Harvard Catalyst Profiles

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Jeffrey R. Holt, Ph.D.

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Title
Institution
Department
Title
Institution
Department

Mentoring
Efficacy of Transfection of Inner and Outer Hair Cells Using Adeno-Associated Virus
Summer, 06/02/13 - 08/10/13

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13DC017050 (HOLT, JEFFREY R) Mar 15, 2018 - Aug 31, 2018
    NIH
    2018 Auditory System Gordon Research Conference & Gordon Research Seminar
    Role: Principal Investigator
  2. R01DC013521 (HOLT, JEFFREY R) Jul 1, 2013 - Jun 30, 2024
    NIH
    TMC gene function in sensory hair cells
    Role: Principal Investigator
  3. R21DC011720 (HOLT, JEFFREY R) Jul 1, 2011 - Jun 30, 2014
    NIH
    Inducible Expression of Exogenous Potassium Channels in Hair Cells
    Role: Principal Investigator
  4. R01DC005439 (HOLT, JEFFREY R) Sep 1, 2001 - Jul 31, 2021
    NIH
    Ion Channel Function in Auditory and Vestibular Hair Cells
    Role: Principal Investigator
  5. R56DC005439 (HOLT, JEFFREY R) Sep 1, 2001 - Jun 30, 2009
    NIH
    Ion Channel Function in Auditory &Vestibular Hair Cells
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Holt JR, Tobin M, Elferich J, Gouaux E, Ballesteros A, Yan Z, Ahmed ZM, Nicolson T. Putting the Pieces Together: the Hair Cell Transduction Complex. J Assoc Res Otolaryngol. 2021 Oct 06. PMID: 34617206.
    Citations:    Fields:    
  2. Taiber S, Cohen R, Yizhar-Barnea O, Sprinzak D, Holt JR, Avraham KB. Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness. EMBO Mol Med. 2021 02 05; 13(2):e13259. PMID: 33350593.
    Citations: 2     Fields:    
  3. Zheng W, Holt JR. The Mechanosensory Transduction Machinery in Inner Ear Hair Cells. Annu Rev Biophys. 2021 05 06; 50:31-51. PMID: 33285080.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  4. Wu J, Solanes P, Nist-Lund C, Spataro S, Shubina-Oleinik O, Marcovich I, Goldberg H, Schneider BL, Holt JR. Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice. Mol Ther. 2021 03 03; 29(3):973-988. PMID: 33212302.
    Citations: 2     Fields:    
  5. Holt JR, Raphael Y. Introduction to the Hearing Research special issue on inner ear gene therapy. Hear Res. 2020 09 01; 394:108010. PMID: 32624335.
    Citations: 1     Fields:    
  6. Yeh WH, Shubina-Oleinik O, Levy JM, Pan B, Newby GA, Wornow M, Burt R, Chen JC, Holt JR, Liu DR. In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness. Sci Transl Med. 2020 06 03; 12(546). PMID: 32493795.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  7. Lee J, Nist-Lund C, Solanes P, Goldberg H, Wu J, Pan B, Schneider BL, Holt JR. Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B. Hear Res. 2020 09 01; 394:107882. PMID: 31980281.
    Citations: 12     Fields:    
  8. Corey DP, Akyuz N, Holt JR. Function and Dysfunction of TMC Channels in Inner Ear Hair Cells. Cold Spring Harb Perspect Med. 2019 10 01; 9(10). PMID: 30291150.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  9. Meng X, Murali S, Cheng YF, Lu J, Hight AE, Kanumuri VV, Brown MC, Holt JR, Lee DJ, Edge ASB. Increasing the expression level of ChR2 enhances the optogenetic excitability of cochlear neurons. J Neurophysiol. 2019 11 01; 122(5):1962-1974. PMID: 31533018.
    Citations: 4     Fields:    Translation:AnimalsCells
  10. Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR. Publisher Correction: Continuous evolution of base editors with expanded target compatibility and improved activity. Nat Biotechnol. 2019 Sep; 37(9):1091. PMID: 31406330.
    Citations: 6     Fields:    
  11. Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR. Continuous evolution of base editors with expanded target compatibility and improved activity. Nat Biotechnol. 2019 09; 37(9):1070-1079. PMID: 31332326.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  12. György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DP. Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss. Nat Med. 2019 07; 25(7):1123-1130. PMID: 31270503.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  13. Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR. Publisher Correction: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders. Nat Commun. 2019 02 08; 10(1):734. PMID: 30737404.
    Citations: 1     Fields:    
  14. Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR. Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders. Nat Commun. 2019 01 22; 10(1):236. PMID: 30670701.
    Citations: 38     Fields:    Translation:AnimalsCells
  15. Holt JR, Geleoc GS. Split otoferlins reunited. EMBO Mol Med. 2019 01; 11(1). PMID: 30573543.
    Citations: 1     Fields:    Translation:Animals
  16. Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JR. TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells. Neuron. 2018 08 22; 99(4):736-753.e6. PMID: 30138589.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  17. Asai Y, Pan B, Nist-Lund C, Galvin A, Lukashkin AN, Lukashkina VA, Chen T, Zhou W, Zhu H, Russell IJ, Holt JR, Géléoc GSG. Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1. Sci Rep. 2018 08 14; 8(1):12124. PMID: 30108254.
    Citations: 7     Fields:    Translation:AnimalsCells
  18. Nakanishi H, Kurima K, Pan B, Wangemann P, Fitzgerald TS, Géléoc GS, Holt JR, Griffith AJ. Tmc2 expression partially restores auditory function in a mouse model of DFNB7/B11 deafness caused by loss of Tmc1 function. Sci Rep. 2018 08 14; 8(1):12125. PMID: 30108230.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  19. Taylor RR, Filia A, Paredes U, Asai Y, Holt JR, Lovett M, Forge A. Regenerating hair cells in vestibular sensory epithelia from humans. Elife. 2018 07 18; 7. PMID: 30019672.
    Citations: 10     Fields:    Translation:HumansCells
  20. Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, Liberman MC, Kong WJ, Holt JR, Chen ZY, Liu DR. Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents. Nature. 2018 01 11; 553(7687):217-221. PMID: 29258297.
    Citations: 135     Fields:    Translation:HumansAnimalsCells
  21. Ahmed H, Shubina-Oleinik O, Holt JR. Emerging Gene Therapies for Genetic Hearing Loss. J Assoc Res Otolaryngol. 2017 Oct; 18(5):649-670. PMID: 28815315.
    Citations: 29     Fields:    Translation:HumansAnimals
  22. Koehler KR, Nie J, Longworth-Mills E, Liu XP, Lee J, Holt JR, Hashino E. Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells. Nat Biotechnol. 2017 06; 35(6):583-589. PMID: 28459451.
    Citations: 76     Fields:    Translation:HumansCells
  23. Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LH. A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear. Nat Biotechnol. 2017 03; 35(3):280-284. PMID: 28165475.
    Citations: 94     Fields:    Translation:AnimalsCells
  24. Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS. Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c. Nat Biotechnol. 2017 03; 35(3):264-272. PMID: 28165476.
    Citations: 95     Fields:    Translation:Animals
  25. Corey DP, Holt JR. Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells? J Neurosci. 2016 10 26; 36(43):10921-10926. PMID: 27798174.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  26. Shibata SB, Ranum PT, Moteki H, Pan B, Goodwin AT, Goodman SS, Abbas PJ, Holt JR, Smith RJH. RNA Interference Prevents Autosomal-Dominant Hearing Loss. Am J Hum Genet. 2016 06 02; 98(6):1101-1113. PMID: 27236922.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  27. Liu XP, Koehler KR, Mikosz AM, Hashino E, Holt JR. Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells. Nat Commun. 2016 05 24; 7:11508. PMID: 27215798.
    Citations: 35     Fields:    Translation:AnimalsCells
  28. Akyuz N, Holt JR. Plug-N-Play: Mechanotransduction Goes Modular. Neuron. 2016 Mar 16; 89(6):1128-1130. PMID: 26985721.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  29. Imtiaz A, Maqsood A, Rehman AU, Morell RJ, Holt JR, Friedman TB, Naz S. Recessive mutations of TMC1 associated with moderate to severe hearing loss. Neurogenetics. 2016 Apr; 17(2):115-123. PMID: 26879195.
    Citations: 16     Fields:    Translation:Humans
  30. Kurima K, Ebrahim S, Pan B, Sedlacek M, Sengupta P, Millis BA, Cui R, Nakanishi H, Fujikawa T, Kawashima Y, Choi BY, Monahan K, Holt JR, Griffith AJ, Kachar B. TMC1 and TMC2 Localize at the Site of Mechanotransduction in Mammalian Inner Ear Hair Cell Stereocilia. Cell Rep. 2015 Sep 08; 12(10):1606-17. PMID: 26321635.
    Citations: 75     Fields:    Translation:AnimalsCells
  31. Pan B, Holt JR. The molecules that mediate sensory transduction in the mammalian inner ear. Curr Opin Neurobiol. 2015 Oct; 34:165-71. PMID: 26218316.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  32. Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR. Tmc gene therapy restores auditory function in deaf mice. Sci Transl Med. 2015 Jul 08; 7(295):295ra108. PMID: 26157030.
    Citations: 103     Fields:    Translation:AnimalsCells
  33. Kawashima Y, Kurima K, Pan B, Griffith AJ, Holt JR. Transmembrane channel-like (TMC) genes are required for auditory and vestibular mechanosensation. Pflugers Arch. 2015 Jan; 467(1):85-94. PMID: 25074487.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  34. Géléoc GS, Holt JR. Sound strategies for hearing restoration. Science. 2014 May 09; 344(6184):1241062. PMID: 24812404.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  35. Horwitz GC, Risner-Janiczek JR, Holt JR. Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neurons. J Gen Physiol. 2014 Apr; 143(4):481-97. PMID: 24638995.
    Citations: 18     Fields:    Translation:AnimalsCells
  36. Holt JR, Pan B, Koussa MA, Asai Y. TMC function in hair cell transduction. Hear Res. 2014 May; 311:17-24. PMID: 24423408.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  37. Zou J, Zheng T, Ren C, Askew C, Liu XP, Pan B, Holt JR, Wang Y, Yang J. Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice. Hum Mol Genet. 2014 May 01; 23(9):2374-90. PMID: 24334608.
    Citations: 30     Fields:    Translation:AnimalsCells
  38. Yu WM, Appler JM, Kim YH, Nishitani AM, Holt JR, Goodrich LV. A Gata3-Mafb transcriptional network directs post-synaptic differentiation in synapses specialized for hearing. Elife. 2013 Dec 10; 2:e01341. PMID: 24327562.
    Citations: 35     Fields:    Translation:HumansCells
  39. Kim YH, Holt JR. Functional contributions of HCN channels in the primary auditory neurons of the mouse inner ear. J Gen Physiol. 2013 Sep; 142(3):207-23. PMID: 23980193.
    Citations: 19     Fields:    Translation:AnimalsCells
  40. Pan B, Géléoc GS, Asai Y, Horwitz GC, Kurima K, Ishikawa K, Kawashima Y, Griffith AJ, Holt JR. TMC1 and TMC2 are components of the mechanotransduction channel in hair cells of the mammalian inner ear. Neuron. 2013 Aug 07; 79(3):504-15. PMID: 23871232.
    Citations: 167     Fields:    Translation:AnimalsCells
  41. Holt JR, Vandenberghe LH. Gene therapy for deaf mice goes viral. Mol Ther. 2012 Oct; 20(10):1836-7. PMID: 23023054.
    Citations: 4     Fields:    Translation:Animals
  42. Geng R, Melki S, Chen DH, Tian G, Furness DN, Oshima-Takago T, Neef J, Moser T, Askew C, Horwitz G, Holt JR, Imanishi Y, Alagramam KN. The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene. J Neurosci. 2012 Jul 11; 32(28):9485-98. PMID: 22787034.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  43. Levin ME, Holt JR. The function and molecular identity of inward rectifier channels in vestibular hair cells of the mouse inner ear. J Neurophysiol. 2012 Jul; 108(1):175-86. PMID: 22496522.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  44. Kawashima Y, Géléoc GS, Kurima K, Labay V, Lelli A, Asai Y, Makishima T, Wu DK, Della Santina CC, Holt JR, Griffith AJ. Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. J Clin Invest. 2011 Dec; 121(12):4796-809. PMID: 22105175.
    Citations: 180     Fields:    Translation:AnimalsCells
  45. Horwitz GC, Risner-Janiczek JR, Jones SM, Holt JR. HCN channels expressed in the inner ear are necessary for normal balance function. J Neurosci. 2011 Nov 16; 31(46):16814-25. PMID: 22090507.
    Citations: 29     Fields:    Translation:Animals
  46. Steigelman KA, Lelli A, Wu X, Gao J, Lin S, Piontek K, Wodarczyk C, Boletta A, Kim H, Qian F, Germino G, Géléoc GS, Holt JR, Zuo J. Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells. J Neurosci. 2011 Aug 24; 31(34):12241-50. PMID: 21865467.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  47. Charizopoulou N, Lelli A, Schraders M, Ray K, Hildebrand MS, Ramesh A, Srisailapathy CR, Oostrik J, Admiraal RJ, Neely HR, Latoche JR, Smith RJ, Northup JK, Kremer H, Holt JR, Noben-Trauth K. Gipc3 mutations associated with audiogenic seizures and sensorineural hearing loss in mouse and human. Nat Commun. 2011 Feb 15; 2:201. PMID: 21326233.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  48. Lelli A, Kazmierczak P, Kawashima Y, Müller U, Holt JR. Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15. J Neurosci. 2010 Aug 25; 30(34):11259-69. PMID: 20739546.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  49. Horwitz GC, Lelli A, Géléoc GS, Holt JR. HCN channels are not required for mechanotransduction in sensory hair cells of the mouse inner ear. PLoS One. 2010 Jan 07; 5(1):e8627. PMID: 20062532.
    Citations: 18     Fields:    Translation:AnimalsCells
  50. Asai Y, Holt JR, Géléoc GS. A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea. J Assoc Res Otolaryngol. 2010 Mar; 11(1):27-37. PMID: 19834762.
    Citations: 18     Fields:    Translation:AnimalsCells
  51. Li H, Liu H, Corrales CE, Risner JR, Forrester J, Holt JR, Heller S, Edge AS. Differentiation of neurons from neural precursors generated in floating spheres from embryonic stem cells. BMC Neurosci. 2009 Sep 24; 10:122. PMID: 19778451.
    Citations: 11     Fields:    Translation:AnimalsCells
  52. Lelli A, Asai Y, Forge A, Holt JR, Géléoc GS. Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea. J Neurophysiol. 2009 Jun; 101(6):2961-73. PMID: 19339464.
    Citations: 95     Fields:    Translation:AnimalsCells
  53. Schwander M, Xiong W, Tokita J, Lelli A, Elledge HM, Kazmierczak P, Sczaniecka A, Kolatkar A, Wiltshire T, Kuhn P, Holt JR, Kachar B, Tarantino L, Müller U. A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5252-7. PMID: 19270079.
    Citations: 46     Fields:    Translation:AnimalsCells
  54. Collado MS, Holt JR. Can neurosphere production help restore inner ear transduction? Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):8-9. PMID: 19118205.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  55. Kesser BW, Hashisaki GT, Holt JR. Gene transfer in human vestibular epithelia and the prospects for inner ear gene therapy. Laryngoscope. 2008 May; 118(5):821-31. PMID: 18300702.
    Citations: 13     Fields:    Translation:HumansCells
  56. Stauffer EA, Holt JR. Sensory transduction and adaptation in inner and outer hair cells of the mouse auditory system. J Neurophysiol. 2007 Dec; 98(6):3360-9. PMID: 17942617.
    Citations: 37     Fields:    Translation:AnimalsCells
  57. Holt JR, Stauffer EA, Abraham D, Géléoc GS. Dominant-negative inhibition of M-like potassium conductances in hair cells of the mouse inner ear. J Neurosci. 2007 Aug 15; 27(33):8940-51. PMID: 17699675.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  58. Oshima K, Grimm CM, Corrales CE, Senn P, Martinez Monedero R, Géléoc GS, Edge A, Holt JR, Heller S. Differential distribution of stem cells in the auditory and vestibular organs of the inner ear. J Assoc Res Otolaryngol. 2007 Mar; 8(1):18-31. PMID: 17171473.
    Citations: 135     Fields:    Translation:AnimalsCells
  59. Risner JR, Holt JR. Heterogeneous potassium conductances contribute to the diverse firing properties of postnatal mouse vestibular ganglion neurons. J Neurophysiol. 2006 Nov; 96(5):2364-76. PMID: 16855108.
    Citations: 21     Fields:    Translation:AnimalsCells
  60. McGee J, Goodyear RJ, McMillan DR, Stauffer EA, Holt JR, Locke KG, Birch DG, Legan PK, White PC, Walsh EJ, Richardson GP. The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles. J Neurosci. 2006 Jun 14; 26(24):6543-53. PMID: 16775142.
    Citations: 88     Fields:    Translation:AnimalsCells
  61. Senften M, Schwander M, Kazmierczak P, Lillo C, Shin JB, Hasson T, Géléoc GS, Gillespie PG, Williams D, Holt JR, Müller U. Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells. J Neurosci. 2006 Feb 15; 26(7):2060-71. PMID: 16481439.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  62. Stauffer EA, Scarborough JD, Hirono M, Miller ED, Shah K, Mercer JA, Holt JR, Gillespie PG. Fast adaptation in vestibular hair cells requires myosin-1c activity. Neuron. 2005 Aug 18; 47(4):541-53. PMID: 16102537.
    Citations: 79     Fields:    Translation:AnimalsCells
  63. Géléoc GS, Risner JR, Holt JR. Developmental acquisition of voltage-dependent conductances and sensory signaling in hair cells of the embryonic mouse inner ear. J Neurosci. 2004 Dec 08; 24(49):11148-59. PMID: 15590931.
    Citations: 39     Fields:    Translation:AnimalsCells
  64. Corey DP, García-Añoveros J, Holt JR, Kwan KY, Lin SY, Vollrath MA, Amalfitano A, Cheung EL, Derfler BH, Duggan A, Géléoc GS, Gray PA, Hoffman MP, Rehm HL, Tamasauskas D, Zhang DS. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature. 2004 Dec 09; 432(7018):723-30. PMID: 15483558.
    Citations: 219     Fields:    Translation:AnimalsCells
  65. Géléoc GS, Holt JR. Developmental acquisition of sensory transduction in hair cells of the mouse inner ear. Nat Neurosci. 2003 Oct; 6(10):1019-20. PMID: 12973354.
    Citations: 74     Fields:    Translation:AnimalsCells
  66. Colclasure JC, Holt JR. Transduction and adaptation in sensory hair cells of the mammalian vestibular system. Gravit Space Biol Bull. 2003 Jun; 16(2):61-70. PMID: 12959133.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  67. Géléoc GS, Holt JR. Auditory amplification: outer hair cells pres the issue. Trends Neurosci. 2003 Mar; 26(3):115-7. PMID: 12591210.
    Citations: 10     Fields:    Translation:AnimalsCells
  68. Holt JR. Viral-mediated gene transfer to study the molecular physiology of the Mammalian inner ear. Audiol Neurootol. 2002 May-Jun; 7(3):157-60. PMID: 12053137.
    Citations: 13     Fields:    Translation:AnimalsCells
  69. Dumont RA, Zhao YD, Holt JR, Bähler M, Gillespie PG. Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia. J Assoc Res Otolaryngol. 2002 Dec; 3(4):375-89. PMID: 12486594.
    Citations: 38     Fields:    Translation:AnimalsCells
  70. Holt JR, Gillespie SK, Provance DW, Shah K, Shokat KM, Corey DP, Mercer JA, Gillespie PG. A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Cell. 2002 Feb 08; 108(3):371-81. PMID: 11853671.
    Citations: 134     Fields:    Translation:AnimalsCells
  71. Holt JR, Corey DP. Two mechanisms for transducer adaptation in vertebrate hair cells. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):11730-5. PMID: 11050202.
    Citations: 37     Fields:    Translation:AnimalsCells
  72. Holt JR, Vollrath MA, Eatock RA. Stimulus processing by type II hair cells in the mouse utricle. Ann N Y Acad Sci. 1999 May 28; 871:15-26. PMID: 10372060.
    Citations: 7     Fields:    Translation:AnimalsCells
  73. Holt JR. Biology in pictures. A sense of colour. Curr Biol. 1999 May 20; 9(10):R351. PMID: 10339436.
    Citations:    Fields:    Translation:AnimalsCells
  74. Holt JR, Johns DC, Wang S, Chen ZY, Dunn RJ, Marban E, Corey DP. Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. J Neurophysiol. 1999 Apr; 81(4):1881-8. PMID: 10200223.
    Citations: 26     Fields:    Translation:AnimalsCells
  75. Holt JR, Corey DP. Ion channel defects in hereditary hearing loss. Neuron. 1999 Feb; 22(2):217-9. PMID: 10069328.
    Citations: 6     Fields:    Translation:HumansAnimals
  76. Holt JR, Corey DP, Eatock RA. Mechanoelectrical transduction and adaptation in hair cells of the mouse utricle, a low-frequency vestibular organ. J Neurosci. 1997 Nov 15; 17(22):8739-48. PMID: 9348343.
    Citations: 35     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.