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Last Name

profileMargaret McLaughlin-Drubin, Ph.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
AddressBrigham and Women's Hospital
Infectious Diseases
181 Longwood Ave
Boston MA 02115
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K01CA143010     (MCLAUGHLIN-DRUBIN, MARGARET ERIN)Sep 21, 2010 - Sep 30, 2013
Epigenetic Reprogramming by the Human Papillomavirus E7 Oncoprotein
Role: Principal Investigator

F32CA121771     (MCLAUGHLIN-DRUBIN, MARGARET ERIN)Jun 6, 2006 - Jun 5, 2007
Role of HPV16 E7/E2F6 interaction in viral oncogenesis
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. McLaughlin-Drubin ME. Human papillomaviruses and non-melanoma skin cancer. Semin Oncol. 2015 Apr; 42(2):284-90. PMID: 25843732.
    View in: PubMed
  2. Xylas J, Varone A, Quinn KP, Pouli D, McLaughlin-Drubin ME, Thieu HT, Garcia-Moliner ML, House M, Hunter M, Munger K, Georgakoudi I. Noninvasive assessment of mitochondrial organization in three-dimensional tissues reveals changes associated with cancer development. Int J Cancer. 2015 Jan 15; 136(2):322-32. PMID: 24862444.
    View in: PubMed
  3. Varone A, Xylas J, Quinn KP, Pouli D, Sridharan G, McLaughlin-Drubin ME, Alonzo C, Lee K, Münger K, Georgakoudi I. Endogenous two-photon fluorescence imaging elucidates metabolic changes related to enhanced glycolysis and glutamine consumption in precancerous epithelial tissues. Cancer Res. 2014 Jun 1; 74(11):3067-75. PMID: 24686167.
    View in: PubMed
  4. Munger K, Gwin TK, McLaughlin-Drubin ME. p16 in HPV-associated cancers. Oncotarget. 2013 Nov; 4(11):1864-5. PMID: 24192550; PMCID: PMC3875753.
  5. McLaughlin-Drubin ME, Park D, Munger K. Tumor suppressor p16INK4A is necessary for survival of cervical carcinoma cell lines. Proc Natl Acad Sci U S A. 2013 Oct 1; 110(40):16175-80. PMID: 24046371; PMCID: PMC3791710.
  6. McLaughlin-Drubin ME, Munger K. Biochemical and functional interactions of human papillomavirus proteins with polycomb group proteins. Viruses. 2013 May; 5(5):1231-49. PMID: 23673719; PMCID: PMC3712305.
  7. Herfs M, Yamamoto Y, Laury A, Wang X, Nucci MR, McLaughlin-Drubin ME, Münger K, Feldman S, McKeon FD, Xian W, Crum CP. A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer. Proc Natl Acad Sci U S A. 2012 Jun 26; 109(26):10516-21. PMID: 22689991; PMCID: PMC3387104.
  8. McLaughlin-Drubin ME, Meyers J, Munger K. Cancer associated human papillomaviruses. Curr Opin Virol. 2012 Aug; 2(4):459-66. PMID: 22658985; PMCID: PMC3422426.
  9. Levitt JM, McLaughlin-Drubin ME, Münger K, Georgakoudi I. Automated biochemical, morphological, and organizational assessment of precancerous changes from endogenous two-photon fluorescence images. PLoS One. 2011; 6(9):e24765. PMID: 21931846; PMCID: PMC3170385.
  10. McLaughlin-Drubin ME, Crum CP, Münger K. Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming. Proc Natl Acad Sci U S A. 2011 Feb 1; 108(5):2130-5. PMID: 21245294; PMCID: PMC3033314.
  11. McLaughlin-Drubin ME, Münger K. Oncogenic activities of human papillomaviruses. Virus Res. 2009 Aug; 143(2):195-208. PMID: 19540281; PMCID: PMC2730997.
  12. McLaughlin-Drubin ME, Münger K. The human papillomavirus E7 oncoprotein. Virology. 2009 Feb 20; 384(2):335-44. PMID: 19007963; PMCID: PMC2661820.
  13. Nguyen CL, McLaughlin-Drubin ME, Münger K. Delocalization of the microtubule motor Dynein from mitotic spindles by the human papillomavirus E7 oncoprotein is not sufficient for induction of multipolar mitoses. Cancer Res. 2008 Nov 1; 68(21):8715-22. PMID: 18974113; PMCID: PMC2597155.
  14. McLaughlin-Drubin M, Münger K. The human papillomavirus type 8 E2 gene encodes a transforming activity sufficient for skin tumor formation in transgenic mice. J Invest Dermatol. 2008 Sep; 128(9):2142-4. PMID: 18695686.
    View in: PubMed
  15. McLaughlin-Drubin ME, Huh KW, Münger K. Human papillomavirus type 16 E7 oncoprotein associates with E2F6. J Virol. 2008 Sep; 82(17):8695-705. PMID: 18579589; PMCID: PMC2519642.
  16. Nguyen, CL McLaughlin-Drubin, ME Munger, K. Human Papillomaviruses and Associated Malignancies. Human Oncogenic Viruses. 2008.
  17. McLaughlin-Drubin ME, Munger K. Viruses associated with human cancer. Biochim Biophys Acta. 2008 Mar; 1782(3):127-50. PMID: 18201576; PMCID: PMC2267909.
  18. Levitt JM, Hunter M, Mujat C, McLaughlin-Drubin M, Münger K, Georgakoudi I. Diagnostic cellular organization features extracted from autofluorescence images. Opt Lett. 2007 Nov 15; 32(22):3305-7. PMID: 18026288.
    View in: PubMed
  19. Drubin DA, McLaughlin-Drubin ME, Clawson GA, Meyers C. A protease inhibitor specifically inhibits growth of HPV-infected keratinocytes. Mol Ther. 2006 Jun; 13(6):1142-8. PMID: 16564747.
    View in: PubMed
  20. McLaughlin-Drubin ME, Bromberg-White JL, Meyers C. The role of the human papillomavirus type 18 E7 oncoprotein during the complete viral life cycle. Virology. 2005 Jul 20; 338(1):61-8. PMID: 15921717.
    View in: PubMed
  21. Sen E, McLaughlin-Drubin M, Meyers C. Efficacy of two commercial preparations of interferon-alpha on human papillomavirus replication. Anticancer Res. 2005 Mar-Apr; 25(2A):1091-100. PMID: 15868951.
    View in: PubMed
  22. Alam S, Bromberg-White J, McLaughlin-Drubin M, Sen E, Bodily JM, Meyers C. Activity and therapeutic potential of ORI-1001 antisense oligonucleotide on human papillomavirus replication utilizing a model of dysplastic human epithelium. Anticancer Res. 2005 Mar-Apr; 25(2A):765-77. PMID: 15868908.
    View in: PubMed
  23. McLaughlin-Drubin ME, Meyers C. Propagation of infectious, high-risk HPV in organotypic "raft" culture. Methods Mol Med. 2005; 119:171-86. PMID: 16350404.
    View in: PubMed
  24. McLaughlin-Drubin ME, Christensen ND, Meyers C. Propagation, infection, and neutralization of authentic HPV16 virus. Virology. 2004 May 1; 322(2):213-9. PMID: 15110519.
    View in: PubMed
  25. McLaughlin-Drubin ME, Meyers C. Evidence for the coexistence of two genital HPV types within the same host cell in vitro. Virology. 2004 Apr 10; 321(2):173-80. PMID: 15051378.
    View in: PubMed
  26. McLaughlin-Drubin ME, Wilson S, Mullikin B, Suzich J, Meyers C. Human papillomavirus type 45 propagation, infection, and neutralization. Virology. 2003 Jul 20; 312(1):1-7. PMID: 12890615.
    View in: PubMed
  27. McLaughlin-Drubin, ME. Development of Genetic Systems to Study the Differentiation-Dependent Life Cycle of Human Papillomaviruses. 2003.
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