Harvard Catalyst Profiles

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Chen Shen, Ph.D.

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Biography
Peking University, ChinaPh.D.07/2015Structural biology
Peking University, ChinaPostdoc01/2017Structural biology/biochemistry
Harvard Medical School/Boston Children's Hospital, USPostdoc11/2021Structural biology/biochemistry/biophysics

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shen C, Li R, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S, Wu H. Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome. Cell. 2021 11 11; 184(23):5759-5774.e20. PMID: 34678144; PMCID: PMC8643277.
    Citations: 8     Fields:    Translation:AnimalsCells
  2. Shen C, Vohra M, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H, DiAntonio A, Milbrandt J. Multiple domain interfaces mediate SARM1 autoinhibition. Proc Natl Acad Sci U S A. 2021 01 26; 118(4). PMID: 33468661; PMCID: PMC7848697.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  3. Shen C, Sharif H, Xia S, Wu H. Structural and mechanistic elucidation of inflammasome signaling by cryo-EM. Curr Opin Struct Biol. 2019 10; 58:18-25. PMID: 31128494.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  4. Shen C, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM, Wu H. Molecular mechanism for NLRP6 inflammasome assembly and activation. Proc Natl Acad Sci U S A. 2019 02 05; 116(6):2052-2057. PMID: 30674671; PMCID: PMC6369754.
    Citations: 32     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.