Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Bradford Barr Lowell, M.D.,Ph.D.

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Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01DK122976 (LOWELL, BRADFORD B) Sep 17, 2019 - Jun 30, 2024
    NIH
    Leveraging the Rich Genetic Diversity of Vagal Motor Neurons to Decode Brain-to-Gut Communication
    Role: Principal Investigator
  2. R01DK111401 (LOWELL, BRADFORD B) Sep 15, 2016 - Jul 31, 2021
    NIH
    Glutamatergic Neurons in the Arcuate Nucleus (ARC) and Regulation of Satiety
    Role: Principal Investigator
  3. R01DK096010 (LOWELL, BRADFORD B) Jul 1, 2012 - Jul 31, 2025
    NIH
    AgRP neurons: circadian control and interactions with the HPA axis
    Role: Principal Investigator
  4. R01DK089044 (LOWELL, BRADFORD B) Aug 5, 2010 - Mar 31, 2024
    NIH
    Leptin, GABAergic Neurons and the Feedback / Feedforward Regulation of Energy Balance
    Role: Principal Investigator
  5. R01DK075632 (LOWELL, BRADFORD B) Jul 1, 2006 - Mar 31, 2025
    NIH
    The AgRP / POMC -> Paraventricular (PVH) -> Parabrachial (PBN) -> Limbic/Reward Satiety Circuit
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gupta A, Balakrishnan B, Karki S, Slayton M, Jash S, Banerjee S, Grahn THM, Jambunathan S, Disney S, Hussein H, Kong D, Lowell BB, Natarajan P, Reddy UK, Gokce N, Sharma VM, Puri V. Human CIDEC transgene improves lipid metabolism and protects against high-fat diet-induced glucose intolerance in mice. J Biol Chem. 2022 09; 298(9):102347. PMID: 35963433; PMCID: PMC9472082.
    Citations: 2     Fields:    Translation:HumansAnimals
  2. De Luca R, Nardone S, Grace KP, Venner A, Cristofolini M, Bandaru SS, Sohn LT, Kong D, Mochizuki T, Viberti B, Zhu L, Zito A, Scammell TE, Saper CB, Lowell BB, Fuller PM, Arrigoni E. Orexin neurons inhibit sleep to promote arousal. Nat Commun. 2022 07 18; 13(1):4163. PMID: 35851580; PMCID: PMC9293990.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Porniece Kumar M, Cremer AL, Klemm P, Steuernagel L, Sundaram S, Jais A, Hausen AC, Tao J, Secher A, Pedersen TÅ, Schwaninger M, Wunderlich FT, Lowell BB, Backes H, Brüning JC. Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nat Metab. 2021 12; 3(12):1662-1679. PMID: 34931084; PMCID: PMC8688146.
    Citations: 3     Fields:    Translation:AnimalsCells
  4. Kim A, Knudsen JG, Madara JC, Benrick A, Hill TG, Abdul Kadir L, Kellard JA, Mellander L, Miranda C, Lin H, James T, Suba K, Spigelman AF, Wu Y, MacDonald PE, Wernstedt Asterholm I, Magnussen T, Christensen M, Vilsbøll T, Salem V, Knop FK, Rorsman P, Lowell BB, Briant LJ. Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes. Elife. 2021 11 17; 10. PMID: 34787082; PMCID: PMC8654374.
    Citations:    Fields:    Translation:HumansAnimals
  5. Kim A, Madara JC, Wu C, Andermann ML, Lowell BB. Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality. Elife. 2021 09 29; 10. PMID: 34585668; PMCID: PMC8601670.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Xiao X, Yeghiazaryan G, Hess S, Klemm P, Sieben A, Kleinridders A, Morgan DA, Wunderlich FT, Rahmouni K, Kong D, Scammell TE, Lowell BB, Kloppenburg P, Brüning JC, Hausen AC. Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity. Nat Commun. 2021 09 02; 12(1):5249. PMID: 34475397; PMCID: PMC8413382.
    Citations: 3     Fields:    Translation:AnimalsCells
  7. Berrios J, Li C, Madara JC, Garfield AS, Steger JS, Krashes MJ, Lowell BB. Food cue regulation of AGRP hunger neurons guides learning. Nature. 2021 Jul; 595(7869):695-700. PMID: 34262177; PMCID: PMC8522184.
    Citations: 6     Fields:    Translation:AnimalsCells
  8. Tao J, Campbell JN, Tsai LT, Wu C, Liberles SD, Lowell BB. Highly selective brain-to-gut communication via genetically defined vagus neurons. Neuron. 2021 07 07; 109(13):2106-2115.e4. PMID: 34077742; PMCID: PMC8273126.
    Citations: 7     Fields:    Translation:AnimalsCells
  9. Bozadjieva-Kramer N, Ross RA, Johnson DQ, Fenselau H, Haggerty DL, Atwood B, Lowell B, Flak JN. The Role of Mediobasal Hypothalamic PACAP in the Control of Body Weight and Metabolism. Endocrinology. 2021 04 01; 162(4). PMID: 33460433; PMCID: PMC7875177.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. Author Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3ß-S100b axis. Nature. 2021 Feb; 590(7845):E31-E33. PMID: 33536624.
    Citations:    Fields:    
  11. Shi Y, Stornetta DS, Reklow RJ, Sahu A, Wabara Y, Nguyen A, Li K, Zhang Y, Perez-Reyes E, Ross RA, Lowell BB, Stornetta RL, Funk GD, Guyenet PG, Bayliss DA. A brainstem peptide system activated at birth protects postnatal breathing. Nature. 2021 01; 589(7842):426-430. PMID: 33268898; PMCID: PMC7855323.
    Citations: 9     Fields:    Translation:AnimalsCells
  12. Jais A, Paeger L, Sotelo-Hitschfeld T, Bremser S, Prinzensteiner M, Klemm P, Mykytiuk V, Widdershooven PJM, Vesting AJ, Grzelka K, Minère M, Cremer AL, Xu J, Korotkova T, Lowell BB, Zeilhofer HU, Backes H, Fenselau H, Wunderlich FT, Kloppenburg P, Brüning JC. PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding. Neuron. 2020 06 17; 106(6):1009-1025.e10. PMID: 32302532.
    Citations: 19     Fields:    Translation:AnimalsCells
  13. Hu B, Jin C, Zeng X, Resch JM, Jedrychowski MP, Yang Z, Desai BN, Banks AS, Lowell BB, Mathis D, Spiegelman BM. ?d T cells and adipocyte IL-17RC control fat innervation and thermogenesis. Nature. 2020 02; 578(7796):610-614. PMID: 32076265; PMCID: PMC7055484.
    Citations: 38     Fields:    Translation:AnimalsCells
  14. Livneh Y, Sugden AU, Madara JC, Essner RA, Flores VI, Sugden LA, Resch JM, Lowell BB, Andermann ML. Estimation of Current and Future Physiological States in Insular Cortex. Neuron. 2020 03 18; 105(6):1094-1111.e10. PMID: 31955944.
    Citations: 33     Fields:    Translation:Animals
  15. Perry RJ, Resch JM, Douglass AM, Madara JC, Rabin-Court A, Kucukdereli H, Wu C, Song JD, Lowell BB, Shulman GI. Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents. Proc Natl Acad Sci U S A. 2019 07 02; 116(27):13670-13679. PMID: 31213533.
    Citations: 20     Fields:    Translation:Animals
  16. Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. Publisher Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3ß-S100b axis. Nature. 2019 Jun; 570(7760):E32. PMID: 31114060.
    Citations: 1     Fields:    
  17. Lowell BB. The Neuroscience of Drives for Food, Water, and Salt. Reply. N Engl J Med. 2019 05 02; 380(18):e33. PMID: 31042849.
    Citations:    Fields:    
  18. Zeng X, Ye M, Resch JM, Jedrychowski MP, Hu B, Lowell BB, Ginty DD, Spiegelman BM. Innervation of thermogenic adipose tissue via a calsyntenin 3ß-S100b axis. Nature. 2019 05; 569(7755):229-235. PMID: 31043739; PMCID: PMC6589139.
    Citations: 49     Fields:    Translation:AnimalsCells
  19. Li MM, Madara JC, Steger JS, Krashes MJ, Balthasar N, Campbell JN, Resch JM, Conley NJ, Garfield AS, Lowell BB. The Paraventricular Hypothalamus Regulates Satiety and Prevents Obesity via Two Genetically Distinct Circuits. Neuron. 2019 05 08; 102(3):653-667.e6. PMID: 30879785; PMCID: PMC6508999.
    Citations: 39     Fields:    Translation:AnimalsCells
  20. Lowell BB. New Neuroscience of Homeostasis and Drives for Food, Water, and Salt. N Engl J Med. 2019 01 31; 380(5):459-471. PMID: 30699320.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  21. Ostrowski L, Speiser PW, Accacha S, Altshuler L, Fennoy I, Lowell B, Rapaport R, Rosenfeld W, Shelov SP, Ten S, Rosenbaum M. Demographics and anthropometrics impact benefits of health intervention: data from the Reduce Obesity and Diabetes Project. Obes Sci Pract. 2019 Feb; 5(1):46-58. PMID: 30847225; PMCID: PMC6381301.
    Citations:    
  22. Machado NLS, Abbott SBG, Resch JM, Zhu L, Arrigoni E, Lowell BB, Fuller PM, Fontes MAP, Saper CB. A Glutamatergic Hypothalamomedullary Circuit Mediates Thermogenesis, but Not Heat Conservation, during Stress-Induced Hyperthermia. Curr Biol. 2018 07 23; 28(14):2291-2301.e5. PMID: 30017482.
    Citations: 23     Fields:    Translation:AnimalsCells
  23. Ross RA, Leon S, Madara JC, Schafer D, Fergani C, Maguire CA, Verstegen AM, Brengle E, Kong D, Herbison AE, Kaiser UB, Lowell BB, Navarro VM. PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse. Elife. 2018 06 15; 7. PMID: 29905528.
    Citations: 23     Fields:    Translation:AnimalsCells
  24. Todd WD, Fenselau H, Wang JL, Zhang R, Machado NL, Venner A, Broadhurst RY, Kaur S, Lynagh T, Olson DP, Lowell BB, Fuller PM, Saper CB. A hypothalamic circuit for the circadian control of aggression. Nat Neurosci. 2018 05; 21(5):717-724. PMID: 29632359; PMCID: PMC5920747.
    Citations: 47     Fields:    Translation:Animals
  25. Resch JM, Fenselau H, Madara JC, Wu C, Campbell JN, Lyubetskaya A, Dawes BA, Tsai LT, Li MM, Livneh Y, Ke Q, Kang PM, Fejes-Tóth G, Náray-Fejes-Tóth A, Geerling JC, Lowell BB. Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling. Neuron. 2017 Sep 27; 96(1):190-206.e7. PMID: 28957668.
    Citations: 29     Fields:    Translation:AnimalsCells
  26. Andermann ML, Lowell BB. Toward a Wiring Diagram Understanding of Appetite Control. Neuron. 2017 Aug 16; 95(4):757-778. PMID: 28817798.
    Citations: 156     Fields:    Translation:HumansAnimalsCells
  27. Fenselau H, Campbell JN, Verstegen AMJ, Madara JC, Xu J, Shah BP, Resch JM, Yang Z, Mandelblat-Cerf Y, Livneh Y, Lowell BB. Corrigendum: A rapidly acting glutamatergic ARC?PVH satiety circuit postsynaptically regulated by a-MSH. Nat Neurosci. 2017 Jul 26; 20(8):1189. PMID: 28745725.
    Citations: 2     Fields:    
  28. Livneh Y, Ramesh RN, Burgess CR, Levandowski KM, Madara JC, Fenselau H, Goldey GJ, Diaz VE, Jikomes N, Resch JM, Lowell BB, Andermann ML. Homeostatic circuits selectively gate food cue responses in insular cortex. Nature. 2017 06 29; 546(7660):611-616. PMID: 28614299.
    Citations: 102     Fields:    Translation:AnimalsCells
  29. Cheng L, Duan B, Huang T, Zhang Y, Chen Y, Britz O, Garcia-Campmany L, Ren X, Vong L, Lowell BB, Goulding M, Wang Y, Ma Q. Identification of spinal circuits involved in touch-evoked dynamic mechanical pain. Nat Neurosci. 2017 Jun; 20(6):804-814. PMID: 28436981; PMCID: PMC5470641.
    Citations: 65     Fields:    Translation:AnimalsCells
  30. Mahoney CE, Agostinelli LJ, Brooks JN, Lowell BB, Scammell TE. GABAergic Neurons of the Central Amygdala Promote Cataplexy. J Neurosci. 2017 04 12; 37(15):3995-4006. PMID: 28235898; PMCID: PMC5391681.
    Citations: 19     Fields:    Translation:AnimalsCells
  31. Agostinelli LJ, Ferrari LL, Mahoney CE, Mochizuki T, Lowell BB, Arrigoni E, Scammell TE. Descending projections from the basal forebrain to the orexin neurons in mice. J Comp Neurol. 2017 May 01; 525(7):1668-1684. PMID: 27997037; PMCID: PMC5806522.
    Citations: 13     Fields:    Translation:AnimalsCells
  32. Campbell JN, Macosko EZ, Fenselau H, Pers TH, Lyubetskaya A, Tenen D, Goldman M, Verstegen AM, Resch JM, McCarroll SA, Rosen ED, Lowell BB, Tsai LT. A molecular census of arcuate hypothalamus and median eminence cell types. Nat Neurosci. 2017 Mar; 20(3):484-496. PMID: 28166221; PMCID: PMC5323293.
    Citations: 267     Fields:    Translation:AnimalsCells
  33. Tejeda HA, Wu J, Kornspun AR, Pignatelli M, Kashtelyan V, Krashes MJ, Lowell BB, Carlezon WA, Bonci A. Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity. Neuron. 2017 Jan 04; 93(1):147-163. PMID: 28056342; PMCID: PMC5808882.
    Citations: 63     Fields:    Translation:AnimalsCells
  34. Mandelblat-Cerf Y, Kim A, Burgess CR, Subramanian S, Tannous BA, Lowell BB, Andermann ML. Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons. Neuron. 2017 Jan 04; 93(1):57-65. PMID: 27989461.
    Citations: 26     Fields:    Translation:AnimalsCells
  35. Fenselau H, Campbell JN, Verstegen AM, Madara JC, Xu J, Shah BP, Resch JM, Yang Z, Mandelblat-Cerf Y, Livneh Y, Lowell BB. A rapidly acting glutamatergic ARC?PVH satiety circuit postsynaptically regulated by a-MSH. Nat Neurosci. 2017 01; 20(1):42-51. PMID: 27869800; PMCID: PMC5191921.
    Citations: 90     Fields:    Translation:AnimalsCells
  36. Keenan WT, Rupp AC, Ross RA, Somasundaram P, Hiriyanna S, Wu Z, Badea TC, Robinson PR, Lowell BB, Hattar SS. A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction. Elife. 2016 09 26; 5. PMID: 27669145.
    Citations: 44     Fields:    Translation:Cells
  37. Garfield AS, Shah BP, Burgess CR, Li MM, Li C, Steger JS, Madara JC, Campbell JN, Kroeger D, Scammell TE, Tannous BA, Myers MG, Andermann ML, Krashes MJ, Lowell BB. Dynamic GABAergic afferent modulation of AgRP neurons. Nat Neurosci. 2016 12; 19(12):1628-1635. PMID: 27643429; PMCID: PMC5382799.
    Citations: 68     Fields:    Translation:AnimalsCells
  38. Vetrivelan R, Kong D, Ferrari LL, Arrigoni E, Madara JC, Bandaru SS, Lowell BB, Lu J, Saper CB. Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice. Neuroscience. 2016 Nov 12; 336:102-113. PMID: 27595887.
    Citations: 34     Fields:    Translation:AnimalsCells
  39. Burgess CR, Ramesh RN, Sugden AU, Levandowski KM, Minnig MA, Fenselau H, Lowell BB, Andermann ML. Hunger-Dependent Enhancement of Food Cue Responses in Mouse Postrhinal Cortex and Lateral Amygdala. Neuron. 2016 Sep 07; 91(5):1154-1169. PMID: 27523426.
    Citations: 35     Fields:    Translation:Animals
  40. Kong D, Dagon Y, Campbell JN, Guo Y, Yang Z, Yi X, Aryal P, Wellenstein K, Kahn BB, Sabatini BL, Lowell BB. A Postsynaptic AMPK?p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons. Neuron. 2016 07 06; 91(1):25-33. PMID: 27321921; PMCID: PMC4938763.
    Citations: 28     Fields:    Translation:AnimalsCells
  41. Williams EK, Chang RB, Strochlic DE, Umans BD, Lowell BB, Liberles SD. Sensory Neurons that Detect Stretch and Nutrients in the Digestive System. Cell. 2016 Jun 30; 166(1):209-21. PMID: 27238020.
    Citations: 183     Fields:    Translation:AnimalsCells
  42. Kondoh K, Lu Z, Ye X, Olson DP, Lowell BB, Buck LB. A specific area of olfactory cortex involved in stress hormone responses to predator odours. Nature. 2016 Apr 07; 532(7597):103-6. PMID: 27001694; PMCID: PMC5094457.
    Citations: 48     Fields:    Translation:AnimalsCells
  43. Crowley NA, Bloodgood DW, Hardaway JA, Kendra AM, McCall JG, Al-Hasani R, McCall NM, Yu W, Schools ZL, Krashes MJ, Lowell BB, Whistler JL, Bruchas MR, Kash TL. Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit. Cell Rep. 2016 Mar 29; 14(12):2774-83. PMID: 26997280.
    Citations: 67     Fields:    Translation:Animals
  44. D'Agostino G, Lyons DJ, Cristiano C, Burke LK, Madara JC, Campbell JN, Garcia AP, Land BB, Lowell BB, Dileone RJ, Heisler LK. Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit. Elife. 2016 03 14; 5. PMID: 26974347.
    Citations: 59     Fields:    Translation:Animals
  45. Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu O, Smith AS, Jain S, Lowell BB, Krashes MJ, Wess J. Corrigendum: Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake. Nat Commun. 2016 Mar 03; 7:11019. PMID: 26936677.
    Citations: 1     Fields:    
  46. Vernia S, Morel C, Madara JC, Cavanagh-Kyros J, Barrett T, Chase K, Kennedy NJ, Jung DY, Kim JK, Aronin N, Flavell RA, Lowell BB, Davis RJ. Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress. Elife. 2016 Feb 24; 5:e10031. PMID: 26910012.
    Citations: 15     Fields:    Translation:AnimalsCells
  47. Krashes MJ, Lowell BB, Garfield AS. Melanocortin-4 receptor-regulated energy homeostasis. Nat Neurosci. 2016 Feb; 19(2):206-19. PMID: 26814590; PMCID: PMC5244821.
    Citations: 103     Fields:    Translation:HumansAnimals
  48. Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu O, Smith AS, Jain S, Lowell BB, Krashes MJ, Wess J. Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake. Nat Commun. 2016 Jan 08; 7:10268. PMID: 26743492; PMCID: PMC4729878.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  49. Ferrari LL, Agostinelli LJ, Krashes MJ, Lowell BB, Scammell TE, Arrigoni E. Dynorphin inhibits basal forebrain cholinergic neurons by pre- and postsynaptic mechanisms. J Physiol. 2016 Feb 15; 594(4):1069-85. PMID: 26613645; PMCID: PMC4753266.
    Citations: 10     Fields:    Translation:AnimalsCells
  50. Geerling JC, Kim M, Mahoney CE, Abbott SB, Agostinelli LJ, Garfield AS, Krashes MJ, Lowell BB, Scammell TE. Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus. Am J Physiol Regul Integr Comp Physiol. 2016 Jan 01; 310(1):R41-54. PMID: 26491097; PMCID: PMC4747895.
    Citations: 44     Fields:    Translation:AnimalsCells
  51. Al-Hasani R, McCall JG, Shin G, Gomez AM, Schmitz GP, Bernardi JM, Pyo CO, Park SI, Marcinkiewcz CM, Crowley NA, Krashes MJ, Lowell BB, Kash TL, Rogers JA, Bruchas MR. Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward. Neuron. 2015 Sep 02; 87(5):1063-77. PMID: 26335648.
    Citations: 144     Fields:    Translation:AnimalsCells
  52. Mandelblat-Cerf Y, Ramesh RN, Burgess CR, Patella P, Yang Z, Lowell BB, Andermann ML. Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales. Elife. 2015 Jul 10; 4. PMID: 26159614.
    Citations: 89     Fields:    Translation:AnimalsCells
  53. Garfield AS, Li C, Madara JC, Shah BP, Webber E, Steger JS, Campbell JN, Gavrilova O, Lee CE, Olson DP, Elmquist JK, Tannous BA, Krashes MJ, Lowell BB. A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci. 2015 Jun; 18(6):863-71. PMID: 25915476; PMCID: PMC4446192.
    Citations: 152     Fields:    Translation:AnimalsCells
  54. Pleil KE, Rinker JA, Lowery-Gionta EG, Mazzone CM, McCall NM, Kendra AM, Olson DP, Lowell BB, Grant KA, Thiele TE, Kash TL. NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci. 2015 Apr; 18(4):545-52. PMID: 25751534; PMCID: PMC4376619.
    Citations: 93     Fields:    Translation:AnimalsCells
  55. Allison MB, Patterson CM, Krashes MJ, Lowell BB, Myers MG, Olson DP. TRAP-seq defines markers for novel populations of hypothalamic and brainstem LepRb neurons. Mol Metab. 2015 Apr; 4(4):299-309. PMID: 25830093.
    Citations: 38     Fields:    
  56. Garfield AS, Shah BP, Madara JC, Burke LK, Patterson CM, Flak J, Neve RL, Evans ML, Lowell BB, Myers MG, Heisler LK. A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia. Cell Metab. 2014 Dec 02; 20(6):1030-7. PMID: 25470549.
    Citations: 80     Fields:    Translation:Animals
  57. Saper CB, Lowell BB. The hypothalamus. Curr Biol. 2014 Dec 01; 24(23):R1111-6. PMID: 25465326.
    Citations: 86     Fields:    Translation:HumansAnimals
  58. Duan B, Cheng L, Bourane S, Britz O, Padilla C, Garcia-Campmany L, Krashes M, Knowlton W, Velasquez T, Ren X, Ross S, Lowell BB, Wang Y, Goulding M, Ma Q. Identification of spinal circuits transmitting and gating mechanical pain. Cell. 2014 Dec 04; 159(6):1417-1432. PMID: 25467445.
    Citations: 211     Fields:    Translation:AnimalsCells
  59. do Carmo JM, da Silva AA, Ebaady SE, Sessums PO, Abraham RS, Elmquist JK, Lowell BB, Hall JE. Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation. Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15; 307(12):R1438-47. PMID: 25339680.
    Citations: 19     Fields:    Translation:AnimalsCells
  60. Shah BP, Vong L, Olson DP, Koda S, Krashes MJ, Ye C, Yang Z, Fuller PM, Elmquist JK, Lowell BB. MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):13193-8. PMID: 25157144.
    Citations: 83     Fields:    Translation:AnimalsCells
  61. Berglund ED, Liu T, Kong X, Sohn JW, Vong L, Deng Z, Lee CE, Lee S, Williams KW, Olson DP, Scherer PE, Lowell BB, Elmquist JK. Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia. Nat Neurosci. 2014 Jul; 17(7):911-3. PMID: 24908101.
    Citations: 66     Fields:    Translation:AnimalsCells
  62. Martin C, Navarro VM, Simavli S, Vong L, Carroll RS, Lowell BB, Kaiser UB. Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. J Neurosci. 2014 Apr 23; 34(17):6047-56. PMID: 24760864.
    Citations: 27     Fields:    Translation:AnimalsCells
  63. Krashes MJ, Shah BP, Madara JC, Olson DP, Strochlic DE, Garfield AS, Vong L, Pei H, Watabe-Uchida M, Uchida N, Liberles SD, Lowell BB. An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature. 2014 Mar 13; 507(7491):238-42. PMID: 24487620.
    Citations: 275     Fields:    Translation:AnimalsCells
  64. Garfield AS, Lowell BB. Was it something I ate? Cell Metab. 2013 Dec 03; 18(6):769-70. PMID: 24315365.
    Citations: 1     Fields:    Translation:Animals
  65. Xu Y, Wu Z, Sun H, Zhu Y, Kim ER, Lowell BB, Arenkiel BR, Xu Y, Tong Q. Glutamate mediates the function of melanocortin receptor 4 on Sim1 neurons in body weight regulation. Cell Metab. 2013 Dec 03; 18(6):860-70. PMID: 24315371.
    Citations: 45     Fields:    Translation:AnimalsCells
  66. Accacha S, Rosenfeld W, Jacobson A, Michel L, Schnurr FJ, Shelov S, Ten S, Boucher-Berry C, Carey DE, Speiser PW, Lowell B, Conroy R, Klein M, Fennoy I, Rapaport R, Rosenbaum M. Plasma advanced glycation end products (AGEs), receptors for AGEs and their correlation with inflammatory markers in middle school-age children. Horm Res Paediatr. 2013; 80(5):318-27. PMID: 24217195.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  67. Krashes MJ, Shah BP, Koda S, Lowell BB. Rapid versus delayed stimulation of feeding by the endogenously released AgRP neuron mediators GABA, NPY, and AgRP. Cell Metab. 2013 Oct 01; 18(4):588-95. PMID: 24093681.
    Citations: 155     Fields:    Translation:AnimalsCells
  68. Fujikawa T, Berglund ED, Patel VR, Ramadori G, Vianna CR, Vong L, Thorel F, Chera S, Herrera PL, Lowell BB, Elmquist JK, Baldi P, Coppari R. Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab. 2013 Sep 03; 18(3):431-44. PMID: 24011077.
    Citations: 67     Fields:    Translation:AnimalsCells
  69. Huang H, Lee SH, Ye C, Lima IS, Oh BC, Lowell BB, Zabolotny JM, Kim YB. ROCK1 in AgRP neurons regulates energy expenditure and locomotor activity in male mice. Endocrinology. 2013 Oct; 154(10):3660-70. PMID: 23885017; PMCID: PMC3776869.
    Citations: 19     Fields:    Translation:AnimalsCells
  70. Xu P, Grueter BA, Britt JK, McDaniel L, Huntington PJ, Hodge R, Tran S, Mason BL, Lee C, Vong L, Lowell BB, Malenka RC, Lutter M, Pieper AA. Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):10759-64. PMID: 23754400.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  71. Allister EM, Robson-Doucette CA, Prentice KJ, Hardy AB, Sultan S, Gaisano HY, Kong D, Gilon P, Herrera PL, Lowell BB, Wheeler MB. UCP2 regulates the glucagon response to fasting and starvation. Diabetes. 2013 May; 62(5):1623-33. PMID: 23434936; PMCID: PMC3636632.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  72. Sohn JW, Harris LE, Berglund ED, Liu T, Vong L, Lowell BB, Balthasar N, Williams KW, Elmquist JK. Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell. 2013 Jan 31; 152(3):612-9. PMID: 23374353.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  73. Lou S, Duan B, Vong L, Lowell BB, Ma Q. Runx1 controls terminal morphology and mechanosensitivity of VGLUT3-expressing C-mechanoreceptors. J Neurosci. 2013 Jan 16; 33(3):870-82. PMID: 23325226.
    Citations: 64     Fields:    Translation:AnimalsCells
  74. Lee S, Bookout AL, Lee CE, Gautron L, Harper MJ, Elias CF, Lowell BB, Elmquist JK. Laser-capture microdissection and transcriptional profiling of the dorsomedial nucleus of the hypothalamus. J Comp Neurol. 2012 Nov 01; 520(16):3617-32. PMID: 22473294.
    Citations: 12     Fields:    Translation:AnimalsCells
  75. Kong D, Tong Q, Ye C, Koda S, Fuller PM, Krashes MJ, Vong L, Ray RS, Olson DP, Lowell BB. GABAergic RIP-Cre neurons in the arcuate nucleus selectively regulate energy expenditure. Cell. 2012 Oct 26; 151(3):645-57. PMID: 23101631.
    Citations: 121     Fields:    Translation:AnimalsCells
  76. Wu Z, Xu Y, Zhu Y, Sutton AK, Zhao R, Lowell BB, Olson DP, Tong Q. An obligate role of oxytocin neurons in diet induced energy expenditure. PLoS One. 2012; 7(9):e45167. PMID: 23028821.
    Citations: 79     Fields:    Translation:AnimalsCells
  77. Huang H, Kong D, Byun KH, Ye C, Koda S, Lee DH, Oh BC, Lee SW, Lee B, Zabolotny JM, Kim MS, Bjørbæk C, Lowell BB, Kim YB. Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling. Nat Neurosci. 2012 Oct; 15(10):1391-8. PMID: 22941110.
    Citations: 50     Fields:    Translation:AnimalsCells
  78. Kozorovitskiy Y, Saunders A, Johnson CA, Lowell BB, Sabatini BL. Recurrent network activity drives striatal synaptogenesis. Nature. 2012 May 13; 485(7400):646-50. PMID: 22660328.
    Citations: 92     Fields:    Translation:AnimalsCells
  79. Liu T, Kong D, Shah BP, Ye C, Koda S, Saunders A, Ding JB, Yang Z, Sabatini BL, Lowell BB. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron. 2012 Feb 09; 73(3):511-22. PMID: 22325203.
    Citations: 138     Fields:    Translation:AnimalsCells
  80. Cohen JY, Haesler S, Vong L, Lowell BB, Uchida N. Neuron-type-specific signals for reward and punishment in the ventral tegmental area. Nature. 2012 Jan 18; 482(7383):85-8. PMID: 22258508.
    Citations: 534     Fields:    Translation:AnimalsCells
  81. Li C, Pleil KE, Stamatakis AM, Busan S, Vong L, Lowell BB, Stuber GD, Kash TL. Presynaptic inhibition of gamma-aminobutyric acid release in the bed nucleus of the stria terminalis by kappa opioid receptor signaling. Biol Psychiatry. 2012 Apr 15; 71(8):725-32. PMID: 22225848.
    Citations: 75     Fields:    Translation:AnimalsCells
  82. Krenzer M, Anaclet C, Vetrivelan R, Wang N, Vong L, Lowell BB, Fuller PM, Lu J. Brainstem and spinal cord circuitry regulating REM sleep and muscle atonia. PLoS One. 2011; 6(10):e24998. PMID: 22043278.
    Citations: 57     Fields:    Translation:AnimalsCells
  83. Vong L, Ye C, Yang Z, Choi B, Chua S, Lowell BB. Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron. 2011 Jul 14; 71(1):142-54. PMID: 21745644.
    Citations: 536     Fields:    Translation:AnimalsCells
  84. Klöckener T, Hess S, Belgardt BF, Paeger L, Verhagen LA, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P, Brüning JC. High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nat Neurosci. 2011 Jun 05; 14(7):911-8. PMID: 21642975.
    Citations: 114     Fields:    Translation:AnimalsCells
  85. Higley MJ, Gittis AH, Oldenburg IA, Balthasar N, Seal RP, Edwards RH, Lowell BB, Kreitzer AC, Sabatini BL. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One. 2011 Apr 22; 6(4):e19155. PMID: 21544206.
    Citations: 88     Fields:    Translation:AnimalsCells
  86. Krashes MJ, Koda S, Ye C, Rogan SC, Adams AC, Cusher DS, Maratos-Flier E, Roth BL, Lowell BB. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest. 2011 Apr; 121(4):1424-8. PMID: 21364278; PMCID: PMC3069789.
    Citations: 621     Fields:    Translation:AnimalsCells
  87. Mochizuki T, Arrigoni E, Marcus JN, Clark EL, Yamamoto M, Honer M, Borroni E, Lowell BB, Elmquist JK, Scammell TE. Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4471-6. PMID: 21368172.
    Citations: 58     Fields:    Translation:AnimalsCells
  88. Rossi J, Balthasar N, Olson D, Scott M, Berglund E, Lee CE, Choi MJ, Lauzon D, Lowell BB, Elmquist JK. Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis. Cell Metab. 2011 Feb 02; 13(2):195-204. PMID: 21284986.
    Citations: 314     Fields:    Translation:AnimalsCells
  89. Liu Y, Abdel Samad O, Zhang L, Duan B, Tong Q, Lopes C, Ji RR, Lowell BB, Ma Q. VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch. Neuron. 2010 Nov 04; 68(3):543-56. PMID: 21040853.
    Citations: 124     Fields:    Translation:AnimalsCells
  90. Kong D, Vong L, Parton LE, Ye C, Tong Q, Hu X, Choi B, Brüning JC, Lowell BB. Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab. 2010 Nov 03; 12(5):545-52. PMID: 21035764.
    Citations: 103     Fields:    Translation:AnimalsCells
  91. Xu Y, Jones JE, Lauzon DA, Anderson JG, Balthasar N, Heisler LK, Zinn AR, Lowell BB, Elmquist JK. A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. J Neurosci. 2010 Nov 03; 30(44):14630-4. PMID: 21048120.
    Citations: 41     Fields:    Translation:Animals
  92. Xu Y, Berglund ED, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver. Nat Neurosci. 2010 Dec; 13(12):1457-9. PMID: 21037584.
    Citations: 51     Fields:    Translation:AnimalsCells
  93. Irani BG, Donato J, Olson DP, Lowell BB, Sacktor TC, Reyland ME, Tolson KP, Zinn AR, Ueta Y, Sakata I, Zigman JM, Elias CF, Clegg DJ. Distribution and neurochemical characterization of protein kinase C-theta and -delta in the rodent hypothalamus. Neuroscience. 2010 Nov 10; 170(4):1065-79. PMID: 20691763.
    Citations: 12     Fields:    Translation:AnimalsCells
  94. Xu Y, Hill JW, Fukuda M, Gautron L, Sohn JW, Kim KW, Lee CE, Choi MJ, Lauzon DA, Dhillon H, Lowell BB, Zigman JM, Zhao JJ, Elmquist JK. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab. 2010 Jul 07; 12(1):88-95. PMID: 20620998.
    Citations: 57     Fields:    Translation:AnimalsCells
  95. Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metab. 2010 Apr 07; 11(4):286-97. PMID: 20374961.
    Citations: 191     Fields:    Translation:AnimalsCells
  96. Olson DP, Pulinilkunnil T, Cline GW, Shulman GI, Lowell BB. Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7598-603. PMID: 20368432.
    Citations: 48     Fields:    Translation:Animals
  97. Hawke Z, Ivanov TR, Bechtold DA, Dhillon H, Lowell BB, Luckman SM. PACAP neurons in the hypothalamic ventromedial nucleus are targets of central leptin signaling. J Neurosci. 2009 Nov 25; 29(47):14828-35. PMID: 19940178.
    Citations: 53     Fields:    Translation:AnimalsCells
  98. van den Pol AN, Yao Y, Fu LY, Foo K, Huang H, Coppari R, Lowell BB, Broberger C. Neuromedin B and gastrin-releasing peptide excite arcuate nucleus neuropeptide Y neurons in a novel transgenic mouse expressing strong Renilla green fluorescent protein in NPY neurons. J Neurosci. 2009 Apr 08; 29(14):4622-39. PMID: 19357287.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  99. Sakata I, Nakano Y, Osborne-Lawrence S, Rovinsky SA, Lee CE, Perello M, Anderson JG, Coppari R, Xiao G, Lowell BB, Elmquist JK, Zigman JM. Characterization of a novel ghrelin cell reporter mouse. Regul Pept. 2009 Jun 05; 155(1-3):91-8. PMID: 19361544.
    Citations: 48     Fields:    Translation:AnimalsCells
  100. Fukuda M, Jones JE, Olson D, Hill J, Lee CE, Gautron L, Choi M, Zigman JM, Lowell BB, Elmquist JK. Monitoring FoxO1 localization in chemically identified neurons. J Neurosci. 2008 Dec 10; 28(50):13640-8. PMID: 19074037.
    Citations: 48     Fields:    Translation:AnimalsCells
  101. Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron. 2008 Nov 26; 60(4):582-9. PMID: 19038216.
    Citations: 131     Fields:    Translation:Animals
  102. Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci. 2008 Sep; 11(9):998-1000. PMID: 19160495.
    Citations: 330     Fields:    Translation:AnimalsCells
  103. Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci. 2008 Aug 10. PMID: 18690230.
    Citations:    
  104. Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS. Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology. 2008 Nov; 149(11):5654-61. PMID: 18669597; PMCID: PMC2584592.
    Citations: 58     Fields:    Translation:AnimalsCells
  105. Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. J Clin Invest. 2008 May; 118(5):1796-805. PMID: 18382766; PMCID: PMC2276395.
    Citations: 185     Fields:    Translation:HumansAnimalsCells
  106. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53. PMID: 18223655.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  107. van de Wall E, Leshan R, Xu AW, Balthasar N, Coppari R, Liu SM, Jo YH, MacKenzie RG, Allison DB, Dun NJ, Elmquist J, Lowell BB, Barsh GS, de Luca C, Myers MG, Schwartz GJ, Chua SC. Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion. Endocrinology. 2008 Apr; 149(4):1773-85. PMID: 18162515; PMCID: PMC2276717.
    Citations: 190     Fields:    Translation:Animals
  108. Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature. 2007 Sep 13; 449(7159):228-32. PMID: 17728716.
    Citations: 312     Fields:    Translation:HumansAnimalsCells
  109. Lazarus M, Yoshida K, Coppari R, Bass CE, Mochizuki T, Lowell BB, Saper CB. EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci. 2007 Sep; 10(9):1131-3. PMID: 17676060.
    Citations: 147     Fields:    Translation:AnimalsCells
  110. McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, Lowell BB, Fanselow MS, Wilson MA, Tonegawa S. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science. 2007 Jul 06; 317(5834):94-9. PMID: 17556551.
    Citations: 421     Fields:    Translation:AnimalsCells
  111. Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab. 2007 May; 5(5):383-93. PMID: 17488640; PMCID: PMC1934926.
    Citations: 212     Fields:    Translation:AnimalsCells
  112. Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB. Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab. 2006 Dec; 4(6):453-64. PMID: 17141629; PMCID: PMC1764615.
    Citations: 86     Fields:    Translation:AnimalsCells
  113. Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006 Jul 20; 51(2):239-49. PMID: 16846858.
    Citations: 141     Fields:    Translation:AnimalsCells
  114. Zhang CY, Parton LE, Ye CP, Krauss S, Shen R, Lin CT, Porco JA, Lowell BB. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab. 2006 Jun; 3(6):417-27. PMID: 16753577.
    Citations: 114     Fields:    Translation:AnimalsCells
  115. Dhillon H, Zigman JM, Ye C, Lee CE, McGovern RA, Tang V, Kenny CD, Christiansen LM, White RD, Edelstein EA, Coppari R, Balthasar N, Cowley MA, Chua S, Elmquist JK, Lowell BB. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006 Jan 19; 49(2):191-203. PMID: 16423694.
    Citations: 387     Fields:    Translation:AnimalsCells
  116. Elmquist JK, Coppari R, Balthasar N, Ichinose M, Lowell BB. Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol. 2005 Dec 05; 493(1):63-71. PMID: 16254991.
    Citations: 167     Fields:    Translation:AnimalsCells
  117. Zigman JM, Nakano Y, Coppari R, Balthasar N, Marcus JN, Lee CE, Jones JE, Deysher AE, Waxman AR, White RD, Williams TD, Lachey JL, Seeley RJ, Lowell BB, Elmquist JK. Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest. 2005 Dec; 115(12):3564-72. PMID: 16322794; PMCID: PMC1297251.
    Citations: 245     Fields:    Translation:AnimalsCells
  118. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell. 2005 Nov 04; 123(3):493-505. PMID: 16269339.
    Citations: 521     Fields:    Translation:AnimalsCells
  119. Solanes G, Pedraza N, Calvo V, Vidal-Puig A, Lowell BB, Villarroya F. Thyroid hormones directly activate the expression of the human and mouse uncoupling protein-3 genes through a thyroid response element in the proximal promoter region. Biochem J. 2005 Mar 15; 386(Pt 3):505-13. PMID: 15496137.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  120. Krauss S, Zhang CY, Lowell BB. The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol. 2005 Mar; 6(3):248-61. PMID: 15738989.
    Citations: 236     Fields:    Translation:HumansCells
  121. Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science. 2005 Jan 21; 307(5708):384-7. PMID: 15662004.
    Citations: 755     Fields:    Translation:HumansAnimalsCells
  122. Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, Tang V, Liu SM, Ludwig T, Chua SC, Lowell BB, Elmquist JK. The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab. 2005 Jan; 1(1):63-72. PMID: 16054045.
    Citations: 213     Fields:    Translation:AnimalsCells
  123. Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004 Oct 01; 119(1):121-35. PMID: 15454086.
    Citations: 562     Fields:    Translation:AnimalsCells
  124. Joseph JW, Koshkin V, Saleh MC, Sivitz WI, Zhang CY, Lowell BB, Chan CB, Wheeler MB. Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression. J Biol Chem. 2004 Dec 03; 279(49):51049-56. PMID: 15448158.
    Citations: 69     Fields:    Translation:AnimalsCells
  125. Balthasar N, Coppari R, McMinn J, Liu SM, Lee CE, Tang V, Kenny CD, McGovern RA, Chua SC, Elmquist JK, Lowell BB. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron. 2004 Jun 24; 42(6):983-91. PMID: 15207242.
    Citations: 457     Fields:    Translation:AnimalsCells
  126. Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest. 2003 Dec; 112(12):1831-42. PMID: 14679178; PMCID: PMC297000.
    Citations: 127     Fields:    Translation:AnimalsCells
  127. Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, Korsmeyer SJ. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature. 2003 Aug 21; 424(6951):952-6. PMID: 12931191.
    Citations: 231     Fields:    Translation:AnimalsCells
  128. Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell. 2003 Jul; 5(1):73-83. PMID: 12852853.
    Citations: 63     Fields:    Translation:AnimalsCells
  129. Lowell BB, Bachman ES. Beta-Adrenergic receptors, diet-induced thermogenesis, and obesity. J Biol Chem. 2003 Aug 08; 278(32):29385-8. PMID: 12788929.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  130. Nakayama A, Bianco AC, Zhang CY, Lowell BB, Frangioni JV. Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging. Mol Imaging. 2003 01; 2(1):37-49. PMID: 12926236.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  131. Joseph JW, Koshkin V, Zhang CY, Wang J, Lowell BB, Chan CB, Wheeler MB. Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes. 2002 Nov; 51(11):3211-9. PMID: 12401712.
    Citations: 67     Fields:    Translation:AnimalsCells
  132. Boucher J, Castan-Laurell I, Le Lay S, Grujic D, Sibrac D, Krief S, Lafontan M, Lowell BB, Dugail I, Saulnier-Blache JS, Valet P. Human alpha 2A-adrenergic receptor gene expressed in transgenic mouse adipose tissue under the control of its regulatory elements. J Mol Endocrinol. 2002 Oct; 29(2):251-64. PMID: 12370125.
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