PMID: 9211919.
    Citations: 46     Fields:    Translation:AnimalsCells
  170. Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB. UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun. 1997 Jun 09; 235(1):79-82. PMID: 9196039.
    Citations: 82     Fields:    Translation:HumansCells
  171. Flier JS, Lowell BB. Obesity research springs a proton leak. Nat Genet. 1997 Mar; 15(3):223-4. PMID: 9054925.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  172. Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM, Lowell BB. Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter. J Biol Chem. 1997 Feb 21; 272(8):5283-90. PMID: 9030601.
    Citations: 45     Fields:    Translation:AnimalsCells
  173. Cinti S, Frederich RC, Zingaretti MC, De Matteis R, Flier JS, Lowell BB. Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue. Endocrinology. 1997 Feb; 138(2):797-804. PMID: 9003017.
    Citations: 28     Fields:    Translation:AnimalsCells
  174. Sarraf P, Frederich RC, Turner EM, Ma G, Jaskowiak NT, Rivet DJ, Flier JS, Lowell BB, Fraker DL, Alexander HR. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med. 1997 Jan 06; 185(1):171-5. PMID: 8996253.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  175. Lowell BB, Flier JS. Brown adipose tissue, beta 3-adrenergic receptors, and obesity. Annu Rev Med. 1997; 48:307-16. PMID: 9046964.
    Citations: 51     Fields:    Translation:HumansAnimals
  176. Lowell BB. Fat metabolism. Slimming with leaner enzyme. Nature. 1996 Aug 15; 382(6592):585-6. PMID: 8757124.
    Citations: